Reactions 1478, p36 - 16 Nov 2013

STerbinafine

Subacute cutaneous lupus erythematosus: 2 casereports

Two women, aged 43 years and 53 years, developedsubacute cutaneous lupus erythematosus (SCLE) whilereceiving terbinafine.

The younger woman, who had a history of systemic lupuserythematosus (SLE) controlled with methylprednisolone, wasadmitted with annular skin lesions, located mainly on theupper part of her body. The skin lesions had developed8 weeks after starting oral terbinafine 250mg daily foronychomycosis of the toe nails. Terbinafine was withdrawn,while methylprednisolone was continued and mometasonewas added. The lesions improved within 3 weeks.

The older woman, who had a history of SLE controlled withmethylprednisolone, was admitted due to severeerythematous lesions forming an annular arrangement on hertrunk and limbs. The lesions had developed 3 weeks afterstarting oral terbinafine 250mg daily for nail tinea. Terbinafinehad been withdrawn 3 days before admission.Methylprednisolone was increased and hydrocortisone wasadded. After 2 weeks, the skin lesions significantly improved,and methylprednisolone was reduced. The skin lesions clearedwithin the next 2 weeks.

Author comment: "In this article we report two womenwith a many years’ history of SLE who developed SCLE afteradministering terbinafine."Kalinska-Bienias A, et al. Terbinafine-induced subacute cutaneous lupuserythematosus in two patients with systemic lupus erythematosus successfullytreated with topical corticosteroids. Postepy Dermatologii i Alergologii 30:261-264, No. 4, 2013. Available from: URL: http://dx.doi.org/10.5114/pdia.2013.37038 - Poland 803095693

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Reactions 16 Nov 2013 No. 14780114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved