m6 - Quality Control of Tablet

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    QUALITY CONTROL OF

    TABLET PROPERTIES

    AGNES NUNIEK WINANTARI

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    MACAM PENGUJIAN

    Pengujian kualitas talet !ang iasa

    "ilakukan# !aitu$

    % P&a'(a)*+*eial Test ,Res(i-

    % N*n.+&a'(a)*+*eial Test ,Ti"ak Res(i-

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    P/ARMACOPOEIAL TESTS

    01 Uni2*'(it! *2 3eig&t

    41 C*ntent *2 a)ti5e ing'e"ient

    61 Uni2*'(it! *2 )*ntent71 8isinteg'ati*n

    91 8iss*luti*n

    :1 F'iailit!

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    NON.P/ARMACOPOEIAL TESTS

    % 8i(ensi*n

    % C'us&ing st'engt&

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    Uni2*'(it! *2 3eig&t

    % 8ite'a+kan +a"a +'*"uk !g (engan"ung

    ;at akti2 9< (g atau lei& !g (e'u+akan

    9

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    Uni2*'(it! *2 3eig&t ,)*nt1-

    % Uji +en!i(+angan **t "a+at (enja"i +ili&an

    untuk (enentukan kese'aga(an kan"ungan

    "ala( talet ila seagian esa' ,>< . >9=-

    talet e'isi ;at akti21

    % C*nt*&$

    ?ese'aga(an **t talet Pa'a)eta(*l :9

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    Uni2*'(it! *2 C*ntent

    % 8ilakukan ila kan"ungan ;at akti2 "ala(

    talet ku'ang "a'i 9< (g

    % 8ilakukan te'&a"a+ 0< talet% S!a'at$ ti"ak *le& lei& "a'i 4 talet !ang

    ka"a'n!a "i lua' 'entang 9.009= "an ti"ak

    *le& lei& "a'i "a'i 0 talet !ang ka"a'n!a"ilua' 'entang 9.049=

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    8isinteg'ati*n

    % 8isinteg'asi $ (engeta&ui 3aktu &an)u'talet

    % 8itujukan untuk talet !ang "ie'ikan le3at(ulut# ke)uali talet kun!a& atau taletle+as la(at

    % Se"iaan "in!atakan &an)u' se(+u'na# ila

    sisa se"iaan !ang te'tinggal +a"a a!akan,kasa- alat uji (e'u+akan (asa lunak !gti"ak (e(+un!ai inti !g jelas

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    % Alat$ "isinteg'ati*nteste'

    ,C*nt*& $ E'3eka-

    % Sa(+le $ : talet% Taung "inaikkan

    "an "itu'unkan "i

    "ala( 3a"a& e'isi)ai'an +a"a 6*C

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    8iss*luti*n

    % Uji "is*lusi"itujukan untuk(engeta&ui 3aktu+ele+asan a&an

    *at "an ka"a'(aksi(u( te')a+ai"l( (e"ia "is*lusi

    % Ba&an *at &a'use'a"a "ala(entuk la'utanseelu( as*'+si

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    % C*nt*&$

    Uji disolusi terhadap tabletParacetamol

    Me"ia "is*lusi$ >

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    F'iailit!

    % Me'u+akan )a'a lain untuk (enguku'

    kekuatan talet1

    % Menggunakan "ua (a)a( alat# !aitu$Rolling and Impact Durability Tester# untuk

    (enentukan "a!a ta&an la(a talet "an

    Abrasion Tablet Tester# untuk (enentukan"a!a ta&an g*'es talet1

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    F'iailit! ,)*nt1-

    % P'insi+$ untuk (enguji ke'a+u&an talet

    te'&a"a+ antingan "an gesekan

    sela(a 3aktu te'tentu1

    % Untuk talet e'**t :9< (g $ 4< talet!ang tela& "iti(ang e'atn!a

    "i(asukkan ke "ala( alat uji "an

    "i+uta' sa(+ai 0

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    F'iailit! Teste'

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    8i(ensi*n

    % ?ese'aga(an uku'an "igunakan untuk

    tujuan estetika1

    % 8ilakukan te'&a"a+ 4< talet "an"itentukan uku'an teal "an "ia(ete'

    talet1

    %S!a'at$ "ia(ete' talet ti"ak *le& 6 kali"an ti"ak *le& @ 0 06 teal talet1

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    C'us&ing St'engt& /a'"ness

    % Talet &a'us (e(+un!ai kekuatan atau

    keke'asan te'tentu aga' "a+at e'ta&an

    te'&a"a+ e'agai gun)angan (ekanik +a"a

    saat manufacturing pac!aging s"ipping1% Alat !ang "igunakan$ /a'"ness Teste'1

    % Ma)a(.(a)a( &a'"ness teste'$ E'3eka#

    M*nsant*# P2i;e'# S)&leunige'# St'*ng.C*% P'insi+$ (enguku' tekanan !ang "i+e'lukan

    untuk (e(ata&kan talet ,satuan$ kil*g'a(-

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    MONSANTO /a'"ness Teste'

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    Uji Stailitas

    % Real ti(e stu"!

    % A))ele'ate" stu"!

    Pa'a(ete' !ang "ia(ati

    O

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    Pele+asan Oat se)a'a In

    Hi5*

    % Pengujian BABE

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    PUSTA?A

    % FI III1 0>>1

    % FI IH1 4