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SYNERGIZING TO NEW HEIGHTS IN HEALTH

FINAL PROGRAM

JULY 10 -13, 2022 | TORONTO, C ANADASHER ATON CENTRE TORONTO HOTEL

ANNUAL CONFERENCE & EXHIBITION

TABLE OFCONTENTSWelcome ........................................................................................................................... 3

Sponsors ............................................................................................................................ 6

General Information ............................................................................................................. 9

SYIS Activities ............................................................................................................... 10

Floorplans .................................................................................................................... 14

TERMIS- AM Council, Staff, Committees, and Reviewers .................................................... 15

TWIG and Committee Meetings ...................................................................................... 16

Awards ........................................................................................................................ 16

Programs ............................................................................................................................ 18

Sunday, July 10:.............................................................................................................. 18

Monday, July 11:............................................................................................................. 20

Tuesday, July 12: ............................................................................................................ 30

Wednesday, July 13: ....................................................................................................... 34

Poster Sessions .................................................................................................................. 40

Author Index ..................................................................................................................... 67

Exhibitor Listing ................................................................................................................. 71

DEAR COLLEAGUES,

It’s wonderful to be back in person and to welcome you, on behalf of our Council, to Toronto, Ontario, Canada for the 2022 Tissue Engineering and Regenerative Medicine International Society – Americas Chapter Annual Meeting. This year’s conference is being organized by Professors Alison McGuigan, Penney Gilbert, both from the University of Toronto, and Carlos Aguilar, from the University of Michigan.

These three stellar conference chairs stayed together throughout the pandemic to deliver what we hope you agree is a fantastic and rich scientific conference, “Synergizing to New Heights in Health.” This theme of synergy reflects the multitude of disciplines that need to come together to achieve success in our goals to regenerate tissues, understand the underlying biology and chemistry, and ultimately make a difference to human health.

Our goal with this conference is to expand our knowledge, share new insights and bring back some fun, with casual conversations, shared dinners, students and young investigators (SYIS) activities. We encourage you to actively participate in all aspects of the meeting: sessions, workshops, and networking. Each year, SYIS plans great events from professional to fun networking, such as the student-meet-mentor lunch, career panel discussion, supports the sharing of outstanding student research through travel and achievement awards, and facilitates student participation with conference leadership. These events provide you with an opportunity to meet with your mentors and peers one-on-one.

We look forward to your contribution to the program and hope that you will enjoy the conference and the city of Toronto.

SINCERELY,

Molly Shoichet, PhD, O.C., O.OntTERMIS-AM Chapter PresidentUniversity Professor, University of Toronto

DEAR TERMIS-AM 2022 PARTICIPANTS,

Our TERMIS-AM 2022 meeting is remarkably important and worthwhile in so many ways. As we emerge a few years of challenging constraints on face-to-face meetings, I am particularly delighted that this is our first TERMIS-AM meeting since before the pandemic. As we return to a more traditional style of meeting, I acknowledge Prof. Molly Shoichet’s leadership as TERMIS-AM Chapter Chair and thank all the TERMIS-AM team for their ongoing work and making it possible for us to meet in Toronto.

TERMIS is the most prominent organisation in the field of tissue engineering and regenerative medicine globally. Among its activities, TERMIS promotes education, research, innovation, clinical translation and social responsibility within the field of tissue engineering and regenerative medicine through regular meetings, training courses, scientific and lay publications, outreach activities and more. TERMIS provides an important international forum for the informed discussion and debate of achievements and challenges of tissue engineering and regenerative medicine therapies.

TERMIS relies on countless contributions by outstanding people who freely give of their time and skills to help our not-for-profit Society. Through its three Chapters, TERMIS functions to broadcast superb tissue engineering and regenerative medicine for the broader benefit of the world. I thank our remarkable and indispensable Sarah Wilburn, fine Chapter Chairs and TERMIS officers, dedicated committees, students and young investigators, our countless volunteers, our members, supporters, industry partners, donors, and more. All of you help to strengthen TERMIS, for now and in the many years ahead.

As participants, you are so fortunate to enjoy Toronto. It is a beautiful setting for a special meeting. A double thank you to Prof. Alison McGuigan, Prof. Penney Gilbert and Prof. Carlos Aguilar and your teams for your hard work towards this fine conference.

I wish you all the very best. Renew your friendships, discover new colleagues, share experiences, discuss exciting discoveries, and contribute to a better world. Enjoy our TERMIS-AM meeting and make sure you celebrate in this great city!

Professor Tony WeissTERMIS Global President

WELCOME TO TISSUE ENGINEERING & REGENERATIVE MEDICINE2022 ANNUAL CONFERENCE AND EXPOSITION

3TERMIS-AM • FINAL PROGRAM


ABOUTTHE SOCIETY

PROGRAM OVERVIEW

THE SOCIETY HAS UPDATED ITS MISSION AS FOLLOWS:

Advancing tissue engineering & regenerative medicine worldwide to generate knowledge with a view to improving patient outcomes globally

Our international community strives to achieve our mission through

» Best practice in governance

» Providing forums for dissemination of knowledge

» Interacting with diversified expertise, topics & culture

» Advancing basic, translational & clinical research

» Supporting our “Student and Young Investigator Sections” (SYIS)

» Advocating for public policies

OUR CORE VALUES ARE:

Honesty; Respect; Scientific Excellence; Integrity; Collaboration; Society Responsibility; Diversity; Transparency.

Welcome to the 2022 TERMIS-AM annual meeting!

We are so excited to welcome you to sunny Toronto for the first TERMIS-AM meeting since 2019! We are proud of the exciting schedule our team of scientific session workshops and special event organizers have put together to bring you the best education and networking you expect from a TERMIS conference! Our three internationally-renowned plenary speakers, fireside chat on commercialization, and 32 abstract-based sessions will show you the latest in TERM techniques and technology, all while taking advantage of the diversity and culture that Toronto offers in the summer months. Partake in a SYIS career panel, join the conversation on regenerative medicine from an indigenous perspective, enjoy a beverage while perusing poster sessions, or visit a local lab during an offsite trip – we’ve got something for everyone! We hope that everyone will enjoy outstanding science and a chance to reconnect with old colleagues and connect with new ones after so much time apart.

Looking forward to engaging with all of you!

Alison McGuigan, Penney Gilbert, Carlos AguilarProgram Co-Chairs

Toronto is located on the traditional lands of the Anishinaabe, Haudenosaunee, Huron-Wendat and Mississaugas of the New Credit. We are grateful for the opportunity to host the 2022 TERMIS-AM conference on this land.


GOLD:

SILVER:

BRONZE:

TERMIS 2022 SPONSORS


TERMIS 2022 SPONSORS

EXHIBITORS:

MEETING SUPPORTERS:

SYIS Events & AwardsSponsors

Women in TERMSponsors

SessionSponsors

GENERAL INFORMATIONAll sessions of the meeting, including exhibits, posters and oral presentations will take place at the Sheraton Centre Toronto Hotel. Photographs and/or videos of any slide or poster presentation are strictly prohibited.

REGISTRATION Vide Foyer

All attendees are expected to register for the meeting. Registration fees include: admittance to all scientific sessions, panel discussions, exhibits, opening reception, poster and exhibition reception and the Conference Reception.

Onsite Registration Hours:

Sunday, July 10, 2022 8:00 AM – 8:30 PM

Monday, July 11, 2022 6:00 AM – 7:30 PM

Tuesday, July 12, 2022 6:00 AM – 7:30 PM

Wednesday, July 13, 2022 7:00 AM – 12:00 PM

MOTHER’S ROOM INFORMATIONVide Office

This is a private, lockable room with a refrigerator for nursing and pumping mothers available from Sunday, July 10 to Wednesday, July 13 during registration hours. Please note, TERMIS-AM is not liable for any unusable items due to a refrigerator malfunction should one occur.

EXHIBIT HOURSSheraton Hall A - F

Sunday, July 10, 2022 | 6:30 PM – 8:30 PM

Welcome Reception/Poster Session 1 6:30 PM – 8:30 PM

Monday, July 11, 2022 | 9:30 AM – 9:00 PM

Morning Break 9:30 AM – 10:00 AM

Afternoon Break 4:15 PM – 4:45 PM

Evening Reception/Poster Session 2 7:00 PM – 9:00 PM

Tuesday, July 12, 2022 | 9:30 AM – 6:30 PM

Morning Break 9:30 AM – 1:00 AM

Afternoon Break 2:30 PM – 3:00 PM

Evening Reception/Poster Session 3 4:30 PM – 6:30 PM

POSTER SESSIONSThe Poster Sessions are an important educational event of this meeting. We hope you support and attend these scientific presentations. All poster presentations will be held in Sheraton Hall A – F. All posters presentations have been assigned a chronological poster number for reference online or in the mobile app. Posters may be viewed during the entire meeting, and authors will be present during the exhibit poster session times.

Sunday, July 10

Poster Set-up 3:30 PM – 5:30 PM

Welcome Reception with Posters 6:30 PM – 8:30 PM

Poster Breakdown Immediately following the end of the Reception.


Monday, July 11


Poster and Exhibit Reception 7:00 PM – 9:00 PM

Poster Breakdown Immediately following the end of the Reception

Tuesday, July 12


Poster and Exhibit Reception 4:30 PM – 6:30 PM

Poster Breakdown Immediately following the end of the Reception

All authors should be present during poster sessions.

OPENING RECEPTIONTake this opportunity to meet and network with fellow attendees, old friends, and new acquaintances before seeing what Orlando has to offer. The Opening Reception will take place in Sheraton Hall A – F, Sunday evening from 6:30 PM – 8:30 PM. This event is included in the registration fee.

CONFERENCE RECEPTION Join your colleagues for the 2022 Evening Conference Reception located in the Grand Ballroom Foyer. This reception will be held on Tuesday, July 12 from 6:30 PM – 8:30 PM. This event is included in the registration fee.

SPEAKER READY ROOMThe Speaker Ready Room is located in VIP Room of the hotel. The Speaker Ready Room is provided for presenters to prepare for their presentations and to ensure a seamless integration of a wide variety of audiovisual technologies in the various meeting rooms. All speakers are required to check their presentation into the speaker ready room at least 2 hours before their presentation.

Speaker Ready Room Hours:

Sunday, July 10, 2022 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 AM – 6:30 PM

Monday, July 11, 2022 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6:00 AM – 6:00 PM

Tuesday, July 12, 2022 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6:00 AM – 4:00 PM

Wednesday, July 13, 2022 . . . . . . . . . . . . . . . . . . . . . . . . 7:00 AM – 11:15 AM

WIFI InstructionsNetwork Name: TERMISAM2022

Password: HTLBiotechnology

Note: This network access is only available in the TERMIS-AM meeting space & exhibit hall.

Downnload the

FREE TERMIS - AMANNUAL CONFERENCE APP

Your one-stop source for maps, schedules, exhibitor

listings and more. Navigate and communicate at the

meeting easier than ever before directly from your

mobile device!

1. Download the event app by EventsAir

1. Type in the Event app code: TERMISAM2022

2. Sign in using your email address and app pin

emailed to you

NEED [email protected]

IOS Android


SYIS ACTIVITIES Some events are ticketed. Events have limited capacity, and admission is on a first-come, first-serve basis.

SYIS SOCIAL Date: Monday, July 11, 2022

Time: 8:30 PM – 9:30 PM

Location: Civic Ballroom North/Civic Ballroom Foyer, 2nd Floor

Availability: Ticketed Event

After the first full day of the conference, this reception is for the students and young investigators to mix and mingle, learn about opportunities to be involved with the organization, and hear an overview of the student events.

SYIS MORNING WALK/RUNDate: Tuesday, July 12, 2022

Time: 6:15 AM – 7:30 AM

Location: Civic Ballroom North/Civic Ballroom Foyer, 2nd Floor

Availability: No restrictions

Enjoy the lovely summer weather Toronto has to offer with the SYIS Morning Walk/Run. This event is for anyone (students, young investigators, and faculty) who wants to wake up and exercise at their leisure before a full day of learning. Participants can meet at Civic Ballroom North and a light breakfast will be provided.

STUDENT-MEET-LUNCHDate: Tuesday, July 12, 2022

Time: 11:30 AM - 1:00 PM

Location: Civic Ballroom South, 2nd Floor

Availability: Ticketed Event

The Student-Meet-Mentor Lunch gives students and young investigators the opportunity to enjoy an invigorating plated lunch with faculty mentors and leaders of the Tissue Engineering and Regenerative Medicine fields. Mentors include session chairs, members of the Scientific Advisory Committee, and local industry leaders.

GENERAL INFORMATION

CAREER PANEL DISCUSSIONDate: Wednesday, July 13, 2022

Time: 11:30 AM - 1:00 PM

Location: Osgoode Ballroom

Availability: 100 members

This discussion panel will consist of young professionals representing careers in academia, industry, government agencies and institutes, and entrepreneurial activities. This is a great opportunity for students and young investigators to hear the recent experiences of these scientists in choosing their career paths, the opportunities, and challenges of their chosen career, and providing advice on how you can achieve your career goals. This interactive panel is designed to facilitate open discussion, and to allow students and young investigators to have their questions answered by the panel and other attendees. At previous meetings, this event has been very beneficial for students and young investigators thinking about pursuing a career in any of these fields.

Meet-the-FTERM MembersDate: Tuesday, July 12, 2022

Time: 9:30 AM - 10:30 AM OR 4:30 PM - 6:30 PM

Location: FTERM booth in exhibit hall (Sheraton A - F)

Availability: No restrictions

Meet with a TERMIS expert (TERM investigator or leading scientist) outside of your institution.


GENERAL INFORMATION

TOP FOUR SYIS ABSTRACT PRESENTATIONS

1Ex Vivo Gene Therapy Of Skin Cells And Autologous Bilayered

Skin Substitutes As A Potential Treatment For Recessive

Dystrophic Epidermolysis Bullosa Skin Wounds

Martin Barbier

Monday, July 11, 2022

Scientific Session 1: Skin, Wound Healing, and Inflammation

Part 1

10:00 AM - 11:30 AM

Presentation Time: 10:30 AM – 10:45 AM

45A Decellularized Cartilage Biomaterials Approach To Pediatric

Laryngotracheal Reconstruction

Paul Gehret


Scientific Session 11: Respiratory, Urologic, & Gastrointestinal

Tissue

2:45 PM - 4:15 PM

Presentation Time: 2:45 PM – 3:00 PM

62Generation Of Tracheal Grafts In A Bioreactor With Human

Induced Pluripotent Stem Cell–Derived Airway Progenitors

Sara Rostami


Scientific Session 13: Recent Progress in Cell Therapy for

Regenerative Medicine & Cancer Treatment

4:45 PM - 6:15 PM

Presentation Time: 6:00 PM – 6:05 PM

127Accelerated Production Of Clinical Grade Reconstructed Skin

Substitutes From Decellularized Tissue–engineered Dermal

Matrices For The Treatment Of Burn Patients

Anabelle Demers

Tuesday, July 12, 2022

Scientific Session 17: Skin, Wound Healing, and Inflammation

Part 2

10:00 AM - 11:30 AM

Presentation Time: 10:00 AM – 10:15 AM


GENERAL INFORMATION

FLOOR PLAN

TERMIS-AM COUNCILBill TawilBrendan HarleyCatherine KuoCherie StablerEric BreyFarshid GuilakHelen LuJohn FisherKaren ChristmanKent LeachKurt KasperLaura SuggsLexi RindoneMarcella VaicikMartha FontanillaMichael DetamoreMolly ShoichetNgan HuangPatricia PrankeRiccardo GottardiSarah StabenfeldtThomas GilbertWarren Grayson

STAFF LIAISONS Sarah WilburnMelanie RyanTatiana VeresDana GrovesRenee Villanova

2022 PLANNING COMMITTEEPenney GilbertAlison McGuiganCarlos Aguilar

2022 SYIS COUNCILLexi RindoneMickael DangNavein ArumugasaamyAustin BowEmi KiyotakePaula FraczekAdam JordensenJacqueline LaroucheErik JacquesNila Wu

2022 SCIENTIFIC ADVISORY COMMITTEEAdam McInnesAdele Doyle Alonzo Cook Andreas KaasiBlanka SharmaBrandon TefftBrendan Leung


GENERAL INFORMATION

Catherine Le Visage Chris Bashur Craig Simmons Daniela BuenoDavid Nisbett Donghui Zhu Evelyn Yim Feng Zhao George ChristGeorge Pins Giuseppe Orlando Hang LinJared Totcher Jeffrey Jacot Jennifer ElisseffJenny RobinsonJordan Miller Kapil BhartiKarina NakayamaKelvin Yeung Laurie Bracaglia Lisa Larkin Lucie Germain Madhu DharMarcella VaicikMark Ungrin Michael FrancisMichael Monaghan Michael McClure Mike Modo Mrignayani KotechaNasim AnnabiNavein Arumugasaamy Ngan HuangNika Shakiba Pamela Yelick Pedro Costa Riccardo GottardiRui Reis Samer ZakySang Jin LeeSarah Heilshorn Scott Sell Shana Kelley Silvia Cere Stephanie SeidlitsStephanie Willerth Subhas Kundu Suzanne TabbaaTiago Fernandes Todd McDevitt Vasillios Sikavitsas Zev Gartner

2022 ABSTRACT REVIEWERS Adetola AdesidaChristabella AdineBrian AguadoPeter AlexanderEben AlsbergKristi Anseth

Amish AsthanaStephen BadylakAndrew BarbasChris BashurEmmanuel BelamieKapil BhartiJeff BiernaskieCheavar Blair Nathalie BockGary BowlinEric BreyBryan BrownAshley BrownDaniela BuenoJason BurdickGulden Camci-UnalAlex ChanLucas ChaseGeorge ChristKaren ChristmanBrianne ConnizzoAlonzo CookElizabeth Cosgriff-HernandezBen CosgrovePedro CostaMargot DamaserSerena DantiLocke Davenport HuyerDavid DeanJan DeprestAnne des RieuxMadhu DharTohid DidarBrian DiekmanAdele DoyleCourtney Dumont Roberto FanganielloHelena FerreiraJohn FisherKaitlin FoggJulie FradetteDavid GammCaroline GargettLucie GermainAziz GhaharyRiccardo GottardiJonathan GrasmanWarren GraysonSarah GreisingThomas GrothBrendan HarleyDaniel HarringtonTodd HoareAkishige HokugoNgan HuangAkira ItoBin JiangAndreas KaasiZin Khaing Maroun KhouryMrignayani KotechaLisa Larkin

Neda Latifi Sang Jin LeeHang LinMahitosh MandalDiego MantovaniAlbino MartinsKristyn MastersAmy McNultyKristin MillerJeffrey MillmanLorenzo MoroniAntonella MottaVéronique MoulinKarina NakayamaNuno NevesAleksandr OvsianikovChittaranjan PatraAndrea PelosoJulie PhilippiCarla PinheiroGeorge PinsStephanie Protze Anand RamamurthiXi (Charlie) RenJenny RobinsonJoseph RocheZvi Schwartz Stephanie SeidlitsAriella ShikanovHeungsoo ShinMolly ShoichetVassilios SikavistasLaShan SimpsonAlexandar Skardal MinJae SongMyron SpectorMitchel StacyJan StegemannYingchao SuLaura SuggsAli TamayolBrandon TefftWalcy TeodoroGeorge TruskeyRocky TuanShyni VargheseSara VasconcelosValerie WallaceJane WangTony WeissJames WellsNick WillettJoyce WongPamela YelickKelvin YeungJames YooMarcy Zenobi-WongFeng ZhaoYufeng ZhengJuncen ZhouDonghui ZhuJanet Zoldan


GENERAL INFORMATION

TWIG ORGANIZATIONAL MEETINGS SCHEDULE* 2022 AWARD WINNERS The objectives of the TWIGs are: 1. to give all members of TERMIS-AM an opportunity to participate

more directly in the life of the society

2. to provide support for programming in specific domains – this is important as the society grows in numbers of members and breadth of topics

3. to provide an opportunity to learn the workings of a professional society with the goal of readying talented, motivated individuals for leadership roles in TERMIS-AM and TERMIS Global

4. to address new and emerging areas impacting tissue engineering and provide a platform to introduce these areas into our meeting

LIFETIME ACHIEVEMENT AWARD Laura Niklason, PhD

SENIOR SCIENTIST AWARDEben Alsberg, PhD

TERMIS–AM EDUCATIONAL, TRAINING & OUTREACH AWARD Patricia Pranke, PhD

OUTSTANDING POSTDOC AWARDJakob Townsend, PhD

YOUNG INVESTIGATOR AWARDFatima Syed–Picard, PhD

MARY ANN LIEBERT, INC. OUTSTANDING STUDENT AWARDCourtney Johnson

TERMIS-AM INNOVATION/COMMERCIALIZATION AWARD RECIPIENT

Guillermo Ameer, ScD

MONDAY, JULY 11, 2022

7:00 AM – 8:00 AM

Simcoe/Dufferin, 2nd Floor Chairs Meeting

4:15 PM – 4:45 PM

Grand Ballroom Centre Skin, Wound Healing, and Inflammation

Grand Ballroom East Dental & Craniofacial

Grand Ballroom West Respiratory, Urologic and Gastrointestinal

Osgoode Ballroom Stem Cells, Cell Therapies, Developmental Biology, & Cell Signaling

TUESDAY, JULY 12, 2022

9:30 AM – 10:00 AM

Grand Ballroom Centre Commercialization & Regulation

Grand Ballroom East Neural & Spine

Grand Ballroom West Ophthalmologic

Osgoode Ballroom Biofabrication & Bioreactors

2:30 PM – 3:00 PM

Grand Ballroom Centre Imaging & Assessment

Grand Ballroom East Musculoskeletal Cardiovascular, Angiogenesis, Blood

Grand Ballroom West Cardiovascular, Angiogenesis, Blood

Osgoode Ballroom Scaffolds, Matrices and Biomaterials

*These meetings are open to all attendees.

2022 WAKE FOREST INSTITUTE FOR REGENERATIVE MEDICINE YOUNG INVESTIGATOR AWARDS RECIPIENTS Erik Jacques Jacqueline Larouche

ANNUAL CONFERENCE AND EXHIBITION PROGRAM SUNDAY, JULY 10, 2022


PROGRAM . SUNDAY

8:00 AM – 8:30 PM RegistrationVide Foyer

11:30 AM – 1:00 PM Lunch (on own)

Description: The global regenerative medicine market was valued at US$23.8 billion (2018), and it is anticipated to grow to US$151 billion by 2026 with an annual growth rate of 26.1 per cent. Cell and gene therapies are being approved and reimbursed. It’s an exciting time to be an entrepreneur in this field. Join Centre for Commercialization of Regenerative Medicine (CCRM) experts and special guests for a brief but helpful overview of the main issues to consider in your entrepreneurial journey from innovator to business leader. A taught case study will cover some of the main points to consider when taking your product or therapy to the marketplace. The afternoon will culminate with a thought–provoking and insightful keynote address from a well–respected leader in the field. You will walk away from this workshop feeling more knowledgeable, confident and inspired.

Workshop Chair: Michael May, CCRM

Program:

12:00 PM – 1:00 PM CCRM sponsored lunch and case study presentation

1:00 PM – 1:15 PM Welcome and introduction, Dr. Michael May

1:15 PM – 2:45 PM Presentations, delivered by CCRM experts:

Introduction to Technology Transfer & Intellectual Property

Vishan Sivagnanam, Commercialization Manager

Manufacturing and Process Development

Dr. Cheryl Birmingham, Director, Process & Analytical Development

Regulatory Affairs in Regenerative Medicine: An Overview

Sanyukta Kher, Regulatory Affairs Consultant

Considerations for Scaling Regenerative Medicine Companies

Dr. Robin Quirk, Vice President, Technology Sourcing & Venture Development

Financing for Early Start-ups – Addressing the Gap!

Dr. Cynthia Lavoie, President and Chief Investment Officer, CCRM Enterprises

Building a Compelling Investor Pitch Deck for Life Science Start-Ups

Matthew Mistry, Senior Associate and Head of CGT Projects, CCRM Enterprises

Considerations for Scaling Regenerative Medicine Companies

Dr. Robin Quirk, Vice President, Technology Sourcing & Venture Development

Description: Stem Cell Network is pleased to host the “3D Bioprinting: Principles and Strategies for Tissue Engineering and Regenerative Medicine” as part of the TERMIS–AM meeting in partnership with Aspect Biosystems and FluidForm TM Inc. Tissue engineering holds the potential to transform drug discovery and clinical practice for regenerative medicine. While the creation of whole organs is a long–term goal, 3D bioprinted tissues already show promise in improving patient care as implantable therapeutic tissues and as more predictive models in drug development.

A multitude of strategies have arisen to recapitulate the structural and functional complexity of human tissues using additive manufacturing methods. A common challenge in the field is that biomaterials that preserve cell viability and promote function may not meet the structural and mechanical requirements of the application. This workshop focuses on strategies to overcome this and other challenges in tissue engineering using extrusion–based bioprinting methods.

The workshop will feature expert speakers working in the field and a panel discussion with industry leaders on the commercialization and translation of 3D bioprinting. The talks will be followed by technology demonstrations of Aspect Biosystems’ microfluidic 3D bioprinting technology and FluidForm’s FRESH printing platform. Both technologies offer strategies for creating complex tissue structures while promoting tissue function.

Workshop Chair: Ellie Arnold, Stem Cell Network

Program:

1:00 PM – 1:10 PM Introduction

1:10 PM – 1:40 PM Stephanie Willerth, University of Victoria

1:40 PM – 2:10 PM Brenda Ogle, University of Minnesota

2:10 PM – 2:15 PM 5 minute break

2:15 PM – 3:05 PM Panel Discussion on Commercialization and Translation

3:05 PM – 3:10 PM 5 minute break

3:10 PM – 4:00 PM Demo stations from Aspect Biosystems and FluidForm

4:00 PM Wrap up and close

PRE–CONFERENCE WORKSHOPS Pre–Registration Required. Ticketed sessions.

12:00 PM – 4:00 PM Pre–Conference Workshop: From Osgoode Ballroom Bench to Boardroom: Commercializing your RM Product or Therapy

1:00 PM – 4:00 PM Pre–Conference Workshop: 3D Ballroom Centre Bioprinting: Principles and Strategies for Tissue Engineering and Regenerative Medicine

Introduction to Technology Transfer & Intellectual Property

Vishan Sivagnanam, Commercialization Manager

Regulatory Affairs in Regenerative Medicine: An Overview

Sanyukta Kher, Regulatory Affairs Consultant

2:45 PM – 3:15 PM Case study discussion with facilitators

3:15 PM – 4:00 PM Keynote Presentation: Bioprinting Tissue Therapeutics to Transform How We Treat Disease

Tamer Mohamed, Chief Executive Officer, Aspect Biosystems


PROGRAM . SUNDAY

Description: This workshop, being organized by Dr. Emilio I. Alarcón at the University of Ottawa Heart Institute & Faculty of Medicine, University of Ottawa, aims to review the current state of the art of biomaterials for cardiac research. We will cover aspects from the material design, fabrication, in vitro & in vivo testing to the preclinical testing & regulatory considerations for use in humans. Participants in the workshop will be part of a dynamic afternoon with speakers from different backgrounds working in the field spanning from chemistry, physics, cell biology, and clinical research in cardiac health.

Workshop Chair: Dr. Emilio I. Alarcón, University of Ottawa

Speakers:

» Dr Edmond W. K. Young, University of Toronto » Dr Golnaz Karoubi, University of Toronto; University Health Network » Dr Houman Savoji, Université de Montréal » Dr Duncan Stewart, University of Ottawa; The Ottawa Hospital » Dr Michael Laflamme, University Health Network; University of Toronto

Program:

Part I

1:00 PM – 1:05 PM Opening Remarks

1:05 PM – 1:20 PM Peptides vs Proteins for the Development of Biomaterials for Cardiopulmonary Repair

1:20 PM – 1:40 PM Microfluidics and Bioprinting as the Next Frontier of Biomaterials for Cardiopulmonary Repair

1:40 PM – 2:20 PM Lung on A Chip: Accelerating Clinical Translation

2:20 PM – 2:55 PM Q&A For Part I

2:55 PM – 3:15 PM Coffee Break & Networking

Part II

2:55 PM – 3:15 PM Cell–Based Therapeutics for Cardiopulmonary Repair

3:15 PM – 3:35 PM Biomaterials–Based Therapies for Heart and Lung Repair

3:35 PM – 3:55 Q&A for Part II

3:55 PM – 4:00 PM Closing Remarks

Description: NSERC CREATE Training Program in Organ–on–a–Chip & Entrepreneurship (TOeP) is organizing a pre–conference workshop geared towards inspiring trainees to engage into a process of taking their discovery out of the lab and into the real world.

Uniquely, our workshop speakers were all (or still are) trainees who haven commercialized the discoveries from their PhD or Post–doctoral training through a start–up company. They were instrumental in growing these companies and have valuable lessons to share to facilitate the journey.

At the end of this workshop, you will be able to: understand how to identify the novel components of your work, improve problem–based design in tissue engineering and regenerative medicine, understand the steps toward commercialization of devices and cell based therapeutics and what elements to include in a successful pitch.

NSERC CREATE TOeP Training program will reimburse the workshop registration fee for the first 30 trainees who register. Reimbursement forms will be available at the workshop.

1:00 PM – 3:00 PM TERMIS–AM Council Meeting (Council Members Only)Simcoe/Dufferin

Opening ProgramGrand Ballroom Centre & West

4:00 PM – 4:15 PM Land Acknowledgement and Traditional Indigenous Prayer

4:15 PM – 4:25 PM TERMIS President and TERMIS–AM Chair Welcome

4:25 PM – 4:30 PM Welcome from the TERMIS–AM 2022 Conference Co–Chairs

4:30 PM – 5:30 PM Fireside Chat on Commercialization with TERMIS–AM Awardees

Moderator: Michael May

Panelists: Michael Laflamme, MD, PhD, Jennifer Elisseeff, PhD, Gordana Vunjak–Novaković, PhD, Guillermo Ameer, ScD

5:30 PM – 6:30 PM Opening Plenary Symposium 1: Freda Miller, PhD, Building and Repairing the Nervous System with Stem Cells

Keynote Sponsored by: CCRM and Stem Cell Network, and Medicine by Design (MbD)

1:00 PM – 4:00 PM Pre–Conference Workshop: Functional Biomaterials in Cardiopulmonary Research: A Road Map from Design to Clinical Translation

1:00 PM – 4:00 PM Pre–Conference Workshop: Entrepreneurship

Grand Ballroom West

Grand Ballroom East

Workshop Chair: Milica Radisic, University of Toronto

Program:

1:00 PM – 1:20 PM Introduction to the Goals of the Workshop

Milica Radisic, Professor and Canada Research Chair (Tier 1) in Organ–on–a–Chip Engineering, University of Toronto; Senior Scientist, Toronto General Research Institute; Director, NSERC CREATE Training Program in Organ–on–a–Chip Engineering and entrepreneurship.

1:20 PM – 1:40 PM From an Idea to a Successful Company – the Story of Rheolution

Anis Hadjenni, CEO and Co–founder, Rheolution Inc,

1:40 PM – 2:00 PM Assessing the Novelty of your Idea – the Story of Ripple

Wendy Neimark, Co–founder and Chief Technology Officer, Ripple Therapeutics

2:00 PM – 2:20 PM Developing a Pitch and Setting your Idea for Successful Fundraising

Milica Vukmirovic, Director of External Programs & Partnerships, Precision Medicine Initiative, PRiME, University of Toronto

2:20 PM – 3:00 PM Networking break

3:00 PM – 3:20 PM Working to Grow your Organ–on–a–chip Startup

Sepand Bafti, Director of Biological Science at Norti

3:20 PM – 3:40 PM Trainee Perspective – Starting a Company During your PhD

Dawn Lin, PhD Candidate at McMaster University & Co– founder Organo–Biotech,

3:40 PM – 4:00 PM PI Perspective on Starting a Company from the Lab

Mohsen Akbari, Associate Professor, University of Victoria

SCIENTIFIC PROGRAM

6:30 PM – 8:30 PM Exhibit Viewing / Welcome Reception / Poster Session 1Sheraton Hall A – F


PROGRAM . MONDAY

MONDAY, JULY 11, 2022


7:00 AM – 8:00 AM Cook Biotech Sponsored Breakfast Symposia – “MetamorphoSIS: The Potential of the Extracellular Matrix Scaffold”

Civic South

For more than 25 years, Cook Biotech has partnered with academic groups to supply clinical–grade ECM scaffolds that can translate your cell therapy innovation from the bench to the bedside. In this breakfast symposium, learn how Cook Biotech can be your trusted partner to bring life–improving solutions to patients. Our team will be on hand to talk with you about collaboration. Please join us for breakfast (limited to 50 attendees).

