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    Pemicu 4

    Rizky Lumalessil

    4051300171

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    LO 1

    Tumor di Otot dan Jaringan

    Lunak

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    Lipoma

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    Lipoma

    gro!t" o# #at cells in a t"in$ %&rouscapsule usually #ound 'ust &elo! t"e skin

    re #ound most o#ten on t"e torso$ neck$

    upper t"ig"s$ upper arms$ and armpits$ &utt"ey can occur almost any!"ere in t"e&ody(

    One or more lipomas may &e present at t"esame time(

    Lipomas are t"e most commonnoncancerous so#t tissue gro!t"(

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    )pidemiology

    Lipomas occur in all age groups &utmost o#ten appear in middle age(

    *ingle lipomas occur !it" e+ual#re+uency in men and !omen(

    ,ultiple lipomas occur more#re+uently in men(

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    )tiology

    T"e cause o# lipomas is notcompletely understood$ &ut t"etendency to de-elop t"em is

    in"erited(

    minor in'ury may trigger t"egro!t"(

    .eing o-er!eig"t does not causelipomas(

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    Risk /actors

    Being between 40 and 60 years old.lt"oug" lipomas can occur at any age$t"eyre most common in t"is age group(

    Lipomas are rare in c"ildren( Having certain other disorders.People

    !it" ot"er disorders$ including adiposisdolorosa$ ,adelung disease$ o!den

    syndrome and 2ardners syndrome$ "a-ean increased risk o# multiple lipomas(

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    *ign and *ymptoms

    small 0(4 in( 1 cm to 1(6 in( 3 cm and#elt 'ust under t"e skin(

    mo-a&le and "a-e a so#t$ ru&&ery

    consistency( 8o not cause pain(

    Remain t"e same size o-er years or gro!-ery slo!ly(

    O#ten t"e most &ot"ersome symptom is t"elocation or increased size t"at makes t"elipoma noticea&le &y ot"ers(

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    8iagnosis

    9sually &e diagnosed &y itsappearance alone

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    Treatment

    Lipomas do not generally re+uire treatment(

    T"ere is no kno!n treatment to pre-ent lipomas or a:ect t"eirgro!t"(

    lipoma may &e surgically remo-ed i# symptoms de-elop$

    suc" as i# t"e lipoma; .ecomes pain#ul or tender(

    .ecomes in#ected or ince oroutpatient surgery center( T"e doctor in'ects a local anest"eticaround t"e lipoma$ makes an incision in t"e skin$ remo-es t"egro!t"$ and closes t"e incision !it" stitc"es sutures

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    R"a&domiosarkoma

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    R"a&domyosarcoma

    cancerous malignant tumor o# t"emuscles t"at are attac"ed to t"e &ones(

    =t can occur in many places in t"e &ody(

    T"e most common sites are t"estructures o# t"e "ead and neck$ t"eurogenital tract$ and t"e arms or legs(

    T"e most common so#t tissue tumor inc"ildren(

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    )tiology

    T"e cause o# r"a&domyosarcoma isunkno!n(

    =t is a rare tumor !it" only se-eral"undred ne! cases per yeart"roug"out t"e 9nited *tates(

    *ome c"ildren !it" certain &irt"

    de#ects are at an increased risk$ andsome #amilies "a-e a gene mutationt"at ele-ates risk(

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    Types

    Embryonal rhabdomyosarcoma

    Alveolar rhabdomyosarcoma

    Anaplastic rhabdomyosarcomaand undiferentiated sarcoma

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    Types

    Embryonal rhabdomyosarcoma(E!"# most common type( =t usually a:ects

    c"ildren in t"eir %rst 5 years o# li#e(T"e cells o# )R,* look like t"e de-eloping

    muscle cells o# a ?@ to A@!eek@old em&ryo(

    )R,* tends to occur in t"e "ead and neck

    area$ &ladder$ -agina$ or in or around t"eprostate and testicles(

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    Types

    Alveolar rhabdomyosarcoma (A!"#Typically a:ects all age groups e+ually$ &ut it is

    t"e type most o#ten seen in older c"ildren andteens(

    T"is type o# r"a&domyosarcoma most o#tenoccurs in large muscles o# t"e trunk$ arms$ andlegs(

