PATOFISIOLOGI VARISELA

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Transcript of PATOFISIOLOGI VARISELA

PATOFISIOLOGI VARISELA

PATOFISIOLOGI VARISELAErika Agustina Kasdjono1061050173

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Struktur Virus Varicella-Zoster 2

Cambridge university, 2005Penularan:Melalui lesi pada kulitAirbone droplet / aerogenplasenta

Electronmicrograph of varisela virusCDC- Dr. Erskin Palmer Klasifikasi Varicella zoster diklasifikasikan sebagai berikut: Family : Herpesviridae sub family : Alphaherpesvirinae Genus : Varicellovirus Species : Varicella zoster 2Reproduksi Virus3

12345Cambridge university, 2005Varicellazoster virus cell attachmentand fusion. (a) Varicellazoster virus attaches to thehost cell surface via interaction of viral glycoproteinsgB, gH and gI with heparan sulphate constituents ofthe host cell-surface proteoglycans. (b) Mannose 6-phosphate (Man-6-P) residues on the viral glycoproteinectodomains then bind to Man-6-P receptors on thehost cell surface and trigger viral penetration. (c) Fusionof the viral and host envelope releases viral tegumentproteins into the host cell cytoplasm, which migrateto and enter the host cell nucleus. (d) Fusion of nakedviral nucleocapsids with the outer nuclear membrane,releases the viral DNA genome into the nucleus,where it circularises.

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Eritema Papula Vesikel Krusta Demam

5 Makula

66Papul7 Vesikel dan Bula8krusta910

Lesi awal

Lesi hari ke 5Lesi hari ke 6

Evolving lessionCDC- JD. MILLER11

Gambaran mikroskopik12

CDC Dr. Erskin PalmerElectronmicrograph of varicella virions Photomicrograph of infected cells Referensi Heather brannon, MD, former about.Com guide, updated july 27, 2007.Ilmu penyakit kulit dan kelamin, edisi ke 6, prof.Dr.Dr. Adhi juanda.Varisela pada anak gejala klinis, pencegahan dan pengobatan.Chairuddin P. LUBIS, bagian ilmu kesehatan anak Fakultas Kedokteran Universitas Sumatera Utara.Ann Arvin, Infectious Disease Division, Stanford University School of Medicine, Stanford, Californ i a.Varisela dan herpes zoster, Ramona Dumasari,Fakultas Kedokteran USU, 2009.

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