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM 1

Ex Vivo Gene Therapy Of Skin Cells And Autologous Bilayered Skin Substitutes As A Potential Treatment For Recessive Dystrophic Epidermolysis Bullosa Skin Wounds

M. A. Barbier1, A. Dakiw Piaceski1, A. Morissette1, A. Larose1, A. Cartier1, S. Villeneuve1, D. Larouche1, K. Ghani2, E. Pope3, M. Caruso2, L. Germain1;

1Département de chirurgie, Centre de Recherche en organogénèse expérimentale de l’Université Laval / LOEX, Québec, QC, CANADA, 2Centre de Recherche sur le cancer de l’Université Laval, Québec, QC, CANADA, 3Hospital for Sick Children and University of Toronto, Toronto, ON, CANADA.

10:45 AM – 11:00 AM 2

Building The Skin–specific Vascular Plexus And Appendages With Perfusion Capabilities

A. Pappalardo1, D. Alvarez Cespedes1, E. Y. Jeon1, L. Sorrells2, H. E. Abaci1;

1Department of Dermatology, Columbia University, New York, NY, 2Department of Biomedical Engineering, Columbia University, New York, NY.

RAPID FIRE PRESENTATIONS:

11:00 AM – 11:05 AM 3

Immunocompetent, Vascularized, Autologous 3D Skin Model Reconstructed By Tissue Engineering

E. Attiogbe1, S. Larochelle1, C. Mainzer2, A. Mauroux3, S. Bordes4, B. Closs4, C. Gilbert5, V. Moulin1; 1LOEX institute, Université Laval, Québec, QC, CANADA, 2R&D, Silab, Saint Viance, FRANCE, 3Silab, Saint–Viance, FRANCE, 4R&D, Silab, Saint–Viance, FRANCE, 5CHU de Québec, Québec, QC, CANADA.

11:05 AM – 11:10 AM Additional Q&A

11:10 AM – 11:15 AM 5

Acute Contact With Macrophages Induces Fibroblast Contraction – A Booster For Tissue Repair

M. Ezzo1,2, J. B. Wang1, G. Pecoraro1, J. Firmino1, P. Pakshir1, B. Hinz1,2;

1Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA, 2Keenan Research Centre for Biomedical Science of the St. Michael’s Hospital, Laboratory of Tissue Repair and Regeneration, Toronto, ON, CANADA.

Session Chairs: Lucie Germain and Véronique Moulin

SYIS Co–Chair: Daniel Gironda

Keynote Speaker: Novel Regulators of Stress Response and Innate Immunity in Skin

10:00 AM – 10:30 AM Pierre A. Coulombe

7:00 AM – 8:00 AM TERMIS–AM TWIGs Chairs MeetingSimcoe/Dufferin

9:30 AM – 10:00 AM Coffee Break in Exhibit HallSheraton Hall A – F

9:30 AM – 10:00 AM TERMIS–AM Membership Business MeetingOsgoode Ballroom All attendees are welcome

10:00 AM – 11:30 AM Scientific Concurrent Sessions 1

Grand Ballroom Centre Session 1: Skin, Wound Healing, and Inflammation Part 1

8:00 AM – 9:00 AM Plenary Symposium 2: Charles Gersbach, PhD Genome and Epigenome Editing for Gene Therapy and Cell Programming

Grand Ballroom Centre & West

8:00 AM – 9:00 AM Award Presentations TERMIS–AM Senior Scientist Award: Eben Alsberg, PhD TERMIS–AM Commercialization/ Innovation Award: Guillermo Ameer, ScD



PROGRAM . MONDAY

11:15 AM – 11:20 AM 6

Matrix Bound Nanovesicles As A Novel Extracellular Matrix Therapy For The Treatment Of Rheumatoid Arthritis

R. J. Crum1, K. Hall1, C. P. Molina1, G. S. Hussey1, E. Graham2, H. Li3, S. F. Badylak1; 1University of Pittsburgh, Pittsburgh, PA, 2Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, 3Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA.

11:20 AM – 11:25 AM 7

Wearable Engineered Human Skin With Region–specific Cellular, Extracellular And Mechanical Properties

A. Pappalardo1, D. Alvarez–Cespedes1, S. Fang2, A. R. Herschman2, E. Jeon1, K. M. Myers2, J. W. Kysar2, H. E. Abaci1; 1Dermatology, Columbia University, New York, NY, 2Mechanical Engineering, Columbia University, New York, NY.

11:25 AM – 11:30 AM 8

Using Physiological Factors To Improve Self–assembled Skin Substitute Pigmentation

K. Ferland1,2, B. Magne1,2, D. Larouche1,2, L. Germain1,2; 1Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX and Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada, Quebec, QC, CANADA, 2CHU de Québec–Université Laval Research Center, Québec, Canada, Quebec, QC, CANADA.

Session Chairs: Brandon Tefft and Ngan Huang

SYIS Co–Chair: Ishita Tandon

Keynote Speaker: Bioengineering Heart Tissue Function Using Microfabricated Elastomers

10:00 AM – 10:45 AM Milica Radisic

ORAL PRESENTATIONS:

10:45 AM – 11:00 AM 10

Covalent Peptide Modification Of Poly(Vinyl Alcohol) Promotes Endothelialization While Reducing Thrombosis

D. E. Anderson1, N. M. Bates1, M. E. Fallon1, H. E. Heidenreich1, Y. Yao2, E. K. Yim2, M. T. Hinds1; 1Biomedical Engineering, Oregon Health and Science University, Portland, OR, 2University of Waterloo, Waterloo, ON, CANADA.

11:00 AM – 11:15 AM 11

Basement Membrane Of Tissue–engineered Small Diameter Vascular Extracellular Matrix Scaffolds Induce Human Endothelial Cell Quiescence

N. A. Shortreed1,2,3, M. Lopera–Higuita1,3,4, S. Dasari5, L. G. Griffiths3; 1Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 2Department of Immunology, Mayo Clinic, Rochester, MN, 3Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, 4Department of Biomedical Engineering & Physiology, Mayo Clinic, Rochester, MN, 5Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.

11:15 AM – 11:30 AM 133

Left And Right Ventricle Myocardial Matrix Hydrogels Enhance Therapeutic Potential Of Cardiac Progenitor Cells

J. Hunter1, A. Hancko1, P. Shakya2, M. Davis2, K. Christman1; 1University of California San Diego, La Jolla, CA, 2Georgia Institute of Technology and Emory University, Atlanta, GA.

11:15 AM – 11:30 AM Additional Q&A

Session Chairs: Lisa Larkin and George Christ

Keynote Speakers:

10:00 AM – 10:20 AM Do’s and Don’ts for TERM Startups: From Founding Through to Commercialization

Michael Francis

10:20 AM – 10:40 AM Challenges and lessons learned from the commercialization of TERM Technologies

Robert Spiro

10:40 AM – 11:00 AM Understanding the Regulatory Considerations for the Path to Market for Autologous Therapies

Jennifer Woodell–May

11:00 AM – 11:30 AM Panel Discussion

Grand Ballroom East Session 2: Understanding the Path to Market for Musculoskeletal Tissue Engineered Products

Grand Ballroom West Session 3: Biomaterials for Endogenous Cardiovascular Repair


PROGRAM . MONDAY

Session Chairs: Roberto Fanganiello and Akishige Hokugo

SYIS Co–Chair: Nicholas Fischer

Keynote Speaker:

10:30 AM – 10:45 AM Tissue Engineering and Craniofacial Regeneration: What are the Innovations?

Pamela Yelick

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM 13

Multicentric Randomized Clinical Trial Using Bone Tissue Engineering Kit In Patients With Cleft Lip And Palate

D. F. Bueno1, A. H. Tovo2, B. Dias3, C. C. Pinheiro4, D. S. Alencar3, D. L. Rocha4, D. Franco5, D. M. Vale6, G. L. Achoa7, H. M. Santos8, H. Cintra3, J. C. Coelli7, J. F. Cunha Filho8, M. Gamborgi7, M. V. Collares2, M. A. Almeida9, R. Faco10, R. C. Lauris10, R. M. Carvalho10, R. M. Pereira11, T. O. Ozawa10, R. L. Pacheco4, R. Riera4;

10:45 AM – 11:00 AM 14

Osteogenic Application Of Diabetic Dental Pulp Cells By Hyperglycemia–upregulation

M. Kim1, H. Eom1, W. V. Giannobile2, C. Park1; 1Dental Biomaterials, Kyungpook National University, Daegu, KOREA, REPUBLIC OF, 2Harvard School of Dental Medicine, Boston, MA.

11:00 AM – 11:15 AM 15

3d Bioprinted Biomimetic Bone Scaffolds For Mandibular Reconstruction

S. Lee, H. Lee, C. Kengla, I. Kim, J. Yoo, A. Atala;

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston–Salem, NC.

11:15 AM – 11:30 AM 17

Biphasic 3d–printed Osteochondral Biomaterial For Temporomandibular Condyle Regeneration

D. Nedrelow, A. Rassi, B. Ajeeb, P. Huebner, M. Detamore;

Biomedical Engineering, University of Oklahoma, Norman, OK.


Pre–Registration Required. Ticketed Session.

A highly regarded and popular event at the conference, the women’s luncheon serves to create a supportive network of women in TERM. Each annual luncheon focuses on a theme that is relevant to the community, providing a platform for attendees to engage with speakers and their peers while discussing the topic.

This year’s theme is “Navigating the New Normal”. The pandemic created massive disruptions to daily life, the workplace, as well as work–home boundaries, and continues to evolve 2 years later. Some changes, such as remote or hybrid workspaces, may remain long–term and will be important to navigate as trainees and early–career scientists advance in their careers. The pandemic has also shone a spotlight on the impact of societal inequities among women and minoritized groups. Studies indicate women have been disproportionately affected in their professions by the pandemic, largely due to shouldering the increased caregiving responsibilities for children and/or elderly family members. The objective of this workshop is to disseminate information about how academic institutions and industries are addressing these pandemic–related challenges, share insights into how institutions and industries will operate going forward given the issues brought to light by the pandemic, and to discuss strategies for navigating these challenges in the careers of women. Topics will include strategies for addressing gaps in training or research activity, professional networking in the era of hybrid or remote workplaces and managing boundaries between work and home life. Though open to all TERMIS attendees, this event will examine the issues that women in particular face and provide tools and support to women in TERM for navigating the “new normal”. The event is also aimed at informing those in mentoring and leadership positions within the TERMIS community of these issues, so they may be become better advocates for their female colleagues and trainees. To accomplish this, we will assemble a panel of women with a breadth of experiences in academic research, academic administration, entrepreneurship, and industry to provide their perspectives.

Speakers:

» Molly Shoichet, University of Toronto

» Gordana Vunjak–Novakovic, Columbia University

» Elizabeth Csaszar, Notch Therapeutics

» Mary Clare McCorry, Advanced Regenerative Medicine Institute

Session Chairs: Sang Jin Lee and John D. Jackson

SYIS Co–Chair: Marta Orlowska

Keynote Speakers:

1:00 PM – 1:30 PM Suspension Bath Bioprinting – Fundamentals and Applications

Megan Cooke

1:30 PM – 2:00 PM 3D Bioprinting: Application-Driven Development

James J. Yoo

ORAL PRESENTATIONS:

2:00 PM – 2:15 PM 18

Innovative Artificial Intelligence Hyper–personalized Organ Regeneration

J. Kim;

R&D Center, ROKIT AMERICA, Los Angeles, CA.

Osgoode Ballroom Session 4: Tissue Engineering Solutions for Craniofacial Regeneration

11:30 AM – 1:00 PM Women in TERM Networking LuncheonCivic Ballroom South Sponsored by: Burroughs Wellcome Fund; The University of Florida Department of BME; School of Biomedical Engineering at the University of British Columbia; University of Maryland Department of Bioengineering

1:00 PM – 2:30 PM Scientific Concurrent Sessions 2

Grand Ballroom Centre Session 5: 3D Bioprinting Methods and Applications

2:15 PM – 2:30 PM 19

In Vivo Printing Of Engineered Multiscale Porous Scaffolds Restores Muscle Function After Volumetric Muscle Loss

M. Samandari1, Y. Endo2, M. Karvar2, A. Mostafavi3, J. Quint1, I. Sinha2, A. Tamayol1; 1Biomedical Engineering, UConn Health Center, FARMINGTON, CT, 2Harvard Medical School, Boston, MA, 3University of Nebraska–Lincoln, Lincoln, NE.

Session Chairs: Donghui Zhu and Kelvin Yeung

SYIS Co–Chair: Lorena Duarte

Keynote Speakers:

1:00 PM – 1:30 PM Design of Biomaterials to Scavenge Proinflammatory Factors

Kam Leong

Session Chairs: Rui Reis

SYIS Co–Chair: Bella Xu

ORAL PRESENTATIONS:

1:00 PM – 1:15 PM 20

Over Coming Tissue Decellularization Deficits: A Balanced Approach Provides Best Results In The Lab And Clinic

P. F. Gratzer1,2,3, M. Glazebrook4, S. Lu5, A. McLaren6, I. Costa7; 1School of Biomedical Engineering, Dalhousie University, Halifax, NS, CANADA, 2Department of Surgery, Dalhousie University, Halifax, NS, CANADA, 3Department of Process Engineering and Applied Science, Dalhousie University, Halifax, NS, CANADA, 4Orthopaedic Surgery, Queen Elizabeth II Health Sciences Centre, Halifax, NS, CANADA, 5Surgery, St. Michael’s Hospital, Toronto, ON, CANADA, 6Orthopedic Surgery, St. Michael’s Hospital, Toronto, ON, CANADA, 7School of Nursing, Lakehead University, Thunder Bay, ON, CANADA.

1:15 PM – 1:30 PM 21

Biomimetic Umbilical Cord Collagen Hydrogel Patch For Corneal Stroma Reconstruction

D. Gunasekaran1,2, U. Tiruchirapalli Sivagnanam1; 1Biological Materials Laboratory, CSIR Central Leather Research Institute, Chennai, INDIA, 2Department of Leather Technology, Anna University, Chennai, INDIA.

1:30 PM – 1:45 PM 22

Monitoring Decellularization Via Absorbance Spectroscopy To Derive Extracellular Matrix Scaffolds: In Vitro And In Vivo Testing For Vocal Fold Application

C. Mora1, A. Biehl2, E. W. Ozpinar2, M. E. Garcia2, D. Sze2, P. Sarker3, J. R. Enders4, S. Khan3, R. C. Branski5, D. O. Freytes2; 1Chemical Engineering, University of Puerto Rico, Mayaguez, PR, 2Joint Department of Biomedical Engineering, NCSU/ UNC–Chapel Hill, North Carolina State University, Raleigh, NC, 3Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 4Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC, 5Rehabilitation Medicine and Otolaryngology–Head and Neck Surgury, NYU– Grossman School of Medicine, New York, NY.


PROGRAM . MONDAY

Grand Ballroom East Session 6: Nature as a Source of TERM Biomaterials and Strategies

Grand Ballroom West Session 7: Biomaterials and Immunomodulation Sponsored by: KeAi Publishing

1:45 PM – 1:50 PM 134

Incorporation Of Decellularized Cartilage Extracellular Matrix Nanoparticles Within Photo Reactive Colloidal Bioinks

M. R. Perez, K. J. Hogan, A. G. Mikos;

Bioengineering, Rice University, Houston, TX.

1:50 PM – 1:55 PM 135

Comparison Of Ectopic Bone Formation Dynamics Using RhBMP6 In Autologous Blood Coagulum As A Carrier With Commercially Available RhBMP2 On An Absorbable Collagen Sponge

N. Ivanjko, N. Stokovic, M. Milesevic, S. Vukicevic;

Laboratory for Mineralized Tissues, School of Medicine University of Zagreb, Zagreb, CROATIA

1:55 PM – 2:00 PM 136

A Dopamine-functionalized Hydrogel System For Therapeutic Delivery Of Extracellular Vesicles

J. Copus;

Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC.

2:00 PM – 2:15 PM 24

Bioengineered Blood Clots As A Novel Material For Tissue Regeneration

S. Jiang, G. Bao, J. Li;

Mechanical Engineering, McGill University, Montreal, QC, CANADA.

2:15 PM – 2:30 PM 25

Recombinant Human Bone Morphogenetic Protein 6 In Autologous Blood Coagulum With Synthetic Ceramic Particles Promotes Spinal Fusion In Sheep

N. Stokovic1, N. Ivanjko1, M. Pecin2, A. Smajlovic2, N. Ivkic2, H. Capak3, Z. Vrbanac3, D. Vnuk2, D. Maticic2, S. Vukicevic1; 1Laboratory for Mineralized Tissues, School of Medicine University of Zagreb, Zagreb, CROATIA, 2Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine University of Zagreb, Zagreb, CROATIA, 3Department of Radiology, Ultrasound Diagnostics and Physical Therapy, Faculty of Veterinary Medicine University of Zagreb, Zagreb, CROATIA.

1:30 PM – 2:00 PM Enabling the Practice of Regenerative Medicine

Guillermo Antonio Ameer


2:00 PM – 2:05 PM 26

Matrix–bound Nanovesicles As Selective Modulators Of The Immune Response

H. Capella–Monsonis, R. J. Crum, S. Badylak;

Surgery, University of Pittsburgh, Pittsburgh, PA.

2:05 PM – 2:10 PM 27

Learning From Cell–Material Interactions To Improve MSC Immunomodulatory Potential

N. Lagneau1, P. Tournier1, B. Halgand2, F. Loll1, C. Le Visage1, J. Guicheux2, V. Delplace1; 1Regenerative Medicine and Skeleton, RMeS UMR 1229, Université de Nantes, Oniris, INSERM, Nantes, FRANCE, 2Regenerative Medicine and Skeleton, RMeS UMR 1229, Université de Nantes, Oniris, INSERM, CHU, Nantes, FRANCE.

2:10 PM – 2:15 PM 28

Real–time Evaluation Of Local Delivery Vehicles For Cancer Immunotherapeutics Within Embedded Spheroid Cultures

R. G. Wylie, V. Huynh;

Chemistry and Chemical Biology, McMaster University, Hamilton, ON, CANADA.

2:15 PM – 2:20 PM 29

Optimization Of Cell–based Therapies With Porous 3d Printed Scaffolds

T. R. Lansberry, R. P. Accolla, J. Liang, A. Simmons, C. Stabler;

Biomedical Engineering, University of Florida, GAINESVILLE, FL.

2:20 PM – 2:25 PM 30

Therapeutic Potential Of Matrix Bound Nanovesicles In Rodent Model Of Ulcerative Colitis

K. T. Hall, S. Fisher, G. S. Hussey, S. F. Badylak;

University of Pittsburgh, Pittsburgh, PA.

2:25 PM – 2:30 PM 31

Matrix–bound Nanovesicles Provide Mechanistic Insight Into Mechanisms Of Heart Disease Progression To Failure

M. C. Cramer1,2, L. Mathews3,4, G. Hussey3,2, W. Schwarzmann5, V. Soman5, J. Sembrat6, M. Rojas6, C. McTiernan6, U. Chandran5, H. Turnquist7,3,4, S. F. Badylak3,2,1; 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 3Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 4Starzl Transplantation Institute, Pittsburgh, PA, 5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, 6Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 7Department of Immunology, University of Pittsburgh, Pittsburgh, PA.

Session Chairs: Adam McInnes

Keynote Speakers:

1:00 PM – 1:10 PM Intro to Tissue Engineering and Regenerative Medicine

Adam McInnes

1:10 PM – 2:30 PM Roundtable Discussion and Q&A with Audience

Guest Panelists:Sara Pitawanakwat, Knowledge KeeperBobbi-Jo Virtue, Knowledge KeeperRob Lackie, Knowledge KeeperElder Blu Waters, Elder

2:30 PM – 2:45 PM Transitional Break

Session Chairs: Pedro Costa

SYIS Co–Chair: Zoubaire Moustaine

Keynote Speakers:

2:45 PM – 3:15 PM Organs-On-Chips & Biofabrication: A Path to Commercialization

Pedro Costa

ORAL PRESENTATIONS

3:15 PM – 3:30 PM 32

Engineering The External And Internal Cell Environment In Liver Tumor Spheroids Using A Microfluidic Device And Oxygenating Macf Microparticles

M. Mansouri, N. Leipzig;

Department of Chemical, Biomolecular, and Corrosion Engineering, University of Akron, Akron, OH.

3:30 PM – 3:45 PM 33

Using A Bioengineered Immune–enhanced Tumor–on–a–chip (itoc) Platform To Improve T Cell Tumor–killing Capabilities

M. Rodriguez, M. Kheradmandi, H. Sivakumar, F. Ilyas, J. Beane, A. Skardal;

Department of Biomedical Engineering, The Ohio State University, Columbus, OH.

3:45 PM – 4:00 PM 34

Intermittent Perfusion Improves Stem Cell Colony Size And Distribution In A 3d–bioprinted Chambered Model

E. R. Komosa, W. Lin, B. M. Ogle;

Biomedical Engineering, University of Minnesota, Minneapolis, MN.


PROGRAM . MONDAY

Osgoode Ballroom Session 8: A First Nations and Metis Perspective on Tissue Engineering & Regenerative Medicine

Grand Ballroom Centre Session 9: Bioreactors and Organs– on–chips in TERM



PROGRAM . MONDAY


4:00 PM – 4:05 PM 35

A Microphysiological System To Model The Endothelial–epithelial Interface

D. G. McDuffie1, R. A. Burgess2, M. G. Helm1, E. Thomas2, A. Agarwal1; 1Biomedical Engineering, University of Miami, Miami, FL, 2Pathology, University of Miami, Miami, FL.

4:05 PM – 4:10 PM 36

Heart–on–a–chip Model Of Sars–cov–2 Cardiac Involvement And Treatment With Induced Pluripotent Stem Cell Derived Extracellular Vesicles

Q. Wu, M. Radisic, n. Rafatian, K. T. Wagner;

University of Toronto, Toronto, ON, CANADA.

4:10 PM – 4:15 PM 37

Design Of A Biomimetic 3D Stretchable Substrate For Growth And Maintenance Of Alveolar Epithelial Cells

M. Nejatian1, F. Aoki2, A. McGuigan3, T. K. Waddell4, G. Karoubi2; 1Institute of Biomaterials and Biomedical Engineering, University Health Network/University of Toronto, Toronto, ON, CANADA, 2Thoracic Surgery/Laboratory Medicine and Pathobiology, University Health Network/University of Toronto, Toronto, ON, CANADA, 3Department of Chemical Engineering, University of Toronto, Toronto, ON, CANADA, 4Thoracic Surgery, University Health Network/University of Toronto, Toronto, ON, CANADA.

Session Chairs: Jenny Robinson and Madhu Dhar

SYIS Co–Chair: Naveed Tavakol

Keynote Speaker: User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate

2:45 PM – 3:15 PM Cole DeForest

ORAL PRESENTATIONS:

3:15 PM – 3:30 PM 38

Spatially Controlled Skin Morphogenesis Via Extracellular Matrix Cues And Morphogen Gradients

E. Y. Jeon, A. Pappalardo, L. Sorrells, H. E. Abaci;

Columbia University Irving Medical Center, New York, NY.

3:30 PM – 3:45 PM 39

Biomimetic Hydrogels With Multi–component Cell Adhesive Ligands For Endothelial Cell Function

M. Shayan1, R. Suhar2, S. Heilshorn2, N. Huang1; 1Cardiothoracic Surgery, Stanford University, Palo Alto, CA, 2Materials Science & Engineering, Stanford University, Palo Alto, CA.


3:45 PM – 3:50 PM 40

Grand Ballroom East Session 10: Biomaterials to Direct Stem Cell Fate

In Vivo Validation Of A Continuous Gradient Porous Scaffold For Osteochondral Defect Repair In A Rabbit Model

K. W. Smith1, S. Ali Akbari Ghavimi1, S. Logterman2, P. M. Gehret1, E. Capuana3, G. Conoscenti4, V. Brucato5, V. La Carrubba5, J. T. Lawrence2, R. Gottardi1; 1Pulmonary Research, Children’s Hospital of Philadelphia, Philadelphia, PA, 2Orthopedic Surgery, Children’s Hospital of Philadelphia, Philadelphia, PA, 3Industrial and Digital Innovation, University of Palermo, Palermo, ITALY, 4Department of civil, environmental, aerospace, and materials engineering, University of Palermo, Palermo, ITALY, 5Engineering, University of Palermo, Palermo, ITALY.

3:50 PM – 3:55 PM Additional Q&A

3:55 PM – 4:00 PM 137

Hypoosmolality Enhances Mesenchymal Stromal Cell Proliferation And Osteogenic Differentiation In 3d Viscoelastic Hydrogels

M. R. Kollert1,2, T. H. Qazi3, V. Vogel2, D. J. Mooney4, G. N. Duda1; 1 Julius Wolff Institute & BIH Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, GERMANY, 2Department of Health Sciences and Technology, ETH Zurich, Zurich, SWITZERLAND, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 4 John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA.

4:00 PM – 4:05 PM 42

Engineering A Matrix To Improve Reproducibility Of Intestinal Organoids

B. C. Martin–Villa1, K. C. Klett2, S. C. Heilshorn3; 1Department of Bioengineering, Stanford University, Stanford, CA, 2Department of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, 3Department of Materials Science & Engineering, Stanford University, Stanford, CA.

4:05 PM – 4:10 PM 43

Biomimetic Hierarchical Patterning And Honey Incorporation In Porous Silk Fibroin Scaffold Improve Mesenchymal Stem Cell Proliferation, Differentiation, Epithelial Transition, And Restrain Senescence

A. Mukhopadhyay1, A. Gope1, J. Chatterjee1, R. Mukherjee2; 1School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, INDIA, 2Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, INDIA.


PROGRAM . MONDAY

4:10 PM – 4:15 PM 44

Additive Manufacturing Strategies To Fabricate Novel Biomimetic Carbon–based Nanocomposites To Control Stromal Cell Differentiation

M. Dhar1, S. Newby2, A. MacDonald2, S. Bourdo3, M. Hung4; 1University of Tennessee, Knoxville, TN, 2Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN, 3Center for Integrative Nanotechnology Sciences, University of Arkansas, Little Rock, AR, 4Roseman University of Health Sciences, South Jordan, UT.

Session Chairs: Andreas Kaasi and Riccardo Gottardi

SYIS Co–Chair: Zheng hong Tan

ORAL PRESENTATIONS:

2:45 PM – 3:00 PM 45

A Decellularized Cartilage Biomaterials Approach To Pediatric Laryngotracheal Reconstruction

P. Gehret1, S. Ali Akbari Ghavimi2, I. Jacobs2, R. Borek2, A. Dumas1, R. Gottardi3,2; 1Bioengineering, University of Pennsylvania, Philadelphia, PA, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA.

3:00 PM – 3:15 PM 46

De– And Recellularized Urethral Reconstruction With Autologous Buccal Mucosal Cells Implanted In An Ovine Animal Model

J. Håkansson1, K. Larsson2, L. Jenndahl1, R. Strehl3, S. Simonsson4, M. Johansson5, T. O. Ekerhult2; 1RISE, Gothenburg, SWEDEN, 2Urology, Sahlgrenska University Hospital, Institution of clinical sciences, Gothenburg, SWEDEN, 3Verigraft AB, Gothenburg, SWEDEN, 4Laboratory medicine, Sahlgrenska University Hospital, Institution of biomedicine, Gothenburg, SWEDEN, 5Clinical Pathology, Sahlgrenska University Hospital, Institution of clinical sciences, Gothenburg, SWEDEN.

3:15 PM – 3:30 PM 47

Development And Delivery Of Renal Progenitor Organoids For Effective Integration In Vivo

D. Lim, I. Kim, J. Kim, A. Atala, J. Jackson, J. Yoo;

Wake Forest Institution for Regenerative Medicine, Winston Salem, NC.

3:30 PM – 3:45 PM 48

Lung–mimetic Sealant For Repairing Pulmonary Air Leak

J. Kim, S. Mir, J. Chen;

Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ.

Grand Ballroom West Session 11: Respiratory, Urologic, & Gastrointestinal Tissue Engineering


3:45 PM – 3:50 PM 49

Gene Expression Of Tracheal Stenosis Suggests That Hypertrophic Tissues Lack Anti–inflammatory Macrophages, TLR4–expressing Cells, And Differentiating Airway Epithelial Cells

J. Weber1, Z. Muslim1, M. Baig1, K. Poulikidis1, A. Al Shetawi2, F. Bhora1; 1Nuvance Health, Danbury, CT, 2Nuvance Health, Poughkeepsie, NY.

3:50 PM – 3:55 PM 50

In Silico Modeling Of BEAS–2B Cell Population Dynamics

A. Mostofinejad1, A. E. Marin–Araujo2,3, D. A. Romero1, T. K. Waddell4,2,5, G. Karoubi4,1,6, C. H. Amon1,2; 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Latner Research Laboratories, University Health Network, Toronto, ON, CANADA, 4Latner Thoracic Surgery Laboratories, University Health Network, Toronto, ON, CANADA, 5Institute of Medical Sciences, University of Toronto, Toronto, ON, CANADA, 6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CANADA.

3:55 PM – 4:00 PM 51

Tissue Engineering Solutions For Vaginal Reconstruction

D. Brownell, S. Chabaud, S. Bolduc;

Faculté de medicine, Université Laval, Québec, QC, CANADA.

4:00 PM – 4:05 PM 138

Human Organ-specific Engineered Urethra Substitute: In Vitro Optimization And Characterization

C. Caneparo, S. Chabaud, S. Bolduc;

Université Laval, Québec, QC, CANADA.

4:05 PM – 4:10 PM 52

Nanoparticles Remain In The Pelvic Region And Promote Elastin Repair In A Pelvic Organ Prolapse Mouse Model

S. Dahal1, B. Balog2, K. Deng2, M. Kuang2, K. Woolley2, S. Thampi1, A. Ramamurthi1, M. Damaser2; 1Bioengineering, Lehigh University, Bethlehem, PA, 2Biomedical Engineering, Lerner Research Institute, Cleveland, OH.

4:10 PM – 4:15 PM 139

Selective Replacement Of The Airway Epithelium In In Vitro-cultured Rat Trachea

J. Kim, J. Chen, S. Mir;

Biomedical Engineering department, Stevens Institute of Technology, Hoboken, NJ.


PROGRAM . MONDAY

Session Chairs: Adele Doyle and Stephanie Seidlits

SYIS Co–Chair: Amanda Juraski

Keynote Speaker: Bioprinting Personalized Neural Tissue Models

2:45 PM – 3:15 PM Stephanie Willerth

ORAL PRESENTATIONS:

3:15 PM – 3:30 PM 53

Motor Function Evaluation Of a Prevascularized Cell–based Tissue–engineered Nerve Tube for Regeneration Of A Rat Sciatic Nerve Defect

A. Thibodeau1,2, T. Galbraith1, C. Fauvel1, H. Khuong1,2, F. Berthod1,2; 1LOEX, centre de recherche du CHU de Québec–Université Laval, Québec, QC, CANADA, 2Département de Chirurgie, Faculté de médecine, Université Laval, Québec, QC, CANADA.

3:30 PM – 3:45 PM 54

Enhancing Axon Regeneration And Orienting Axon Extension Using Scaffold–free Dental Pulp Stem Cell–based Nerve Conduits

M. D. Drewry1, M. T. Dailey2, K. Rothermund3, F. N. Syed–Picard3; 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pittsburgh, PA, 3Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA.

3:45 PM – 4:00 PM 55

Engineered Thermostabilized Chondroitinase ABC To Enable Tissue Regeneration Post Stroke

N. Letko Khait1, S. Zuccaro1, M. Hettiaratchi1,2, M. O’meara3, Q. Sirianni1, M. Shoichet1,4; 1Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 2Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, 3Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 4Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

4:00 PM – 4:15 PM 56

Effects Of Enriched Astrocyte Phenotypic On ECM Composition And Interneuron Axon Growth Promotion

S. Vardhan, A. Merchant, S. Sakiyama–Elbert;

Biomedical Engineering, UT Austin, Austin, TX.

Osgoode Ballroom Session 12: Frontiers in Spatiotemporal Control for Neural Tissue Engineering


Grand Ballroom Centre Session 13: Recent Progress in Cell Therapy for Regenerative Medicine & Cancer Treatment

4:15 PM – 4:45 PM Coffee Break in Exhibit Hall

Sheraton Hall A – F

4:15 PM – 4:45 PM TWIG Organizational Meetings

Grand Ballroom Centre Skin, Wound Healing, and Inflammation

Grand Ballroom East Dental & Craniofacial

Grand Ballroom West Respiratory, Urologic and Gastrointestinal

Osgoode Ballroom Stem Cells & Cell Therapies & Developmental Biology and Cell Signaling

Session Chairs: Nasim Annabi

SYIS Co–Chair: Yasmin Alshoubaki

Keynote Speaker: Metacells: Redesigning Living Cells for Regenerative Medicine

4:45 PM – 5:15 PM Farshid Guilak

ORAL PRESENTATION:

5:30 PM – 5:45 PM 58

Incidence And Function Of Matrix–bound Nanovesicles Through Evolution

W. D’Angelo1, S. Johnson1, L. Quijano1, S. El–Mossier1, B. Palo2, J. Birkhimer1, S. F. Badylak1; 1University of Pittsburgh, Pittsburgh, PA, 2University of Michigan, Ann Arbor, MI.