    R,* cells look like t"e normal muscle cellsseen in a 10@!eek@old #etus(

    R,* tends to gro! #aster t"an )R,* andusually re+uires more intensi-e treatment(

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    Types

    Anaplastic rhabdomyosarcoma andundiferentiated sarcoma naplastic r"a&domyosarcoma #ormerly called

    pleomorphic rhabdomyosarcoma is anuncommon type t"at occurs in adults &ut is-ery rare in c"ildren(

    9sing la& tests$ doctors can tell t"at t"esecancers are sarcomas$ &ut t"e cells donBt "a-eany #eatures t"at "elp classi#y t"em #urt"er(

    .ot" o# t"ese uncommon cancers tend to gro!+uickly and usually re+uire intensi-e treatment(

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    *ymptoms

    T"e most common symptom is a mass t"at may or may not &epain#ul(

    Ot"er symptoms -ary depending on location o# t"e tumor(

    Tumors in t"e nose or t"roat may cause &leeding$ congestion$s!allo!ing pro&lems$ or neurological pro&lems i# t"ey eCtendinto t"e &rain(

    Tumors around t"e eyes may cause &ulging o# t"e eye$pro&lems !it" -ision$ s!elling around t"e eye$ or pain(

    Tumors in t"e ears$ may cause pain$ "earing loss$ or s!elling(

    .ladder and -aginal tumors may cause lead to trou&le startingto urinate or "a-ing a &o!el mo-ement$ or poor control o#urine(

    ,uscle tumors may lead to a pain#ul lump and are o#tent"oug"t to &e an in'ury(

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    )Cam and Tests

    8iagnosis o# r"a&domyosarcoma is o#ten delayed &ecause o#lack o# symptoms$ and &ecause t"e tumor may appear at t"esame time as a recent in'ury( )arly diagnosis is important&ecause r"a&domyosarcoma spreads +uickly(

    complete p"ysical eCam s"ould &e done( Tests mayinclude; .iopsy o# t"e tumor

    "est C@ray

    T scan o# t"e c"est to look #or spread o# t"e tumor

    T scan o# t"e tumor site

    .one marro! &iopsy may s"o! t"e cancer "as spread

    .one scan to look #or spread o# t"e tumor

    ,R= scan o# t"e tumor site

    *pinal tap lum&ar puncture

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    Treatment

    T"e precise treatment depends on t"e site and type o#r"a&domyosarcoma(

    )it"er radiation or c"emot"erapy$ or &ot"$ !ill &e used &e#ore ora#ter surgery( =n general$ surgery and radiation t"erapy are usedto treat t"e primary site o# t"e tumor( "emot"erapy is used to

    treat disease at all sites in t"e &ody( "emot"erapy is an essential part o# treatment to pre-ent #urt"er

    spread o# t"e cancer( ,any di:erent c"emot"erapy drugs areacti-e against r"a&domyosarcoma( *ome o# t"ese drugs include; 8acar&azine

    8oCoru&icin )piru&icin

    2emcita&ine

    =#os#amide

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    omplication

    omplications #rom c"emot"erapy

    Location in !"ic" surgery is notpossi&le

    ,etastasis

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    Prognosis

    E"ile aggressi-e treatment is usuallynecessary$ most c"ildren !it"r"a&domyosarcoma !ill ac"ie-e

    long@term sur-i-al( ure depends ont"e speci%c type o# tumor$ itslocation$ and t"e amount t"at "as

    spread(

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    /i&rosarkoma

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    /i&rosarcoma

    /i&rosarcoma is a tumor o#mesenc"ymal cell origin t"at iscomposed o# malignant %&ro&lasts in

    a collagen &ackground(

    =t can occur as a so#t@tissue mass oras a primary or secondary &one

    tumor(

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    )pidemiology

    /i&rosarcoma represents only a&out 10F o# musculoskeletal sarcomas andless t"an 5F o# all primary tumors o# &one( Go kno!n racial predilection

    eCists(

    /i&rosarcoma o# &one occurs slig"tly more commonly in men t"an in!omen(

    /i&rosarcoma o# &one can &e diagnosed in patients o# any age$ &ut it is

    diagnosed more commonly in patients in t"e #ourt" decade o# li#e( =t isusually located in t"e lo!er eCtremities$ especially t"e #emur and ti&ia(

