LAMPIRAN - eprints.unwahas.ac.ideprints.unwahas.ac.id/1839/7/LAMPIRAN.pdf · Lampiran 3. Uji...
Transcript of LAMPIRAN - eprints.unwahas.ac.ideprints.unwahas.ac.id/1839/7/LAMPIRAN.pdf · Lampiran 3. Uji...
LAMPIRAN
Lampiran 1. Surat Keterangan Hasil Determinasi Tanaman Binahong
(Anredera cordifolia (Ten.) Steenis)
Lampiran 1. Lanjutan…
Lampiran 1. Lanjutan…
Lampiran 2. Uji regresi linier sifat fisik salep ekstrak etanol daun binahong
basis kombinasi vaselin album-cera alba
1. pH
Vaselin album-Cera alba 80%:20%, 90%:10% dan 100%
Model Summaryb
Model R R Square Adjusted R
Square
Std. Error of the
Estimate
1 ,310a ,096 -,033 ,04734
a. Predictors: (Constant), formula
b. Dependent Variable: pH
ANOVAa
Model Sum of Squares Df Mean Square F Sig.
1
Regression ,002 1 ,002 ,744 ,417b
Residual ,016 7 ,002
Total ,017 8
a. Dependent Variable: pH
b. Predictors: (Constant), formula
Coefficientsa
Model Unstandardized Coefficients Standardized
Coefficients
T Sig.
B Std. Error Beta
1 (Constant) 5,449 ,042 130,507 ,000
Formula ,017 ,019 ,310 ,862 ,417
a. Dependent Variable: pH
2. Viskositas
Vaselin album-Cera alba 80%:20%, 90%:10% dan 100%
Model Summaryb
Model R R Square Adjusted R
Square
Std. Error of the
Estimate
1 ,958a ,917 ,905 8,357
a. Predictors: (Constant), formula
b. Dependent Variable: viskositas
Lampiran 2. Lanjutan…
Model Summaryb
Model R R Square Adjusted R
Square
Std. Error of the
Estimate
1 ,958a ,917 ,905 8,357
a. Predictors: (Constant), formula
b. Dependent Variable: viskositas
Coefficientsa
Model Unstandardized Coefficients Standardized
Coefficients
T Sig.
B Std. Error Beta
1 (Constant) 161,111 7,370
21,860 ,000
formula -30,000 3,412 -,958 -8,793 ,000
a. Dependent Variable: viskositas
3. Daya sebar
Vaselin album-Cera alba 80%:20%, 90%:10% dan 100%
Model Summaryb
Model R R Square Adjusted R
Square
Std. Error of the
Estimate
1 ,973a ,947 ,940 ,57821
a. Predictors: (Constant), formula
b. Dependent Variable: dayasebar
ANOVAa
Model Sum of Squares Df Mean Square F Sig.
1
Regression 42,135 1 42,135 126,029 ,000b
Residual 2,340 7 ,334
Total 44,475 8
a. Dependent Variable: dayasebar
b. Predictors: (Constant), formula
Lampiran 2. Lanjutan…
Coefficientsa
Model Unstandardized Coefficients Standardized
Coefficients
T Sig.
B Std. Error Beta
1 (Constant) 7,279 ,510
14,274 ,000
formula 2,650 ,236 ,973 11,226 ,000
a. Dependent Variable: dayasebar
4. Daya lekat
Vaselin album-Cera alba 80%:20%, 90%:10% dan 100%
Model Summaryb
Model R R Square Adjusted R
Square
Std. Error of the
Estimate
1 ,979a ,958 ,952 ,08357
a. Predictors: (Constant), formula
b. Dependent Variable: dayaLekat
ANOVAa
Model Sum of Squares Df Mean Square F Sig.
1
Regression 1,127 1 1,127 161,318 ,000b
Residual ,049 7 ,007
Total 1,176 8
a. Dependent Variable: dayaLekat
b. Predictors: (Constant), formula
Coefficientsa
Model Unstandardized Coefficients Standardized
Coefficients
T Sig.