5:45 PM – 5:50 PM 59

Personalized Tumoroids Of Ovarian Cancers For Studying Cancer Stem–like Cell Regulation And Chemoresistance

M. Bregenzer1, P. Mehta2, K. Burkhard1, D. Zamarin3, Y. Yang–Hartwich4, G. Mehta1,2,5; 1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Materials Science and Engineering, University of Michigan, Ann Arbor, MI, 3Gynecologic Medical Oncology and Immunotherapeutics, Memorial Sloan Kettering Cancer Center, New York, NY, 4Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, CT, 5Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI.

5:50 PM – 5:55 PM Additional Q&A


PROGRAM . MONDAY

5:55 PM – 6:00 PM 61

Probing Notch1–dll4 Signaling In Osteogenic Differentiation Of Human Mesenchymal Stem Cells Using Single Cell Nanobiosensor

S. Wang;

Department of Chemistry, Chemical and Biomedical Engineering, University of New Haven, West Haven, CT.

6:00 PM – 6:05 PM 62

Generation Of Tracheal Grafts In A Bioreactor With Human Induced Pluripotent Stem Cell–Derived Airway Progenitors

R. Varma1, S. Rostami1, A. Marin–Araujo1, F. Aoki1, D. Romero2, C. Amon2, T. K. Waddell3, S. Haykal1, G. Karoubi1; 1University Health Network/University of Toronto, Toronto, ON, CANADA, 2University of Toronto, Toronto, ON, CANADA, 3Thoracic Surgery, University Health Network/University of Toronto, Toronto, ON, CANADA.

6:05 PM – 6:10 PM 63

Clonal Mesenchymal Stromal Cell Sheets Exhibit Enhanced Immunomodulatory Properties

C. M. Dunn1,2, S. Kameishi2, D. W. Grainger1,2, T. Okano3,2; 1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 2Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 3Institute for Advanced Biomedical Sciences, Tokyo Women’s Medical University (TWIns), Tokyo, JAPAN.

6:10 PM – 6:15 PM 64

Differences In Human And Animal Primary Neural Stem Cell Responses To Inflammatory And Regenerative Cues

A. Galuta1, D. Ghinda1,2,3, R. Sandarage1, J. F. Kwan1, S. Chen4, A. Auriat4, E. C. Tsai1,2,3; 1Neuroscience, University of Ottawa, OTTAWA, ON, CANADA, 2Ottawa Hospital Research Institute, Ottawa, ON, CANADA, 3The Ottawa Hospital, Ottawa, ON, CANADA, 4Ottawa Hospital Research Institute, OTTAWA, ON, CANADA.

Session Chairs: Penney Gilbert and Jose Cadavid

SYIS Co–Chair: Lena Neufeld

ORAL PRESENTATION:

4:45 PM – 5:00 PM 121

Synthesis Of Catheters With Antifouling Properties Using Gamma Radiation–induced Zwitterionic Grafts

L. Duarte–Peña, E. Bucio–Carrillo;

Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares UNAM, Mexico City, MEXICO.

5:00 PM – 5:15 PM 122

Characterization And Evaluation Of Infusible Extracellular Matrix Derived Biomaterial Binding To Damaged Endothelium

M. Diaz1, A. Banka2, M. Vratsanos3, K. Gnanasekaran3, N. Gianneschi4, L. Eniola–Adefeso2, K. Christman1; 1Bioengineering, UCSD, La Jolla, CA, 2Chemical Engineering, Univeristy of Michigan, Ann Arbor, MI, 3Chemistry, Northwestern University, Evanston, IL, 4Chemistry, Materials Science and Engineering, Biomedical Engineering, Northwestern University, Evanston, IL.

5:15 PM – 5:30 PM 123

Effects Of Carrier Solutions On The Viability And Efficacy Of Canine Adipose–derived Mesenchymal Stem Cells

T. Sultana1, A. Dayem2, S. Lee2, S. Cho2, J. Lee3,4; 1Biomedical Science, Florida State University, Tallahassee, FL, 2Department of Stem Cell and Regenerative Biotechnology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF, 3Biomedical Science and Technology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF, 4Department of Veterinary Obstetrics and Theriogenology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF.

5:30 PM – 5:45 PM 124

High–stiffness, Bioprintable Cartilage Matrix Hydrogels That Promote Cell Viability And Adhesion

E. A. Kiyotake1, M. E. Cheng1, E. E. Thomas2, M. S. Detamore1; 1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 2Biomedical Engineering, University of Michigan, Ann Arbor, MI.

Grand Ballroom East Session 14: Distinguished TERMIS Travel Awardees


PROGRAM . MONDAY

5:45 PM – 6:00 PM 125

Novel Human Placental Derived Extracellular Matrix For Healing Estrogen–deprived Elderly Chronic Skin Wounds

H. D. Zomer1, P. McFetridge2, P. S. Cooke1; 1Physiological Sciences, University of Florida, Gainesville, FL, 2Biomedical Engineering, University of Florida, Gainesville, FL.

6:00 PM – 6:15 PM 126

Comparison Of Collagen II And Decellularized Hyaline Cartilage Scaffolds Derived From Bovine Trachea For Cartilage Tissue Engineering

A. M. Flórez, R. A. Jiménez, M. A. Torres, M. R. Fontanilla;

Pharmacy, Universidad Nacional de Colombia, Bogotá, COLOMBIA.

Session Chairs: Kapil Bharti and Molly Shoichet

SYIS Co–Chair: Mickael Dang

Keynote Speaker: Treating Inherited Retinal Degenerative Blindness

4:45 PM – 5:15 PM Budd A. Tucker

ORAL PRESENTATIONS:

5:15 PM – 5:30 PM 65

Sustained Release Of RdCVF–Sh3 To Rescue Cone Photoreceptor Death

L. Huo1, C. Teal2, D. Isaacs3, M. Ho2, H. Harada4, T. Léveillard5, P. Monnier6, M. Shoichet1,3,2; 1Institute of Medical Sciences, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 4Vision Division, Krembil Research Institute, Toronto, ON, CANADA, 5Department of Genetics, Institut de la Vision, Paris, FRANCE, 6Department of Physiology, University of Toronto, Toronto, ON, CANADA.

5:30 PM – 5:45 PM 66

Injectable And Biodegradable Vitreous Substitute

A. E. Baker1, A. Forman1, H. Cui1, M. Dang1, R. Devenyi2, M. S. Shoichet1; 1Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 2Ophthalmology & Vision Science, University of Toronto, Toronto, ON, CANADA.

Grand Ballroom West Session 15: Cell Therapeutic Approaches for Retinal Degenerative Diseases

Osgoode Ballroom Session 16: Biofabrication and Software Tools in TERM

5:45 PM – 6:00 PM 67

Matrix Bound Nanovesicles Reduce Neuroinflammation And Protect Retinal Ganglion Cells Following Intracameral Injection Of Hyaluronic Acid Modeling Glaucoma

J. Chang, M. Dewey, S. Badylak;

McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

6:00 PM – 6:15 PM 68

Optic Nerve Regeneration With Matrix–bound Nanovesicles And Fluvastatin

M. J. Dewey1, T. Kuwajima2, J. Chang1, G. Campbell1, S. F. Badylak1; 1University of Pittsburgh, Pittsburgh, PA, 2Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA.

Session Chairs: Pedro Costa and James Yoo

SYIS Co–Chair: Elizabeth Komosa

Keynote Speakers:

4:45 PM – 5:15 PM Computationally–driven Strategies for Tissue Engineering and Regenerative Medicine

Adele Doyle

5:15 PM – 5:45 PM 3D Bioprinting and Translational Considerations

James Yoo

ORAL PRESENTATIONS:

5:15 PM – 6:00 PM 69

Microfluidic–enabled Biofabrication Of 3D Hydrogel Architectures And Light–driven Digitalization Of Dynamic Cancer Responses

C. F. Guimarães1, L. Gasperini1, R. Ahmed2, A. P. Marques1, U. Demirci2, R. L. Reis1; 13B’s Research Group, University of Minho, Guimarães, PORTUGAL, 2Canary Center for Cancer Early Detection, Stanford University School of Medicine, Radiology Department, Palo Alto, CA.

6:00 PM – 6:15 PM 70

A Perfusable Vascularized Placental Barrier Model Utilizing Human Trophoblast Stem Cells

S. Kouthouridis, L. Abdul, A. Sotra, S. Raha, B. Zhang;

McMaster, Hamilton, ON, CANADA.


PROGRAM . TUESDAY

TERMIS–AM Educational, Training & Outreach Award: Patricia Pranke, PhD

Outstanding Postdoc Award: Jakob Townsend, PhD

Young Investigator Award: Fatima Syed–Picard, PhD

Mary Ann Liebert, Inc. Outstanding Student Award: Courtney Johnson

7:00 PM – 9:00 PM Exhibit Viewing / Reception / Poster Session 2Sheraton Hall A – F

8:30 PM – 9:30 PM 2023 Planning Team MeetingSimcoe/Dufferin, 2nd Floor

8:30 PM – 9:30 PM SYIS SocialCivic Ballroom North/Civic Ballroom Foyer Pre–Registration Required. Ticketed event.


6:15 AM – 7:30 AM SYIS Morning Walk/RunCivic Ballroom North / Civic Ballroom Foyer

7:00 AM – 8:00 AM Sponsor Satellite SessionsOsgoode Ballroom

7:30 AM – 7:20 AM CELLINK – “Developing Patient Specific Tissue Models Using a High Throughput Light–based Bioprinter”

Session Chairs: Brice Magne

SYIS Co–Chair: Jonathan Dorogin

ORAL PRESENTATIONS:

10:00 AM – 10:15 AM 127

Accelerated Production Of Clinical Grade Reconstructed Skin Substitutes From Decellularized Tissue–engineered Dermal Matrices For The Treatment Of Burn Patients

A. Demers, B. Magne, M. Lemire–Rondeau, R. Guignard, F. Auger, L. Germain;

Département de Chirurgie, LOEX, Université Laval, Québec, QC, CANADA.

Using a novel DLP based bioprinting method, we developed a patient specific biomimetic model for spinal cord injury repair. The model effectively captured the spinal cord anatomy and mechanical property leading to effective neural stem cell delivery and maturation in vivo at the spinal cord lesion site. Given the microscale printing resolution of our bioprinter, linear microchannels were readily fabricated in the biomimetic implant to align and guide regenerating axons for functional recovery. The bioinks used for printing the model were highly biocompatible with tunable degradation rate which significantly reduced foreign body reaction to the implant and further improved functional outcomes. The bioprinting platform and methodology developed here can be readily extended to other stem cell delivery and therapeutic applications as well as disease modeling purposes.

7:30 AM – 7:50 AM ARMI|BioFab – “Translating Tissue Technologies from Lab Bench to Commercial Manufacturing Line”

The path to commercialization of a tissue product introduces unique challenges in process scalability, product consistency, and high final product costs. Furthermore translating these technologies requires navigating a complex set of regulatory guidelines, recruiting a qualified workforce, and raising funds to support development. The Advanced Regenerative Manufacturing Institute (ARMI) is non–profit organization whose mission is to make practical the scalable, consistent, cost–effective manufacturing of cells, tissue and organs. ARMI is carrying out its mission by convening a diverse ecosystem of academic, industry, and nonprofit organizations to drive impactful advanced research and

6:15 PM – 7:00 PM Announcement & Awards Presentations


10:00 AM – 11:30 AM Scientific Concurrent Sessions 5 Grand

Ballroom Centre Session 17: Skin, Wound Healing, and Inflammation Part 2

TUESDAY, JULY 12, 2022

development activities that address TEMP manufacturing capability gaps. ARMI and its members are working to:

» Develop platform technologies for the manufacturing of cells, tissues and organs that are responsive to industry needs

» Apply technology development to demonstrate scalable, modular, automated and closed manufacturing for cell, tissue and organ biofabrication

» Close the skills gap in tissue and organ manufacturing by providing lifelong training opportunities

» Disseminate knowledge and technologies through membership community engagement

» Focus early on developing a conducive regulatory strategy

» Develop and implement standards into manufacturing practice

Please join us for this scientific session to learn more about the translation work ARMI is funding and how you could engage with ARMI to advance your science toward commercialization.

8:00 AM – 9:00 AM Plenary Symposium 3: Andres Garcia, PhD

Grand Ballroom Centre & West Synthetic Hydrogels for Regenerative Medicine

9:00 AM – 9:30 AM TERMIS–AM Lifetime Achievement Award: Grand Ballroom Centre & West Laura Niklason, PhD

9:30 AM – 10:00 AM Coffee Break in Exhibit HallSheraton Hall A – F

9:30 AM - 10:00 AM TWIG Organizational Meetings

Grand Ballroom Centre Commercialization & RegulationGrand Ballroom East Neural & SpineGrand Ballroom West OphthalmologicOsgoode Ballroom Biofabrication & Bioreactors

10:15 AM – 10:30 AM 128

Effect of Neuropeptides on Reepithelialization and Angiogenesis in Skin Wound Healing Models Produced from Diabetic Patient Cells

M. M. Lemarchand, T. De Serres–Bérard, S. Bellenfant, T. Galbraith, F. Berthod;

Surgery, CHU de Québec – Université Laval, Québec, QC, CANADA.

10:30 AM – 10:45 AM 129

Antibacterial Poly(oligoethylene Glycol Methacrylate) (poegma)–based Nanofibrous Hydrogel Scaffolds For Wound Healing

F. Xu, G. Randhawa, M. Lamb, E. Cudmore, T. Hoare;

Chemical Engineering, McMaster University, Hamilton, ON, CANADA.

10:45 AM – 11:00 AM 130

Tridimensional Cell Culture Of Dermal Fibroblasts Promotes Exosome–mediated Secretion Of Extracellular Matrix Proteins

V. Clément1, V. Roy1, L. Touzel Deschênes2, N. Dupré3, F. Gros–Louis4; 1Médecine, Université Laval, Quebec, QC, CANADA, 2Regenerative Médecine, CRCHUQ, Québec, QC, CANADA, 3Neurology, CHU de Québec, Quebec, QC, CANADA, 4Surgery, Université Laval, Quebec, QC, CANADA.

11:00 AM – 11:15 AM 131

Novel 3D Hydrogel System For Tailoring Stem Cell Biologics To Improve Wound Healing

J. Hodge1, A. Mellott2, J. Robinson3; 1Bioengineering, University of Kansas, Lawrence, KS, 2Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, 3Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS.

11:15 AM – 11:30 AM 132

Polyphosphate Releasing Biocompatible Hydrogel Nanoparticle Emulsions For Chronic Wound Healing

R. Negru1, F. Borges2, J. Park1, Y. Tsai1, S. Hyoju3, O. Zaborina3, M. Vaicik1, F. Teymour2, J. Alverdy3, G. Papavasiliou1; 1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 2Chemical Engineering, Illinois Institute of Technology, Chicago, IL, 3University of Chicago, Chicago, IL.

Session Chairs: Tiago Fernandes and Lisa Larkin

SYIS Co–Chair: Emi Kiyotake

Keynote Speakers:

10:00 AM – 10:30 AM The Blueprint of Cartilage and Early OA Treatment Development

Mark Hurtig

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM 71

Utilizing Auto–regulated RUNX2 Suppression To Improve MSC–derived Cartilage Matrix Accumulation During Synovial Inflammation

G. Kaur1, A. Knights2, T. Maerz2, R. Coleman1; 1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Orthopedic Surgery, University of Michigan, Ann Arbor, MI.

10:45 AM – 11:00 AM 72

Biomechanical Analysis Of A Cell Therapy And Tissue Engineering Strategy For Articular Cartilage Restoration – A Pre–clinical Study

R. R. Faria1, J. P. Santanna1, I. D. Assad1, C. C. Pinheiro2, T. L. Fernandes1, D. F. Bueno2, A. J. Hernandez1; 1Sports Medicine, Universidade de Sao Paulo, Sao Paulo, BRAZIL, 2Hospital Sírio–Libanes, Sao Paulo, BRAZIL.

11:00 AM – 11:15 AM 73

Loading Of Tissue–engineered Cartilage Determines The Fate Of Chondrocyte

B. Kim, I. Cohen, L. Bonassar;

Cornell University, Ithaca, NY.

11:15 AM – 11:30 AM 74

Acceleration Of Scaffold–free Hyaline Cartilage Formation By Layering Juvenile Chondrocyte Sheets

N. F. Metzler1,2, M. Kondo2, D. W. Grainger1,2, T. Okano2,3; 1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 2Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 3Institute for Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (TWIns), Tokyo, JAPAN.


PROGRAM . TUESDAY

Grand Ballroom East Session 18: Articular Cartilage Bioengineering & Regeneration


PROGRAM . TUESDAY

Session Chairs: Chelsea Bahney and Michael FrancisPresenting Finalists:

Pascal Medical Start–up Jingyao Deng

Pumpinheart Donald Hickey

Re:pair Therapeutics Luca Hategan

Grand Ballroom West Session 19: Business Plan Competition – Presentation of Full Business Plan Proposals

Osgoode Ballroom Session 20: Regeneration in the Context of Aging


Osgoode Ballroom Session 21: 3D Tissue–Engineered Cancer/Disease Modeling and Organoids Part 1

Session Chairs: Hang Lin and Rocky Tuan

SYIS Co–Chair: Erik Jacques

Keynote Speaker:

10:00 AM – 10:30 AM Aging of the Synovial Joint: Disease Pathogenesis, Tissue Chip Models, and Regenerative Therapies

Rocky Tuan

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM 75

Facilitation Of Bone Defect Healing By IL–4 Over–expressing MSCs

S. B. Goodman1, N. Zhang2, M. Ueno3, F. Yang4; 1Orthopaedic Surgery and Bioengineering, Stanford University, Redwood City, CA, 2Orthopaedic Surgery, Stanford University, Stanford, CA, 3Orthopaedic Surgery, Saga University, Saga, JAPAN, 4Orthopaedic Surgery and Bioengineering, Stanford University, Stanford, CA.

10:45 AM – 11:00 AM 76

Nap1l2 Drives Mesenchymal Stem Cell Senescence

M. Hu, L. Xing, D. Liu;

Department of Endodontics, Tianjin Medical University School of Stomatology, Tianjin, CHINA.

11:00 AM – 11:15 AM 77

Loss Of Vitamin A Metabolism And Retinoic Acid Signaling In Aging Drives Muscle Stem Cell Dysfunction

P. Fraczek, C. Aguilar;

Biomedical Engineering, University of Michigan, Ann Arbor, MI.

11:15 AM – 11:30 AM 78

Surface Functionalized Stem Cells Derived Extracellular Vesicles For Vascular Elastic Matrix Regenerative Repair

S. Thampi, A. Ramamurthi;

Bioengineering, Lehigh University, Bethlehem, PA.

11:30 AM – 1:00 PM Lunch on Own

11:30 AM – 1:00 PM SYIS Student Meet Mentor Lunch

Civic Ballroom South Sponsored by: Medicine by Design (MbD)

Pre–Registration Required. Ticketed sessions.

Session Chairs: Eliza Fong and Rui Reis

SYIS Co–Chair: Nila Wu

Keynote Speaker:

1:00 PM – 1:20 PM An Engineered 3D In Vitro Model Of Pancreatic Cancer To Assess The Effect Of Tissue Architecture And Fibroblast Content On Cellular Phenotype And Behavior

J.L. Cadavid

ORAL PRESENTATIONS:

1:20 PM – 1:35 PM 79

Generation Of An Organoid Model Of Adrenocortical Carcinoma Drug Response, Invasion, And Metastasis

H. Sivakumar1, M. Rodriguez1, X. Zheng2, J. Zent1, K. Nairon1, J. Leight1, P. Dedhia1, A. Skardal1; 1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2Division of Surgical Oncology, The Ohio State University, Columbus, OH.

1:35 PM – 1:50 PM 83

Effects of Matrix Stiffness On Glioblastoma Metabolism

S. K. Seidlits1, A. Sohrabi1, A. Lefebvre2, M. Condro3, H. I. Kornblum3, M. A. Digman2;

1Biomedical Engineering, University of Texas at Austin, Austin, TX, 2Biomedical Engineering, University of California, Irvine, Irvine, CA, 3University of California, Los Angeles, Los Angeles, CA.

1:50 PM – 2:05 PM 81

Patient–derived Myeloma 3d Organoid Model To Study Effects On Tumor Microenvironment

H. M. Rashad1, J. Scolnick2, G. Insuasti3, G. Porada4, C. Rodriguez1;1Hematology/Oncology, Atrium Health Wake Forest Baptist, Winston Salem, NC, 2National University of Singapore, Singapore, SINGAPORE, 3Department of Pathology, Atrium Health Wake Forest Baptist, Winston Salem, NC, 4Wake Forest Institute for Regenerative Medicine, Winston Salem, NC.

2:05 PM – 2:20 PM 82 – Microengineered Perfusable 3d– bioprinted Cancer Model For Mimicry Of Tumor Microenvironment

L. Neufeld, R. Satchi–Fainaro;

Physiology and Pharmacology, Tel Aviv University, Tel Aviv, ISRAEL.


PROGRAM . TUESDAY

Session Chairs: George Christ and Michael McClure

SYIS Co–Chair: Jacqueline Larouche

Keynote Speaker:

1:00 PM – 1:30 PM Regenerative Therapeutics for Repair of Polytraumatic Volumetric Muscle Loss Injuries

George Christ

ORAL PRESENTATION:

1:30 PM – 1:45 PM 84

Neutrophil And Natural Killer Cell Imbalances Prevent Muscle Stem Cell Mediated Regeneration Following Murine Volumetric Muscle Loss

J. Larouche1, S. Kurpiers1, P. Fraczek1, B. Yang1, C. Davis2, J. Castor–Macias1, K. Sabin1, S. Brooks2, C. Aguilar3; 1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 3Biomedical Engineering, Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI.

Keynote Speaker:

1:45 PM – 2:00 PM Super Regenerators and Lack of Regeneration After Volumetric Muscle Loss Injury: What is the Connection?

Sarah Greising

ORAL PRESENTATIONS:

2:00 PM – 2:15 PM 85

3d Printed Composite Skeletal Muscle Fascicles For The Treatment Of Volumetric Muscle Loss

J. P. Quint, M. Samandari, A. Tamayol;

Biomedical Engineering, University of Connecticut Health Center, Farmington, CT.

Session Chairs: William Wagner and Kenton Gregory

SYIS Co–Chair: Samaneh Toufanian

Keynote Speakers:

1:00 PM – 1:10 PM Introduction

Karina Nakayama

1:10 PM – 1:30 PM Leveraging Mechanics to Direct Cartilage Regeneration

Riccardo Gottardi

1:30 PM – 1:50 PM Stem Cell and ECM Therapies for the Mitigation of Muscle Atrophy after Nerve Injury

Kacey Marra

1:50 PM – 2:10 PM Tissue Regeneration after Severe Extremity Injury Using Autologous Bone Marrow Mononuclear Cells

Kenton Gregory

ORAL PRESENTATIONS:

2:10 PM – 2:20 PM 87

Modulating Rehabilitation Intensity To Improve Functional Regeneration Of Severe Bone Fractures

K. E. Nash1, J. Harrer1, K. Leguineche1, A. S. Lin1, B. Klosterhoff2, N. Willett1, R. E. Guldberg1; 1Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, Eugene, OR, 2McKinsey & Company, St. Louis, MO.

2:20 PM – 2:30 PM 88

Slow Stretch And Cyclic Load Differentially Regulate Maturation In Tissue Engineered Ligament–to–bone Attachments

M. E. Brown, J. L. Puetzer;

Biomedical Engineering, Virginia Commonwealth University, Richmond, VA.

Grand Ballroom East Session 22: Strategies for Regeneration of Complex Muscle Defects

Grand Ballroom West Session 23: Regenerative Rehabilitation: Integrating Mechanical Stimulation with TERM

2:20 PM – 2:30 PM 140

Microgravity-induced Mitochondrial Dysfunction In Human IPSC-based 3d Engineered Heart Tissues

D. B. Mair1, J. H. Tsui1, T. Higashi2, L. Stoddart1, M. A. Williams1, E. Ahn1, P. H. Lee3, S. Countryman4, N. J. Sniadecki2, D. Kim1; 1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 2Mechanical Engineering, University of Washington, Seattle, WA, 3Pathology and Laboratory Medicine, Brown University, Providence, RI, 4Bioserve Space Technologies, Boulder, CO.

2:15 PM – 2:30 PM 86

Combination Therapy For Enhanced Functional Recovery And Neuromuscular Regeneration Of Volumetric Muscle Loss Injuries

O. Sergent1, J. Passipieri1, A. Killaars2, S. Brown2, R. Upasani1, K. Healy2, G. Christ1; 1Biomedical Engineering, University of Virginia, Charlottesville, VA, 2University of California, Berkeley, Berkeley, CA.


PROGRAM . WEDNESDAY

1:30 PM – 2:00 PM Biomaterials for Women’s Health in Tissue Engineering

Shelby White

ORAL PRESENTATIONS:

2:00 PM – 2:15 PM 89

Engineering High Throughput Screening Platforms Of Cervical Cancer

I. Cadena, K. C. Fogg, 2016;

Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR.

2:15 PM – 2:30 PM 141

Sex Differences In Human Mesenchymal Stromal Cells And Meniscal Fibrochondrocytes Response To Fibrous Scaffold Properties And Estrogen Treatment

K. E. Knewtson1, J. G. Gonzalez Flores2, A. R. Podgorny3, C. Zhong4, D. M. Pacicca5,6, J. L. Robinson1,2; 1Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, 2Bioengineering Graduate Program, University of Kansas, Lawrence, KS, 3Center for Computational Biology, University of Kansas, Lawrence, KS, 4Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS, 5Department of Orthopaedic Surgery, Children’s Mercy Hospital, Kansas City, MO, 6School of Medicine, University of Missouri-Kansas City, Kansas City, MO.

2:30 PM – 3:00 PM Coffee Break in Exhibit HallSheraton Hall A – F

2:30 PM – 3:00 PM TWIG Organizational Meetings

Grand Ballroom Centre Imaging & Assessment

Grand Ballroom East Cardiovascular, Angiogenesis, Blood

Grand Ballroom West Scaffolds, Matrices and Biomaterials

Osgoode Ballroom Musculoskeletal

3:00 PM – 3:45 PM Jensen Tissue Engineering Award: Stephen Badylak, DVM, PhD, MD



Session Chairs: Evelyn Yim and Catherine Le VisageSYIS Co–Chair: Raja Rajeshwari ThadaKeynote Speakers: 8:00 AM – 8:20 AM TBD Barbara Chan

8:20 AM – 8:40 AM Nanostructured Synthetic Hydrogels for Promoting Tissue Regeneration Todd Hoare

8:40 AM – 9:00 AM Regenerative Engineering for Joint Injury and Osteoarthritis Blanka Sharma


9:00 AM – 9:05 AM 91Jagged1 Immobilized Viscoelastic Hydrogel Induces Bile Duct Organoid FormationM. Rizwan1, C. Ling2, M. Ogawa3, S. Ogawa3, G. Keller3, M. S. Shoichet2; 1Biomedical Engg, Michigan Technological University, Houghton, MI, 2University of Toronto, Toronto, ON, CANADA, 3University Health Network, Toronto, ON, CANADA.

WEDNESDAY, JULY 13, 2022


Grand Ballroom Centre Session 25: Bioactive Biomaterials for Soft Tissue Engineering

Session Chairs: Jenny Robinson and Jon Grasman

SYIS Co–Chair: Chrisoula Chappell

Keynote Speakers:

1:00 PM – 1:30 PM Engineered Biomimetics to Promote Ovarian Folliculogenesis in Vitro and in Vivo

Ariella Shikanov

Osgoode Ballroom Session 24: Biomaterials for Women’s Health in Tissue Engineering

3:45 PM – 4:15 PM WFIRM Awards: Jacqueline Larouche and Erik Jacques Grand Ballroom Centre & West

4:15 PM – 4:30 PM Transitional Break

4:30 PM – 6:30 PM Exhibit Viewing / Reception / Poster Session 3Sheraton Hall A – F

6:30 PM – 8:30 PM Evening Conference ReceptionGrand Ballroom Foyer 7:15 PM – 7:45 PM SYIS Awards AnnouncementsOsgoode Ballroom

SYIS Scientific Excellence Awards: Martin A. Barbier; Anabelle Demers; Paul Gehret; Sara Rostami, DVMSponsored by Advanced Healthcare Materials/WileySYIS Career Development Award: Adriana Flórez Sponsored by Science Translational Medicine/AAAS

8:30 PM – 9:30 PM 2024 Planning Team MeetingSimcoe/Dufferin, 2nd Floor

9:05 AM – 9:10 AM 92Injectable, Pore–forming, Perfusable Double–network Hydrogels Resilient To Extreme Biomechanical StimulationsG. Bao, S. Taheri, J. Li, L. Mongeau; McGill University, Montreal, QC, CANADA.

9:10 AM – 9:15 AM 93Biofunctional Peptide–based 3D Matrices For Advanced Tissue EngineeringA. Ross; University of Ottawa Heart Institute, Ottawa, ON, CANADA.

9:15 AM – 9:20 AM 94Extracellular Matrix Hydrogel Platform For The Interrogation Of The Role Of Inflammation In T Cell Migration In Type 1 DiabetesM. M. Samojlik1, S. N. Patel1, Y. Li2, A. T. Fernandez1, T. M. Brusko2, C. E. Mathews2, E. A. Phelps1, C. L. Stabler1; 1Biomedical Engineering, University of Florida, Gainesville, FL, 2Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.

9:20 AM – 9:25 AM 95RhCollagen – The Ideal Building Block For 3D Printed And Injectable Scaffolds For Regenerative MedicineM. Rubinchik–Stern, R. Mashiach, S. Louzoun–Zada, N. Orr; R&D, CollPlant LTD, Rehovot, ISRAEL.

9:25 AM – 9:30 AM 142Biocompatible Peg Diacrylate Hydrogel Nanocomposite Emulsion Scale Down For SiRNA Drug Delivery Platforms For Adipocyte Beiging R. Negru1, J. Park1, F. Teymour2, G. Papavasiliou1, M. Vaicik1; 1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 2Chemical Engineering, Illinois Institute of Technology, Chicago, IL.

Session Chairs: Marcella Vaicik and Eric Brey

SYIS Co–Chair: Heta Lad

Keynote Speaker:

8:00 AM – 8:30 AM In Vitro and In Vivo Oxygen Imaging Assessment of Islet Transplantation Devices

Mrignayani Kotecha

ORAL PRESENTATIONS:

8:30 AM – 8:50 AM 97

High–frequency Ultrasound To Assess The Acoustic Properties Of Cell–laden Hydrogels In Vitro

J. A. Sebastian1,2, E. M. Strohm3, E. Chérin4, B. Mirani1,2, Z. Mirzaei1,2, C. Démoré4, M. C. Kolios3, C. A. Simmons1,2;


PROGRAM . WEDNESDAY

Grand Ballroom East Session 26: Non–invasive Imaging and Analysis of Engineered Tissues

Grand Ballroom West Session 27: Cell–based Approaches to Cardiac Regeneration & Repair

1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, ON, CANADA, 3Department of Physics, Ryerson University, Toronto, ON, CANADA, 4Sunnybrook Research Institute, Toronto, ON, CANADA.

8:50 AM – 9:10 AM 98

CT–visible Microspheres Enable In Vivo Tracking Of Biomaterial Distribution After Ultrasound–guided Intramyocardial Injection

A. Bettini1, P. Patrick2, R. M. Day1, D. J. Stuckey2; 1Centre for Precision Healthcare, University College London, London, UNITED KINGDOM, 2Centre for Advanced Biomedical Imaging, University College London, London, UNITED KINGDOM.

9:10 AM – 9:30 AM 99

Comprehensive Toolbox For Functional Analysis Of Ipsc Derived Cardiomyocytes

D. E. Cortes1,2, B. Toma3, Y. Wu2, A. Saraf3,4,5; 1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Developmental Biology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, Heart and Vascular Institute, Pittsburgh, PA, 4Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, 5Department of Medicine, Aging Institute, Pittsburgh, PA.