    /i&rosarcoma o# t"e so#t tissues usually a:ects a !ider age spectrum o#patients t"an %&rosarcoma o# t"e &one does$ !it" an age range o# 35@55years( =t o#ten arises in t"e so#t tissues o# t"e t"ig" and t"e posterior knee(=t is generally a large$ painless mass deep to #ascia and "as an ill@de%ned

    margin( n in#antile #orm in c"ildren H 10 y o# %&rosarcoma eCists( 9nlike

    %&rosarcoma in adults$ it "as an eCcellent prognosisIe-en in t"e #ace o#

    metastatic disease at presentationI!"en treated !it" a com&ination o#neoad'u-ant and ad'u-ant c"emot"erapy and resection

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    )tiology

    /i&rosarcoma$ like ot"er so#t@tissuesarcomas$ "as no de%nite cause(urrent researc" indicates t"at many

    sarcomas are associated !it" geneticmutations(

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    *ign and *ymptoms

    *arcomas in-ol-ing &one; pain and s!elling a#ter a long duration o# symptoms(

    T"ey may e-en gro! large enoug" to t"reaten t"e structural integrityo# t"e &one and cause pat"ologic #racture as t"e initial presentation(

    *o#t@tissue sarcomas; painless masses(

    .ecause t"ese lesions #re+uently arise deep to t"e muscular #ascia$t"ey may &ecome eCtremely large tumors prior to diagnosis(

    ,ost lesions occur around t"e knee$ in t"e proCimal #emur and"ip region$ or in t"e proCimal arm( /indings are nonspeci%c and

    can -ary #rom a %Ced$ %rm mass to a localized area o#tenderness(

    Geurologic or -ascular c"anges are late %ndings and indicateeCtensi-e disease in-ol-ement

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    88

    /i&rous dysplasia

    /i&rous "istiocytoma

    Osteosarcoma Paget sarcoma

    ,alignant %&rous "istiocytoma

    ,alignant neurosarcoma

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    Treatment

    ,edical T"erapy Radiation treatment and c"emot"erapy$ can

    impro-e local control and may make t"eappearance o# clinically e-ident metastaticdisease less likely( T"e use o# c"emot"erapy iscontro-ersial$ &ut c"emot"erapy is generallyused in &one lesions( Radiation t"erapy is usedin con'unction !it" surgery #or so#t@tissue

    %&rosarcomas$ !it" or !it"out c"emot"erapy *urgical T"erapy

    *urgical resection !it" a cu: o# normal tissue!ide margins

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    omplication

    Local recurrence may occur in up to?0F o# cases and is t"e reason t"atpostoperati-e radiation$ preoperati-e

    radiation$ or &ot" are o#tenrecommended( Local recurrence isreduced to a&out 65F !"en

    postoperati-e irradiation is used(

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    Prognosis

    /or congenital %&rosarcoma o# &one inc"ildren$ t"e prognosis !"ic" is relatedto age and to time to diagnosis is muc"

    &etter$ !it" t"e disease "a-ing long@term sur-i-al rates o# "ig"er t"an 50F(

    *o#t@tissue %&rosarcoma is associated

    !it" a 40@?0F sur-i-al rate at 5 years(T"e in#antile #orm "as an e-en &etter 5@year sur-i-al rate$ in eCcess o# A0F(

