makalah fenol fitokimia

download makalah fenol fitokimia

of 31

  • date post

    05-Jul-2018
  • Category

    Documents

  • view

    212
  • download

    0

Embed Size (px)

Transcript of makalah fenol fitokimia

  • 8/16/2019 makalah fenol fitokimia

    1/31

    UNIVERSITAS 17

     AGUSTUS 1945

    FAKULTAS FARMASI

    FITOKIMIA 2

    DAMERIA SIAHAAN 1343050006

    ASTI EKA SAFITRI 1443050050

    ACHMAD RIDHO 1443050054

    SHINTA FEBRIYANTI 1443057055

    TRI MULYANINGSIH 1443057056

    SENDY PERMANA 1443057052

    FEBRY DIAN LESTARYANA

    1443057060

    FEN

  • 8/16/2019 makalah fenol fitokimia

    2/31

    DAFTAR PUSTAKA

    JUDUL ............................................................................................................................ i

    DAFTAR PUSTAKA ..................................................................................................... 1

    BAB I

    1.1 DEFINISI DAN STRUKTUR FENOL ............................................................... 2

    1.2 TATA NAMA FENOL ........................................................................................ 3

    1.3 KARAKTERISTIK FENOL ................................................................................ 4

    1.4 KLASIFIKASI FENOLIK DAN TURUNAN SENYAWA ................................ 5

    1.5 DETEKSI REAKSI WARNA SENYAWA FENOL ........................................... 10

    1.5.1 CONTOH SENYAWA FENOL ......................................................... 15

    1.6 BIOSINTESIS SENYAWA FENOL ................................................................... 24

    1. DAFTAR PUSTAKA ........................................................................................... 34

    BAB I

    I. DEFINISI DAN STRUKTUR FENOL

    FENOL 2016 1

  • 8/16/2019 makalah fenol fitokimia

    3/31

    S!"#$%$ &!"'(i) *!+,-$)$" !"#$%$ #$"/ $"#$) i!*,)$" -$$

    ,*,$". F!"'(i) *!*i(i)i i"i" $+'*$i) $, $$, (!i /,/, i+')i OH

    $" /,/, 7 /,/, ($i" -!"#!+$"#$. S!"#$%$ i"i i!+i "$*$ !+$$+)$" "$*$

    !"#$%$ i",)"#$8 &!"'(. S!"#$%$ &!"'( )!$"#$))$" *!*i(i)i /,/, i+')i(

    (!i $+i $, !i"//$ i!, polifenol. S!"#$%$ &!"'( *!(i-,i $"!)$ +$/$*

    !"#$%$ #$"/ !+$$( $+i ,*,$" #$"/ *!*-,"#$i i+i $*$8 #$i, i"i"

    $+'*$i) #$"/ *!"/$","/ $, $$, ,$ /,/, 9OH.

    S!"#$%$ &!"'(i) i $($* !+$-$

    $"/$ (,$8 *!*-,"#$i :$+i$i +,),+  

    #$"/ (,$8 *,$ i!*,)$" i !*,$ $"$*$"8 $,"8 ,"/$

    $" ,$. Ri,$" !"#$%$ &!"'(i) $($* !($ i)!$,i +,),+"#$8 $"$+$ ($i"

    &($:'"'i8 &!"'( *'"'i)(i) !!+$"$8 &!"i( -+'-$"'i8 -'(i&!"'( (i/"i"8 *!($"i"8

    $""i"8 $" ),i"'" &!"'(i).

    B$"#$) !"#$%$ &!"'(i) $($*i *!"/$","/ !),+$"/9),+$"/"#$ $, /,/,

    i+')i( $" (!i $"#$) #$"/ *!*!",) !"#$%$ !!+8 !!+ $$, /(i')i$

    $+i-$$ !"#$%$ !$"#$. S!"#$%$ !!+ $$, !!+ &!"'( !+!, *!*i(i)i

    )!($+,$" #$"/ (!i !$+ $($* $i+ $+i-$$ !"#$%$ &!"'( $" !"#$%$

    /(i')i$"#$.