Session Chairs: Craig Simmons and Stephanie Protze

SYIS Co–Chair: Saif Rjaibi

Keynote Speaker:

8:00 AM – 8:30 AM Cell Therapies for the Cardiac Conduction System

Stephanie Protze

ORAL PRESENTATIONS:

8:30 AM – 8:45 AM 100

Functional Maturity Of Pluripotent Stem Cell–Derived Cardiomyocytes Is Advanced With A Novel Maturation Medium Formulation

N. Callaghan1, L. Durland1, W. Chen2, U. Kuzmanov3, M. Z. Miranda1, Z. Mirzaei1, R. Ireland1, M. M. Kim1, J. Audet1, P. Santerre1, A. Gramolini3, S. Mital4, J. Ellis5, P. Backx2, C. Simmons1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Department of Biology, York University, Toronto, ON, CANADA, 3Department of Physiology, University of Toronto, Toronto, ON, CANADA, 4The Hospital for Sick Children, Toronto, ON, CANADA, 5Department of Molecular Genetics, University of Toronto, Toronto, ON, CANADA.


PROGRAM . WEDNESDAY

8:45 AM – 9:00 AM 101

Fibrin, Bone Marrow Cells And Macrophages Interactively Modulate Cardiomyoblast Fate: An In Vitro Study

I. Borrego1, A. Frobert1, s. Cook2, M. N. Giraud1; 1Unifr, Fribourg, SWITZERLAND, 2HFR, Fribourg, SWITZERLAND.

9:00 AM – 9:15 AM 102

Harnessing The Potential Of Immune Cells To Promote Cardiac Repair Following Myocardial Infarction

Y. K. Alshoubaki, B. Nayer, E. Salimova, Y. Lu, J. Tan, G. del Monte Nieto, M. Martino;

Australian Regenerative Medicine Institute, Monash University, Clayton, AUSTRALIA.

9:15 AM – 9:30 AM 103

Proteomic Profiling Of Cardiac Tissue After Cell–based Therapies

N. Makkaoui1, V. Prasad1, H. Toren1, T. Carmona1, K. Li1, J. Maxwell2; 1Emory University School of Medicine, Atlanta, GA, 2Wake Forest Institute for Regenerative Medicine, Winston–Salem, NC.

Session Chairs: Feng Zhao and Ngan Huang

SYIS Co–Chair: Alexane Thibodeau

Keynote Speakers:

8:00 AM – 8:30 AM Engineering Anastomotic and Structured Microvessels for Soft Tissue Regeneration

Feng Zhao

8:30 AM – 9:00 AM Stem Cells, Diabetes, and Vascular Regeneration

Sara Nunes Vasconcelos

ORAL PRESENTATIONS:

9:00 AM – 9:10 AM 104

Vasculature–on–a–chip Platform With Innate Immunity Enables Identification Of Angiopoietin–1 Derived Peptide As A Therapeutic For Sars–cov–2 Induced Inflammation

X. Lu;


9:10 AM – 9:20 AM 105

Physiologically Engineered In–vitro Model Of Lymphatic Vessel Growth & Function Using HA–Hydrogels

L. Alderfer, F. Fan, D. Hanjaya–Putra;

University of Notre Dame, Notre Dame, IN.

Osgoode Ballroom Session 28: Engineering Microvasculature for Tissue Regeneration

Sponsored By: MCS / The Microcirculatory Society, Inc.


Grand Ballroom Centre Session 29: 3D Tissue–Engineered Cancer/Disease Modeling and Organoids Part 2

9:20 AM – 9:30 AM 106

Vascularized Heart–On–A–Chip For Drug Testing And Disease Modeling

Y. Zhao1, M. Radisic1, G. Vunjak–Novakovic2; 1University of Toronto, Torono, ON, CANADA, 2Columbia University, NYC, NY.

9:30 AM – 9:45 AM Coffee Break Grand Ballroom Foyer

Session Chairs: Eliza Fong and Rui Reis

SYIS Co–Chair: Ahmad Galuta

Keynote Speaker:

9:45 AM – 10:05 AM Engineering Tumor Explants with Biomaterials

Eliza Fong

ORAL PRESENTATIONS:

10:05 AM – 10:20 AM 107

Investigating The Effects Of Microenvironmental Features On Tumor Cell Heterogeneity In Pancreatic Cancer Using A 3D In Vitro Model

N. Landon–Brace1, J. L. Cadavid2, S. Latour1, I. L. Co1, E. Bugbee1, A. P. McGuigan2; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

10:20 AM – 10:35 AM 108

Probing The Interaction Of Macrophages And Tumour Cells In The Hypoxic Pancreatic Cancer Microenvironment Using A 3D In Vitro Model

I. L. Co1, N. Landon–Brace1, S. Lamorte2, A. Fomina1, J. L. Cadavid1,3, Z. Xia3, T. L. McGaha2,4, A. P. McGuigan1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CANADA, 3Dept of Chemical Engineering and Applied Sciences, University of Toronto, Toronto, ON, CANADA, 4Dept of Immunology, University of Toronto, Toronto, ON, CANADA.

10:35 AM – 10:50 AM 109

Microbiome Metabolites Alter Immune Checkpoint Blockade Efficacy In Novel Immunoreactive Cancer Organoid Model

E. N. Shelkey, S. Soker;



PROGRAM . WEDNESDAY

10:50 AM – 11:05 AM 143

Colorectal Cancer Secretome Promotes Fibroblast Activation And Suppresses Pericyte Function In 3d Premetastatic Niche Model

K. Nairon1, A. Skardal2,1; 1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH.


11:05 AM – 11:10 AM 111

Modular Hydrogels Enable Ex Vivo Prostate Cancer Xenograft Culture Alongside Stromal Fibroblasts In A High–throughput Microfluidic Plate

A. Bonteanu1, D. Iyer2, P. Shepherd3, R. Kittles4, N. M. Navone3, K. Bircsak2, D. Harrington5; 1Department of Bioengineering, Rice University, Houston, TX, 2MIMETAS US Inc, Gaithersburg, MD, 3Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 4City of Hope, Duarte, CA, 5Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX.

11:10 AM – 11:15 AM 112

IFlowplate– A Customized 384–Well Plate For The Culture Of Perfusable And Vascularized Colon Organoids

S. Rajasekar, D. S. Lin, L. Abdul, A. Liu, A. Sotra, F. Zhang, B. Zhang;


Session Chairs: Michael McClure and Lisa Larkin

SYIS Co–Chair: Vimala Devi Mohan

Keynote Speaker:

9:45 AM – 10:15 AM Impacts of Aging Upon the Host Response to Extracellular Matrix–Based Biomaterials

Bryan Brown

ORAL PRESENTATIONS:

10:15 AM – 10:30 AM 113

3d Printed Biphasic Inductive PCL Scaffolds For Treating Large Osteochondral Defects In Porcine Model

P. W. Whitlock1, J. Hall2, J. Lin2, S. Murab3; 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH, 3Indian Institute of Technology Mandi, Mandi HP–175075, INDIA.

Grand Ballroom East Session 30: ECM Technologies in Musculoskeletal Repair

Grand Ballroom West Session 31: Regenerative Medicine Applications to Organ Transplantation Medicine

10:30 AM – 10:45 AM 114

Development Of Photocrosslinkable Colloidal Composite Decellularized Cartilage Extracellular Matrix Bioinks

K. Hogan1,2, M. Perez1, A. G. Mikos1; 1Bioengineering, Rice University, Houston, TX, 2Medical Scientist Training Program, Baylor College of Medicine, Houston, TX.

10:45 AM – 11:00 AM 144

Development Of Antibacterial Hydrogels Based On Hyaluronic Acid And ɛ-poly-l-lysine For Bone Tissue Regeneration

K. Salma-Ancane1, A. Sceglovs1, I. Kreicberga1, A. Ramata-Stunda2, V. Nikolajeva2, D. Loca1; 1Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Riga Technical University, Riga, LATVIA, 2Department of Microbiology and Biotechnology, Faculty of Biology, University of Latvia, Riga, LATVIA.

11:00 AM – 11:15 AM 116

Engineering Pre–vascularized Bone Tissue Through Simulating Endochondral Ossification

H. Lin, X. Zhang;

University of Pittsburgh School of Medicine, Pittsburgh, PA.

Session Chairs: Giuseppe Orlando and Kim Solez

SYIS Co–Chair: Tania Sultana

Keynote Speakers:

9:45 AM – 10:15 AM Developing Targeted Cell Therapies for Liver Disease

Shinichiro Ogawa

10:15 AM – 10:45 AM The Potential of Regenerating Ischemically Damaged Renal Allografts

Lauren Brasile

ORAL PRESENTATIONS:

10:45 AM – 11:00 AM 117

An Open Thin Film Microwell Beta Cell Delivery Device For Type 1 Diabetes

R. de Vries1, D. de Bont1, R. Goutchtat2, E. J. de Koning3, T. Hubert4, F. Pattou5, A. A. van Apeldoorn1; 1MERLN institute for technology–inspired regenerative medicine, Maastricht University, Maastricht, NETHERLANDS, 2Université de Lille, Lille, FRANCE, 3Department of Endocrinology, Leiden University Medical Center, Leiden, NETHERLANDS, 4Faculté de Médecine de Lille Pôle Recherche, Université de Lille, Maastricht, NETHERLANDS, 5Department of General and Endocrine Surgery, University Hospital Lille, Lille, FRANCE.


PROGRAM . WEDNESDAY

Osgoode Ballroom Session 32: Biometal Mediated Tissue Regeneration

Session Chairs: Kelvin Yeung and Donghui Zhu

SYIS Co–Chair: Lorena Duarte

Keynote Speakers:

9:45 AM – 10:15 AM Additive Manufactured Biodegradable Metal Scaffolds for Bone Tissue Engineering

Donghui Zhu

10:15 AM – 10:45 AM Osteoimmunomodulated Bone Healing By Sequential Intervention Of Divalent Cation

Kelvin Yeung

ORAL PRESENTATIONS:

10:45 AM – 11:00 AM 119

3d Printing Of LEGO®–inspired Titanium Scaffold For Patient–specific Regenerative Medicine

S. S. Lee1, X. Du1, T. Smit1, D. Seiler2, M. de Wild2, S. J. Ferguson1; 1Institute for Biomechanics, ETH Zurich, Zurich, SWITZERLAND, 2Institute for Medical and Analytical Technologies, University of Applied Sciences Northwestern Switzerland, Muttenz, SWITZERLAND.

11:00 AM – 11:15 AM 120

Osteoimmunomodulated Bone Healing By Sequential Intervention Of Divalent Cation

K. Yeung, W. Qiao;

Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, HONG KONG.

11:15 AM – 11:30 AM Closing CeremonyGrand Ballroom Centre


1:00 PM – 2:30 PM SYIS Career Panel DiscussionOsgoode Ballroom Sponsored by: Medicine by Design (MbD), and Burroughs Wellcome Fund

Panelists: Erin Bedford, PhD, Aspect Biosystems Mary Clare McCorry, PhD, ARMI Alanna Gannon, PhD, Wiley

2:30 PM – 5:00 PM SYIS Lab Tours at JLABS and CRAFTPre–registration required. Meet in the Osgoode Ballroom at 2:30 pm.

11:00 AM – 11:15 AM 118

3d Bioprinted Kidney–derived Bioink Constructs For Renal Tissue Regeneration

S. Lee, G. Carreno Galeano, J. Yoo, A. Atala;


POSTER SESSION 1Sunday, July 10, 20226:30 PM - 8:30 PM


POSTER SESSION . SUNDAY

3D Bioprinting Methods and Applications

A 1

Microfluidics-based Coaxial 3d Bioprinting Of Hydrogels For Salivary Tissue Engineering

Y. Yin1,2, E. J. Vazquez-Rosado3,1, A. Farach4, D. A. Harrington1,2; 1Department of Diagnostic and Biomedical Sciences, UT Health Science Center at Houston, Houston, TX, 2Department of Bioengineering, Rice University, Houston, TX, 3Department of Biology, University of Puerto Rico-Mayagüez, Mayagüez, PUERTO RICO, 4Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX.

A 2

Hand-held Biopen For Corneal Tissue Regeneration

D. N. García;

Maastrich University, Maastrich, NETHERLANDS.

A 4

3d Conduit Model Bio Printing For Mimicking The Human Intestines. Son1, d. Lee1, j. Seok1, d. Kim2, s. park1, j. Lee1; 1Nano Convergence & Manufacturing Systems Research Division, Korea Institute of Machinery & Materials, Dajeon, KOREA, REPUBLIC OF, 2Seoul national university, seoul, KOREA, REPUBLIC OF.

A 6

Fresh Bioprinting Of Cellularized Dynamic Hydrazone-crosslinked Poly(oligoethylene Glycol Methacrylate) Hydrogels

E. Mueller, F. Xu, T. Hoare;


A 7

Shape-adaptable Printhead Enables Single-step Conformal Bioprinting Of Tissue Sheets Onto Physiologically Curved Surfaces

L. Wei1, S. Singh1, E. Samiei1, T. Veres2,1, A. Guenther1,3; 1Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Life Sciences Division, National Research Council of Canada, Boucherville, QC, CANADA, 3Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

A 8

Hepatoprotective Bioink for 3d Bioprinting of Liver

J. Anupama Sekar, P. R. Anil Kumar;

Division of Tissue Culture, Department of Applied Biology, Sree Chitra Tirunal Institiute for Medical Sciences and Technology, Thiruvananthapuram, INDIA.

A 9

Engineering Soft Connective Tissues With Mimetic Biaxial Mechanical Properties Using Melt Electrowriting

B. Mirani1,2,3, S. O. Mathew4, N. Latifi1,3, S. Zahavi3, B. G. Amsden4, C. A. Simmons1,2,3; 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Translational Biology and Engineering Program, University of Toronto – Ted Rogers Centre for Heart Research, Toronto, ON, CANADA, 4Department of Chemical Engineering, Queen’s University, Kingston, ON, CANADA.

A 10

Real-time Measurement Of Cell Concentration During Bioprinting

A. A. Matavosian, J. Matthews, L. J. Bonassar;

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY.

A 11

Three-dimensional Bioprinting Of Tissue With A Branching Vessel Network

I. Goldfracht, Y. Zagury, M. Machour, J. Zavin, S. Levenberg;

Biomedical Engineering, Technion- Israel Institute of Technology, Haifa, ISRAEL.

A 12

Evaluation Of The Acoustic Droplet Ejection Method For Bioprinting Regarding Bioinks, Printing Parameters And Cellular 3d Printed Structures

S. Jentsch, H. Fischer;

Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Aachen, GERMANY.

A 13

Understanding The Mechano-biological Pathways Involved In Bioprinted Skin Remodeling

S. Anis1, K. Willson1, S. Soker2, A. J. Atala2; 1Biomedical Engineering, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, 2Wake Forest Institute for Regenerative Medicine, Winston Salem, NC.

A 14

Clickable Dynamic Bioinks

P. Tournier1, N. Lagneau1, B. Halgand1, F. Loll1, J. Guicheux2, C. Le Visage1, V. Delplace1; 1Regenerative Medicine and Skeleton, RMeS, UMR 1229, Université de Nantes, Oniris, INSERM, Nantes, FRANCE, 2Regenerative Medicine and Skeleton, RMeS, UMR 1229, Université de Nantes, Oniris, CHU Nantes, INSERM, Nantes, FRANCE.

3D Tissue -Engineered Cancer/Disease Modeling and Organoids A 15

The Anti-metastatic Effect Of Pdk4 Inhibition In Bladder Cancer Via Akt, Erk, And Jnk Signaling Pathway

E. Lee1, B. Yoon1, M. Jeon1, S. Chun2, J. Lee1, J. Chung1, B. Kim1, T. Kwon1, Y. Ha1; 1Kyungpook National Univeristy, Daegu, KOREA, REPUBLIC OF, 2Kyungpook National Univeristy Hospital, Daegu, KOREA, REPUBLIC OF.

A 16

3D Microgels To Quantify Tumor Cell Properties And Therapy Response Dynamics

N. C. Wu1, J. L. Cadavid1,2, X. Tan2, S. Latour2, S. Scaini2, A. P. McGuigan1,2; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

A 17

Sex-specific Differences In Kidney Function Of (non-) Diabetic Patients

S. Sangita Swapnasrita;

cell Biology Inspired Tissue Engineering, MERLN, Maastricht University, Maastricht, NETHERLANDS.

A 18

Elucidating The Consequence Of The Inflammatory Human Astrocyte Secretome On Bioengineered Neural Organoids

S. Aghlara-Fotovat, First1,2, M. Anderson2, C. Cvetkovic2, M. Patel2, A. Tahanis2, O. Veiseh1, R. Krencik2; 1Bioengineering, Rice University, Houston, TX, 2Neurosurgery, Houston Methodist Research Institute, Houston, TX.

A 19

Bisphenol A Could Promote Bladder Cancer Progression

È. Pellerin1, F. Pellerin1, S. Chabaud1, F. Pouliot1,2, M. Pelletier1,3, S. Bolduc1,2; 1Centre de Recherche du CHU de QuébecUniversité Laval, Québec, QC, CANADA, 2Department of Surgery, Faculty of Medicine, Laval University, Québec, QC, CANADA, 3Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, Laval University, Québec, QC, CANADA.

A 20

Development Of Synovial Joint Organ-on-a-chip For Modelling Cartilage Compression And Immune Cell Interactions In Osteoarthritis

K. Cheung1, L. Banh2,3, M. Chan2,3, H. Shao1,3, S. Viswanathan2,3,4, E. Young1,3; 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Toronto, ON, CANADA, 3Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 4Division of Hematology, Department of Medicine, University of Toronto, Toronto, ON, CANADA.

A 21

In Vitro Metastasis-on-a-chip Model Offers Insight Into Rcan1-4’s Activity As A Metastasis Suppressor In Thyroid Cancer

K. Nairon1, N. Rajan2, M. Ringel2,3, A. Skardal3,1; 1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, 3The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH.

A 23

Modeling HFpEF Diastolic Dysfunction In A Heart-on-a-chip Platform

O. Mourad1,2, S. S. Nunes Vasconcelos1,2,3; 1Experimental Therapeutics, Toronto General Hospital Research Institute, Toronto, ON, CANADA, 2Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CANADA.

A 24

Breast Cancer Organoids As A Model For Testing Personalized Therapies

N. Wajih1, R. A. Erali1, S. D. Forsythe1, M. M. Howard-McNatt2, A. Chiba3, K. Votanopoulos3, S. Soker1; 1Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 2Surgical oncology, Atrium Health Wake Forest Baptist, Winston-Salem, NC, 3Surgical Oncology, Atrium Health Wake Forest Baptist, Winston-Salem, NC.

A 25

Bioengineered Silk Scaffolds Incorporating Crypt And Villi Architecture And Oxygen Gradients For Microbiome Culture

S. Rudolph, Y. Chen, D. Kaplan, B. Longo;

Biomedical Engineering, Tufts University, Medford, MA.

A 26

A Novel 3D Co-culture Model Of Primary Open Angle Glaucoma

H. C. Lamont1, M. Jones2, I. Masood3, A. J. El Haj1, L. M. Grover1, L. J. Hill1; 1Healthcare Technologies Institute, University of Birmingham, Birmingham, UNITED KINGDOM, 2Cell Guidance Systems Ltd, Cambridge, UNITED KINGDOM, 3Institute of Clinical Sciences, University of Birmingham, Birmingham, UNITED KINGDOM.

A 27

Studying Glioblastoma Induced Blood Brain Barrier Changes Using An In Vitro Tissue Engineered Model

T. DePalma1, A. Skardal1,2; 1Biomedical Engineering, The Ohio State University, Columbus, OH, 2The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH.

A 28

Sensitizing Glioma Stem Cells To Temozolomide In Hyaluronan Hydrogel-Based Glioblastoma Organoids

J. Che1, T. DePalma1, L. S. Mezache1, R. Veeraraghavan1, K. Swindle-Reilly1,2,3, A. Skardal1,4; 1Biomedical Engineering, The Ohio State University, Columbus, OH, 2Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 3Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, 4The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH.



Articular Cartilage Bioengineering & Regeneration

A 29

Mechanistic Study Comparing The Chondrogenic Potential Of Primary Mesenchymal Stem Cells And Ipsc-derived Multipotent Cells

H. Lin, S. Xiang;


A 30

Glycosaminoglycans Contribution To The Mechanical And Electrokinetic Properties Of The Articular Cartilage

A. Pieters, M. Garon;

Biomomentum Inc., Laval, QC, CANADA.

A 31

Physicochemical Characterization Of Peptide Tethered Thiolated Gelatin Microparticles For Cartilage Tissue Engineering

E. Y. Jiang, H. A. Pearce, S. Desroches, A. G. Mikos;


A 32

Sirna Delivery To Control Aggrecan Deposition By Fibrochondrocytes For Meniscus Tissue Engineering

S. G. Lopez, L. J. Bonassar;

Biomedical Engineering, Cornell University, Ithaca, NY.

A 33

Articular Cartilage Repair By Tissue Engineering And Cell Therapy: A Pre-clinical Trialimaging Evaluation

A 34

Sexual Dimorphisms In Meniscal Spheroid Regeneration

J. C. Bradford1, D. K. Chavez1, A. Morrell2, J. L. Robinson1; 1Bioengineering, University of Kansas, Lawrence, KS, 2Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS.

Bioactive Biomaterials for Soft Tissue Engineering

A 35

An In Vitro 3D Printed Platform To Investigate Vascularization For Enhancing Peripheral Nerve Repair

R. Steiner1,2, J. Buchen1,2, L. Alvarez1,2, P. Pasquina1,3, S. Jariwala1,2; 1Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, 2Henry M. Jackson Foundation, Bethesda, MD, 3Walter Reed National Military Medical Center, Bethesda, MD.

A 36

Injectable Porous Hydrogels For Muscle Regeneration Using A Perfluorocarbon Emulsion As An In-situ Porogen

S. Toufanian1, A. Lofts2, R. Baksh1, T. R. Hoare1; 1Chemical Engineering, McMaster University, Hamilton, ON, CANADA, 2School of Biomedical Engineering, McMaster University, Hamilton, ON, CANADA.

A 37

Development Of Artificial Retinas For The Treatment Of Degenerative Eye Disease And The Augmentation Of Human Vision

M. T. Gwiazda, M. L. Turner, S. Webb;

The Department of Chemistry, The University of Manchester, Manchester, UNITED KINGDOM.

A 38

Amniotic Membrane Nanoparticles: An Ingenious Approach Towards Regenerative Medicine And Ocular Wound Healing

R. Thada1, D. Gunasekaran1, U. Tiruchirapalli Sivagnanam2; 1Department of Leather Technology (Housed at CSIR-CLRI), AC Tech Campus, Anna University, Chennai, INDIA, 2Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai, INDIA.

A 39

Nanofibrous Drug Eluting Coating Of Vascular Graft For The Treatment Of Vascular Graft Infections

S. Serpelloni1, M. Rahimi2, F. Taraballi1; 1Center for musculoskeletal regeneration, Houston Methodist Academic Institute, Houston, TX, 2Department of Vascular surgery, Houston Methodist Hospital, Houston, TX.

A 40

3d Printed Custom Designed Tissue Engineered Vascular Graft Provides Optimal Attenuated Neointimal Hyperplasia And Flow Dynamics In Porcine Pulmonary Artery Reconstruction Model

T. Dunn1, H. Matsushita1, N. Lee1, K. Nurminsky1, P. Mass2, V. Cleveland2, K. Nelson3, D. Rodgers1, K. Kawaji4, J. Johnson3, L. Oliveri2, A. Krieger5, N. Hibino1,6, H. Hayashi7; 1Cardiothoracic Surgery, University of Chicago, Chicago, IL, 2Department of Cardiology, Children’s National Medical Center, Washington, DC, 3Nanofiber Solutions, Dublin, OH, 4Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 5Department of Mechanical Engineering, University of Maryland, Baltimore, MD, 6Department of Cardiovascular Surgery, Advocate Children’s Hospital, Oak Lawn, IL, 7University of Chicago, Chicago, IL.

A 41

Effects Of Processing On The Properties Of Biomaterials Derived From Decellularized Porcine Organs And Correlation With Insulin-secreting Cell Responses

V. Dhandapani1,2, S. Abdollahi1,2, V. Girard1,2, P. Vermette1,2; 1Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, QC, CANADA, 2Faculté de médecine et des sciences de la santé, Centre de recherche du CHUS, Sherbrooke, QC, CANADA.

A 42

A Quantitative Tack On The Nano Construct For The Modulation Of Inflammatory Cytokines In Burn Scars

N. Panneerselvam Manimegalai1,2, U. Tiruchirapalli Sivagnanam1; 1Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai, INDIA, 2Department of Leather Technology, Alagappa College of Technology, Anna University, Chennai, INDIA.



Biofabrication and Software Tools in TERM

A 43

Modeling Of Mass Transfer Processes In A Gel Matrix Applied To 3d Bioprinting Technology

D. Khramtsov1,2, A. Moshin1,2, D. Nekrasov1,2, O. Sulyagina1,2; 1Department of Low Temperature Engineering, Moscow Polytechnic University, Moscow, RUSSIAN FEDERATION, 2Department of Chemical Engineering, MIREARussian Technological University, Moscow, RUSSIAN FEDERATION.

A 44

Effects Of PEGDA+GelMA Bioink On Adipose Derived Cells

Z. Congress, M. Brovold, J. Huh, S. Soker;

Wake Forest Insitute for Regenerative Medicine, winston-salem, NC.

Biomaterials and Immunomodulation

A 45

Response Of Primary Human Osteoblast To Second-generation Spinal Bone Graft

L. Jongpaiboonkit1, P. Li2, C. Ogden1, I. Dunkley1, J. Badura1; 1Spine and Biologics, Medtronic, Memphis, TN, 2Applied Research, Medtronic, Sterling, MA.

A 46

Modular Oxygen-generating Biomaterials For In Situ Resolution Of Hypoxia And Ischemia

R. P. Accolla, J. Liang, T. R. Lansberry, I. Labrada, M. Loaisiga, B. Lopez Sardi, C. Stabler;

Biomedical Engineering, University of Florida, Gainesville, FL.

A 47

Porcine Breast Tissue Processing Utilizing Supercritical Carbon Dioxide

H. Abe1, T. Fujisato2, K. Sawada3; 13-104-4-109,Higashiasakayama-chou, Sakai-city, JAPAN, 25-7-12 Midorigaoka, Toyonaka-city, JAPAN, 32-13-14 Daidouminami, Osaka-city, JAPAN.

A 48

Adhesive Nanofibrous Hydrogel Demonstrates Synergistic Effect Of Chemo-immunotherapy For Osteosarcoma Treatment

C. Lee;

Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, TAIWAN.

Biomaterials for Endogenous Cardiovascular Repair

A 50

Effective Method To Enhance HUVEC Proliferation Through ROS Generated By Photosensitizer Immobilized PET Film

S. Hong1,2, M. Koo1,2, M. Lee1, E. Go1,3, J. Park1,2,3; 1Department of Medical Engineering, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2Department of Medical Engineering, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Department of Medical Device Engineering and Management, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF.

A 51

Immunoengineered Mxene Quantum Dots For Treatment Of Allograft Vasculopathy

W. Yan, A. Rafieerad, K. N. Alagarsamy, A. Srivastava, N. Sareen, R. Arora, S. Dhingra;

Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, MB, CANADA.

A 52

Effect Of Surface Topographies On Vascular Smooth Muscle Cell Proliferation And Phenotype Changes

Y. Yao, D. David, A. Zaw, J. Kunihiro, E. K. Yim;

University of Waterloo, Waterloo, ON, CANADA.

A 53

Engineering Surface Modified Low Temperature Plasma Treated Polytetrafluoroethylene Scaffolds For Vascular Tissue Regeneration

A. B. Montgomery, K. Vig;

Biological Sciences, Alabama State University, Montgomery, AL.

A 55

Novel Lipopolyplexes Using Targeting Branched Peptides Selective For Her2-positive Breast Cancer Optimised For The Delivery Nucleic Acid

G. Peregrino1, L. Kudsiova2, M. Santin3; 1School of Architecture, Technology and Engineering, University of Brighton, Brighton, UNITED KINGDOM, 2School of Applied Sciences Centre, University of Brighton, Brighton, UNITED KINGDOM, 3School of Applied Sciences, University of Brighton, Brighton, UNITED KINGDOM.

Stem Cell Fate

A 56

Application Of Porcine Kidney-derived Extracellular Matrix As Coating, Hydrogel, And Scaffold Materials For Renal Proximal Tubular Epithelial Cell

M. JEON, E. Lee, S. Chun, B. Yoon, H. Kim, J. Chung, J. Lee, Y. Ha, T. Kwon, K. Byeon, B. Kim;

BioMedical Research Institute, Daegu, KOREA, REPUBLIC OF.

A 57

Injectable Nanofibrous Micro-carrier With Tailored Degradable Properties As A Nextgeneration Cell Delivery System For Specific Tissue Engineering Application

N. Sarviya;

Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, INDIA.



A 58

Biodegradable Hybrid Scaffold With Polydeoxyribonucleotide/bone Morphogenetic Protein-2 Nanocomplex Using Human Fetal Derived Mesenchymal Stem Cells For Bone Regeneration

D. Han1, J. Lee1, D. Kim2; 1CHA university, Seongnam-si, KOREA, REPUBLIC OF, 2Chung-Ang university, Seoul, KOREA, REPUBLIC OF.

A 59

In Vitro Cytocompatibility And Pro-osteogenic Effect Of Octacalcium Phosphate

I. Kovrlija1, K. Menshikh2, A. Cochis2, L. Rimondini2, J. Locs1,3, D. Loca1,3; 1Rudolfs Cimdins Riga Biomaterials Innovation and Development Centre, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Riga Technical University, Pulka 3, LV-1007, Riga, LATVIA, 2Center for Translational Research on Autoimmune and Allergic Disease—CAAD, Department of Health Sciences, Università del Piemonte Orientale, 28100, Novara, ITALY, 3Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Kalku Street 1, LV-1658, Riga, LATVIA.

Bio-metals Mediated Tissue Regeneration

A 60

Thymoquinone Intercalated Strontium-iron Layered Double Hydroxides For Bone Regeneration

G. Sekar Jeyakumar1,2, G. Ramanathan1, U. Tiruchirappalli Sivagnanam1,2; 1Biological Material Laboratory, CSIR-Central Leather Research Institute, Chennai, INDIA, 2Department of Leather Technology, Anna University, Chennai, INDIA.

Bioreactors and Organs-on-chips in TERM

A 61

3D Printing Of Elastomeric Microtubes Via Coaxial Extrusion For High Throughput Organ-on-a-chip Device Fabrication

C. Liu1, S. B. Campbell1,2, J. Li3, J. Kieda1, P. R. Herman3, M. Radisic1,2,4; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2University Health Network, Toronto, ON, CANADA, 3Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, CANADA, 4Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

A 62

A Modular Microreactor For The Maintenance Of Multilayer Tissues Or Multi-tissue Structures

L. Gasperini1,2, A. I. Soares1,2, Z. Eltayari1,2, R. L. Reis1,2, A. P. Marques1,2; 13B’s Research Group, Barco, PORTUGAL, 2ICVS/3B’s, Braga, PORTUGAL.

A 63

Generation Of Innervated Tissue Chip To Study Joint Pain

H. Lin, M. Makarczyk;


A 64

Development Of A Universal Bioreactor Platform For Regenerative Medicine Applications

P. Lee1, A. Mehta1, D. Lim1, E. Renteria1, Y. Ju1, F. Marini1, J. Kim1, T. Criswell1, T. Shupe1, A. Atala1, M. Gurcan2, S. Soker1, J. Hunsberger3, J. Yoo1; 1Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, 2Center for Biomedical Informatics at Wake Forest School of Medicine, Winston-Salem, NC, 3RegenMed Development Organization, Winston-Salem, NC.

A 65

Development Of A Perfusion Bioreactor For The Fabrication Of Bioengineered Intevertebral Discs Components

A. Upenieks1,2, P. Santerre2,3, R. Kandel1,2,4; 1Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA, 4Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, CANADA.

A 67

A High-throughput Platform With 128 Perfusable Vessels To Study Endothelial Barrier Integrity

D. S. Lin1, S. Rajasekar1, F. Zhang2, B. Zhang1,2; 1Department of Chemical Engineering, McMaster University, Hamilton, ON, CANADA, 2School of Biomedical Engineering, McMaster University, Hamilton, ON, CANADA.

A 68

3d Printed Biomimetic Human Gut-on-a-chip Platforms For Oral Drug Delivery Testing

N. Taebnia1,2, R. Zhang1, T. L. Andresen1, N. B. Larsen1; 1Department of Health Technology, Technical University of Denmark (DTU), Kgs. Lyngby, DENMARK, 2Department of Physiology and Pharmacology, Karolinska institute, Solna, Stockholm, SWEDEN.

A 69

TANDEM: Biomicrofluidic Systems With Transverse And Normal Diffusional Environments For Multidirectional Signaling

M. D. Mohan, E. W. Young;

Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, CANADA.