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    /i&romatosis

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    8e%nition

    /i&romatosis is a condition !"ere%&rous o-ergro!t"s o# dermal andsu&cutaneous connecti-e tissue

    de-elop tumors called %&romas(T"ese %&romas are usually &enignnon@cancerous(

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    lassi%cation

    Ju-enile

    dult *uper%cial #acial %&romatoses

    8eep musculoaponeurotic%&romatoses

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    lassi%cation

    Ju-enile ongenital generalised %&romatosis

    in#antile myo%&romatosis

    poneurotic %&roma =n#antile digital %&romatosis

    ggressi-e in#antile %&romatosis

    /i&romatosis colli 8ermato%&rosis lenticularis .usc"ke@

    Ollendor# syndrome

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    lassi%cation

    dult *uper%cial #acial %&romatoses

    Palmar 8upuytren contracture and plantar Ledder"osedisease %&romatosis

    Penile %&romatosis Peyronie disease nuckle pads

    8ermato%&roma

    Godular #asciitis

    )lasto%&roma

    /i&rous papule o# t"e #ace 8eep musculoaponeurotic %&romatoses

    8esmoid tumours aggressi-e %&romatoses )Ctraa&dominal %&romatosis

    &dominal %&romatosis

    =ntraa&dominal %&romatosis e(g( pel-ic %&romatosis

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    /eature o# /i&romatosis

    *uper%cial %&romatoses

    *lo! gro!ing tumour

    *mall size

    rise #rom #ascia or aponeurosis

    Less aggressi-e

    8eep %&romatoses

    Rapidly gro!ing tumour

    9sually reac" large size

    O#ten in-ol-e deeper structures muscles o#t"e trunk and eCtremities

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    =n#antile digital%&roma

    nuckle pads8ermato%&roma

    /i&rous papulePeriungual%&roma

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    )tiology

    T"e cause o# %&romatosis remains unclear(

    =n some types o# %&romatosis suc" asdesmoid tumours it is t"oug"t t"at t"e

    condition may &e related to trauma$ "ormonal#actors$ or "a-e a genetic association(

    *uper%cial %&romatoses suc" as palmar$plantar and penile %&romatosis "a-e

    sometimes &een linked to certain diseasessuc" as dia&etes$ li-er disease and"ypertension(

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    Treatment

    ,anagement o# %&romatosisdepends on t"e indi-idual disease(

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    Liposarkoma

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    Liposarcoma

    cancerous malignant tumor t"atde-elops #rom #at cells(

    an de-elop any!"ere$ &ut typicallyappear in t"e deep #at tissues o# t"elim&s or a&domen in people ages 50to ?5(

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    )pidemiology

    Liposarcomas are slig"tly more commonin males t"an in #emales

    T"e mean patient age at onset is 50

    years( lt"oug" liposarcomas account #ora&out 17F o# all so#t tissue sarcomas$t"ey are in-ol-ed in only 4F o# c"ild"oodso#t tissue sarcomas( ases o# liposarcoma

    are reported in young adults andteenagers$ &ut cases in c"ildren are rare

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    $athophysiology

    Liposarcoma is a lipogenic tumor o# largedeep@seated connecti-e tissue spaces( /usionproteins created &y c"romosomala&normalities are key components o#mesenc"ymal cancer de-elopment( na&normality o# &and 16+13 "as &eenassociated !it" t"e de-elopment o#liposarcomas( T"e most commonc"romosomal translocation is t"e FUS-CHOP#usion gene$ !"ic" encodes a transcription#actor necessary #or adipocyte di:erentiation(

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    )tiology

    Go !ell@esta&lis"ed causati-e #actor"as &een identi%ed$ alt"oug" trauma"as &een implicated(

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    *ymptoms

    ,ost people !it" liposarcoma do not#eel sick( T"ey mig"t notice a lump!"ic" can &e so#t or %rm to t"e

    touc" t"at is usually painless andslo! gro!ing( 9n#ortunately$ tumorsin t"e a&domen can gro! to &e +uite

    large &e#ore t"ey are #ound(

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    8iagnosis

    p"ysical eCam Lumps t"at are 5cm or larger and deep@

    seated$ %rm and %Ced to underlying

    structures are usually consideredsuspicious(

    =maging tests and o#ten include an K@

    ray and an ,R=( needle or a surgical &iopsy(

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    88

    Lipomas

    Geuro%&romatosis

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    Treatment

    "urgeryis t"e treatment #or primary liposarcomast"at "a-e not yet spread to ot"er organs