    D$($* )!$$$" *,+"i8 !"#$%$ &!"'( !+,-$ ;$ -$$ #$"/ i$) !+%$+"$8

    !$-i

  • 8/16/2019 makalah fenol fitokimia

    4/31

    C l

    O H

    N O

    2

    O H

    B r

    O H4

    Kl! r!"  #$!

    l %ρ- klor

    ofen

    ol)

    2 $&'r !"# $!l

    %ο- nitro

    feno

    l)

    3 Br! (! "#$

    !l % -ɱ bro

    of 

    enol

    )

    *!*!+(,)$" $$"#$ ,$, !"#$%$ #$"/ $-$ *!"'"'+)$" H. S!"#$%$ &!"'(i) 

    *!+,-$)$" '"' i!$( $+i !"#$%$ #$"/ *,$ *!"'"'+)$" $'* H.

    II. TATA NA!A FENOL

    M!",+, !&i"ii8 &!"'( $$($ i+')i!";!"$. F!"'( $$($ "$*$ ,*,*

    ,",) !"#$%$. N$*$ IUPAC (International Union of Pure and Applied 

    Chemistry) $$($ !";!"'(8 i,+,")$" $($* $+$ #$"/ $*$ !-!+i "$*$9"$*$

    IUPAC ,",) $(''( $(i&$i). K!i)$ *'(!),( &!"'( i/$"i)$" !"/$" )!('*-')9

    )!('*-') $*$$"8 $i) orto, meta, para #!* $$, i!* -!"'*'+$" $-$

    i/,"$)$".

    D$($* )!,$ )$,8

  • 8/16/2019 makalah fenol fitokimia

    5/31

    III. KARAKTERISTIK SEN"A#A FENOLSi&$ 9i&$ $+i &!"'(8 $$($ > $. M!*-,"#$i /,/, i+')i !$-i ,)$" !+*$,) /'('"/$" $()''( $"

     ,)$" -,($ !+*$,) $$ .

     . T!+*$,) $$* )$+'($ #$"/ !+i&$ $$* (!*$.

    . Ti$) !+%$+"$ !"/$" %,

  • 8/16/2019 makalah fenol fitokimia

    6/31

    I$. KLASIFIKASI FENOLIK DAN TURUNAN SEN"A#A K($i&i)$i F!"'(i) !+$/i $$ 4 *$$*8 #$i,>

    %. Fenol &e'er(n

    S!$+$ ,*,* !"#$%$ &!"'(i) !!+$"$ *!*i(i)i i&$ $)!+ii$(8

    $"i!-i) $" $"i!(*i"i). S!"#$%$ $+i )!('*-') i"i $i( ,i,i /,/,

    &!"'( $($* -'ii orto, meta dan  -$+$. C'"' !"#$%$ &!"'(i) !!+$"$

    #$"/ !+,i,i '(! ,$ $" $, /,/, 7OH !+,+, 7 ,+, $$($

     floroglukinol 183859+ii+')i!";!"$ $" +!'+)i"'( 1839

    ii+')i!";!"$.

    *.  A& fenolt

    A$* &!"'($ $$($ ,+,"$" $+i /'('"/$" $$* i+')i i"$*$8 #$"/

    *!*i(i)i )!(i*-$$" #$"/ i"//i $($* i"i"/ !( $"$*$". H$( i"i *!*,"/)i")$"

    ,",) $-$ *!*!+i)$" )!,","/$" #$"/ i/"i&i)$" i i$"/ )!!$$"8 )$+!"$

    !"#$%$ $$* &!"'($ '"'"#$ $$* &!+,($ *!*i(i)i $)i:i$ $"i)$")!+ $"

    $"i')i$". S!($i" i, 1. S!$/$i $"i')i$"8 $$* &!+,($ )!*,"/)i"$" *!"!+$()$" +$i)$( !$8

    !-!+i  spesies oksigen reaktif  ROS. ROS )!*,"/)i"$" #$"/ *!"#!$)$"

    DNA +,$) $" *!*-!+!-$ -!",$$". Ji)$ i$*$)$" -$$ $$* $)'+$

    $" :i$*i" E8 $$* &!+,($ )!*,"/)i"$" $-$ *!"/,+$"/i +! ')i$i $"

     -!*!",)$" i*!+ i*ii"! $($* ),(i #$"/ *!"!/$ -!",$$".