A 70

Development And Evaluation Of A Fully Enclosed Bioreactor Environment (FEBE) For Automated Biofabrication Of Implantable Tissue Engineered Muscle Repair Constructs

R. Bour, G. Garner, S. Peirce, G. Christ;

University of Virginia, Charlottesville, VA.



Cell Therapeutic Approaches for Retinal Degenerative Diseases

A 71

Enrichment And Characterization Of Human Corneal Exosomes: Impact On Corneal Wound Healing

P. Desjardins1,2,3, R. Berthiaume1,3, C. Couture1,2,3, P. Anney1,3, A. Tchatchouang1,3, S. Proulx1,3, V. J Moulin2,3, L. Germain2,3, S. Guérin1,3; 1Département d’ophtalmologie et d’ORL-CCF, Faculté de médecine, Université Laval., Quebec, QC, CANADA, 2Département de chirurgie, Faculté de médecine, Université Laval., Quebec, QC, CANADA, 3Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Quebec, QC, CANADA.

A 72

Investigating The Role And Mechanisms Of Extracellular Vesicle Signalling In Human Cardiac Tissue-on-a-chip Models

K. T. Wagner1,2, M. Radisic1,3,2; 1Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Toronto General Research Institute, University Health Network, Toronto, ON, CANADA.

A 73

Prosthetic Aortic Valve Fabrication Using An Origami-Inspired Folding Approach

W. Yuan, B. Tefft;

Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI.

A 74

Study Of Aortic Calcific Valve Disease By CRISPR-Cas9 RUNX2 Knock-Out In A Tissue Engineered 3D Model

A. Brodeur1,2, M. Jaguenaud3, V. Roy1, P. Mathieu1, J. Fradette1, F. Gros-Louis1, J. Ruel3; 1Department of surgery, Faculty of medicine, Laval University, Quebec, QC, CANADA, 2Division of Regenerative Medicine, CHU de Québec Research Centre, Laval Univsersity, Québec, QC, CANADA, 3Department of mechanical engineering; Faculty of science and engineering, Laval University, Quebec, QC, CANADA.

A 75

Engineering Allogenic Heart Valve Tissues For Preclinical Testing In A Porcine Model

N. Latifi1,2, M. Lecce3,2,4, B. Mirani1,2,4, T. Sokhanvar1,2, N. Siqueira2,4, M. Bartkevics5, J. Maynes6, P. Santerre2,4,7, C. Simmons1,2,4; 1Mechanical & Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Translational Biology & Engineering Program, The Ted Rogers Centre for Heart Research, Toronto, ON, CANADA, 3Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 4Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 5Division of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, ON, CANADA, 6Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, CANADA, 7Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

ECM Technologies in Musculoskeletal Repair

A 76

Development Of Decellularized ECM-based 3D Bioprinted Muscle Constructs With Dual Growth Factors Delivery For Repairing Volumetric Muscle Loss Injury

Y. Ju, A. Poerio, H. Lee, A. Alwan, S. Lee, A. Atala, J. Yoo;


A 78

Biomechanical Of Abdominal Wall Mesh Implant In A Pig: A Case Study To Develop An Experimental Design.

J. Ortiz-Ortiz1, G. Carbajal-de-La-Torre1, M. A. Espinosa-Medina1, N. N. Zurita-Méndez1, M. Ballesteros-Almanza2, R. E. Pérez-Sánchez3; 1Facultad de Ingeniería Mecánica, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, MEXICO, 2Facultad de Biología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, MEXICO, 3Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, MEXICO.

Engineering Microvasculature for Tissue Regeneration

A 79

Engineering Hierarchical Vascular Chimeras By Combining Human Microvessels With Explanted Murine Vessels

E. A. Margolis, L. S. Choi, N. E. Friend, A. J. Putnam;


A 80

Effects Of Platelet-derived Growth Factors On Vascular Smooth Muscle Cells On Compliance Mismatched Polymer Film

Y. Jeong1, K. Chiam2, E. K. Yim1; 1Department of Chemical Engineering, University of Waterloo, Waterloo, ON, CANADA, 2A*STAR Bioinformatics Institute, Singapore, SINGAPORE.

Frontiers in Spatiotemporal Control for Neural Tissue Engineering

A 81

Induction Of Plxna4 Gene In Human Umbilical Cord-derived Mesenchymal Stem Cells Differentiation By Low Intensity Sub-sonic Vibration

h. cho;

Research Institute of Integrative Life Sciences, Dongguk University, Gyeonggi-do, KOREA, REPUBLIC OF.

A 82

Electrical Stimulation Of Schwann Cells On HA-CNT Nanofibers

J. R. Senanayake, H. Sundararaghavan;

Biomedical Engineering, Wayne State University, Detroit, MI.



Nature as a Source of TERM Biomaterials and Strategies

A 83

Ex Vivo Perfusion Decellularization Of Rat Hindlimbs For Vascular Composite Allotransplantation

A. Adil1,2, G. Karoubi1,3,4, S. Haykal1,2,5; 1Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto General Hospital, University of Toronto, Toronto, ON, CANADA, 2Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CANADA, 3Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CANADA, 4Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 5Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, CANADA.

A 84

‘Super-elastic’ FibrinHa Hydrogels

A. Yayon;

Procore Ltd., Nes Ziona, ISRAEL.

A 85

Proteolytic Degradation And Biophysical Properties Of Collagen Are Modulated By Glycation

M. Vaez1, M. Asgari2, L. Bozec1; 1Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA, 2Department of Mechanical Engineering, McGill University, Montreal, QC, CANADA.

A 86

Porous Anisotropic O-carboxymethyl-chitosan/alginate And No-carboxymethyl-chitosan/alginate Scaffolds For Regenerative Medicine

A. C. Juraski, A. R. Azzoni;

Chemical Engineering, University of Sao Paulo, Sao Paulo, BRAZIL.

A 87

Decellularized Porcine Small Intestine Matrix For Clinical Applications In Skin Regenerative Medicine

S. M. Galvis Escobar1, J. D. Molina Sierra2, J. P. Ruiz Soto1, M. A. Rego Londoño1, L. C. Veloza Angulo2, C. Londoño Pelaez1, C. Pineda Molina1; 1Faculty of Engineering, Universidad CES, Medellin, COLOMBIA, 2Faculty of Veterinary and Zootechnics, Universidad CES, Medellin, COLOMBIA.

A 88

Bioengineering Vascularized Flap Allografts For Reconstruction Of Large Soft Tissue Defects

M. Xu1, T. Waddell1,2, S. Haykal1,3; 1Latner Thoracic Surgery Research Laboratories, Toronto, ON, CANADA, 2Division of Thoracic Surgery, Toronto, ON, CANADA, 3Division of Plastic and Reconstructive Surgery, Toronto, ON, CANADA.

A 89

Compositional Analysis Confirms Matrix Bound Nanovesicles Have Tissue Specific Characteristics Suggesting A Regulatory Role In Homeostasis

N. J. Turner1, L. M. Quijano1, G. S. Hussey1, P. Jiang2, S. F. Badylak1, S. F. Badylak1;

1McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 2Department of Biological, Geological and Environmental Science, Cleveland State University, Cleveland, OH.

Non-invasive Imaging and Analysis of Engineered Tissues

A 90

A Development of Swept Source Optical Coherence Tomography (Ss-Oct) Based Forward-Viewing Endoscopic Probe for Neurosurgical Guidance and Precision Brain Tumor Biopsy

S. Lee, K. Kim;

Pusan National University, Busan, KOREA, REPUBLIC OF.

Recent Progress in Cell Therapy for Regenerative Medicine and Cancer Treatment

A 91

Characterization And Identification Of Exosomes Harvested From Stem Cell Cultures

B. Bhasker;

Transfusion medicine, Sparsh Hospital, BANGALORE, INDIA.

A 92

An Assessment Of Different Behaviours Between Tonsil-derived Stem Cell And Myogenic Differentiated Cell Using Electrotaxis Analysis

E. Go1,2, M. Lee1, M. Koo1,3, S. Hong1,3, J. Park1,2,3; 1Department of Medical Engineering, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 22Department of Medical Device Engineering and Management, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Department of Medical Engineering, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF.

A 93

DMSO-Free Cryopreservation Formulation As An Alternative Cryopreservation Method For Cell-based Therapeutics

A. Pennybaker, R. Alfano;

InVitria, Aurora, CO.

A 94

Effect Of Hepatic Progenitor Cells Derived From Human Placental Stem Cells On Acute Hepatic Failure In A Mouse Model

W. Zhao;

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC.

A 95

Three-dimensional Culture Of Mouse Blastocyst On Uterine Stromal Cells

M. Nakatani, T. Fujisato;

Osaka institute of technology, Osaka, JAPAN.



A 96

The Regeneration Of Human Uterine Tube EpitheliumFrom ,,basal Cells“ To Intercalary Peg Cells

A 97

Heat-inactivation Of Fetal And Newborn Sera Did Not Impair The Expansion And Scaffold Engineering Potentials Of Fibroblasts

S. Chabaud, F. Pellerin, È. Pellerin, C. Caneparo, M. Pelletier, S. Bolduc;

Université Laval, Québec, QC, CANADA.

A 99

Effect Of The ADMSC’s Secretome On Tumor Cell Lines Treated With Plant Extracts

J. A. Ramirez1, B. Rivera2, M. C. Jimenez3, A. Tobón1, A. Barreto3, L. M. Restrepo1; 1University of Antioquia, Medellin, COLOMBIA, 2Unviversity of Antioquia, Medellin, COLOMBIA, 3Pontificia Universidad Javeriana, Bogota, COLOMBIA.

Regeneration in the Context of Aging

A 100

Dna Damage Assessment In Bi-layered Skin Constructs With Recombinant Keratinocytes And Fibroblasts

N. Mahajan1, A. Gorkun1,2,3, M. Wu1, K. Willson1, A. Jorgensen1, S. Soker1, A. J. Atala1; 1WFIRM, Wake Forest University, Winston-Salem, NC, 2FSBSI Institute of General Pathology and Pathophysiology, Moscow, RUSSIAN FEDERATION, 3Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.

Regenerative Medicine Applications to Organ Transplantation Medicine

A 101

Novel Ice-recrystallization Inhibitors Emerge As Effective Cryoprotectants For The Long-term Storage Of Dermal Constructs And Complex Tissues For Transplantation

J. Dagher1, S. Mangan2, R. N. Ben2, V. J. Moulin3; 1Axe Médecine Régénératrice, Université Laval, Québec, QC, CANADA, 2University of Ottawa, Ottawa, ON, CANADA, 3Chirurgie, Université Laval, Québec, QC, CANADA.

A 102

Enhancement Of Contractility And Myokine Secretion Of Tissue-engineered Skeletal Muscle By Electrical And Mechanical Stimulations

R. SAKUTA, S. KOGANO, S. YOKOYAMA, T. NAKAMURA, T. FUJISATO;

Biomedical Eng, Osaka Inst Tech, Osaka, JAPAN.

A 103

Biomechanical Cues Of Hydrogel Regulate Adipose-derived Stem Cells For Nucleus Pulposus Regeneration

Y. Liu1, X. Li2, L. Li3, S. Jiang2, D. Juncker1, L. Haglund3, J. Li2; 1Biological and Biomedical Engineering, McGill University, Montreal, QC, CANADA, 2Mechanical Engineering, McGill University, Montreal, QC, CANADA, 3Experimental Surgery, McGill University, Montreal, QC, CANADA.

Respiratory, Urologic, & Gastrointestinal Tissue Engineering

A 104

Engineering Of Volumetric Skeletal Muscle Tissue For Accelerated Restoration Of Pelvic Floor Muscle Function

J. Kim, I. Ko, M. Jeon, I. Kim, J. Jackson, S. Lee, A. Atala, J. Yoo;

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC.

A 105

The Delivery Of The Recombinant Protein Cocktail Identified By Stem Cell-derived Secretome Analysis Accelerates Kidney Repair After Renal Ischemia-reperfusion Injury

J. Kim, H. Yang, M. Kim, K. Cho, D. Kim, H. Yim, Z. Atala, J. Jackson, I. Ko, J. Yoo;


A 107

Stimulation Of Exosome Secretion By Urine-derived Stem Cells With Controlled Release Of Hepatic Growth Factor

A. Alwan, F. Khalil, T. Dixon, E. Estrada, E. Opara, Y. Zhang;

Wake Forest Institute for Regenerative Medicine, winston salem, NC.

Skin, Wound Healing, and Inflammation

A 108

Perfusable Human Mesenchymal Stem Cell Patch Ameliorates Innate Immune Response

D. Sharma1, L. Hu1, T. Chen1, A. Sharma1, W. He2, J. Goldman2, A. J. Walsh1, F. Zhao1,2; 1Biomedical Engineering, Texas A&M University, College station, TX, 2Biomedical Engineering, Michigan Technological University, Houghton, MI.

A 110

Oxygenating And Antibacterial Macf Hydrogel Dressings Reduce Infection On An Infected Diabetic Wound Model

H. Durr1, S. Abri2, N. D. Leipzig2; 1Biology, University of Akron, Akron, OH, 2Chemical and Biomedical Engineering, University of Akron, Akron, OH.

A 111

Development Of Stem Cell Secretome-based Protein Therapies For Wound Healing Applications

J. Kim1, D. Green1, Y. Ju1, J. Jackson1, S. Lee1, B. Vaughan1, A. Atala1, C. Nykiforuk2, J. Yoo1; 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC, 2Emergent BioSolutions, Winnipeg, MB, CANADA.



A 112

Evaluation of Incisional Wound Treatment with UBM Particulate in a Swine Model

A. Mesaris, A. Vora, N. Remlinger, T. Gilbert, S. Saini;

Integra LifeSciences, Princeton, NJ.

A 113

Inositol-requiring Enzyme 1 (ire1) Regulates The Gallotannin-induced Differentiation Of Human Osteosarcoma Saos-2 Cell Line

S. KIM;

Kongju National University, Gongju-Si, KOREA, REPUBLIC OF.

A 114

Equibiaxial Mechanical Stimulation Reverses The Pro-Fibrotic Transcriptome Of Senescent Dermal Fibroblasts

J. L. Guo, M. Griffin, N. J. Guardino, K. Chen, D. B. Abbas, G. C. Gurtner, M. T. Longaker;

Surgery, Stanford University, Stanford, CA.

A 115

Characterizing The Immune Response Induced By Allogeneic Skin Fibroblasts

B. Magne, L. Germain;

Laval University / LOEX, Québec, QC, CANADA.

A 119

Collagen Hybridizing Peptide Detect Acetic Acid Degraded Collagen In Tissue

S. Huang, N. Ng, L. Bozec;


Strategies for Regeneration of Complex Muscle Defects

A 121

Neural Cell Integration Into 3d Bioprinted Skeletal Muscle Constructs For Restoration Of Muscle Function

J. Kim, Y. Seol, I. Ko, I. Kim, J. Jackson, J. Yoo, S. Lee, A. Atala;


A 122

Towards Innervation Of Bioengineered Muscle Constructs: Development Of A Sustained Neurotrophic Factor Delivery And Release System

A. Poerio1, V. Mashanov1, D. Lai1, M. Kim1, E. Billman1, M. Kaufmann1, Y. Ju1, J. Kim1, S. Lee1, J. Jackson1, F. Cleymand2, J. Mano3, A. Atala1, J. Yoo1; 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC, 2Institut Jean Lamour, Universit´e de Lorraine, Nancy, FRANCE, 3Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Aveiro, PORTUGAL.

A 123

Developing An Approach For Efficient Innervation Of Bioengineered Skeletal Muscle Constructs

V. Mashanov, A. Alwan, M. Kim, D. Lai, A. Poerio, E. Billman, M. Kaufmann, J. Jackson, S. Lee, A. Atala, Y. Ju, J. Kim, J. Yoo;


A 124

Impact Of Passaging Of Primary Skeletal Muscle Cell Isolates On The Engineering Of Skeletal Muscle

O. M. Wroblewski1, C. Kennedy2, E. E. Vega-Soto2, C. E. Forester1, E. Su2, M. H. Nguyen2, P. S. Cederna3, L. Larkin1; 1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 3Plastic Surgery, University of Michigan, Ann Arbor, MI.

A 125

Impact Of Human Skeletal Muscle Isolate Cell-seeding Density On The Structure And Function Of Scaffold-Free Tissue Engineered Skeletal Muscle Units

O. M. Wroblewski1, M. H. Nguyen2, P. S. Cederna3, L. M. Larkin2; 1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 3Plastic Surgery, University of Michigan, Ann Arbor, MI.

Tissue Engineering Solutions for Craniofacial Regeneration

A 126

Hemidesmosome-instructive Materials Control Pericellular Laminin Matrix Presentation For Oral Epithelial Attachment

N. G. Fischer1, D. A. De Jong1, C. Aparicio2,1; 1University of Minnesota, Minneapolis, MN, 2UIC Barcelona – Universitat Internacional de Catalunya, Barcelona, SPAIN.

A 127

Graphene Based Materials For Bone Tissue Regeneration

G. L. Achôa1, P. Almeida2, A. Clements3, Y. Roca3, J. R. Ferreira4, T. L. Fernandes1, R. Riera1, M. T. Amano1, A. Hokugo3, R. Jarrahy3, G. F. Lenz e Silva2, D. F. Bueno1; 1Hospital Sírio-Libanês, São Paulo, BRAZIL, 2Escola Politécnica da Universidade de São Paulo, São Paulo, BRAZIL, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, 4R-Crio Company, Campinas, BRAZIL.




POSTER SESSION . MONDAY

POSTER SESSION 2Monday, July 11, 2022 7:00 PM - 9:00 PM


B 1

Fluidic Seeding Enhances Bioengineered Tissue Fabrication In A Closed Biomanufacturing System

S. Piet1, R. Bour2, A. Capulli3, K. McGrath3, Z. Kops3, M. Tilley3, R. Andrews3, D. Hile1, M. McCorry1, S. Jacobson3, G. Christ2, T. Bollenbach1; 1ARMI, Manchester, NH, 2University of Virginia, Charlottesville, VA, 3DEKA Integrated Solutions Corp., Manchester, NH.

B 2

Enhancing Extrusion Bioprinting Resolution By Manipulation Of Hydrogel Charge Interactions

S. T. McLoughlin, J. P. Fisher;

Bioengineering, University of Maryland, College Park, MD.

B 3

Computational Investigation Of 3D Hybrid-Printed MEHA/PCL Scaffolds Within A Tubular Perfusion Bioreactor System

R. H. Choe1,2, N. M. Eby1,2, B. Kuzemchak1,2, J. Osborne1,2, J. Fisher1,2; 1Fischell Department of Bioengineering, University of Maryland, College Park, MD, 2Center for Engineering Complex Tissues, College Park, MD.

B 4

A Sound Waves-based Platform For 3d Cancer Model Development

N. Di Marzio, M. Alini, T. Serra;

AO Research Institute Davos, Davos Platz, SWITZERLAND.

B 5

Recombinant Human Collagen-Based Bioinks For Biofabrication Applications

R. Zarka, R. Mashiach, S. Luz-Nir, T. Milner, N. Orr;

R&D, CollPlant, Rehovot, ISRAEL.

B 6

One Step Formation Of Protein-Based Tubular Structure For Functional Devices And Tissues

W. Gao, A. Guenther;

Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA.

B 7

A Poly(N-isopropylacrylamide)-based Dual-Gelling Bioink And Poloxamer Support Bath For High-Resolution Bioprinting

A. M. Navara, Y. Kim, Y. Xu, C. L. Crafton, M. Diba, J. L. Guo, A. G. Mikos;


B 8

Production Of Vascularized Functional Liver Tissue Constructs With Long-term Survival

K. Willson, S. Lee, Y. Moon, C. Bishop, J. Yoo, A. Atala;

Biomedical Engineering, Wake Forest University, WINSTON SALEM, NC.

B 9

Modulating MSC/OC Co-culture Conditions To Investigate The Role Of OCs In Bone Tissue Eng.

E. Jabari1,2, R. H. Choe1,3, J. Choi1,2, J. Fisher1,2; 1Fischell Department of Bioengineering, University of MarylandCollege Park, College Park, MD, 2Center for Engineering Complex Tissue, College Park, MD, 3Center for Engineering Complex Tissue, College park, MD.

B 10

Anatomic Images-based 3d Bioprinting And Computational Simulation Of Human Lung Tissue

N. I. Moldovan;

3D Tissue Bioprinting Core Laboratory, Indiana Institute for Medical Research at Richard L. Roudebush VA Medical Center, Indianapolis, IN.

B 11

Expresion Of Pluripotency Markers In Thermal Injet Bioprinted Adult Human Fibroblast

T. Boland;

The University of Texas at El Paso, El Paso, TX.

B 12

An Extrusion-based Bioink Artifact For Quantifying Printability And The Influence Of Printing Parameters And Cell Density On Bioink Printing Outcomes

S. Lee1, G. Gillispie1, J. Fisher2, A. Mikos3, J. Yoo1, A. Atala1; 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 2Fischell Department of Bioengineering, University of Maryland, College Park, MD, 3Rice University, Houston, TX.

B 13

Induction Of Hair Folliculogenesis Within 3d Bioprinted Multi-layered Skin-mimetic Construct

M. Kang, S. Lee, H. Jang, H. Jo, D. Han;

Pusan National University, Busan, KOREA, REPUBLIC OF.

B 14

Development Of A 3D Bioprinted Vascularized Thick Liver Construct

Y. Moon1,2, K. Willson1,2, C. Bishop1,2, A. Atala1,2, J. Yoo1,2, S. Lee1,2; 1WFIRM, Wakeforest University, winston salem, NC, 2Wake Forest Institute for Regenerative Medicine, Winston salem, NC.

3D Tissue -Engineered Cancer/Disease Modeling and Organoids

B 15

Expression Of Fibronectin And Tenascin-c In Native And Engineered Tissues Of Fuchs Endothelial Corneal Dystrophy And Their Role On Cell Adhesion And Migration

A. Tchatchouang1,2,3, S. Jacob1,2,3, I. Brunette4, P. J. Rochette1,2,3, S. Proulx1,2,3; 1Centre de recherche du CHU de Québec-Université Laval, Québec, QC, CANADA, 2Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Quebec, QC, CANADA, 3Département d’ophtalmologie et d’ORL – CCF, Faculté de médecine, Université Laval, Quebec, QC, CANADA, 4Centre de recherche de l’hôpital Maisonneuve-Rosemont, Montréal, QC, Canada, Montréal, QC, CANADA.

B 16

Evaluation Of Natural Killer Cell Homing Through Ecm Hydrogels To Drug-treated Melanoma Organoids

S. Chakraborty1, V. Bharti1, A. Davies2, A. Vilgelm3, A. Skardal1; 1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, 3Department of Pathology, The Ohio State University, Columbus, OH.

B 18

Biomimetic Nanofibrous Microspheres For 3D Tumor Model With Enriched Cancer Stem Cells

S. M. Basu1, N. Sarviya1,2, J. Giri1; 1Biomedical Engineering, Indian Institute of Technology, Hyderabad, INDIA, 2Chemistry and Biotechnology, Swinburne Institute of Technology, Victoria, AUSTRALIA.

B 19

Three-Dimensional Cancer Models In The Lab: A Tool To Advance Detection & Therapy Of High-grade Brain Cancer

M. Vaez Zadeh1, B. Heng1, A. Guller1,2,3, G. J. Guillemin1, A. Nadort4,2; 1Department of Biomedical Sciences, Macquarie University, Sydney, AUSTRALIA, 2ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, AUSTRALIA, 3The Graduate School of Biomedical Engineering, University of New South Wales, Sydney, AUSTRALIA, 4Department of Physics and Astronomy, Macquarie University, Sydney, AUSTRALIA.

B 20

Characterization Of A New Patient-derived Melanoma Organoid Model

D. J. Gironda1, A. Gorkun2, N. Mahajan2, K. Wilson2, S. Soker2, A. J. Atala2; 1Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 2WFIRM, Wake Forest School of Medicine, Winston-Salem, NC.

B 21

Ex-vivo Organoid Model To Assess Tumor Specific ECM Architecture

N. Edenhoffer1, E. Forbes2,3, K. Votanopoulos4, W. Zhang2,3, S. Soker1; 1Wake Forest School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, 2Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 3Center for Cancer Genomics and Precision Oncology, Wake Forest Baptist Medical Center, Winston-Salem, NC, 4Department of Surgery, Wake Forest University, Winston-Salem, NC.

B 22

Cancer Associated Fibroblast Chemosensitivity In An Appendiceal Cancer Organoid Model

P. A. Laney, S. D. Forsythe, S. Soker, K. Votanopoulos;

Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC.

B 23

Engineered Heart Tissue Microphysiological System Identified Oxidative And Mitochondrial Stress Due To Exposure To Galactic Cosmic Radiation

L. Stoddart, D. B. Mair, R. Teuben, M. A. Williams, S. Lei, L. Tung, K. R. Boheler, D. Kim;

Biomedical Engineering, Johns Hopkins University, Baltimore, MD.

B 24

Astronaut-on-a-Chip: Human, Multi-Organ Platform For Assessing Extended Effects Of Cosmic Radiation

D. N. Tavakol1, T. Nash1, Y. Kim1, M. Liberman1, A. O’Connell1, Y. Zhu1, S. He1, P. Graney1, S. Fleischer1, K. Yeager1, M. Summers1, D. Teles1, G. Garty2, K. Leong1, D. Brenner2, G. Vunjak-Novakovic1; 1Biomedical Engineering, Columbia University, New York City, NY, 2Center for Radiological Research, Columbia University, New York City, NY.

B 25

Development Of A High-content Assay For Studying Muscle Endogenous Repair

S. T. Rjaibi1, E. Jacques2, A. Meysami2, N. T. Li1, N. Gulati2, R. Cao2, S. Davoudi2, A. P. McGuigan1, P. M. Gilbert3; 1Chemical Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Cell and Systems Biology, University of Toronto, Toronto, ON, CANADA.

B 26

3d Human Renal Tubular Organoids Generated From Urine-derived Stem Cells For Nephrotoxicity Screening

C. Bosholm1, H. Guo1, N. Deng1, L. Dou2, H. Ding2, T. Criswell1, A. Atala2, C. M. Furdui2, Y. Zhang1; 1WFIRM, Wake Forest Biomedical WFIRM, winston salem, NC, 2WFIRM, Wake Forest Biomedical WFIRM, Winston Salem, NC.

B 27

Decoding The Roles Of Nk Cells In High Grade Serous Carcinoma Using An Engineered Tumour Microenvironment

M. B. Pugh-Toole1, N. Dawe2, J. E. Boudreau1,3, B. Leung1,2,4; 1Pathology, Dalhousie University, Halifax, NS, CANADA, 2Biomedical Engineering, Dalhousie University, Halifax, NS, CANADA, 3Microbiology & Immunology, Dalhousie University, Halifax, NS, CANADA, 4Applied Oral Sciences, Dalhousie University, Halifax, NS, CANADA.




B 28

Biomechanical Analysis Of A Cell Therapy And Tissue Engineering Strategy For Articular Cartilage Restoration: A Pre-clinical Study

J. P. SantAnna1, R. R. Faria2, C. C. Pinheiro3, C. G. Tabet1, A. J. Hernandez1, D. F. Bueno3, T. L. Fernandes1; 1Grupo de Medicina do Esporte, Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, BRAZIL, 2University of Sao Paulo, Sao Paulo, BRAZIL, 3Sírio-Libânes Hospital, Sao Paulo, BRAZIL.

B 29

A Composite Silk Fibroin/PCL/nano-Hydroxyapatite Based Solution Blow Spun Scaffold For Enhanced Bone Tissue Regeneration

D. DARSHNA, D. Singh, P. Srivastava;

School of Biochemical Engineering, IIT-BHU, Varanasi, INDIA.

B 31

Application Of Magnetic Particle Imaging Technology To Assess Nanoparticle Localization To Cartilage

T. Ajayi, S. Liu, C. Rosen, C. Rinaldi, B. Sharma;

Biomedical Engineering, University of Florida, Gainesville, FL.

B 32

Directed Differentiation Of Human Induced Pluripotent Stem Cells Into Mesenchymal Lineages By Optogenetic Control Of TGF-β Signaling

J. Y. Wu, G. Vunjak-Novakovic;

Biomedical Engineering, Columbia University, New York, NY.


B 33

Incorporation Of Flavonoids Into Extracellular Matrix Hydrogels For Tissue Engineering Applications

D. Nalband1, S. Knapp1, G. Cruse2, D. Freytes1; 1Joint Department of Biomedical Engineering, North Carolina State University / University of North Carolina Chapel Hill, Raleigh, NC, 2Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC.

B 34

Fabrication Of Poly(HEMA-co-MMA) Scaffold Having Surface Roughness And Modulus For Soft-tissue Engineering

J. Kim, Y. Cho, B. Kim, S. Ki, J. Park, T. Kim;

TE BIOS. Co. LTD, Chungcheongbuk-do, KOREA, REPUBLIC OF.

B 37

Mitigation Of Esophageal Metaplasia By Oral Administration Of An Esophageal ECM Hydrogel

G. Lorenz1, L. Saldin2, D. Nascari1, A. Omstead3, L. Quijano1, M. Lebaudy1, A. Gorbunova3, P. Joseph3, X. Li1, J. G. Bartolacci1, J. Naranjo1, A. Abo-Zed4, S. Ayazi3, K. Newhams3, Y. Komatsu3, K. Hall1, G. Hussey1, N. J. Turner1, B. Jobe3, A. H. Zaidi3, S. F. Badylak1;

1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2ECM Therapeutics, Inc., Warrendale, PA, 3Esophageal and Lung Institute, Pittsburgh, PA, 4UPMC Mercy Adult Internal Medicine, Pittsburgh, PA.

B 38

Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine

T. Vikranth, T. Dale, N. Forsyth;

School of Pharmacy and Bioengineering, Keele University, Stoke-On-Trent, UNITED KINGDOM.

B 40

3d Scaffolds From Agglomeration Of Collagen-gelatin Particles Associated With A Plant Extract Of Aloe Vera: Design, Elaboration And Physicochemical Characterization And In Vitro Biological Performance.

R. A. Jimenez1,2, D. Millan1,3, A. Sosnik4, M. Fontanilla1; 1Deparment of Pharmacy, Universidad Nacional de Colombia, Bogota, COLOMBIA, 2Department of Chemistry, Universidad El Bosque, Bogota, COLOMBIA, 3School of Medicine, Universidad El Bosque, Bogota, COLOMBIA, 4Department of Materials Science and Engineering, Israel Institute of Technology, Technion, Haifa, ISRAEL.

B 41

OsseoGEN®: ALP Promoting Osteoinductive Enriched Viable Cellular Bone Matrix

V. Richardson1, A. Govil2, B. Choi1; 1Research and Development, Advanced Biologics, Carlsbad, CA, 2President, Advanced Biologics, Carlsbad, CA.


B 42

Incorporation Of Decellularized Muscle Tissue Into A PEGDA Based Bioink

S. Mischo, M. Brovold, K. Speckl, S. Soker;

Wake Forest Insitute for Regenerative Medicine, winston-salem, NC.


B 46

Recapitulating Human Macrophage Invasion Behaviour In A Gelatin- Hyaluronan Click- Crosslinked Cryogel

A. A. Chin1, L. C. Bahlmann2, A. E. Baker1, C. Xue2, S. Liu1, M. Meier-Merziger3, D. Karakas4, L. Zhu2, I. Co2, S. Zhao2, A. McGuigan2, J. Kuruvilla5, R. C. Laister5, M. S. Shoichet1; 1Department of Chemical Engineering & Applied Sciences, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Department of Chemistry, Johannes Gutenberg University, Mainz, GERMANY, 4University of Toronto, Toronto, ON, CANADA, 5Princess Margaret Cancer Centre, Toronto, ON, CANADA.



B 47

The Clearance Of Latent Cytomegalovirus In Donor Lungs Before Transplantation Using CRISPR/Cas9

Y. Lau, O. F. Khan;

Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

B 48

Multi-stimuli Responsive Biphasic Dual Network Hydrogel For Drug Delivery

N. Kumar1, S. K. Ghorai2, B. Ghosh3, S. Dhara4, S. Chattopadhyay2; 1Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur, INDIA, 2Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur, INDIA, 3Department of Physics and Technology, UiT The Arctic University of Norway, Tromso, NORWAY, 4School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, INDIA.


B 49

Novel Micro-nano Structured Titanium With Selective Endothelial Cell Proliferation And Smooth Muscle Cell Inhibition For Cardiovascular Application

V. Kannigaipair Manivasagam, K. Popat;

Mechanical Engr, Colorado State University, Fort Collins, CO.