    T"e com&ination o# surgery and radiationtherapy"as &een s"o!n to pre-ent recurrence at

    t"e surgical site in a&out A5@0F o# liposarcomacases

    T"e role o# c"emot"erapy in t"e treatment o#liposarcoma is not clearly de%ned$ &ut it may &e

    recommended in certain situations !"ere patientsare at "ig" risk o# recurrence or already "a-e!idespread disease(

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    LO 6

    9lkus pada Tungkai

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    9lkus Tropicum

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    8e%nisi

    suatu ulkus dengan ciri@ciri k"assering terdapat didaera" tropik$&er&entuk k"as$ &er&au &usuk dan

    dise&a&kan ole" mikroorganisme

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    Penye&a&

    penye&a& yg paling pasti &elumdiketa"ui$ diduga dise&a&kansim&iosis dua macam

    mikroorganisme .orrelia -incenti dan.acillus #usi#ormis

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    )pidemiologi

    umur ; ?@10 ta"un

    'enis kelamin ; le&i" &anyak padapria

    / k # k "i

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    /aktor@#aktor yg mempengaru"itim&ulnya penyakit

    daera" ; tropis

    musim ; "u'an

    ke&ersi"an ; "igiene yg &uruk dangizi yg kurang( terkadang dpt tim&ulaki&at gigitan serangga

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    2e'ala

    dimulai dg luka kecil MMN ter&entukpapula yg dg cepat meluas men'adi-esikel MMN -esikel peca" dan

    men'adi ulkus kecil$ setela" diin#eksiole" mikroorganisme$ ulkus meluaske samping dan ke dalam dan

    mem&eri &entuk k"as ulkus tropikum

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    Pemeriksaan ulit

    lokalisasi ; tungkai &a!a" dan lengan

    e

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    2am&ar istopatologi

    ulkus dg se&ukan sel radang akutP,G serta sel dara" mera"

    pada dermis$ ditemukan pele&aran

    u'ung6 pem&ulu" dara" disertaise&ukan sel plasma

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    Pemeriksaan pem&antula&

    pemeriksaan rutin ; leukositosis$ L)8meningkat

    pemeriksaan k"usus ; mikroskop

    lapangan gelap mencari .orrelia-incenti atau .acillus #usi#ormis

    pe!arnaan .urry ; utk meli"at

    .orrelia -incenti

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    8iagnosis .anding

    ulkus &anal

    ulkus -arikosus

    ulkus karena 'amur$ tu&erkulosis

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    Penatalaksanaan

    umum ; istira"at$ diet tinggi kaloritinggi protein$ meng"indar gigitanserangga

    k"usus ; sistemik ; in'eksi penisilin 00(000 =9

    selama 7 "ari atau amoksisilin 4C500

    mg selama 5@10 "ari topikal ;

    kompres ,nO4 15000@110(000

    'ika lesi &ersi" di&eri salep salisil 6F

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    Prognosis

    &aik

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    9lkus Tro%k

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    8e%nisi

    suatu ulkus kronik yg dise&a&kangangguan tro%k$ &iasanya di'umpaipada penderita lepra$ 8,$ dan ta&es

    dorsalis gangguan tro%k ; aki&at neuropati

    peri#er

    ulkus tim&ul didaera" kulit yg seringmendapat tekanan anestetik

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    Penye&a& dan )pidemiologi

    Penye&a& ; gangguan tro%k setempat

    )pid umur ; pada usia de!asa

    'enis kelamin ; #rekuensinya sama padapria dan !anita

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    2e'ala

    mula@mula terdapat koreng pdtelapak kaki'ari tangan$ namunkarena pada penderita lepra ter'adi

    anestesi$ aki&atnya tidak lagimerasakan tekanan saat &eker'a s"gkoreng makin mem&esar dg atro%

