Memantine
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Reactions 1476, p22 - 2 Nov 2013 S Memantine Hyperkalaemia in an elderly patient: case report A 98-year-old woman developed hyperkalaemia while receiving memantine. The woman, who had a history of Alzheimer’s disease and dementia, had been hospitalised after breaking her leg. After being admitted, she developed hyperactive delirium with worsening insomnia that was complicated by her dementia. She was diagnosed with delirium complicated by dementia, and she received memantine 5 mg/day [route not stated]; her dosage was increased to 10 mg/day, 3 days later. She was also receiving unspecified antibacterials and non-steroidal anti- inflammatories. Her psychotic manifestations improved but, 5 days after starting the drug, laboratory tests showed that her potassium level had increased as had her serum creatinine and BUN levels. It was concluded that memantine had worsened the woman’s renal function; the drug was discontinued and her serum potassium level subsequently normalised. Author comment: "Herein, we report a patient with Alzheimer’s dementia and hyperkalaemia possibly associated with memantine administration." Tsukamoto T, et al. Memantine-associated hyperkalaemia in a patient with Alzheimer’s disease. Psychogeriatrics 13: 180-181, No. 3, Sep 2013. Available from: URL: http://dx.doi.org/10.1111/psyg.12022 - Japan 803095012 1 Reactions 2 Nov 2013 No. 1476 0114-9954/13/1476-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Memantine
Reactions 1476, p22 - 2 Nov 2013
SMemantine
Hyperkalaemia in an elderly patient: case reportA 98-year-old woman developed hyperkalaemia while
receiving memantine.The woman, who had a history of Alzheimer’s disease and
dementia, had been hospitalised after breaking her leg. Afterbeing admitted, she developed hyperactive delirium withworsening insomnia that was complicated by her dementia.She was diagnosed with delirium complicated by dementia,and she received memantine 5 mg/day [route not stated]; herdosage was increased to 10 mg/day, 3 days later. She was alsoreceiving unspecified antibacterials and non-steroidal anti-inflammatories. Her psychotic manifestations improved but,5 days after starting the drug, laboratory tests showed that herpotassium level had increased as had her serum creatinine andBUN levels.
It was concluded that memantine had worsened thewoman’s renal function; the drug was discontinued and herserum potassium level subsequently normalised.
Author comment: "Herein, we report a patient withAlzheimer’s dementia and hyperkalaemia possibly associatedwith memantine administration."Tsukamoto T, et al. Memantine-associated hyperkalaemia in a patient withAlzheimer’s disease. Psychogeriatrics 13: 180-181, No. 3, Sep 2013. Availablefrom: URL: http://dx.doi.org/10.1111/psyg.12022 - Japan 803095012
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Reactions 2 Nov 2013 No. 14760114-9954/13/1476-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