B 50

Mending A Broken Heart On The Spot With Spray Nanoparticles

M. Munoz1, C. Cimenci1, K. Goel1, M. Comtois-Bona1, M. Zuniga-Bustos2, A. Ross1, B. Truong1, B. Rotstein1, H. Poblete2, E. Suuronen1, E. Alarcon1; 1Biomaterials, University of Ottawa Heart Institute, Ottawa, ON, CANADA, 2Departamento de Bioinformática, Centro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, CHILE.

B 51

Polyvinyl Alcohol Tubular Structures, A Promise For Cardiovascular Diseases

L. M. Arroyave1, L. M. Restrepo1, S. Estrada1, C. P. Ossa1, M. Restrepo2; 1Universidad de Antioquia, Medellín, COLOMBIA, 2Verasonics Colombia, Medellín, COLOMBIA.

B 52

Biofunctionalization Of Electrospun Bilayered Scaffolds For Vascular Tissue Engineering

Y. Ju, J. Jeong, H. Lee, I. Kim, A. Atala, J. Yoo, S. Lee;


Biomaterials for Women’s Health in Tissue Engineering

B 53

Engineering High Throughput Screening Platforms Of Endometrial Cancer

I. Cadena, M. A. Buchanan, K. C. Fogg, 2016;

Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR.

B 54

Injectable Interpenetrating Network Tumor Microenvironments To Study Mechanobiology In Ovarian Cancer

E. N. Horst, G. Mehta;


Biomaterials to Direct Stem Cell Fate

B 55

Comparative Analysis For Surface Functionalization Methods Of PLGA Composite With Extracellular Vesicles

D. Han, J. Woo, K. Ko;

CHA university, Seongnam-si, KOREA, REPUBLIC OF.

B 56

Injectablemineralized collagen-based hydrogel For Osteogenic Differentiation

Z. Zhang1, L. Z. Luo1, K. Kimmins1, S. Mathews2, M. Rasti2, S. Viswanathan1, E. D. Sone1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Genetics and Development, University Health Network, Toronto, ON, CANADA.


B 58

Engineering Of A Cellular Microenvironment For Brain Repair After Haemorrhagic Stroke

I. Louca, E. Pinteaux;

Department of Neuroscience and Experimental Psychology, The University of Manchester, Manchester, UNITED KINGDOM.




B 59

High Frequency Low Magnitude Vibration Reduces Transendothelial Breast Cancer Migration Via Osteocyte Regulation

X. Song;


B 60

VA-on-a-chip Platform For Modelling Vascular Anomalies

T. H. Nguyen1,2, S. Rissanen1, P. Junttila1, M. Ansarizadeh2, V. Ronkainen2, M. Kaakinen2, L. Eklund2, P. Singh1;

1Finnadvance company, Oulu, FINLAND, 2University of Oulu, Oulu, FINLAND.

B 61

Fibroblast And Myofibroblast Contraction: The Self-assembly Approach

É. Savard1,2, B. Magne1,2, R. Gauvin1,2, D. Larouche1,2, V. J. Moulin1,2, L. Germain1,2; 1Department of surgery, Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Québec, QC, CANADA, 2CHU de Québec-Université Laval Research Centre, Québec, QC, CANADA.

B 62

An Accessible, User-friendly Method For Integration Of Thin Matrix-derived Membranes To Model Tissue Interfaces In Organ-on-a-chip Devices

J. Newton, E. Young;


B 63

Design Of A Mechanobioreactor To Apply Anisotropic Biaxial Strain To Large, Thin Biomaterials For Tissue Engineered Heart Valve Applications

E. Wong1,2,3, S. Parvin Nejad2,3, K. D’Costa2,3, N. Machado Siqueira2,3, J. P. Santerre2,3,4, C. A. Simmons1,2,3; 1Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Translational Biology and Engineering Program, The Ted Rogers Centre for Heart Research, Toronto, ON, CANADA, 4Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

B 64

Versatile Automated Decellularization Method For The Derivation Of Extracellular Matrix Hydrogels

A. Biehl1, A. M. Gracioso Martins1, Z. G. Davis1, C. A. Mora-Navarro2, M. B. Fisher1, D. O. Freytes1; 1Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, 2Chemical Engineering Department, University of Puerto Rico-Mayaguez, Mayaguez, PR.

B 65

A Microphysiological System Coupling Of Non-alcoholic Fatty Liver Disease (NAFLD) To Endocrine Pancreatic Islets: Towards The Association And Causal Link Between NAFLD And Type 2 Diabetes (T2D)

J. Aleman1,2, R. Krishnamurthy3, C. Wiegan3, R. DeBiasio1, G. LaRocca1, L. Vernetti1,4, M. Miedel1,4, A. Gough1,4, A. Stern1,4, I. Banerjee3,2, D. Taylor1,4,2; 1University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, 2Bioengineering, University of Pittsburgh, Pittsburgh, PA, 3Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, 4Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA.

B 66

Airway Organoids For Disease And Toxicity Modeling And Countermeasuredevelopment

K. Sutton;


B 67

Intervertebral Disc Bioreactor With Complex Loadings

R. Huo1, X. Li1, Y. Liu2, D. Phillips3, J. Li1; 1Mechanical Engineering, McGill University, Montreal, QC, CANADA, 2Biological and Biomedical Engineering, McGill University, Montreal, QC, CANADA, 3Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, CANADA.


B 68

3d Printed Flexible Heart Case For Ex Vivo Organ And Tissue Maturation

M. Comtois-Bona, A. Spasojevic, M. Munõz, E. I. Alarcon;

University of Ottawa Heart Institute, Ottawa, ON, CANADA.

B 69

Cell Carriers Suitable For Culturing Human Corneal Epithelial Cells For The Production Of Tissue-engineered Human Corneal Epithelium

G. Le-Bel1,2, P. Desjardins1,2, S. Matthyssen3, C. Koppen3, M. Griffith4, L. Germain1,2, S. Guérin1; 1Département d’ophtalmologie, Université Laval, CUO-recherche/LOEX, Centre de recherche du CHU de QuébecUniversité Laval, Québec, QC, CANADA, 2Département de chirurgie, Université Laval, Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Centre de recherche du CHU de QuébecUniversité Laval, Québec, QC, CANADA, 3Department of Ophthalmology, University Hospital Antwerp, Antwerp, BELGIUM, 4Laboratoires Antoine Turmel, Polyclinique de l’Hopital Maisonneuve-Rosemont, Montréal, QC, CANADA.

B 71

Optimising Culture Of Ipsc-derived Cardiomyocytes On A Pro-survival Substrate

A. Bettini1, D. J. Stuckey2, R. M. Day1; 1Centre for Precision Healthcare, University College London, London, UNITED KINGDOM, 2Centre for Advanced Biomedical Imaging, University College London, London, UNITED KINGDOM.



B 72

Engineered Tissue For Pulmonary Valve Monocusp Augmentation

M. Lecce1,2, N. Latifi2,3, B. Mirani1,2,3, J. P. Santerre1,2,4, C. A. Simmons1,2,3; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, CANADA, 3Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 4Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

B 73

A Gelatin Polyurethane Composite Electrospun Scaffold With Cardiac Tissue-compliant Character

Y. Chen1,2, W. Wei3, B. Mirani1,2,4, C. A. Simmons1,2,4, J. Santerre1,2,5; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, CANADA, 3Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 4Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 5Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

B 74

Isolated Microvessels Promote Human Induced Pluripotent Stem Cell-derived Cardiomyocyte Survival And Cardiac Functional Recovery After Infarction In Type 2 Diabetic Rats

X. Sun1, J. Wu1, R. Li1,2, S. S. Nunes1,3,4; 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, CANADA, 2Division of Cardiovascular Surgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, CANADA, 3Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 4Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, CANADA.


B 75

Effects Of Hyaluronic Acid And Collagen Type I On Osteogenic Differentiation Of MSCs In GAG-chitosan Microcapsules

C. M. Gabrion, H. W. Matthew;

Chemical Engineering & Materials Science, Wayne State University, Detroit, MI.


B 77

Hemodynamic Flow Improves In Vitro Vessel Network Stability

H. Shao1,2, E. W. Young1,2;

1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

B 78

Integrating Engineered Macro Vessels With Self-assembled Capillaries In 3d Implantable Tissue For Promoting Vascular Integration In-vivo

L. Debbi, B. Zohar, M. Shuhmaher, Y. Shandalov, I. Goldfracht, S. Levenberg;

Biomedical engineering, Technion, Haifa, ISRAEL.

B 79

Development Of An In Vitro Model To Mimic The Human Vascular Stem Cell Niche

S. Meermeyer1, A. Laporte2, D. Stöbener3, A. Joshi4, D. Brüggemann4, M. Weinhart2, C. Lee-Thedieck1; 1Institute of Cell Biology and Biophysics, Leibniz University Hannover, Hannover, GERMANY, 2Institute of Physical Chemistry and Electrochemistry, Leibniz University Hannover, Hannover, GERMANY, 3Organic Chemistry, Freie Universität Berlin, Berlin, GERMANY, 4Institute for Biophysics, University of Bremen, Bremen, GERMANY.


B 80

Design And Development Of Apparatus For Customized Fabrication Of Polycaprolactone/chitosan Conduits For Spatiotemporal Promotion Of Peripheral Nerve Tissue Regeneration

K. Nawrotek, M. Kubicka, D. Zawadzki, M. Mąkiewicz;

Faculty of Process and Environmental Engineering, Lodz University of Technology, Lodz, POLAND.

B 81

A Hybrid Protein Bioscafold Modulates The Cellular Function And Genetic Process Of Neural Cells

L. Yao, H. Vishwa, T. Shippy, B. Li;

Wichita State University, Wichita, KS.

Nature as a Source of TERM Biomaterials and Strategies

B 83

Antibacterial Hyaluronic Acid Based Hydrogels For Drug Delivery And Local Bone Regeneration

D. Loca1,2, K. Aunina1,2, A. Ramata-Stunda3, V. Nikolajeva3; 1Rudolfs Cimdins Riga Biomaterials Innovation and Development Centre, Riga Technical University, Riga, LATVIA, 2Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LATVIA, 3Department of Microbiology and Biotechnology, Faculty of Biology, University of Latvia, Riga, LATVIA.

B 84

Bio-inspired Modification Of Collagen Hydrogels To Achieve High Extensibility For Auricular Tissue Engineering

L. Slyker1, L. J. Bonassar2; 1Biomedical Engineering, Cornell University, Ithaca, NY, 2Cornell University, Ithaca, NY.



B 85

Design And Evaluation Of 3D Scaffolds Formed With Collagen From Internal Eggshell Membrane, Bioactive Glass And Polycaprolactone

N. N. Zurita-Méndez, G. Carbajal-De la Torre, J. Ortiz-Ortiz, M. A. Espinosa-Medina;

Facultad de Ingeniería Mecánica, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, MEXICO.

B 86

Bioengineering Of Transplantable Organoids For Liver Injury Repair

T. MIR;

Transplant Research and Innovation, King Faisal specialist Hospital and Research Centre, Riyadh, SAUDI ARABIA.


B 88

Deep-LUMEN AssayHuman Lung Epithelial Spheroid Classification From Brightfield Images Using Deep Learning

L. Abdul, S. Rajasekar, D. S Y Lin, S. Venkatasubramania Raja, A. Sotra, A. Liu, B. Zhang;

Department of Biomedical Engineering, McMaster University, Hamilton, ON, CANADA.


B 90

Restoration Of Kidney Function In Chronic Kidney Disease (ckd) Using Autologous Human Renal Cells

S. K. George, J. Huling, M. Abolbashari, T. Kim, T. Aboushwareb, J. D. Jackson, A. Atala, J. J. Yoo;

WFIRM, Wake Forest School of Medicine, Winston-Salem, NC.

B 91

Mitochondrial And Sarcomere Disorganization Is Evident In Human IPSC Derived Cardiomyocytes With Patient Derived And Genetically Engineered NOTCH1 Mutations

J. Lewis1, B. Toma1,2, S. Mukherjee1, A. Saraf1,2,3; 1Heart and Vascular Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 2Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, 3Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

B 92

Investigating The Neural Control Of Fibroblasts During Regeneration Using A Novel Co-culture Device

S. Cariba1, S. Kouthouridis2, B. Zhang2, S. L. Payne1; 1Biomedical Sciences, University of Guelph, Guelph, ON, CANADA, 2Chemical Engineering, McMaster University, Hamilton, ON, CANADA.

B 93

Effect Of Diabetes Mellitus On DNA Accessibility Within Mesenchymal Stem Cells From Patients With Peripheral Artery Disease

C. T. Hoffmann1, Y. Jung2, M. Sasaki1, F. Li1, V. Corces2, L. Brewster1;

1Department of Surgery, Division of Vascular Surgery, Emory University, Atlanta, GA, 2Department of Human Genetics, Emory University, Atlanta, GA.

B 94

Bioengineered Ovarian Follicles Derived From Ovarian Stem Cells For Hormone And Fertility Treatments

S. Sivanandane, R. C. Sequeira, A. W. Bradshaw, J. D. Wininger, T. Criswell, J. D. Jackson, H. Sadri-Ardekani, J. J. Yoo, A. Atala;

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.

B 95

Adult Human Ovary-derived Oogonia Stem Cells Produce Oocyte-like Cells In Vitro

R. C. Sequeira, S. Sivanandane, J. D. Wininger, T. Criswell, J. D. Jackson, J. J. Yoo, A. Atala;

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

B 97

BX2X2

S. Mohammadi, S. Shafiei;

NIGEB, Tehran, IRAN, ISLAMIC REPUBLIC OF.

B 98

TelocytesSignificant Yet Unrecognized Cell Population In The Human Uterine TubesDo They Play A Role In Tubal Regeneration And Female Idiopathic Infertility?

M. Klein1, J. Zahumensky2, L. Danisovic3, M. Csobonyeiova1, I. Varga1; 1Institute of Histology and Embryology, Comenius University in Bratislava, Faculty of Medicine, Bratislava, SLOVAKIA, 22nd Department of Gynaecology and Obstetrics, Comenius University in Bratislava, Faculty of Medicine, Bratislava, SLOVAKIA, 3Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava, Faculty of Medicine, Bratislava, SLOVAKIA.

B 99

High-content 3D In Vitro Model Supports Muscle Stem Cell Quiescence

E. C. Jacques1,2, K. Kuang3, P. M. Gilbert1,2; 1Department of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Terrence Donnelly Centre for Cellular & Biomolecular Research, Toronto, ON, CANADA, 3University of Toronto, Toronto, ON, CANADA.

Regeneration in the Context of Aging

B 100

Genetic In Vivo Cellular Conversion And Environmental Enrichment, A New Approach To Promote Post Stroke Recovery

A. Gresita1,2, E. Petcu1, A. Popa-Wagner3,2; 1Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 2University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA, 3Department of Biomedical Sciences, University of Duisburg-Essen, University Hospital Essen, Essen, GERMANY.



Regenerative Medicine Applications to Organ Transplantation Medicine

B 101

Homologation Of Bioadhesives In The United States Of America And CanadaA Review

V. Dhandapani, D. Groleau, P. Vermette;

Department of Chemical and Biotechnological Engineering, Universite de Sherbrooke, Sherbrooke, QC, CANADA.

Regenerative Rehabilitation: Integrating Mechanical Stimulation with TERM

B 102

Sex Matters Of Knee Osteoarthritis In Vitro

Z. Ma, D. Li, M. Kunze, A. Mulet-Sierra, L. Westover, A. Adesida;

Surgery, University of Alberta, Edmonton, AB, CANADA.

B 103

Mechanical Unloading Of Engineered Human Meniscus Models Under Simulated Microgravity

D. X. Li1, Z. Ma1, R. K. Chee1, M. Kunze1, A. Mulet-Sierra1, M. Sommerfeldt1, L. Westover2, D. Graf3, A. B. Adesida1; 1Surgery, University of Alberta, Edmonton, AB, CANADA, 2Mechanical Engineering, University of Alberta, Edmonton, AB, CANADA, 3School of Dentistry, University of Alberta, Edmonton, AB, CANADA.


B 104

Bioengineered Skeletal Muscle Construct Using An Allogeneic Scaffolding System For Pelvic Muscle Reconstruction

J. Kim, W. Kim, Y. Ju, I. Kim, H. Lee, J. Vaughan, J. Yoo;


B 106

Re-epithelialization Of A Decellularized Lung Scaffold With Induced Progenitor-like Cells Using Interrupted Reprogramming

D. Taniguchi1, A. Eiliazadeh1,2, P. Duchesneau1, T. Waddell1,2,3, G. Karoubi1,4,5; 1Division of Thoracic Surgery, University Health Network, Toronto, ON, CANADA, 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Institute of Medical Science, University of Toronto, Toronto, ON, CANADA, 4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CANADA, 5Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA.


B 107

Synthesis And Characterization Of Hydrogels Designed For Skin Tissue Engineering

K. VIG, M. Ahmed;

Biological sciences, Alabama State University, Montgomery, AL.

B 111

Insights Into The Importance Of Hyaluronic Acid Molecular Weight On Vocal Fold Wound Healing And Inflammation

K. Basu1, J. Li1, S. Nejati1, G. Bao1, M. Pamenter2, L. Mongeau1; 1Department of Mechanical Engineering, McGill University, Montreal, QC, CANADA, 2Department of Biology, University of Ottawa, Ottawa, ON, CANADA.

B 112

Effects Of Compression On Self-assembled Fibroblast And Myofibroblast Dermal Sheets

É. Savard1,2, B. Magne1,2, R. Gauvin1,2, D. Larouche1,2, V. J. Moulin1,2, L. Germain1,2; 1Department of surgery, Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Québec, QC, CANADA, 2CHU de Québec-Université Laval Research Centre, Québec, QC, CANADA.

B 113

Evaluation Of The Wound Healing Effect Of Porcine-derived Extracellular Matrix-based Dressing In Rabbit Ear Ischemic Model

Y. Jo1,2, K. Jang1,2, K. Shim1,2, C. Kim3, E. Park3, S. Kang1,2, S. KIM1,2; 1Department of Veterinary Surgery, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, GWANGJU, KOREA, REPUBLIC OF, 2Biomaterial R&BD Center, Chonnam National University, Gwangju, KOREA, REPUBLIC OF, 3Research Institute, T&R Biofab, Sungnam-si, KOREA, REPUBLIC OF.

B 114

Light-activated Peptide-based Adhesive For Wound Healing

A. MacAdam;

University of Ottawa Heart Institute, Ottawa, ON, CANADA.

B 115

Enhanced Wound Repair By Grafting Of Stratified Stem Cell Sheet Using ROS-generating Polymer Film

M. Koo1,2, S. Hong1,2, M. Lee1, E. Go1,3, J. Park1,2,3; 1Department of Medical Engineering, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 2Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF, 3Department of Medical Device Engineering and Management, Yonsei University College of Medicine, Seoul, KOREA, REPUBLIC OF.

B 116

Airbrushed Core-shell Nanofiber With Dual Therapy For Wound Healing Application

P. Roopmani1, J. Giri2; 1Indian institute of technology, Hyderabad, INDIA, 2Biomedical engineering, Indian institute of technology, Hyderabad, INDIA.



B 117

Mechanical Priming On Skin-soft Elastomer Substrates Improves The Wound Healing Potential Of Human Mesenchymal Stromal Cells

D. Son1,2, M. Walraven2, M. Im2, A. Vilaysan2, J. E. Davies2, B. Hinz1,2; 1Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, ON, CANADA, 2Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

B 118

Polyurethane With Instant And Persistent Antimicrobial Efficacy Against Bacteria And SARS-CoV-2

T. Repetto1, A. Dhyani2, D. Bartikofsky3, C. Mirabelli3, Z. Gao2, S. Snyder1, G. Mehta1, S. VanAken4, C. Wobus3, J. VanEpps4, A. Tuteja1; 1Materials Science and Engineering, University of Michigan, Ann Arbor, MI, 2Macromolecular science and engineering, University of Michigan, Ann Arbor, MI, 3Microbiology and Immunology, University of Michigan, Ann Arbor, MI, 4Emergency Medicine, University of Michigan, Ann Arbor, MI.

B 119

New Generation Of Tissue Adhesives Based On Waste Proteins And Plant Polyphenol

H. Jafari1,2, P. Ghaffari1, S. Niknezhad3, A. Shavandi1; 1Université Libre de Bruxelles, Brussels, BELGIUM, 2University of Waterloo, Waterloo, ON, CANADA, 3Shiraz University of Medical Sciences, Shiraz, IRAN, ISLAMIC REPUBLIC OF.

B 120

Electrospun Polycaprolactone Collagen And Tgfb3 Scaffolds Stimulates The Secretion Of Angiogenic And Epithelial Growth Factors Involved In Wound Healing

L. A. Lizarazo Fonseca, G. A. Salguero, B. A. Camacho, I. Z. Silva Cote;

Bogotá, Instituto Distrital de Ciencia Biotecnología e Innovación en Salud, Bogotá DC, COLOMBIA.


B 121

Efficacy Of P24 As A Cryoprotective Agent For Rat Satellite Cells

C. S. Kennedy, L. M. Larkin, M. Nguyen, O. Wroblewski, E. Vega, E. Su;

Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.

B 122

Muscadine Grape Extract Improves Skeletal Muscle Regeneration Through Macrophage Attenuation

J. M. Poteracki;

Wake Forest Institute of Regenerative Medicine, Wake Forest University, Winston-Salem, NC.

B 123

Characterization Of Myogenic And Fibrogenic Cell Within A Primary Skeletal Muscle Isolate

C. E. Forester, O. Wroblewski, C. Kennedy, L. M. Larkin;


B 124

Comparative Analysis Of Two Volumetric Muscle Loss Injury Models Using An Automated Method For Fiber Quantification

S. Shriver1, O. Sergent1, M. Rariden1, A. Killaars2, G. Christ1, K. Healy2; 1Biomedical Engineering, University of Virginia, Charlottesville, VA, 2Bioengineering, University of California, Berkeley, Berkeley, CA.

B 125

The Effects Of Metabolism On Muscle Regeneration

J. Castor-Macias1, J. Larouche1, J. Markworth2, C. Aguilar1; 1University of Michigan, Ann Arbor, MI, 2Purdue University, Lafayette, IN.


B 126

Thiolated Bone And Tendon Tissue Particles Covalently Bound In Hyaluronic Acid Hydrogels For Calvarial Bone Regeneration

J. M. Townsend1, G. Sali2, H. B. Homburg2, N. T. Cassidy1, M. E. Sanders1, K. Fung3, B. T. Andrews4, R. J. Nudo5, B. N. Bohnstedt6, M. S. Detamore1; 1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 2Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Neuropathology/Surgical Pathology, University of Oklahoma Health Sciences Center, Norman, OK, 4Department of Otolaryngology, University of Iowa Health Clinic, Iowa City, IA, 5Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, 6Department of Neurosurgery, Indiana University Health, Indianapolis, IN.

B 127

Hydroxypropylmethyl Cellulose (hpmc) Cross-linked Keratin/hydroxyapatite Scaffold Fabrication, Characterization And In Vitro Biocompatibility Assessment For Alveolar Bone Regeneration.

S. Feroz1, N. Muhammad2, P. Cathro3, G. Dias1; 1Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, NEW ZEALAND, 2Department of Dental Materials, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, PAKISTAN, 3Sir John Walsh Research Institute, University of Otago, University of Otago, Dunedin, NEW ZEALAND.



POSTER SESSION 3Tuesday, July 12, 20224:30 PM - 6:30 PM


C 1

Muscle Cell Maturation On 3D-Printable Plant-protein Enriched Scaffolds, For Cultured Meat Development

I. Ianovici1, I. Redensky1, Y. Zagury1, N. Lavon2, S. Levenberg1; 1Biomedical Engineering, TechnionIsrael Institute of Technology, Haifa, ISRAEL, 2Aleph-Farms Ltd., Rehovot, ISRAEL.

C 2

Microfluidic 3D Bioprinting: A Tool For Developing Tissue Therapeutics

V. Russo, C. T. Dickman, R. Jalili, S. A. Campbell, S. Pan, N. Hakimi, R. Agarwal, Y. Yu, K. Khan, K. Jahan, H. H. Tong, E. Bedford, S. Beyer, E. Roos, T. Mohamed, S. Getsios, S. Wadsworth;

Aspect Biosystems, Vancouver, BC, CANADA.

C 3

Multicompartmental Bioprinting For Skeletal Muscle Tissue Engineering

M. Samandari1, F. Alipanahrostami1, M. M. Alvarez2, G. Trujillo-de Santiago2, A. Tamayol1; 1Biomedical Engineering, Uconn Health Center, FARMINGTON, CT, 2Tecnologico de Monterrey, Monterrey, MEXICO.

C 6

A Novel Bioprinted Pancreatic Tumor: Goodbye To Flat Biology

S. R. Gaikwad, S. K. Srivastava;

Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, Abilene, TX.

C 7

Print-and-grow: A Novel Support Material For Counteracting Cellular Traction Forces In 3d Bioprinted Hydrogels

M. Machour1, N. Hen2, I. Goldfracht1, D. Safina1, M. Davidovich-Pinhas3, H. Bianco-Peled2, S. Levenberg1; 1Biomedical Engineering, TechnionIsrael Institute of Technology, Haifa, ISRAEL, 2Chemical Engineering, TechnionIsrael Institute of Technology, Haifa, ISRAEL, 3Biotechnology and Food Engineering, TechnionIsrael Institute of Technology, Haifa, ISRAEL.

C 8

In Vivo Printing Of VEGF-Releasing Scaffolds Enhances The Quality Of Healing In Porcine Full Thickness Wounds

M. Samandari1, K. Nuutila2, J. Quint1, Y. Endo2, Y. Zhang2, A. Tamayol1, I. Sinha2; 1Biomedical Engineering, Uconn Health Center, FARMINGTON, CT, 2Harvard Medical School, Boston, MA.


POSTER SESSION . TUESDAY

C 9

Development Of 3D Printed Personalized Grafts Based On Bone Extracellular Matrix For Bone Regeneration

R. Hayam, L. Baruch, M. Machluf;

Biotechnolgy and food engineering, Technion, Haifa, ISRAEL.

C 11

Incorporating Elastomeric Particles Into Bioinks To Enhance 3d-printed Tissues Stability

S. Landau, R. Lu, M. Liu, Y. Zhao, J. Kieda, M. Radisic;

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

C 12

Fresh 3d Bioprinted Patient-specific Extracellular Matrix Hydrogel Patches For Volumetric Muscle Loss

A. Behre1, J. Tashman1, C. Dikyol1, D. J. Shiwarski1, S. Johnson2, R. J. Crum3, G. Hussey3, S. F. Badylak3, A. W. Feinberg1; 1Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 2Biomedical Engineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 3McGowan Institute for Regenerative Medicine, Pittsburgh, PA.

C 13

Biocompatible PEGDA Formulation For Vat-polymerization 3d Printing

V. Karamzadeh, A. Sohrabi Kashani, M. Shen, D. Juncker;

Biomedical Engineering, McGill University, Montreal, QC, CANADA.

C 14

Electrohydrodynamic Printing Of Cellulose Acetate With Bioactive Glass For The Reinforcement Of Hydrogels For Tissue Engineering

J. Lee, J. Moon, J. Kim, C. Park, C. Kim;

Jeonbuk National University, Jeonju, KOREA, REPUBLIC OF.

C 15

Preparation Of 3d Printing Scaffold Using Aliphatic Polycarbonate As A Bioink And Evaluation Of Biocompatibility

Y. Ji, M. Kim;

Ajou university, Suwon, KOREA, REPUBLIC OF.

3D Tissue -Engineered Cancer/Disease Modeling and Organoids

C 16

Development Of A 3D In Vitro Model Of The Malignant Hematopoietic Stem Cell Niche

L. Schaar1, A. Raic1, N. Dilger1, M. Ringhoffer2, C. Lee-Thedieck1; 1Cell Biology, Leibniz Universität Hannover, Hannover, GERMANY, 2Städtisches Klinikum Karlsruhe, Karlsruhe, GERMANY.



C 17

Development Of An In Vitro Muscle Endogenous Repair Assay (MEndR) To Compress Drug Discovery Pipeline

B. Xu1,2, S. Davoudi1, E. Jacques1, J. L. Cadavid2, A. P. McGuigan1,2, P. M. Gilbert1; 1Institute of Biomedical Engineering, University of Toronto, TORONTO, ON, CANADA, 2Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

C 18

Generation Of Macro-scale And Mature Lung Organoids Through Engineering Cell Microenvironment

A. Reyes Valenzela1, M. Turner2, J. Hanrahan2, L. Mongeau3; 1Biomedical Engineering, McGill University, Montreal, QC, CANADA, 2Department of Physiology, McGill University, Montreal, QC, CANADA, 3Mechanical Enginering, McGill University, Montreal, QC, CANADA.

C 19

β-cyclodextrin-doxorubicin Self-assembly Enhances The Efficiency Of Doxorubicin Delivery In Breast Cancer Cells-a Theoretical Approach To The Formation Of Inclusion Complex

A. Hasan1, J. KS2, S. Joseph3, R. Augustine1, A. Ali Zahid1, Y. B Dalvi4, S. Thomas5, N. Kalarikkal6; 1Mechanical and Industrial Engineering, Qatar University, Doha, QATAR, 2Mechanical and Industrial Engineering, Qatar University, Alappuzha, INDIA, 3Chemistry, Mahatma Gandhi University, India, INDIA, 4Research and Technology, Pushpagiri Medical College, Kottayam, INDIA, 5Chemistry, Mahatma Gandhi University, Kottayam, INDIA, 6Physics, Mahatma Gandhi University, Kottayam, INDIA.

C 20

Development And Characterization Of T-SLICE: An In Vitro Cancer Model That Recapitulates The Tumour Microenvironment

N. Dawe1, M. Pugh-Toole2, N. Jafari1, S. Nersesian3, J. Boudreau3, P. Marcato2, B. Leung1; 1Biomedical Engineering, Dalhousie University, Halifax, NS, CANADA, 2Pathology, Dalhousie University, Halifax, NS, CANADA, 3Microbiology & Immunology, Dalhousie University, Halifax, NS, CANADA.

C 21

Extracellular Matrix Model For Testing Cancer Invasion

J. Heiss, N. Treacher, H. Tavana;

Biomedical Engineering, The University of Akron, Akron, OH.

C 22

A 3d In Vitro Disease Model To Study Obesity-associated Adipocyte Dysfunction And Hypoxia

V. M. Pieters1, S. T. Rjaibi2, K. Singh2, P. M. Gilbert1, A. P. McGuigan2; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Department of Chemical Engineering, University of Toronto, Toronto, ON, CANADA.

C 23

Effects of Microgravity on Human iPSC-derived 3D Brain Models of Parkinson’s Disease and Multiple Sclerosis

D. Marotta1, L. IJaz1, L. Barbar1, J. Stein2, H. Joshi1, T. Clements3, A. Bratt-Leal2, J. Loring2, J. Stoudemire4, P. Grisanti4, S. Noggle1, V. Fossati1;

1Brain Modeling, New York Stem Cell foundation Research Institute, New York, NY, 2The Scripps Research Institute, La Jolla, CA, 3SpaceTango, Lexington, KY, 4National Stem Cell Foundation, Louisville, KY.

C 24

Decellularized Intestine Extracellular Matrix Facilitates 3D Tumor Microtissue Self-Assembly

M. J. Buckenmeyer, E. A. Brooks, M. T. Wolf;

Laboratory of Cancer Immunometabolism, National Cancer Institute, Frederick, MD.

C 25

3D Retinal Organoids: Scaled-up And Reproducible

K. Tamada1,2, M. Ho1,3, H. Nonaka2, H. Nishida2, Y. Honma2, M. Shoichet1,3,4; 1Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, CANADA, 2Regenerative Medicine Research and Planning Division, Rohto Pharmaceutical Co., Ltd., Kyoto, JAPAN, 3Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 4Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

C 26

Engineering 3d Skeletal Muscle Constructs To Model Age-related Regenerative Defects And Responses To Intervention

K. Wang1, S. H. Smith2, H. Iijima1, A. Mallepally2, Z. R. Hettinger1,3, S. G. Shroff2, F. Ambrosio1,2,4; 1Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 4McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

C 27

A Hybrid Compucell3d Model Of Metastatic Cancer Migration In A Remodeling Extracellular Matrix

Y. T. Nguyen Edalgo1, T. O. Benson2, A. N. Ford Versypt2; 1Oklahoma State University, Stillwater, OK, 2University at Buffalo, The State University of New York, Buffalo, NY.

C 28

Investigation Of The Effect Of Cell-cell Interaction On Cardiovascular Organoid Development

E. Kim, H. Kong;

University of Illinois at Urbana-Champaign, Urbana, IL.


C 30

Articular Cartilage Regeneration By Skeletal Stem Cells With BMP2 And Anti-cancer Drug

E. Takematsu, X. Tong, M. G. Butler, C. Chan;

Stanford University, Palo Alto, CA.