B Std. Error Beta
1 (Constant) 2,489 ,074
33,769 ,000
Formula -,433 ,034 -,979 -12,701 ,000
a. Dependent Variable: dayaLekat
Lampiran 3. Uji stabilitas fisik salep ekstrak etanol daun binahong basis
kombinasi vaselin album-cera alba
A. Formula 1
1. pH
Tests of Normality
Siklus Kolmogorov-Smirnov
a Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
Ph
siklus 0 ,227 3 . ,983 3 ,747
siklus 1 ,196 3 . ,996 3 ,878
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,301 3 . ,912 3 ,424
siklus 4 ,227 3 . ,983 3 ,747
siklus 5 ,301 3 . ,912 3 ,424
siklus 6 ,232 3 . ,980 3 ,726
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
pH
Levene Statistic df1 df2 Sig.
,382 6 14 ,878
ANOVA
Ph
Sum of Squares Df Mean Square F Sig.
Between Groups ,029 6 ,005 1,136 ,392
Within Groups ,060 14 ,004
Total ,090 20
Lampiran 3. Lanjutan…
2. Viskositas
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic Df Sig.
viskositasF1
siklus 0 ,175 3 . 1,000 3 1,000
siklus 1 ,292 3 . ,923 3 ,463
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,175 3 . 1,000 3 1,000
siklus 4 ,175 3 . 1,000 3 1,000
siklus 5 ,253 3 . ,964 3 ,637
siklus 6 ,292 3 . ,923 3 ,463
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
viskositasF1
Levene Statistic df1 df2 Sig.
1,165 6 14 ,378
ANOVA
viskositasF1
Sum of Squares Df Mean Square F Sig.
Between Groups 3457,143 6 576,190 2,689 ,060
Within Groups 3000,000 14 214,286
Total 6457,143 20
Lampiran 3. Lanjutan…
3. Daya sebar
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic df Sig.
dayasebarF1
siklus 0 ,283 3 . ,934 3 ,505
siklus 1 ,304 3 . ,908 3 ,412
siklus 2 ,330 3 . ,866 3 ,284
siklus 3 ,347 3 . ,835 3 ,202
siklus 4 ,233 3 . ,979 3 ,722
siklus 5 ,374 3 . ,776 3 ,058
siklus 6 ,182 3 . ,999 3 ,937
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayasebarF1
Levene Statistic df1 df2 Sig.
,790 6 14 ,592
ANOVA
dayasebarF1
Sum of Squares Df Mean Square F Sig.
Between Groups 1,728 6 ,288 2,995 ,043
Within Groups 1,346 14 ,096
Total 3,073 20
Lampiran 3. Lanjutan…
Multiple Comparisons
4Dependent Variable: dayasebarF1
LSD
(I) siklus (J) siklus Mean
Difference (I-J)
Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
siklus 0
siklus 1 ,22333 ,25315 ,393 -,3196 ,7663
siklus 2 ,27000 ,25315 ,304 -,2729 ,8129
siklus 3 ,51667 ,25315 ,061 -,0263 1,0596
siklus 4 ,77333* ,25315 ,009 ,2304 1,3163
siklus 5 ,59667* ,25315 ,034 ,0537 1,1396
siklus 6 ,85000* ,25315 ,005 ,3071 1,3929
*. The mean difference is significant at the 0.05 level.
4. Daya lekat
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic Df Sig.
dayaLekatF1
siklus 0 ,385 3 . ,750 3 ,000
siklus 1 ,175 3 . 1,000 3 1,000
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,385 3 . ,750 3 ,000
siklus 4 ,175 3 . 1,000 3 1,000
siklus 5 ,253 3 . ,964 3 ,637
siklus 6 ,175 3 . 1,000 3 1,000
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayaLekatF1
Levene Statistic df1 df2 Sig.
