44

Lampiran 1. Surat keterangan determinasi daun pepaya

45

Lanjutan lampiran 1

46

Lampiran 2. Gambar pohon pepaya yang digunakan untuk penelitian

47

Lampiran 3. Hasil uji saponin pada serbuk daun pepaya

48

Lampiran 4. Gambar tablet pada berbagai formula

49

Lampiran 5. Perhitungan bobot setiap eksipien

a. Gelatin

0,416% =

x 800 = 3,33 mg

0,832% =

x 800 = 6,66 mg

b. Explotab

2% =

x 800 = 16 mg

8% =

x 800 = 64 mg

c. Talk

6% =

x 800 = 48 mg

d. Avicel 101

F1 = 800 - (327+3,33+16+48)mg = 405,67 mg

F2 = 800 - (327+6,66+16+48)mg = 402,34 mg

F3 = 800 - (327+3,33+64+48)mg = 357,67 mg

F4 = 800 - (327+6,66+64+48)mg = 354,34 mg

50

Lampiran 6. Hasil uji sifat fisik granul

a. Kecepatan alir

Replikasi F 1

(g/detik)

F 2

(g/detik)

F 3

(g/detik)

F 4

(g/detik)

1 12,75 10,88 12,66 12,37

2 12,82 10,99 13,03 11,8

3 12,78 11,42 12,75 11,9

Rata-rata 12,78333 11,09667 12,81333 12,02333

SD 0,035119 0,285365 0,192959 0,304357

b. Sudut diam

Replikasi F 1 (0) F 2 (

0) F 3 (

0) F 4 (

0)

1 33,15 31,83 34,1 32,57

2 32,65 33,49 34,23 33,57

3 33,07 33,31 34,48 33,7

Rata-rata 32,95667 32,87667 34,27 33,28

SD 0,268576 0,910897 0,193132 0,618304

c. Pengetapan

Replikasi F 1 (%) F 2 (%) F 3 (%) F 4 (%)

1 7 7 9 6

2 8 10 8 7

3 6 8 6 7

Rata-rata 7 8,333333 7,666667 6,666667

SD 1 1,527525 1,527525 0,57735

d. Kadar air

F 1 (%) F 2 (%) F 3 (%) F 4 (%)

2,50 6,00 3,00 3,50

51

Lampiran 7. Hasil uji sifat fisik tablet

a. Keseragaman bobot

Nomor F 1 F 2 F 3 F 4

1 794,7 772 781 797,8

2 799,3 764,8 792,4 798,4

3 797,3 771,2 796,3 780,7

4 795,3 771,4 782,3 786,8

5 798,8 777,2 796,4 792,8

6 795 775 791,9 796,8

7 797,8 776,5 797,4 779,1

8 799,2 767,5 796,4 792,6

9 793,4 764,1 798 796,8

10 794 776,5 790,5 785

11 794 771,1 794,7 787,2

12 796,9 766,9 791,1 785,4

13 795,9 767,9 796 796

14 794,4 763 794,8 778,5

15 796,7 778 794,3 790,8

16 791 778,2 799,9 799,7

17 797 767,2 784 797,6

18 795,1 768,3 788,8 789,5

19 794,2 771,2 791,2 785,2

20 797,8 776,1 791,2 799,8

Rata-rata 795,89 771,205 792,43 790,825

SD 2,161359 4,880948 5,187749 7,013061

CV 0,27 0,63 0,65 0,89

b. Kekerasan

Nomor F 1 (kg) F 2 (kg) F 3 (kg) F 4 (kg)

1 6,91 3,77 8,35 7,5

2 7,57 3,69 8,17 7,96

3 7,57 3,52 8,15 7,44

4 7,5 3,85 7,62 6,99

5 7,51 3,35 8,24 7,63

Rata-rata 7,412 3,636 8,106 7,504

SD 0,282524 0,201196 0,282719 0,350756

52

Lanjutan lampiran 7

c. Kerapuhan

Replikasi F 1 (%) F 2 (%) F 3 (%) F 4 (%)

1 0,19 0,36 0,24 0,19

2 0,22 0,4 0,16 0,21

3 0,18 0,41 0,17 0,23

Rata-rata 0,196667 0,39 0,19 0,21

SD 0,020817 0,026458 0,043589 0,02

d. Waktu hancur

Replikasi F 1

(menit)

F 2

(menit)

F 3

(menit)

F 4

(menit)