C 31

Presence Of Superficial Zone Chondrocytes May Be Necessary To Obtain Bioengineered Cartilage With Zonal Characteristics In Vitro

T. Manzoni1, E. Delve2, S. Regmi3, T. Schmidt4, R. Kandel2, J. Parreno1; 1Biology, University of Delaware, Newark, DE, 2Lunenfeld-Tanenbaum Research Institute, Toronto, ON, CANADA, 3University of Calgary, Calgary, AB, CANADA, 4University of Connecticut Health Center, Farmington, CT.

C 32

The Effect Of Elevated Nutrient Availability On Chondrocyte Metabolism And Cartilage Tissue Formation

R. Tarantino, S. Waldman;

Ryerson University, Toronto, ON, CANADA.

C 33

Articular Cartilage Repair By Tissue Engineering And Cell Therapy: A Pre-clinical Trialimaging Evaluation

J. P. Santanna1, R. R. Faria1, C. C. Pinheiro2, V. D. Aiello3, T. L. Fernandes1, D. F. Bueno2, A. J. Hernandez1; 1Sports Medicine, Universidade de Sao Paulo, Sao Paulo, BRAZIL, 2Hospital Sírio-Libanes, Sao Paulo, BRAZIL, 3Universidade de Sao Paulo, Sao Paulo, BRAZIL.

C 34

Evaluating The Chondrogenic Potential Of Rat, Equine, And Human Mesenchymal Stem Cells In A 3D Spheroid Culture System

B. Ajeeb1, E. A. Kiyotake1, P. A. Keefe1, N. Phillips2, J. Hatzel2, L. Goodrich2, M. S. Detamore1; 1The University of Oklahoma, Norman, OK, 2Colorado State University, Fort Collins, CO.


C 37

Auricular Cartilage Tissue-Engineering with Gentle Laser-Micropore Technique

D. Baranovskii1, I. Klabukov2, E. Isaev3, P. Shegay2, A. Kaprin4; 1Biomatherials and tissue structures Lab., National Medical Research Radiological Center, Obninsk, RUSSIAN FEDERATION, 2Department of regenerative medicine, National Medical Research Radiological Center, Obninsk, RUSSIAN FEDERATION, 3Institute for laser and plasma technologies, Obninsk Institute for Nuclear Power Engineering, Obninsk, RUSSIAN FEDERATION, 4National Medical Research Radiological Center, Obninsk, RUSSIAN FEDERATION.

C 41

Microfluidic Fabrication Of Degradable Cell-supportive Zwitterionic Hydrogel Microparticles (microgels) For Diverse Applications

A. Abrishamkar, C. Pham, E. Mueller, T. Hoare;

McMaster University, Hamilton, ON, CANADA.

C 42

Developing A Novel Composite Bioink Based On Silk Fibroin/cellulose Nanocrystals

S. Nejati, L. Mongeau;

McGill University, Montreal, QC, CANADA.


C 43

Octopus Suction Cup-mimicking Soft Manipulator For Rapid Transport And Fabrication Of Multi-layered Tissue

S. Kang1, B. Kim2, C. Lee3, H. Kong1; 1University of Illinois at Urbana-Champaign, Urbana, IL, 2KICET – Korea Institute of Ceramic Engineering and Technology – ISTC, Jinjusi, KOREA, REPUBLIC OF, 3Purdue University, West Lafayette, IN.


C 44

Macrophage-Modulating Microgels for Regenerative Healing

S. Mohammadi1, H. Ravanbakhsh2, S. Taheri2, G. Bao2, L. Mongeau2; 1Mechanical Engineering, McGill University, Montreal, QC, CANADA, 2McGill University, Montreal, QC, CANADA.

C 45

Moderate-affinity Affibodies Control The Release And Bioactivity Of Bone Morphogenetic Protein-2

J. Dorogin1, V. R. Spaulding2, K. M. Fear3, H. B. Hochstatter4, P. Hosseinzzadeh1, M. H. Hettiaratchi1; 1Bioengineering, University of Oregon, Eugene, OR, 2Chemistry, University of Oregon, Eugene, OR, 3Biology, University of Oregon, Eugene, OR, 4Human Physiology, University of Oregon, Eugene, OR.

C 46

Lipid Nanoparticles With Low Immunogenicity For Nucleic Acid Delivery

J. Couture-Senécal, G. Tilstra, O. F. Khan;

Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

C 47

Mechanobiology Of Macrophage Function In Hyperglycemic Conditions

C. D. Johnson, D. Fischer, H. ArandaEspinoza, J. P. Fisher;

Bioengineering, University of Maryland, College Park, MD.

C 48

Preparation And Evaluation Of A Doxorubicin Loaded Intratumorally Injectable, In-situ Forming Click Cross-linked Hyaluronic Acid Hydrogel

H. JU, M. KIM;

Ajou university, Suwon, KOREA, REPUBLIC OF.




C 50

Development Of A Cardiac Bio-prosthesis

J. JEHL, A. POERIO, S. Fleutot, M. Lovera-Leroux, F. Cleymand;

Départment 4 N2EV: “Nanomatériaux, Électronique et Vivant”, Institut Jean Lamour, Nancy, FRANCE.

C 51

Seeded Microparticles Containing ASC Conditioned Media Enhance Acute Patency In Silk-based Vascular Grafts

K. Lorentz1, A. Marini1, L. Bruk1, P. Gupta2, B. Mandal2,3, M. DiLeo4,5,6, J. Weinbaum1,7,5, D. Vorp1,5,6; 1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, INDIA, 3Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati, INDIA, 4Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 5McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 6Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, 7Pathology, University of Pittsburgh, Pittsburgh, PA.

C 52

Cardiac Tissue Inflammation And Microbiota Composition Analysisin 5/6 Nephrectomy-induced Chronic Kidney Disease Rodent Model

J. PARK1,2, S. Oh1, S. Jung3,2, I. Jo1, T. Song4; 1Department of Molecular Medicine, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 2Graduate Program in System Health Science and Engineering, Seoul, KOREA, REPUBLIC OF, 3Department of Biochemistry, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 4Department of Neurology, Ewha Womans University, Seoul, KOREA, REPUBLIC OF.

C 53

Development of Electrospun Graft From Pcl/ Decellularized Ecm Hybrid Polymer for Small-Caliber Vascular Application

A. Han1, Y. Ju2, S. Min1, S. Min1; 1Department of surgery, Seoul national university hospital, Seoul, KOREA, REPUBLIC OF, 2Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC.

Biomaterials for Women’s Health in Tissue Engineering

C 54

Investigation Of Endothelial Cell Viability And Growth On 3d Printed Gelma Vascular Networks

C. Chappell;

University of Manchester, Manchester, UNITED KINGDOM.

Biomaterials to Direct Stem Cell Fate

C 55

Synthesis And Physicochemical Characterization Of PCL-graphene-doped PEDOT Electroconductive Scaffold For Bone Regeneration

M. Kenter1, K. Kenter2, A. Akkouch2; 1WMU Homer Stryker M.D. School of Medicine, Kalamazoo, MI, 2Orthopaedic Surgery, WMU Homer Stryker M.D. School of Medicine, Kalamazoo, MI.

C 56

Enzyme-degradable, Reversible Crosslinked Hydrogel For Cell Culture

M. Dang1, K. A. Smith1, A. E. Baker1, A. Fokina2, M. S. Shoichet1; 1Chemical Engineering, University of Toronto, Toronto, ON, CANADA, 2N/A, Toronto, ON, CANADA.

C 57

Edible Films For Cultivated Meat Production

Y. Yao;

biomedical engineering, tufts university, medford, MA.

C 58

Effect Of Bioactive Glasses On Viability, Adhesion And Differentiation Of Stem Cells

T. Medeiros1, N. Maurmann1, M. Trevelin Souza2, E. Zanotto2, P. Pranke1,3; 1Hematology and Stem Cell Laboratory, Faculty of Pharmacy and Postgraduate Program in Physiology, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 2CeRTEV–Center for Research, Technology, and Education in Vitreous Materials, Federal University of São Carlos, São Carlos, BRAZIL, 3Stem Cell Research Institute (Instituto de Pesquisa com Células-tronco), Porto Alegre, BRAZIL.


C 59

Thermoresponsive Single Wall Carbon Nanotubes Reinforced Collagen/chitosan Hydrogels Compatible For Bone Tissue Engineering

K. Kaur, C. Murphy;

Department of Anatomy & regenerative Medicine, Royal College of Surgeons, Dublin, IRELAND.


C 60

In Vitro Valve-on-chip Platform To Assess Early Calcific Disease Progression

I. Tandon, C. Gish, N. Sturdivant, A. Ozkizilcik, C. Dunn, P. Ravishankar, A. Walls, L. Ferreira, K. Balachandran;

Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR.



C 61

A Novel Biomimetic Knee Joint Bioreactor for the In Vitro Regeneration of Osteochondral Lesions

N. -. Campillo;

RESEARCH AND DEVELOPMENT, REGEMAT 3D S.L., Granada, SPAIN.

C 62

A Tissue Bioreactor For Retinal Organoid Microenvironmental Control

E. Drabbe1,2, R. Gupta1, T. Arcari1, E. Rippes1, A. Agarwal1,3, D. Pelaez2,3,1; 1Department of Biomedical Engineering, University of Miami, Miami, FL, 2Department of Ophthalmology, University of Miami, Miami, FL, 3Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.

C 63

Multiscale Fractal Shape Cues Support Hierarchical Maturation Of Podocytes Via Curvature-induced Extracellular Matrix Patterning

A. Korolj1,2, P. Aggarwal3, T. Cui2, S. Song2, L. Shamaei4, N. Rafatian2, A. Radisic2, S. Rodriguez-Ramirez5, C. Liu2, M. Li2, K. Wagner2, E. Virlee3, S. Clotet-Freixas5, M. Sadrzadeh4, T. Filleter2, U. Broeckel3, A. Konvalinka5, M. Radisic2; 1Harvard MGH, Boston, MA, 2University of Toronto, Toronto, ON, CANADA, 3Medical College of Wisconsin, Milwaukee, WI, 4University of Alberta, Edmonton, AB, CANADA, 5University Health Network, Toronto, ON, CANADA.

C 64

3d Bioprinted Collagen-based Resistance Vessels And Multiscale Vascular Microfluidics

D. Shiwarski1, A. Hudson1, J. Tashman1, A. Straub2, A. Feinberg1; 1Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA.

C 65

Millipillar: A Platform For The Generation And Real-time Assessment Of Human Engineered Cardiac Tissues For Patient-specific Disease Modeling

T. R. Nash, S. Fleischer, M. A. Tamargo, Y. Kim, O. F. Vila, K. Yeager, M. B. Summers, Y. Zhao, R. I. Lock, G. Vunjak-Novakovic;

Biomedical Engineering, Columbia University, New York, NY.

C 66

Bioimplant-on-a-chip For Investigating Osseointegration Of Periodontal Ligament-like Tissues On Bioengineered Implants

J. Chung1, S. Park1, J. Kim1, J. Han1, Y. Gwon2, M. Lee3, J. Lim1, S. Jeong1, J. Lee4, P. Garg1, S. Pandey1, J. Kim2, H. Seonwoo5, K. Jang6; 1Department of Biosystems Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF, 2Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, KOREA, REPUBLIC OF, 3Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 4Department of Animal Science & Technology, Sunchon National University, Suncheon, KOREA, REPUBLIC OF, 5Department of Convergent Biosystems Engineering, Sunchon National University, Suncheon, KOREA, REPUBLIC OF, 6Division of Agro-System Engineering, Gyeongsang National University, Jinju, KOREA, REPUBLIC OF.

C 67

MetaboractorBridge Between Stability And Enhanced Metabolism

M. K. Orlowska1, J. Krycer1, R. Mills1, M. Doran2, J. E. Hudson1; 1Cardiac Bioengineering, QIMR Berghofer Medical Research Institute, Brisbane, AUSTRALIA, 2Stem Cell Therapies, Translational Research Institute, Brisbane, AUSTRALIA.

C 68

Modular Integration Of Endothelialized Barrier For Disease Modelling.

B. P. Suthar, C. Alver, M. Suarez, M. Helm, A. Agarwal;

Biomedical Engineering, University of Miami, Miami, FL.

C 69

Human Skin-on-a-chip Platform For Transdermal Drug Toxicological Screening

A. M. Gonçalves1, S. Spitz2, T. Schellhorn3, F. Leal1, A. Moreira1, P. Ertl2, P. F. Costa1; 1Biofabics Lda., Porto, PORTUGAL, 2Technische Universität Wien, Vienna, AUSTRIA, 3InoCure, Prague, CZECH REPUBLIC.


C 71

Targeting HSV-1 Corneal Infection Utilizing Pro-regenerative, Anti-viral Corneal Implants

K. Malhotra1,2, O. Buznyk3,4, M. Groleau1,2,5, M. M. Islam3,6, E. Edin1,2,3, B. Poudel1,2, P. Fagerholm2, A. Fois5,7, S. Lesage8,7, J. R. Jangamreddy3,9, M. Robert1, A. Liszka3, H. K. Patra3,5, M. Griffith1,3; 1Dept. of Ophthalmology, University of Montreal and Maisonneuve-Rosemont Hospital Research Centre, Montreal, QC, CANADA, 2Centre de recherche du Centre hospitalier de l’Université de Montréal, Montreal, QC, CANADA, 3Dept. of Clinical and Experimental Medicine, Linköping University, Linköping, SWEDEN, 4Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine, Odessa, UKRAINE, 5Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, CANADA, 6Schepens Eye Research Institute (Current affiliation), Boston, MA, 7Department of Immunology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, QC, CANADA, 8Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal,, Montreal, QC, CANADA, 9UR Advanced Therapeutics Pvt Ltd (Current affiliation), Hyderabad, INDIA.

Cell-based Approaches to Cardiac Regeneration & Repair

C 72

Delivery Of Secretome-based Therapies Targeting The Regeneration And Repair Of Cardiac Tissues

S. Chung1, J. T. Maynes2, J. P. Santerre1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Hospital for Sick Children, Toronto, ON, CANADA.



C 73

Molecular Circuits For Biophysical Sensing In Cardiovascular System

X. Yu, A. Doyle;

Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA.

C 74

Scaffold-seeded Smooth Muscle Cells For Treatment Of Murine Abdominal Aortic Aneurysm

M. Shayan1, J. Mulorz2, C. Hu3, N. F. Huang1; 1Cardiothoracic Surgery, Stanford University, Stanford, CA, 2Cardiovascular Medicine, Stanford University, Stanford, CA, 3Cardiothoracic Surgery, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.


C 76

Resorbable Layered Double Hydroxides-Based Composite Implants Synergistically Acclerates Critical-sized Defect Closure Using Preclinical Rabbit Model

V. Mohan1, A. V K2, U. Tiruchirapalli Sivagnanam1; 1Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai, INDIA, 2Biomedical Engineering, GKM College of Engineering & Technology, Chennai, INDIA.

C 77

Biobased Elastomer Nanofibers For Guiding IPSC-derived Skeletal Muscle

A. Cheesbrough1,2, F. Sciscione2, F. Riccio1, P. Harley1, L. R’Bibo11, G. Ziakas2, A. Darbyshire2, I. Lieberam1, W. Song2; 1Centre for Gene Therapy and Regenerative Medicine, King’s College London, London, UNITED KINGDOM, 2Department of Surgical Biotechnology, University College London, London, UNITED KINGDOM.


C 78

Nanopatterned Collagen Scaffolds Prolong Viability Of Induced Pluripotent Stem Cell-derived Endothelial Cells In The Ischemic Limb

G. Yang1, C. Alcazar2, C. Hu2, T. Zaitseva3, M. Paukshto3, N. F. Huang1; 1Cardiothoracic Surgery, Stanford University, Stanford, CA, 2Cardiothoracic Surgery, Veterans Affairs Palo Alto Health Care System, Stanford, CA, 3Fibralign Corporation, Union City, CA.

C 79

Affinity-based Biomaterials For Angiogenic Protein Delivery

H. B. Hochstatter1, J. R. O’Hara-Smith2, C. L. Asnes3, J. Dorogin3, S. C. Oh4, M. H. Hettiaratchi3; 1Department of Human Physiology, University of Oregon, Eugene, OR, 2Institute of Molecular Biology, University of Oregon, Eugene, OR, 3Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, 4Department of Biology, University of Oregon, Eugene, OR.

C 80

Engineering Cardiac Regenerative Therapies To Stimulate Angiogenesis And Tissue Remodeling

A. J. Minor, S. M. Roser, K. Zahiri, E. Song, M. Kobayashi, C. Polucha, K. L. Coulombe;

School of Engineering, Brown University, Providence, RI.


C 81

Hyaluronan-based Hydrogels As Repair Mediators In Acute Spinal Cord Injury

J. J. Herrera1, D. A. Harrington2; 1Diagnostic & Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, 2Diagnostic & Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX.

Nature as a Source of TERM Biomaterials and Strategies Engineering

C 82

Umbilical Cord-derived BiomaterialsAnalysis Of Material Characteristics Following Processing

A. Roy, M. Mantay, C. Brannan, J. Breedlove, S. Griffiths;

StimLabs, LLC, Roswell, GA.

C 83

Impact Of Mechanical Strain Profile And Pregnancy Hormones On Elastin Synthesis In An Engineered 3D Uterine Tissue Culture Model

C. A. Nietupski, S. C. Schutte;

Biomedical Engineering, University of Cincinnati, Cincinnati, OH.

C 85

Porous Scaffolds From Zn/hap/rgo For Bone Tissue Engineering: Antimicrobial And In-vitro Evaluations

A. Hasan1, M. Khan1, S. Abd Razak2; 1Mechanical and Industrial Engineering, Qatar University, Doha, QATAR, 2Centre of Advanced Composite Materials, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Johor, MALAYSIA.

C 86

Scaffolds Based On Chitosan, Collagen And Jatropha Mollissima Extract With Potential For Tissue Engineering

M. F. de Souza1, A. F. Tomaz2, M. M. Macêdo1, H. N. da Silva1, R. C. Barbosa1, W. B. de Sousa1, A. A. Tavares1, M. V. Lia Fook1; 1Academic Unit of Materials Engineering, Federal University of Campina Grande, Campina Grande, BRAZIL, 2Physiotherapy Department, State University of Paraíba, Campina Grande, BRAZIL.



C 87

Heparin-mimetic Alginate Sulfate Substrates For Controlled Growth Factor Binding And Tissue Repair

R. Mhanna, G. Kfoury, V. El Habbaki;

Biomedical Engineering, American University of Beirut, Beirut/Lebanon, LEBANON.

C 88

Synthesis And Characterization Of Photo-cross Linkable Sericin Hydrogels For Stem Cell Encapsulation

S. I. Kader;

Pathology and Forensic, University of Al-Nahrain, Baghdad, IRAQ.


C 89

In Vivo Oxygen Imaging Of Oxygen Generating Cellular Implant Devices

S. Patel1, N. Viswakarma2, C. Stabler3, B. Epel4, M. Kotecha1; 1O2M Technologies, LLC, Chicago, IL, 2O2M Technologies™, LLC, Chicago, IL, 3Biomedical EngineeringDiabetes Tissue Engineering Laboratory, University of Florida, Gainsville, FL, 4University of Chicago, Chicago, IL.


C 90

The Linc Complex Mediates Skeletal Muscle Repair Via Modulation Of Satellite Cell Kinetics And Fate

L. A. Moyle1, O. McKee-Muir1, A. Montgomery-Song1, K. Gorospe1, S. Cancelliere1, S. Davoudi1, E. Li1, E. Gomes2, D. Hodzik3, P. Gilbert1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, PORTUGAL, 3Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO.

C 93

Inhibition of Inosine Monophosphate Dehydrogenase (impdh) Induces Osteogenesis of Tonsil-derived Mesenchymal Stem Cells (TMSCs) by Altering Histone Deacetylase Activities

S. Oh1, Y. Jang1, Y. Choi1,2, S. Choi1, S. Jung3,2, I. Jo1,4; 1Department of Molecular Medicine, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 2Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 3Department of Biochemistry, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 4Department of Biochemistry, Korean Fund for Regenerative Medicine (KFRM), Seoul, KOREA, REPUBLIC OF.

C 94

Genomic Profiling Of Human Tonsil-derived Mesenchymalstem Cells Exposed To Far-infrared Irradiation Using Transcriptome Analysis

Y. Choi1,2, S. Oh1, J. Park1,2, S. Jung3,2, I. Jo1,4;

1Department of Molecular Medicine, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 2Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 3Department of Biochemistry, Ewha Womans University, Seoul, KOREA, REPUBLIC OF, 4Korean Fund for Regenerative Medicine, Seoul, KOREA, REPUBLIC OF.

C 95

Mechanical Environment Imprints Fibrotic Memory In Mesenchymal Stromal Cells By Epigentic Modifications

F. S. Younesi, N. Andonian, D. Ok Son, M. Lodyga, B. Hinz;

Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA.

C 96

Culture Of Autologous Corneal Epithelia For The Treatment Of Unilateral Limbal Stem Cell Deficiency

L. Guérin1, R. Bazin2, A. Faucher1, L. Germain3; 1Service d’ophtalmologie, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, CANADA, 2Département d’ophtalmologie, Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, CANADA, 3Département de chirurgie, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, QC, CANADA.

C 97

Suspension Culture Of Human Mesenchymal Stromal Cells On Dissolvable Microcarriers In An Animal Component Free Culture System

K. Bertram1, R. Wagey1, J. Christie1, A. Sampaio1, A. B. Mogen2, A. B. Bergeron3, H. A. Sherman3, A. C. Eaves1,4, A. C. Eaves1, S. A. Louis1, R. Conder1; 1STEMCELL Technologies, Vancouver, BC, CANADA, 2Corning Incorporated, Tewksbury, MA, 3Corning Incorporated, Kennebunk, ME, 4Terry Fox Laboratory, Vancouver, BC, CANADA.

C 98

Osteogenic And Neurogenic Differentiation Of Dental Pulp Stem Cells Promoted By Biphasic Pulsed Micro-current Stimulation For Dental Pulp Complex Tissue Regeneration

J. Chung1, J. Kim1, S. Park2, H. Kim2, J. Han1, M. Lee3, J. Lim2, S. Jeong2, P. Garg4, S. Pandey4, H. Seonwoo5, K. Jang6; 1Department of Biosystems Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF, 2Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF, 3Harvard Medical School Division of Engineering in Medicine, Brigham and Women’s Hospital, Cambridge, MA 02139, USA., MA, 4Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, KOREA, REPUBLIC OF, 5Interdisciplinary Program in IT-Bio Convergence System, Sunchon National University, Suncheon, KOREA, REPUBLIC OF, 6Division of Agro-System Engineering, Gyeongsang National University, Jinju, KOREA, REPUBLIC OF.

C 99

In-silico Screening Of Dietary Polyphenols To Target C-x-c Motif Chemokine Ligand 12 In Breast Cancer

A. Mishra1, Y. Pathak1, M. Chaudhary2, V. Tripathi1; 1gautam buddha university, greater noida, INDIA, 2Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, greater noida, INDIA.



C 100

Rheumatoid Synovial Fluid Increases The Immunomodulatory Activity Of Urine-derived Stem Cells

M. Debreova-Cehakova1, Z. Varchulova Novakova2, A. Nicodemou1, D. Ivanisova2, M. Culenova2, S. Ziaran1, L. Danisovic2; 1National Institute of Rheumatic Diseases, Piestany, SLOVAKIA, 2Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, SLOVAKIA.

C 102

A Tale Of Two Printers: Clinical Grade Manufacture Of Patient Specific Bioresorbable Airway Support Devices Using Selective Laser Sintering And Fused Deposition Modeling

H. Ramaraju, S. Hollister;

Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.

Regenerative Rehabilitation: Integrating Mechanical Stimulation with TERM

C 103

Comparative Effects Of Basic Fibroblast Growth Factor Delivery Or Rehabilitative Exercise For Treatment Of Volumetric Muscle Loss

C. Hu1, B. Ayan2, G. Chiang1, N. F. Huang2; 1Cardiothoracic Surgery, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 2Cardiothoracic Surgery, Stanford University, Stanford, CA.

C 104

Optimization Of The Electrical Stimulation Parameters For Micro-muscles Engineered From Human Primary Myoblasts

Y. Tiper1, A. B. Morton2, S. S. Segal2, P. M. Gilbert1; 1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO.


C 105

Partial Decellularization Removes Immunogenicity Of Tracheal Allografts

Z. Tan1,2, L. Liu1, S. Dharmadhikari1, S. Sperber1, K. Shontz1, S. Reynolds3, C. Breuer1, T. Chiang1; 1Center for Regenerative Medicine, Nationwide Children’s Hospital, COLUMBUS, OH, 2The Ohio State University, Columbus, OH, 3Center for Perinatal Research, Nationwide Children’s Hospital, COLUMBUS, OH.

C 106

PCL- And Gelatin-based Electrospun Biological Scaffolds For In Vitro Lung Tissue Engineering

A. Moreira1, A. M. Gonçalves1, T. Schellhorn2, F. Leal1, P. Ertl3, Y. Kohl4, P. F. Costa1; 1BIOFABICS Lda., Porto, PORTUGAL, 2InoCure s.r.o., Prague, CZECH REPUBLIC, 3Vienna University of Technology, Vienna, AUSTRIA, 4Fraunhofer Institute for Biomedical Engineering (IBMT), Sulzbach, GERMANY.

C 107

Anti-obesity And Hepatoprotective Effects Of Protein Hydrolysates Derived From Protaetia Brevitarsis In An Obese Mouse Model

B. Yoon1, S. Chun2, E. Lee1, M. Han3, J. Chung4, Y. Ha4, J. Lee4, H. Kim4, D. Kim5, G. Beik6, B. Jang7, T. Kwon4, S. Lee8, B. Kim4; 1Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, KOREA, REPUBLIC OF, 2BioMedical Research Institute, Kyungpook National University Hospital, Daegu, KOREA, REPUBLIC OF, 3Department of Pathology, School of Medicine, Kyungpook National University Hospital, Daegu, KOREA, REPUBLIC OF, 4Department of Urology, School of Medicine, Kyungpook National University Hospital, Daegu, KOREA, REPUBLIC OF, 5Department of Laboratory Animal Research Support Team, Yeungnam University Medical Center, Daegu, KOREA, REPUBLIC OF, 6OkChundang Research institute, Daegu, KOREA, REPUBLIC OF, 7Department of Internal Medicine, School of Medicine, Yeungnam University, Daegu, KOREA, REPUBLIC OF, 8Department of Food Science and Technology, Keimyung University, Daegu, KOREA, REPUBLIC OF.


C 108

Tissue Engineered Construct Based On Mesenchymal Stromal Cells And Acellular Dermis Promotes Cutaneous Lesions Repair In Porcine Model

L. S. Correa, G. Salguero, B. Camacho, I. Z. Silva;

Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud, Bogotá, COLOMBIA.

C 109

The Potential Of The Whole Adipose Tissue To Heal The Acute Burns

E. Mahdipour, J. Rohani Ivari;

Mashhad University of Medical Sciences, Mashhad, IRAN, ISLAMIC REPUBLIC OF.

C 110

Removing Accessibility Barriers In Regenerative Medicine: Safe And Efficacious Ribonucleic Acid Nanoparticles That Do Not Require Cold Storage

A. Manning, O. F. Khan;


C 112

Developing a Controlled-release Nanoparticle Platform for the Oral Delivery of Long Non-coding Rna to Treat Inflammatory Bowel Disease

J. Pang, O. F. Khan;


C 113

Recent Advances In Wound Healing Patches For Chronic And Diabetic Wounds

A. Hasan1, M. Asad-Ullah1, N. Ashammakhi2; 1Mechanical and Industrial Engineering, Qatar University, Doha, QATAR, 2Mechanical and Industrial Engineering, Qatar University, Los Angeles, CA.



C 114

Detailed Characterization Of Human Lyophilized Amnion As A Bioactive Wound Dressing Material For Treating Chronic Wounds

S. Sarkar, J. Rajput, V. Rathi, A. Poundarik;

Department of Biomedical Engineering, Indian Institute of Technology Ropar, Ropar, INDIA.

C 116

Health Education In The Self Care Process Of The Chronic Wounds Healing Of The Diabetic Foot

A. F. Tomaz1, G. A. Morais1, M. F. Souza2, R. C. Barbosa2, A. A. Tavares2, W. J. Sousa2, M. V. Fook2; 1Physiotherapy Department, State University of Paraíba, Campina Grande, BRAZIL, 2CERTBIO, Federal University of Campina Grande, Campina Grande, BRAZIL.

C 117

Induction of Polyaniline as Electro-Active Based Biomaterial Incorporated in Silk Fibroin/Polycaprolactone Nanofibrous Scaffold for Full-Thickness Wound Healing Application

R. Rajasekaran1, V. Seesala2, A. k. ojha1, M. Banerjee3, S. Dhara1; 1Smst, IIT Kharagpur, KHARAGPUR, INDIA, 2Smst, IIT KHARAGPUR, KHARAGPUR, INDIA, 3RMSOEE, IIT Kharagpur, KHARAGPUR, INDIA.

C 118

Developing Chitosan And 1 4 Naphthoquinone Membrane As A Potential Biomaterial For Skin Cancer Management

A. F. Tomaz1, R. C. Barbosa2, W. J. Sousa2, M. A. Gutierrez3, A. G. Lima4, M. V. Fook2; 1Physiotherapy Department, State University of Paraíba, Campina Grande, BRAZIL, 2CERTBIO, Federal University of Campina Grande, Campina Grande, BRAZIL, 3Chemistry Departament, Universidad Simon Bolívar, Caracas, VENEZUELA, BOLIVARIAN REPUBLIC OF, 4Mechanich Department, Federal University of Campina Grande, Campina Grande, BRAZIL.

C 120

A Wearable Bioreactor To Promote Limb Regeneration In An Adult Murine Digit Amputation Model

C. Li, V. Fitzpatrick, B. Longo, D. Kaplan;

Tufts University, Medford, MA.

C 121

In Vivo Evaluation Of A Bilayer Scaffold From PLGA/Fibrin Spun Membrane And Fibrin Hydrogel Layer For Skin Regeneration

J. Girón1,2, N. Maurmann1,2, L. Oliveira1, B. Alcantara1, C. Vieira2, G. Leipnitz2,3, F. Meyer4, M. Oliveira5, P. Rigon5, P. Pranke1,2,6; 1Hematology & Stem Cell Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 2Post Graduate Program in Biological Sciences: Physiology, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 3Post Graduation Program in Biological Sciences: Biochemistry, Biochemistry Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, BRAZIL, 4Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 5Department of Morphological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 6Stem Cell Research Institute (Instituto de Pesquisa com Células-tronco), Porto Alegre, BRAZIL.


C 122

Short- And Long-term Biomechanics And Muscle Volume Recovery With Injectable Biomaterials-based Vocal Fold Augmentation

S. Miar1, G. Gonzales1, R. Malka2, G. R. Dion3, T. Guda1; 1University of Texas at San Antonio, San Antonio, TX, 2Department of Otolaryngology, Brooke Army Medical Center, Fort Sam Houston, TX, 3US Army Institute of Surgical Research, Fort Sam Houston, TX.

C 123

Nerve-stimulated In Vivo Contraction Of Rat Tibialis Anterior Muscle As A Functional Test For Skeletal Neuromuscular Therapeutics

M. Rariden, G. Killian, E. M. Donohue, J. A. Passipieri, G. J. Christ;

University of Virginia, Charlottesville, VA.

C 124

Humoral Factors Induce ICU-acquired Weakness Distinguishing Features In A 3D Human Skeletal Muscle Culture Model

H. Lad1, J. Correa2, J. Batt3, P. M. Gilbert4; 1Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, ON, CANADA, 3Division of Respirology, Department of Medicine, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, ON, CANADA, 4Biomedical Engineering, Cells and Systems Biology, University of Toronto, Toronto, ON, CANADA.

C 125

Repairing Volumetric Muscle Loss By Combining Skeletal Muscle Units And Hyaluronic Acid Hydrogel In The Tibialis Anterior Muscle In Rats

E. E. Vega-Soto1, E. Su1, S. S. Novakova1, A. Killaars2, K. E. Healy2, G. J. Christ3, L. M. Larkin1; 1University of Michigan, Ann Arbor, MI, 2University of California, Berkeley, CA, 3University of Virginia, Charlottesville, VA.

C 126

Engineered Skeletal Muscle Constructs For Type 2 Diabetes Treatment

M. Beckerman1, D. Safina1, H. Shoyhat1, Y. Bachinsky1, E. Karnieli2, P. J. Bilan3, E. C. Lewis4, S. Levenberg1; 1Biomedical Engineering, Technion, Haifa, ISRAEL, 2Medicine, Technion, Haifa, ISRAEL, 3Cell Biology Program, The Hospital for Sick Children, Toronto, ON, CANADA, 4Faculty of health sciences, Ben-Gurion University of the Negev, Beer Sheva, ISRAEL.