,549 6 14 ,763
Lampiran 3. Lanjutan…
Test Statistics a,b
dayaLekatF1
Chi-Square 7,227
Df 6
Asymp. Sig. ,300
a. Kruskal Wallis Test
b. Grouping Variable: siklus
B. Formula 2
1. pH
Tests of Normality
Siklus Kolmogorov-Smirnov
a Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
pHF2
siklus 0 ,232 3 . ,980 3 ,726
siklus 1 ,227 3 . ,983 3 ,747
siklus 2 ,269 3 . ,949 3 ,567
siklus 3 ,276 3 . ,942 3 ,537
siklus 4 ,301 3 . ,912 3 ,424
siklus 5 ,208 3 . ,992 3 ,826
siklus 6 ,219 3 . ,987 3 ,780
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
pHF2
Levene Statistic df1 df2 Sig.
1,077 6 14 ,421
Lampiran 3. Lanjutan…
ANOVA
pHF2
Sum of Squares df Mean Square F Sig.
Between Groups ,023 6 ,004 1,129 ,395
Within Groups ,048 14 ,003
Total ,072 20
2. Viskositas
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic Df Sig.
viskositasF2
siklus 0 ,385 3 . ,750 3 ,000
siklus 1 ,175 3 . 1,000 3 1,000
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,175 3 . 1,000 3 1,000
siklus 4 ,175 3 . 1,000 3 1,000
siklus 5 ,253 3 . ,964 3 ,637
siklus 6 ,385 3 . ,750 3 ,000
a. Lilliefors Significance Correction
Test Statisticsa,b
viskositasF2
Chi-Square 8,383
Df 6
Asymp. Sig. ,211
a. Kruskal Wallis Test
b. Grouping Variable: siklus
Test of Homogeneity of Variances
viskositasF2
Levene Statistic df1 df2 Sig.
,469 6 14 ,820
Lampiran 3. Lanjutan…
3. Daya sebar
Tests of Normality
Siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
dayasebarF2
siklus 0 ,267 3 . ,951 3 ,576
siklus 1 ,233 3 . ,979 3 ,722
siklus 2 ,283 3 . ,934 3 ,505
siklus 3 ,184 3 . ,999 3 ,930
siklus 4 ,311 3 . ,898 3 ,378
siklus 5 ,276 3 . ,942 3 ,534
siklus 6 ,264 3 . ,955 3 ,590
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayasebarF2
Levene Statistic df1 df2 Sig.
1,815 6 14 ,168
ANOVA
dayasebarF2
Sum of Squares df Mean Square F Sig.
Between Groups 20,950 6 3,492 4,195 ,013
Within Groups 11,652 14 ,832
Total 32,601 20
Lampiran 3. Lanjutan…
Multiple Comparisons
Dependent Variable: dayasebarF2
LSD
(I) siklus (J) siklus Mean
Difference (I-J)
Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
siklus 0
siklus 1 1,02667 ,60796 ,113 -,2773 2,3306
siklus 2 1,29333 ,60796 ,052 -,0106 2,5973
siklus 3 1,28000 ,60796 ,054 -,0239 2,5839
siklus 4 2,80333* ,60796 ,000 1,4994 4,1073
siklus 5 2,90000* ,60796 ,000 1,5961 4,2039
siklus 6 2,66000* ,60796 ,001 1,3561 3,9639
*. The mean difference is significant at the 0.05 level.
4. Daya lekat
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic Df Sig.
dayaLekatF2
siklus 0 ,175 3 . 1,000 3 1,000
siklus 1 ,175 3 . 1,000 3 1,000
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,253 3 . ,964 3 ,637
siklus 4 ,175 3 . 1,000 3 1,000
siklus 5 ,175 3 . 1,000 3 1,000
siklus 6 ,175 3 . 1,000 3 1,000
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayaLekatF2
Levene Statistic df1 df2 Sig.
,239 6 14 ,956
Lampiran 3. Lanjutan…
ANOVA
dayaLekatF2
Sum of Squares Df Mean Square F Sig.