    'aringan sekitarnya serta an"idrosis

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    Pemeriksaan ulit

    Lokalisasi ;telapak kaki$ u'ung 'aridan sela pangkal 'ari kaki

    e

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    2am&aran istopatologi

    ulkus dg se&ukan sel radang kronikdisertai sel epiteloid

    terkadang ditemuka sel datia

    Lang"arns

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    Pemeriksaan La&

    pemeriksaan &akteriologik dr sekretulkus

    pemeriksaan dara" rutin$ gula

    dara"$.T

    &iakan sekret ulkus dan u'i resistensi

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    8iagnosis .anding

    9lkus piogenik ; &tk o-al$ pinggirmeninggi$ dasar &er&en'ol6$ sekretprodukti#$ daera" sekitar reda$

    pera&aan nyeri$ indurasi positi#

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    Penatalaksanaan

    umum ; istira"at

    k"usus ; terapi ter"adap etiologiprimernya sistemik ; penisilin 00(000 =9 selama 7

    "ari Q anti&iotik lain yg sensiti#

    topikal ; kompres ,nO4 110(000

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    Prognosis

    &aik$ sepan'ang pengo&atanpenye&a&nya &aik

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    73/104

    9lkus Piogenik

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    74/104

    8e%nisi

    in#eksi kulit yg menim&ulkan ulkustidak k"as$ dise&a&kan ole"streptokok atau sta%lokok

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    75/104

    Penye&a& dan )pidemiologi

    Penye&a& ; streptokok dan sta%lokok

    )pidemiologi umur ; le&i" sering pd anak6

    'enis kelamin ; #rekuensinya samadengan pria dan !anita

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    2e'ala

    tim&ul korengulkus dg tanda6radang di sekitarnya$ scr lam&atmengalami nekrosis dan menye&ar

    scr serpiginosa

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    77/104

    Pemeriksaan ulit

    lokalisasi ; ekstremitas

    e

  • 7/26/2019 pemicu 4 rizky

    78/104

    2am&aran istopatologi

    tampak reaksi sel di 'aringan dengansel plasma$ dan sel lim#oid

    ik &

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    79/104

    Pemeriksaan La&

    kultur sekret ulkus dan tes resistensi

    8i i . di

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    80/104

    8iagnosis .anding

    9lkus tropikum dan ulkus karenapenye&a& lain spt antraks$tu&erkulosis atau #ram&usia

    P t l k

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    Penatalaksanaan

    umum ; &ersi"kan de&ridementulkus

    k"usus sistemik ; penisilin ?00(000@1$6 'uta =9

    intramuskular selama 5@7 "ari eritromisin 4C500 mg selama 7 "ari

    topikal ; salep salisil 6FQ 'ika &erat dgkompres P 110(000 atau gGO3 1@6F

    P i

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    Prognosis

    &aik

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    83/104

    9lkus 8eku&itus

    8 % i i

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    84/104

    8e%nisi

    ulkus yg tim&ul karena tekanan &erat&adan pada tempat tidur

    P & & d ) id i l i

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    85/104

    Penye&a& dan )pidemiologi

    Penye&a& ; tekanan &erat &adan pdtempat tidur

    )pidemiologi umur ; semua umur terutama orang tua

    'enis kelamin ; #rekuensinya sama pdpria dan !anita

    / kt P di i i

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    86/104

    /aktor Predisposisi

    penderita penyakit kronik spt 8,$malnutrisi$ keganasan$ dan orang@orang yg tidak dapat &ergerak le&i"

