Post on 16-Jul-2015
BIOCHEMISTRY II
COMPOSED BY :EKA GUNARTI NINGSIH
(RSA1C111005)ELIS YULIAWATI
(RSA1C111006)
XENOBIOTIC
Copyright : Buku Ajar Biokimia Mahasiswa Kedokteran. 2011
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
H + O2 + NADPH + H+ R—OH + H2O + NADP
Copyright : Buku Ajar Biokimia Mahasiswa Kedokteran. 2011
Reaksi Epoksidasi dan
hidroksilasi
Reaksi
Deaminasi
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
Four primary enzymes:
1. Glucuronosyltransferase—glucuronic acid
2. Sulfotransferase—sulfate
3. Glutathione-S-transferase—glutathione (GSH)
4. Acetyltransferase—acetyl
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
Copyright 2008, The Johns Hopkins University and Michael A. Trush.
R+GSH R-S-G
ASETILASI
Copyright : www.issx.org
METILASI
Copyright : www.issx.org
PRIMER SEKUNDER TERSIER
ALKILASITERBENTUKNYA
RADIKAL BEBAS
TOKSISITAS OKSIGEN
CARA KERUSAKAN SEL
CEDERA SEL
MUTASI GEN
Faktor Yang Mempengaruhi
1. Faktor Genetik
2. Faktor Lingkungan
3. Umur dan Jenis Kelamin
4. Interaksi antara Xenobiotik dengan Senyawa Endogen
ANY QUESTION??