BIOCHEMISTRY II

COMPOSED BY :EKA GUNARTI NINGSIH

(RSA1C111005)ELIS YULIAWATI

(RSA1C111006)

XENOBIOTIC

Copyright : Buku Ajar Biokimia Mahasiswa Kedokteran. 2011

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

H + O2 + NADPH + H+ R—OH + H2O + NADP

Copyright : Buku Ajar Biokimia Mahasiswa Kedokteran. 2011

Reaksi Epoksidasi dan

hidroksilasi

Reaksi

Deaminasi

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

Four primary enzymes:

1. Glucuronosyltransferase—glucuronic acid

2. Sulfotransferase—sulfate

3. Glutathione-S-transferase—glutathione (GSH)

4. Acetyltransferase—acetyl

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

Copyright 2008, The Johns Hopkins University and Michael A. Trush.

R+GSH R-S-G

ASETILASI

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METILASI

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PRIMER SEKUNDER TERSIER

ALKILASITERBENTUKNYA

RADIKAL BEBAS

TOKSISITAS OKSIGEN

CARA KERUSAKAN SEL

CEDERA SEL

MUTASI GEN

Faktor Yang Mempengaruhi

1. Faktor Genetik

2. Faktor Lingkungan

3. Umur dan Jenis Kelamin

4. Interaksi antara Xenobiotik dengan Senyawa Endogen

ANY QUESTION??