    muda" terkena ulkus deku&itus

    2 ' l

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    87/104

    2e'ala

    dimulai dg eritema pd daera" ygtertekan

    ulkus mengeluarkan 'aringan

    nekrosis &er!arna kecoklatan se&agian ulkus ditutupi ole" 'aringan

    nekrosis &er!arna "itam yg

    menyerupai mem&ran

    P ik lit

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    Pemeriksaan ulit

    lokalisasi ; pinggang$ &okong dantempat6 yg &anyak mengalamitekanan

    e

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    89/104

    2am&aran istopatologi

    ulkus dg dinding rata atau &ergaung

    pada dasarnya ditemukan se&ukansel6 radang akut

    pd su&kutis didapatkan pele&aran P8dan se&ukan sel6 radang

    Pemeriksaan La&

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    90/104

    Pemeriksaan La&

    kultur dara" dan tes resistensi

    8iagnosis .anding

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    91/104

    8iagnosis .anding

    ulkus gangrenosa ole" karena 8,$&iasanya &er&au &usuk dg 'arnekrosis yg produkti#

    ulkus &anal; sering &er&entuk tidakteratur dan &ersi#at akut

    Penatalaksanaan

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    Penatalaksanaan

    "ilangkan tekanan pd daera"6 yg terkenadg mengu&a"@u&a" posisi

    mengusa"akan agar -entilasi antara&adan dan tempat tidur &er'alan lancar

    sistemik ; anti&iotik spektrum luas sptamoksisilin 4C500 mg selama 15@30 "ari(*iklosporin 1@6 g"ari selama 3@10 "ariatau golongan kuinolon 4C500 mg"ari

    selama 14 "ari topikal ; salep anti&iotik spt salep

    kloram#enikol 6F

    Prognosis

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    93/104

    Prognosis

    &aik selama pengo&atan penyakitdasar &er"asil &aik

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    94/104

    9lkus 2angrenosum

    8e%nisi

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    95/104

    8e%nisi

    ulkus yg tim&ul pd penderita6 dgkeadaan umum &uruk atau penderitapenyakit kronik

    Penye&a& dan )pidemiologi

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    96/104

    Penye&a& dan )pidemiologi

    Penye&a& ; streptokok danmikroorganisme lain

    )pidemiologi umur ; le&i" &anyak pd orang tua'enis kelamin ; #rekuensi yg sama pd pria

    dan !anita

    /aktor Predisposisi

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    /aktor Predisposisi

    &iasanya tim&ul pd penderitapenyakit6 yg menye&a&kan keadaantu&u" lema"$ spt 8,$ keganasan$

    kusta dan malnutrisi

    2e'ala

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    98/104

    2e'ala

    mula6 tim&ul papula6 kecil di kulit$dalam !aktu cepat tim&ul a&ses danselan'utnya ter&entuk ulkus dg si#at6

    MMN tak teratur$ sekret ulkus$ 'arnekrosis yg "itam$ dg &er&au &usuk

    penderita mengelu" panas dan nyeri

    Pemeriksaan ulit

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    99/104

    Pemeriksaan ulit

    lokalisasi ; ekstremitas in#erior danu'g6 'ari

    e

  • 7/26/2019 pemicu 4 rizky

    100/104

    2am&aran istopatologi

    9lkus tidak k"as$ ditutupi ole" 'arnekrosis dan sel6 polinuklear$ selplasma dan lim#osit

    pada dermissu&kutis terdptpele&aran P8

    Pemeriksaan La&

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    101/104

    Pemeriksaan La&

    pemeriksaan dara" utk gula dara"$kultur dan tes resistensi

    8iagnosis .anding

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    102/104

    8iagnosis .anding

    ulkus &anal ; &iasanya tidak &er&au$keadaan umum penderita takterpengaru"

    ulkus tro%k ; &iasanya ter'adigangguan sensi&ilitas$ tak produkti#dg dasar yg le&i" &ersi"

    Penatalaksanaan

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    103/104

    Penatalaksanaan

    kom&inasi pengo&atan dgpengo&atan penyakit dasarnya

    sistemik ; anti&iotik spektrum luas

    spt amoksisilin 4C500 mg"ariselama 10@14 "ari( *iklosporin 1@6g"ari selama 10@14 "ari( Preparatkuinolon 6C650 mg"ari selama 10@

    14 "ari topikal ; kompres ,nO4 15(000

    atau larutan po-idon yodium 5@10F

    Prognosis

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    Prognosis

    &iasanya &aik &ila penyakit dasarnyadapat diatasi