C 127

Polycaprolactone, Alginate, And Bioceramic Scaffold For Bone Regeneration

L. Oliveira1, N. Maurmann1, M. Briao1, B. Alcantara1, R. L. Siqueira2, P. Pranke1,3; 1Hematology and Stem Cell Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, BRAZIL, 2CeRTEV–Center for Research, Technology, and Education in Vitreous Materials, Vitreous Materials Lab, Federal University of São Carlos, São Carlos, BRAZIL, 3Stem Cell Research Institute (Instituto de Pesquisa com Células-tronco), Porto Alegre, BRAZIL.



ABSTRACT AUTHOR INDEXAbaci, H. E. ........................................ 2, 38, 7

Abdul, L. ............................................. 112, 70

Accolla, R. P. ...............................................29

Achoa, G. L. ................................................13

Agarwal, A. ................................................35

Aguilar, C. .............................................77, 84

Ahmed, R. ..................................................69

Ahn, E. .....................................................140

Ajeeb, B. ....................................................17

Alderfer, L. ................................................105

Alencar, D. S............................................... 13

Ali Akbari Ghavimi, S. .............................40, 45

Almeida, M. A. ............................................13

Al Shetawi, A.............................................. 49

Alshoubaki, Y. K. ........................................102

Alvarez Cespedes, D. .................................2, 7

Amon, C. ..............................................62, 50

Anderson, D. E. ............................................11

Aoki, F. .................................................37, 62

Assad, I. d. .................................................72

Atala, A. ..........................................118, 15, 47

Attiogbe, E. ..................................................3

Audet, J. ....................................................100

Auriat, A. ....................................................64

Backx, P. ...................................................100

Badylak, S.................... 6, 26, 30, 31, 58, 67, 68

Baig, M. .....................................................49

Baker, A. E. .................................................66

Balog, B. ....................................................52

Bao, G. .................................................24, 92

Barbier, M. A. ................................................1

Bates, N. M. ................................................11

Beane, J. .....................................................33

Berthod, F. .................................................53

Bettini, A. ...................................................98

Bhora, F. .....................................................49

Biehl, A. .....................................................22

Bircsak, K.................................................. 111

Birkhimer, J................................................. 58

Bolduc, S. ............................................138, 51

Bonassar, L. ................................................73

Bonteanu, A. ..............................................111

Bordes, S. ....................................................3

Borek, R. ....................................................45

Borrego, I. .................................................101

Bourdo, S................................................. 44


AUTHOR INDEX

Branski, R. C. ..............................................22

Bregenzer, M............................................. 59

Brooks, S................................................... 84

Brown, M. E. ..............................................88

Brown, S. ...................................................86

Brownell, D. ................................................51

Brucato, V. ..................................................40

Brusko, T. M. ...............................................94

Bueno, D. F. ...........................................13, 72

Bugbee, E. ................................................107

Burgess, R. A. .............................................35

Burkhard, K. ...............................................59

Cadavid, J. L. .......................................107, 108

Cadena, I. ..................................................89

Callaghan, N. ............................................100

Campbell, G............................................... 68

Caneparo, C. .............................................138

Capak, H. ...................................................25

Capella-Monsonis, H. ..................................26

Capuana, E. ................................................40

Carmona, T. ...............................................103

Carreno Galeano, G................................... 118

Cartier, A. .....................................................1

Caruso, M. ....................................................1

Carvalho, R. M. ............................................13

Castor-Macias, J. .........................................84

Chabaud, S. .........................................138, 51

Chandran, U. ..............................................31

Chang, J. ...............................................67, 68

Chatterjee, J. ...............................................43

Chauhan, M................................................ 41

Chen, J. ..............................................139, 48

Chen, S. ....................................................64

Chen, W. ..................................................100

Chérin, E. ..................................................97

Christ, G. ...................................................86

Christman, K. ............................................133

Cintra, H. ...................................................13

Closs, B. ....................................................3

Co, I. L. ..............................................107, 108

Coelli, J. C. .................................................13

Cohen, I. ....................................................73

Coleman, R. ................................................71

Collares, M. V. .............................................13

Condro, M. ................................................83

Conoscenti, G. ..........................................40

Cook, s. ...................................................101

Copus, J. ..................................................136

Cortes, D. E. ..............................................99

Costa, I. ....................................................20

Countryman, S.......................................... 140

Cramer, M. C. .............................................31

Crum, R. J. ..............................................26, 6

Cui, H........................................................ 66

Cunha Filho, J. F. ..........................................13

Dahal, S..................................................... 52

Dailey, M. T. ...............................................54

Dakiw Piaceski, A. ..........................................1

Damaser, M. ...............................................52

Dang, M. ....................................................66

D’Angelo, W. ..............................................58

Dasari, S. ....................................................10

Davis, C. ....................................................84

Davis, M. ..................................................133

Day, R. M................................................... 98

de Bont, D. ................................................117

Dedhia, P. ...................................................79

de Koning, E. J. ...........................................117

del Monte Nieto, G. ...................................102

Delplace, V. ................................................27

Demirci, U.................................................. 69

Démoré, C................................................. 97

Deng, K. ....................................................52

Detamore, M. ..............................................17

Devenyi, R. .................................................66

de Vries, R. ................................................117

Dewey, M. .............................................67, 68

de Wild, M. ...............................................119

Dhar, M...................................................... 44

Dias, B. .......................................................13

Digman, M. A. ............................................83

Drewry, M. D. ..............................................54

Du, X. ........................................................119

Dumas, A................................................... 45

Dunn, C. M. ................................................63

Durland, L. ................................................100

Ekerhult, T. O. .............................................46

Ellis, J. .......................................................100

El-Mossier, S. ..............................................58

Enders, J. R................................................. 22

Endo, Y. ......................................................19

Eom, H. ......................................................14

Ezzo, M. .......................................................5

Faco, R. ......................................................13

Fallon, M. E. .................................................11

Fan, F. .......................................................105

Fang, S. .......................................................7

Faria, R. R. ..................................................72

Fauvel, C. ...................................................53

Ferguson, S. J. ............................................119

Ferland, K. ...................................................8

Fernandes, T. L. ...........................................72

Fernandez, A. T. ..........................................94

Firmino, J. ....................................................5

Fisher, S. ....................................................30

Fogg, K. C. ................................................89

Fomina, A. ................................................108

Forman, A. ................................................66

Fraczek, P. .............................................77, 84

Franco, D. ...................................................13

Freytes, D. O. ..............................................22

Frobert, A. .................................................101

Galbraith, T. ................................................53

Galuta, A. ..................................................64

Gamborgi, M. .............................................13

Garcia, M. E. ..............................................22

Gasperini, L. ...............................................69

Gehret, P. .............................................40, 45

Germain, L. ................................................1, 8

Ghani, K. ......................................................1

Ghinda, D. .................................................64

Giannobile, W. V. .........................................14

Gilbert, C. ...................................................3

Giraud, M. N. ............................................101

Giri, J. .........................................................41

Glazebrook, M. ..........................................20

Gonzalez Flores, J. G. .................................141

Goodman, S. B. ..........................................75

Gope, A. ....................................................43

Gottardi, R. ...........................................40, 45

Goutchtat, R. ............................................117

Graham, E. .................................................6

Grainger, D. W. ......................................63, 74

Gramolini, A. ............................................100

Grande, D. A. ...........................................115

Gratzer, P. F. ...............................................20

Griffiths, L. G. .............................................10

Guicheux, J. ...............................................27

Guimarães, C. F. .........................................69

Guldberg, R. E. ..........................................87


AUTHOR INDEX

Gunasekaran, D. ..........................................21

Håkansson, J. ..............................................46

Halgand, B. ................................................27

Hall, J. .......................................................113

Hall, K. ........................................................6

Hall, K. T. ....................................................30

Hancko, A. ................................................133

Hanjaya-Putra, D. .......................................105

Harada, H. .................................................65

Harrer, J. .....................................................87

Harrington, D. ............................................111

Haykal, S. ...................................................62

Healy, K. ....................................................86

Heidenreich, H. E. ........................................11

Heilshorn, S. .........................................39, 42

Helm, M. G................................................ 35

Hernandez, A. J. .........................................72

Herschman, A. R. .........................................7

Hettiaratchi, M. ..........................................55

Higashi, T. ...............................................140

Hinds, M. T. ................................................11

Hinz, B. ......................................................5

Ho, M. .......................................................65

Hogan, K. ...........................................114, 134

Hu, M. .......................................................76

Huang, N. ..................................................39

Hubert, T. ..................................................117

Huebner, P. .................................................17

Hung, M. ..................................................44

Hunter, J. ..................................................133

Huo, L. ......................................................65

Hussey, G. .........................................6, 30, 31

Huynh, V. ...................................................28

Ilyas, F. ......................................................33

Insuasti, G. .................................................81

Ireland, R. ................................................100

Isaacs, D. ...................................................65

Ivanjko, N. ...........................................135, 25

Ivkic, N. .....................................................25

Iyer, D. .......................................................111

Jackson, J. ...................................................47

Jacobs, I. ....................................................45

Jenndahl, L. .................................................46

Jeon, E. Y. .............................................2, 7 38

Jiang, S. ......................................................24

Johansson, M.............................................. 46

Johnson, S. .................................................58

Kameishi, S. ................................................63

Karoubi, G. ......................................37, 50, 62

Karvar, M. ...................................................19

Kaur, G. ......................................................71

Keller, G. ....................................................91

Kengla, C. ..................................................15

Khan, S. ....................................................22

Kheradmandi, M. .......................................33

Khuong, H. ................................................53

Killaars, A................................................... 86

Kim, B. ......................................................73

Kim, D.-H. ................................................140

Kim, I. ...................................................15, 47

KIM, J. ...................................................18, 47

Kim, J. ........................................................47

Kim, J. .................................................139, 48

Kim, M. M. ...............................................100

Kim, M. ......................................................14

Kittles, R. ...................................................111

Klett, K. C. .................................................42

Klosterhoff, B. .............................................87

Knewtson, K. E. ..........................................141

Knights, A. ..................................................71

Kolios, M. C. ...............................................97

Komosa, E. R. .............................................34

Kondo, M. .................................................74

Kornblum, H. I. ...........................................83

Kouthouridis, S. ..........................................70

Kuang, M. ..................................................52

Kurpiers, S. .................................................84

Kuwajima, T. ...............................................68

Kuzmanov, U. ............................................100

Kwan, J. F. ...................................................64

Kysar, J. W. ....................................................7

La Carrubba, V. ...........................................40

Lagneau, N. ................................................27

Lamorte, S. ................................................108

Landon-Brace, N. ................................107, 108

Lansberry, T. R. ............................................29

Larochelle, S. ................................................3

Larose, A. .....................................................1

Larouche, D. ..............................................1, 8

Larouche, J. ................................................84

Larsson, K. ..................................................46

Latour, S. ...................................................107

Latterich, M. ..............................................115

Lauris, R. C. .................................................13

Lawrence, J. T. .............................................40

Lee, H. .......................................................15

Lee, P. H. ..................................................140

Lee, S. .................................................118, 15

Lee, S. S. ..................................................119

Lefebvre, A. ...............................................83

Leguineche, K. ............................................87

Leight, J. ....................................................79

Leipzig, N. ................................................32

Lelkes, P. I. .................................................60

Letko Khait, N. ............................................55

Léveillard, T. ...............................................65

Le Visage, C. ..............................................27

Li, H. ............................................................6

Li, J. ......................................................24, 92

Li, K. .........................................................103

Li, Y. ...........................................................94

Liang, H. ...................................................115

Liang, J.-P. ..................................................29

Lim, D. .......................................................47

Lin, A. S. .....................................................87

Lin, D. S. ....................................................112

Lin, H. .......................................................116

Lin, J. .........................................................113

Lin, W.-H. ...................................................34

Ling, C. .......................................................91

Liu, A. .......................................................112

Liu, D. ........................................................76

Logterman, S. .............................................40

Loll, F. ........................................................27

Lopera-Higuita, M. .......................................10

Louzoun-Zada, S. ........................................95

Lu, S. .........................................................20

Lu, X. .......................................................104

Lu, Y.-Z. .....................................................102

MacDonald, A. ...........................................44

Maerz, T. .....................................................71

Magne, B. ....................................................8

Mainzer, C. ..................................................3

Mair, D. B. ................................................140

Makkaoui, N. ............................................103

Mansouri, M. ..............................................32

Marin Araujo, A. E. ......................................50

Marin-Araujo, A. .........................................62

Marques, A. P. ............................................69

Martino, M. ...............................................102

Martin-Villa, B. C. .........................................42

Mashiach, R. ...............................................95

Matavosian, A. A. ............................................

Mathews, C. E. ...........................................94

Mathews, L. ................................................31

Maticic, D. .................................................25

Mauroux, A. .................................................3

Maxwell, J. ................................................103

McDuffie, D. G. ...........................................35

McGaha, T. L. ...........................................108

McGuigan, A. P. ............................37, 107, 108

McLaren, A.-M. ..........................................20

McTiernan, C. ............................................31

Mehta, G. ..................................................59

Mehta, P. ...................................................59

Merchant, A. ..............................................56

Metzler, N. F. ..............................................74

Mikos, A. G. .......................................114, 134

Milesevic, M. .............................................135

Mir, S. .................................................139, 48

Miranda, M. Z. ..........................................100

Mirani, B. ...................................................97

Mirzaei, Z. ...........................................100, 97

Mital, S. ...................................................100

Molina, C. P. ................................................6

Mongeau, L. ..............................................92

Monnier, P. ................................................65

Mora, C. ....................................................22

Morissette, A. ...............................................1

Mostafavi, A. ...............................................19

Mostofinejad, A. .........................................50

Moulin, V. ....................................................3

Mukherjee, R. .............................................43

Mukhopadhyay, A. ......................................43

Murab, S. ..................................................113

Muslim, Z. ..................................................49

Myers, K. M. ................................................7

Nairon, K. ............................................143, 79

Nash, K. E. ..................................................87

Naughton, G. K. ........................................115

Navone, N. M. ............................................111

Nayer, B. ..................................................102

Nedrelow, D. ..............................................17

Negru, R. ..................................................142

Nejatian, M. ...............................................37

Neufeld, L. .................................................82

Newby, S. ..................................................44

Ogawa, M. .................................................91

Ogawa, S................................................... 91

Ogle, B. M. ................................................34

Okano, T. 63, ..............................................74

O’meara, M. ...............................................55

Orr, N. .......................................................95

Ozawa, T. O. ...............................................13

Ozpinar, E. W. ...........................................22

Pacheco, R. L. .............................................13

Pacicca, D. M. ............................................141

Pakshir, P. .....................................................5

Palo, B. ......................................................58

Papavasiliou, G. .........................................142

Pappalardo, A. .....................................2, 38, 7

Park, C. .......................................................14

Park, J. ......................................................142

Passipieri, J. ................................................86

Patel, S. N. .................................................94

Patrick, P. ....................................................98

Pattou, F. ...................................................117

Pecin, M. ....................................................25

Pecoraro, G. ................................................5

Pereira, R. M. ..............................................13

Perez, M. ............................................114, 134

Phelps, E. A. ..............................................94

Pinheiro, C. C. .......................................13, 72

Podgorny, A. R. ..........................................141

Pope, E......................................................... 1

Porada, G. ..................................................81

Poulikidis, K. ...............................................49

Prasad, V. ..................................................103

Puetzer, J. L. ................................................88

Qiao, W. ...................................................120

Quijano, L. .................................................58

Quint, J. ................................................19, 85

Radisic, M. ..........................................106, 36

Rafatian, n. .................................................36

Raha, S. .....................................................70

Rajan, N. ..................................................143

Rajasekar, S. ..............................................112

Rajendran, J. ...............................................41

Ramamurthi, A. ......................................52, 78

Rashad, H. M. .............................................81

Rassi, A. ......................................................17

Redden, R. A. ..............................................60

Reis, R. L. ....................................................69

Riera, R. ......................................................13

Ringel, M. .................................................143

Rizwan, M................................................... 91

Robinson, J. L. ............................................141

Rocha, D. L. .................................................13

Rodriguez, C. ..............................................81

Rodriguez, M........................................ 33, 79

Rojas, M. .....................................................31

Romero, D. ............................................50, 62

Roopmani, P. ...............................................41


AUTHOR INDEX

Ross, A. ......................................................93

Rostami, S. .................................................62

Rothermund, K. ...........................................54

Rubinchik-Stern, M. .....................................95

Sabin, K. ....................................................84

Sakiyama-Elbert, S....................................... 56

Salimova, E. ..............................................102

Samandari, M. .......................................19, 85

Samojlik, M. M. ...........................................94

Sandarage, R. .............................................64

Santanna, J. P. .............................................72

Santerre, P. ................................................100

Santos, H. M. ..............................................13

Saraf, A...................................................... 99

Sarker, P..................................................... 22

Satchi-Fainaro, R.......................................... 82

Schwarzmann, W. ........................................31

Scolnick, J. ..................................................81

Sebastian, J. A. ............................................97

Seidlits, S. K. ...............................................83

Seiler, D. ....................................................119

Sembrat, J. ..................................................31

Sergent, O. .................................................86

Shakya, P. ..................................................133

Shayan, M.................................................. 39

Shelkey, E. N. ............................................109

Shepherd, P............................................... 111

Shoichet, M. ..............................55, 65, 66, 91

Shortreed, N. A........................................... 10

Simmons, A. ...............................................29

Simmons, C. ........................................97, 100

Simonsson, S. .............................................46

Sinha, I....................................................... 19

Sirianni, Q. .................................................55

Sivakumar, H. ........................................33, 79

Skardal, A. .....................................143, 33, 79

Smajlovic, A................................................ 25

Smit, T....................................................... 119

Smith, K. W. ...............................................40

Sniadecki, N. J. ..........................................140

Sohrabi, A................................................. 83

Soker, S. ..................................................109

Soman, V. ..................................................31

Sorrells, L. ..............................................2, 38

Sotra, A. ..............................................112, 70

Stabler, C. ............................................29, 94

Stoddart, L. ...............................................140

Stokovic, N. .........................................135, 25

Strehl, R. ..................................................46

Strohm, E. M. .............................................97

Stuckey, D. J. ..............................................98

Suhar, R. ....................................................39

Syed-Picard, F. N. .......................................54

Sze, D. ......................................................22

Taheri, S. ...................................................92

Tamayol, A. ...........................................19, 85

Tan, J. .......................................................102

Teal, C. ......................................................65

Teymour, F. ................................................142

Thampi, S. ............................................52, 78

Thibodeau, A. ............................................53

Thomas, E. .................................................35

Tiruchirapalli Sivagnanam, U. .........................21

Toma, B. .....................................................99

Toren, H. ...................................................103

Tournier, P. .................................................27

Tovo, A. H. ..................................................13

Tsai, E. C. ...................................................64

Tsui, J. H. ..................................................140

Turnquist, H. ................................................31

Ueno, M. ....................................................75

Upasani, R. .................................................86

Vaicik, M. ..................................................142

Vale, D. M. ..................................................13

van Apeldoorn, A. A. ..................................117

Vardhan, S. ................................................56

Varma, R. ....................................................62

Villeneuve, S. ................................................1

Vnuk, D. .....................................................25

Vrbanac, Z. .................................................25

Vukicevic, S. ........................................135, 25

Vunjak-Novakovic, G. .................................106

Waddell, T. K. ...................................37, 50, 62

Wagner, K. T. ..............................................36

Wang, J. B. ...................................................5

Wang, S. .....................................................61

Weber, J. ....................................................49

Whitlock, P. W. ...........................................113

Willett, N. ..................................................87

Williams, M. A. ..........................................140

Woolley, K. .................................................52

Wu, Q....................................................... 36

Wu, Y. ........................................................99

Wylie, R. G. ................................................28

Xia, Z. .......................................................108

Xing, L. .......................................................76

Yang, B. .....................................................84

Yang, F. .....................................................75

Yang-Hartwich, Y. .......................................59

Yao, Y. .........................................................11

Yeung, K. ..................................................120

Yim, E. K. .....................................................11

Yoo, J. .............................................118, 15, 47

Zamarin, D. ................................................59

Zent, J. .......................................................79

Zhang, B. .............................................112, 70

Zhang, F. ...................................................112

Zhang, N. ...................................................75

Zhang, X. ...................................................116

Zhao, Y. ....................................................106

Zheng, X. ...................................................79

Zhong, C. ..................................................141

Zimber, M. .................................................115

Zuccaro, S. .................................................55


AUTHOR INDEX

EXHIBITOR LISTINGS

1901 Nelson Miller Parkway

Louisville, KY 40223

United States

Email: [email protected]

Website: www.advancedsolutions.com

Advanced Solutions Life Sciences is dedicated to the discovery, design, and development of integrated software, hardware, and biological solutions for the biomedical and biotechnology fields of science and industry. Advanced Solutions offers a full-service business model including its patented BioAssemblyBot 3D Biofabrication Technology Platforms, TSIM Software, patent pending VIPM, Professional Services and Supplies.

The Technology Center

400 Commercial St.

Manchester, NH 03101

United States


Website: www.armiusa.org/

ARMI | BioFabUSA is manufacturing the future of biofabrication. Our mission is to make practical the large-scale manufacturing of engineered tissues and tissue-related technologies, to benefit existing industries and grow new ones. Visit: https://www.armiusa.org/ to learn more.


Website: www.aspectbiosystems.com

Aspect Biosystems is a biotechnology company creating bioprinted tissue therapeutics to transform how we treat disease. Aspect is applying its microfluidic 3D bioprinting technology internally to develop these advanced cell therapies and partnering with leading researchers and industry innovators worldwide to tackle the biggest challenges in regenerative medicine. Learn more at www.aspectbiosystems.com.

970 Michelin, Suite 200

Laval, QC H7L 5C1

Canada


Website: biomomentum.com

Biomomentum manufactures and commercializes testing devices for the mechanical characterization of biomaterials and cartilage. The Mach-1™ multiaxial mechanical tester is the only all-in-one device designed for compression, tension, shear, friction, torsion and indentation mapping. The Mach-1™ is now used in many university labs and is deemed an excellent educational tool.


Website: www.ccrm.ca

Holtenauer Str. 74

Kiel, 24105

Germany


Website: cellbox-solutions.com

Cellbox Solutions GmbH is a young technology company focusing on innovative logistic solutions for the global BioMedTech industry. Our portable CO2 incubator, the Cellbox, provides a controlled environment for the transport of living cells and biological structures, where temperature and CO2 can be adjusted to ensure optimal incubation conditions.


EXHIBITOR LISTINGS

ADVANCED SOLUTIONS LIFE SCIENCES, LLC

ARMI/BIOFABUSA

ASPECT BIOSYSTEMS

BIOMOMENTUM INC.

CCRM

CELLBOX SOLUTIONS GMBH

BOOTH: 27

BOOTH: 13

BOOTH: 4

BOOTH: 8

BOOTH: 21

BOOTH: 1

2000 Kraft Drive

Blacksburg, VA 24060

United States


Website: www.cellink.com

CELLINK is a global leader in developing and delivering life-science solutions, equipping hundreds of labs and thousands of scientists worldwide with cutting-edge technologies that fuel groundbreaking scientific breakthroughs. With a commitment to quality and innovation, our bioprinters, imaging systems and bioinks have contributed to revolutionary advancements in academic and clinical medicine.

564 Weber St. N Unit #11

Waterloo, Ontario N2L 5C6

Canada


Website: www.cellscale.com

CellScale is an industry leader mechanical testing and bioreactor systems. Our mechanical test systems are specifically designed for biomaterials and incorporate controlled environments, image capture and analysis software, and a range of gripping mechanisms. Our cell culture systems enable mechanically active environments in 2D or 3D.


Website: www.ceologics.com

Our mission is to improve the quality of human cell culture and research everywhere and become the go-to manufacturer of iPSC-derived cells for all applications. With Life Sciences and Pharmaceutical research still relying on research methods from the 20th century, the stage is set for next-generation human cell models.


Website: www.collagenmatrix.com


Website: www.collplant.com


Website: www.essentbiologics.org

Essent Biologics is a nonprofit biotechnology company setting a new standard in human-derived biomaterials and comprehensive data for research. Starting with the donor, Essent Biologics acts as the catalyst to advance regenerative medicine, biopharmaceutical and cell therapy research from benchtop to bedside.

CELLINK

CELLSCALE BIOMATERIALS TESTING

CELOGICS

COLLAGEN MATRIX

COLLPLANT

ESSENT BIOLOGICS

BOOTH: 24

BOOTH: 31

BOOTH: 15

BOOTH: 28

BOOTH: 25

BOOTH: 17


EXHIBITOR LISTINGS


Website: www.htlbiotech.com

HTL is the leader in production and development of pharmaceutical grade biopolymers that are used by leading pharmaceutical and medical device companies to transform the lives of millions of patients in ophthalmology, dermatology, medical aesthetics, rheumatology, urology and more. HTL is at the forefront of innovation by creating new types of biopolymers and chemical modifications, while exploring innovative applications such as tissue engineering, regenerative medicine or drug delivery.

Researchers are given easy access to the best quality Hyaluronic Acid with molecular weights from 10 kDa to 3000 kDa, thanks to a partnership with Echelon Biosciences – a global leader in supplying reagents, assays and screening services for academic research and pharmaceutical development. To learn more about HTL: https://htlbiotech.com/

HTL

BOOTH: 18


Website: www.iff.com

IFF

BOOTH: 26

3515 Lyman Boulevard

Chaska, MN

United States


Website: www.lifecore.com

Do you need a source of Pharmaceutical Grade Sodium Hyaluronate for your TERM research and product development? For over 35 years, our hyaluronan has improved the lives of more than 100 million patients. Lifecore’s pharmaceutical grade hyaluronan is produced by bacterial fermentation in its U.S. based FDA registered/ISO 13485 certified-facility. Lifecore offers convenient quantities of sodium hyaluronate over a broad range of average molecular weights (5,000 Da. to 3M Da.) All its research lots of sodium hyaluronate are derived from pharmaceutical lots, are lot traceable, and come with a certificate of analysis.

How can we assist you in overcoming your challenges and realize your market opportunities? Visit us at our booth to learn more about our sodium hyaluronate and cGMP pharmaceutical compliant aseptic filling capabilities or contact Rebecca at [email protected] or 952-368-6321.

140 Huguenot Street

New Rochelle, NY 10801

United States


Website: www.liebertpub.com

Tissue Engineering, the Official Journal of TERMIS, is the preeminent, biomedical journal advancing the field with cutting-edge research and applications on all aspects of tissue growth and regeneration. This multidisciplinary journal brings together the principles of engineering and life sciences in tissue development and regenerative medicine.

598 Airport Boulevard Suite 900

Morrisville, NC 27560

United States


Website: www.nitta-gelatin.com

With over 100 years in the gelatin and collagen markets, Nitta Gelatin is a trusted supplier of versatile, leading-edge protein ingredients. Our beMatrix™ biomedical gelatin products are created using proprietary technology to yield unmatched safety and quality. With exceptionally low endotoxin levels and enhanced purity, beMatrix™ products are well suited for a range of biomedical applications.

450 Technology Drive Suite 300

Pittsburgh, PA 15219

United States

Phone: 412-624-5303


Website: www.mcgowan-pitt.edu

McGowan Institute is a national center of expertise in medical research focusing on the development and delivery of regenerative medicine therapies that reestablish tissue and organ function impaired by disease, trauma, or congenital abnormalities. Its core program areas include tissue engineering and biomaterials, cellular therapies, artificial organs and medical devices, and clinical translation. The institute maintains a broad program that ranges from basic research through clinical implementation, and McGowan faculty have been effective in establishing commercial start-up companies based on newly developed technologies and therapies.

LIFECORE BIOMEDICAL, LLC

MARY ANN LIEBERT, INC. PUBLISHERS

NITTA GELATIN, NA, INC.

MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE AT THE UNIVERISTY OF PITTSBURGH

BOOTH: 23

BOOTH: 29

BOOTH: 6

BOOTH: 3


EXHIBITOR LISTINGS

Pinnauallee 4

Uetersen 25436

Germany


Website: www.nordmark-biochemicals.com

Nordmark Biochemicals offers high quality products for cell isolation, including Collagenase NB 6 GMP Grade and animal-free Collagenase AF-1 GMP Grade. As one of the world’s largest manufacturers of pharmaceutical collagenase, we provide translational enzymes - research and GMP Grade collagenases and neutral proteases – to simplify the path from research to the clinic. Contact us at [email protected] www.nordmark-biochemicals.com

2242 W Harrison St., STE: 201-18

Chicago, Il 60612

United States


Website: https://oxygenimaging.com/

NORDMARK BIOCHEMICALS

O2M TECHNOLOGIES, LLC

BOOTH: 9

BOOTH: 7

396 University Ave.

Westwood, MA 02090

United States


Website: www.optics11life.com

Optics11 manufactures micromechanical testing systems to measure the viscoelastic properties of soft materials such as engineered tissue, hydrogels, and even samples as small as cells and organoids. We offer the stand alone Piuma, the Chiaro which adapts to most inverted microscopes, and the brand-new high throughput Pavone. Visit our booth or online at www.Optics11Life.com to learn more.

OPTICS11 USA

BOOTH: 30

5333 Casgrain Ave. Suite 712

Montreal, QB H2T 1X3

Canada


Website: www.rheolution.com

Rheolution manufactures mechanical testing devices for soft biomaterials. The ElastoSens™ Bio allows contactless, non-destructive testing of hydrogels, bioprinted scaffolds and blood clots and features removable sample holders for long-range studies. With volume detection and tracking of up to three samples simultaneously, the ElastoSens™ Bio will simplify and streamline your research.


Website: www.scintica.com

Scintica is a leading supplier of medical research solutions and provides elite applications, support, and a platform for scientists to share their science. We carry a diverse portfolio of products, from imaging systems (PET, CT, MRI, optical, DEXA, intravital microscopy, photoacoustic and high-frequency ultrasound), incubators, tissue culture analysis, and more

5 Crescent Ave

Rocky Hill, NJ 08553

United States


Website: http://www.thermofisher.com/peprotech

PeproTech is a business unit within the Thermo Fisher Scientific Biosciences Division, specializing in manufacturing high quality cytokine products and providing exceptional service to the global life science and cell therapy markets. Our products include Recombinant Human, Murine and Rat Cytokines, Animal-Free Recombinant Cytokines, GMP Cytokines, Antibodies and ELISA Kits.

RHEOLUTION INC.

SCINTICA

PEPROTECH, INC., PART OF THERMO FISHER SCIENTIFIC

BOOTH: 10

BOOTH: 22

BOOTH: 19


EXHIBITOR LISTINGS


Website: smithfieldbioscience.com

Smithfield BioScience is a supplier of porcine-derived bioproducts ranging from active pharmaceutical ingredients to finished medical devices. Smithfield’s vertically integrated platform encompasses a secure and fully traceable source of porcine materials as well as quality, regulatory, and R&D teams to provide product safety and innovation. For more information, visit smithfieldbioscience.com.

SMITHFIELD BIOSCIENCE

BOOTH: 16

6425 Wea Woodland Dr.

Lafayette, IN 47909

United States


Website: www.tissue-source.com

Tissue Source is your trusted provider of porcine tissues for medical devices, biologics, pharmaceuticals, research and development, testing and education. Our QMS is certified to ISO 13485:2016 and is also ISO 22442-2 and FDA 21 CFR 820 compliant. For more information, visit us at www.tissue-source.com or call 765.746.6679.


Website: https://en.tokaihit-excyte.com/bioreactor

Tokai Hit- We are the leading-edge company of live-cell microscope incubation systems and new products focusing on regenerative medicine and tissue engineering. We have various instruments designed for Dynamic Culture: New Dimension 4D culture, offering perfusion culturing with pulse control and pressure stimulation, bioreactor, and micro-perfusion system along with customization.

TISSUE SOURCE, LLC

TOKAI HIT CO., LTD

BOOTH: 5

BOOTH: 2

Medical Center Boulevard

Winston-Salem, NC 27157

United States


Website: www.wakehealth.edu

The Wake Forest Institute for Regenerative Medicine is an international leader in translating scientific discovery into clinical therapies, working on more than 40 different tissues and organs, with many world firsts. A part of Wake Forest University, the institute collaborates globally to make a difference in patients’ lives through regenerative medicine.

WAKE FOREST INSITUTE FOR REGENERATIVE MEDICINE (WFIRM)

BOOTH: 201

SAVE THE DATE 2023

SAVE THE DATE 2024 WORLD CONGRESS

SAVE – THE - DATE

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DDAATTEESS:: JJuunnee 2255 –– 2288,, 22002244

Conference Co-Chairs: Dr. Nasim Annabiand Dr. Elizabeth Cosgriff-Hernandez