Sistim Pencernaan Fisiologi (H.O KULIAH )

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    FAAL SISTEM PENCERNAAN 

    Dr. H. SONNY P LAKSONO M.Kes

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    Overview of 

    GI Processes

    Food

    Secretion

    Digestion

    Absorption

    Boo! "esses

    Motiit#

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    Mo$t%

    •on# p&rt in'o'e! in ingestion

    •Or& c&'it#( b$cc& c&'it#

    •Lips) c%ee*s) %&r! &n! so+t p&&te &n!

    tong$e

    •Most &cti'it# re&te! to &ccessor#

    org&ns ,teet%) s&i'&r# g&n!s) &n!

    tong$e-

    •Foo! is c%ee!) /i0e! it% s&i'&

    cont&ining en1#/es) begins s&oing

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    &ccessor# !igesti'e org&ns

    •Organs

     –teeth, tongue, gallbladder, glands

      ( salivary glands, liver, pancreas) •contribute to food breakdown

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    P%&r#n0

    •orop%&r#n0 to &r#ngop%&r#n0

    •,n&sop%&r#n0 not in'o'e! in !igestion-

    •Co//on p&ss&ge +or +oo!) +$i!s &n! &ir 

    •No p%#sic& or /ec%&nic& !igestion

    •Absorption2 none

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    Esop%&g$s

    •/$sc$&r t$be &bo$t 34c/ ,56 inc%es- ong •Co&pse! %en not in $se •Ro$te! %ere &s epigottis coses o++ &r#n0 to +oo! entr#

    •7oins sto/&c% &t c&r!i&c sp%incter  •Secretes /ore /$c$s +or $bric&tion •No p%#sic& or /ec%&nic& !igestion • P%&r#n0 &n! esop%&g$s &re con!$its +ro//o$t% to sto/&c%

    •Absorption2 none

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    Digestion

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    Cephalic Phase

    • Anticipatory/Sensory

    • Mediated via vags/Ach

     ! Chief cells secrete acid

     ! Parietal cells secrete pepsinogen

     ! G cells secrete gastrin

    • "ags also #ediates via pancreas

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    Gastric Phase

    • $egins with arrival of food in sto#ach

    • Two sti#li%

     ! stretch receptors in sto#ach

     ! digested protein

    • G cells in antr# sti#lated &y vags and

     &y protein

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    Digesti'e process in'o'es 8 essenti& &cti'ities

    5. ingestion2 t&*ing +oo! in  – bo$s2 &n &/o$nt o+ +oo! p&ssing t%ro$g% tr&ct

    3. prop$sion2 /o'es +oo! t%ro$g% tr&ct  – s&oing2 'o$nt&r#  – perist&sis2 in'o$nt&r# /$sc$&r &'es /o'es +oo! +or&r!

    9. /ec%&nic& !igestion2 p%#sic& c%eing) /i0ing) c%$rning – seg/ent&tion2 r%#t%/ic oc& constrictions o+ intestine +or /i0ing

    :. c%e/ic& !igestion2 c&t&bois/( bre&*!on o+ po#/ers into /ono/ers b# en1#/es  – begins in /o$t%) essenti&# co/pete in s/& intestine

    4. &bsorption2 p&ss&ge o+ !igeste! en! pro!$cts &cross & into boo!

     – /ono/ers) 'it&/ins) /iner&s &n! &ter   – p&ss t%ro$g% /$cos& ces ining tr&ct  – s/& intestine /&;or &bsorption site

    8. !e+ec&tion2 ei/in&tes in!igestibe s$bst&nces &n! ot%er &stes +ro/ bo!# 'i& &n$s in +or/ o+ +eces

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    Sto/&c%

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    Microanato#y of the Gt The $asic Plan

    • Mcosa

    • Scosa

    • Msclaris

    • Serosa

    • 'egional variations (

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    Secretion of )ater and *lectrolytes

    Na+

    +

    !l"

    Na +

    + !l"

    Na+

    #$O

    L

    > M

    E N

    %nterocyte

    %nterocyte &ight 'unction

    +

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    S/& Intestine

    •/&;or !igesti'e org&n •Longest p&rt o+ &i/ent&r# c&n&

     –,928 %o$r ;o$rne#-

    •9 s$b!i'isions –5- !$o!en$/ •s%ortest b$t ots going on •Hep&top&ncre&tic &/p$&2 bie !$ct &n! /&in p&ncre&tic !$ct enter 

     –3- ;e;$n$/ •/i!!e portion

     –9- ie$/ •&st p&rt ;oins &rge intestine &t ieocec& '&'e

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    +, Secretion &y Parietal Cells

    +

    #+

    %nterocyte

    %nterocyte

    L

    > M

    E N

    !O$ + #$O

    #!O " + #+ 

    !l "

    #!O"

    CA

    !O$

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    +CO- . Secretion &y Pancreatic Cells

    %nterocyte

    %nterocyte

    + Na+

    L

    > M

    E N

    !l"

    #!O"

    CA

    !O$ + #$O

    # +

     + #!O "

    !O$

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    A&sorption

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    Pri#ary S&stances A&amp