    2. D!"/$" ,i -$$ !%$" $" ,i i" :i+'8 *!"/$+$)$" $%$ $$* &!+,($

    )!*,"/)i"$" *!*i(i)i ,,"/$" !"/$" $)i:i$ $"i,*'+ -!+($%$"$" )$")!+ 

    FENOL 2016 5

  • 8/16/2019 makalah fenol fitokimia

    7/31

     -$#,$+$ $" )$")!+ $i. A$* &!+,($ *!*i(i)i )!*,"/)i"$" !$/$i

     -!"!/$ )$")!+ #$"/ !&!)i&8 #$"/ i!$)$" '(! -$-$+$" !"#$%$

    )$+i"'/!"i)8 !-!+i !";'-i+!"! $" 49"i+'G,i"'(i"! 19')i$. N$*," -!+(,

    *!"

    A$* &!"'($ $$($ !"#$%$ &!"'(i) #$"/ $-$ i$i()$" $($ $,"#$

    i$($ !"/$" +!$)i )'"!"$i :$"i((i !"/$" $$* *$('"$.

    A$-," +,*, $"/," $$* &!+,($ $$($ !$/$i>

    =$*$+> R,*, $"/," $$* &!+,($

    A$* &!"'($ i)!$,i $-$ *!"$i()$" $" *!*-!+),$ %$+"$ $"'i$"i".

    C'"' $$* &!"'($ #$"/ $-$ !+-!+$" !$/$i )'9-i/*!"$i !+!, $$($

    $$* i"$-$ $" $$* &!+,($. K'9-i/*!"+$i

  • 8/16/2019 makalah fenol fitokimia

    8/31

    $$+ )$+'" #$"/ !+i+i $+i i"i" !";!"$ C6 #$"/ !+i)$ -$$ ,

  • 8/16/2019 makalah fenol fitokimia

    9/31

    ii) ii 300C. A$* i"$*$ !+*$,) !"#$%$ &!"'( #$"/

    i$i()$" $+i (i"$$" $$* i)i*$ $" +!$)i !+i),"#$.

    B$$" $$+"#$ $$($ &!"i($($"i" $" i+'i" $*$ !-!+i $$*

    )$&!$8 $$* -9),*$+$8 $" $$* &!+,($. K!!*-$ !"#$%$

    !+!, -!"i"/ ,)$" )$+!"$ !+$-$ *!(i*-$ $($* !",) 

    $) !+i)$ !$8 *!($i")$" )$+!"$ *!+!)$ i,$ *!"

    18245 /+*3. A$* i"$*$ *!"ii -$$ ,, 300 C8 52 F8 !"/$" ii) 

    (!(! 133 C8 21 F. D$-$ ($+, $($* $*-$i 500 */(i!+8 !"/$" )!$$*$"

    -K$ 4844. A$* i"$*$ *!*-,"#$i ii) "#$($ -$$ ,, 100 C 212 F. A$*

    i"$*$ i/,"$)$" !$/$i -!"#!$-8 i"i/' i"!i)8 $" -+',) &$+*$i !+!",.

    K!/,"$$" ,$*$ i$($ $($* -!*,$$"*!i(8 !i( $" !";i( !!+ ,",)i i",+#

    FENOL 2016 8

  • 8/16/2019 makalah fenol fitokimia

    10/31

    *i"#$) %$"/i. A$* i"$*$ *!+,-$)$" -+!),+'+8 ;$ -!"$,(, ,",) -!*$"i

    $-$+$* *!($(,i $*i"$i #$"/ i)$$(ii9!";i*