1 15 12 19 15

2 14 10 20 16

3 12 11 18 15

Rata-rata 1,527525 1 1 0,57735

SD 13,66667 11 19 15,33333

53

Lampiran 8. Hasil pemeriksaan sifat fisik granul dengan metode factorial

design

a. Kecepatan alir

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 12.18 1

A-gelatin -0.62 1 1.00

B-explotab 0.24 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

kecepatan alir = +12.18

-0.62 * A

+0.24 * B

+0.22 * A * B

Final Equation in Terms of Actual Factors:

kecepatan alir = +14.74667

-0.59359 * gelatin

-0.017917 * explotab

+5.56807E-003 * gelatin * explotab

b. Sudut diam

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 33.35 1

A-gelatin -0.27 1 1.00

B-explotab 0.43 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

sudut diam = +33.35

-0.27 * A

+0.43 * B

-0.23 * A * B

Final Equation in Terms of Actual Factors:

sudut diam = +32.30000

+0.067067 * gelatin

+0.046250 * explotab

-5.69319E-003 * gelatin * explotab

54

Lanjutan lampiran 8

c. Pengetapan

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 7.42 1

A-gelatin 0.083 1 1.00

B-explotab -0.25 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

pengetapan = +7.42

+0.083 * A

-0.25 * B

-0.58 * A * B

Final Equation in Terms of Actual Factors:

pengetapan = +4.67000

+0.63263 * gelatin

+0.062500 * explotab

-0.014577 * gelatin * explotab

d. Kadar air

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 3.75 1

A-gelatin 1.00 1 1.00

B-explotab -0.50 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

kadar air = +3.75

+1.00 * A

-0.50 * B

-0.75 * A * B

Final Equation in Terms of Actual Factors:

kadar air = -2.16667

+1.35135 * gelatin

+0.072917 * explotab

-0.018769 * gelatin * explotab

55

Lampiran 9. Hasil pemeriksaan sifat fisik tablet dengan metode factorial

design

a. Keseragaman bobot

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 0.61 1

A-gelatin 0.15 1 1.00

B-explotab 0.16 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

keseragaman bobot = +0.61

+0.15 * A

+0.16 * B

-0.030 * A * B

Final Equation in Terms of Actual Factors:

keseragaman bobot = -0.25667

+0.12012 * gelatin

+0.010417 * explotab

-7.50751E-004 * gelatin * explotab

b. Kekerasan

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 6.67 1

A-gelatin -1.09 1 1.00

B-explotab 1.14 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

kekerasan = +6.67

-1.09 * A

+1.14 * B

+0.79 * A * B

Final Equation in Terms of Actual Factors:

kekerasan = +12.00000

-1.44845 * gelatin

-0.051250 * explotab

+0.019770 * gelatin * explotab

56

Lanjutan lampiran 9

c. Kerapuhan

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 0.25 1

A-gelatin 0.052 1 1.00

B-explotab -0.048 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

kerapuhan = +0.25

+0.052 * A

-0.048 * B

-0.042 * A * B

Final Equation in Terms of Actual Factors:

kerapuhan = -0.043333

+0.074074 * gelatin

+3.33333E-003 * explotab

-1.06356E-003 * gelatin * explotab

d. Waktu hancur

Factor Coefficient

Estimate

df Standard

Error

95% Cl

Low

95% Cl

High

VIF

Intercept 14.75 1

A-gelatin -1.58 1 1.00

B-explotab 2.42 1 1.00

AB0.22 1 1.00

Final Equation in Terms of Coded Factors:

waktu hancur = +14.75

-1.58 * A

+2.42 * B

-0.25 * A * B

Final Equation in Terms of Actual Factors:

waktu hancur = +14.23000

-0.70170 * gelatin

+0.13188 * explotab

-6.25626E-003 * gelatin * explotab

57

Lampiran 10. Hasil statisitik uji antara formula 1 dengan formula optimum

One-Sample Statistics

N Mean Std. Deviation Std. Error Mean

FORMULA1 8 9.6100 10.75277 3.80168

FORMULAOPTIMUM 8 9.5963 10.75220 3.80148

One-Sample Test

Test Value = 2

95% Confidence Interval of the

Difference

t df Sig. (2-tailed)

Mean Difference Lower Upper

FORMULA1 2.002 7 .085 7.61000 -1.3795 16.5995

FORMULAOPTIMUM 1.998 7 .086 7.59625 -1.3928 16.5853