Between Groups ,031 6 ,005 ,440 ,840
Within Groups ,167 14 ,012
Total ,198 20
C. Formulasi 3
1. pH
Tests of Normality
Siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic df Sig. Statistic df Sig.
pHF3
siklus 0 ,232 3 . ,980 3 ,726
siklus 1 ,301 3 . ,912 3 ,424
siklus 2 ,175 3 . 1,000 3 1,000
siklus 3 ,219 3 . ,987 3 ,780
siklus 4 ,321 3 . ,881 3 ,328
siklus 5 ,219 3 . ,987 3 ,780
siklus 6 ,201 3 . ,994 3 ,856
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
pHF3
Levene Statistic df1 df2 Sig.
1,577 6 14 ,226
ANOVA
pHF3
Sum of Squares df Mean Square F Sig.
Between Groups ,029 6 ,005 1,262 ,335
Within Groups ,054 14 ,004
Total ,082 20
Lampiran 3. Lanjutan…
2. Viskositas
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic df Sig. Statistic Df Sig.
viskositasF3
siklus 0 ,175 3 . 1,000 3 1,000
siklus 1 ,253 3 . ,964 3 ,637
siklus 2 ,253 3 . ,964 3 ,637
siklus 3 ,175 3 . 1,000 3 1,000
siklus 4 ,253 3 . ,964 3 ,637
siklus 5 ,175 3 . 1,000 3 1,000
siklus 6 ,253 3 . ,964 3 ,637
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
viskositasF3
Levene Statistic df1 df2 Sig.
,340 6 14 ,904
ANOVA
viskositasF3
Sum of Squares df Mean Square F Sig.
Between Groups 714,286 6 119,048 ,543 ,767
Within Groups 3066,667 14 219,048
Total 3780,952 20
Lampiran 3. Lanjutan…
3. Daya sebar
Tests of Normality
siklus Kolmogorov-Smirnova Shapiro-Wilk
Statistic Df Sig. Statistic df Sig.
dayasebarF3
siklus 0 ,379 3 . ,765 3 ,033
siklus 1 ,323 3 . ,879 3 ,322
siklus 2 ,329 3 . ,868 3 ,289
siklus 3 ,275 3 . ,943 3 ,541
siklus 4 ,203 3 . ,994 3 ,847
siklus 5 ,338 3 . ,853 3 ,249
siklus 6 ,276 3 . ,942 3 ,537
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayasebarF3
Levene Statistic df1 df2 Sig.
1,733 6 14 ,186
Test Statisticsa,b
dayasebarF3
Chi-Square 6,324
Df 6
Asymp. Sig. ,388
a. Kruskal Wallis Test
b. Grouping Variable: siklus
Lampiran 3. Lanjutan…
4. Uji daya lekat
Tests of Normality
Siklus Kolmogorov-Smirnov
a Shapiro-Wilk
Statistic Df Sig. Statistic df Sig.
dayaLekat
F3
siklus 0 ,175 3 . 1,000 3 1,000
siklus 1 ,175 3 . 1,000 3 1,000
siklus 2 ,253 3 . ,964 3 ,637
siklus 3 ,175 3 . 1,000 3 1,000
siklus 4 ,253 3 . ,964 3 ,637
siklus 5 ,175 3 . 1,000 3 1,000
siklus 6 ,253 3 . ,964 3 ,637
a. Lilliefors Significance Correction
Test of Homogeneity of Variances
dayaLekatF3
Levene Statistic df1 df2 Sig.
,427 6 14 ,849
ANOVA
dayaLekatF3
Sum of Squares Df Mean Square F Sig.
Between Groups ,098 6 ,016 1,040 ,441
Within Groups ,220 14 ,016
Total ,318 20
Lampiran 4. Hasil uji stabilitas salep ekstrak etanol daun binahong basis
kombinasi vaselin album selama 6 siklus
F1 Vaselin album-cera alba 80%:20%
Siklus
Pengujian
Organoleptik
Homogenitas
pH Viskosit
as (dPa-s)
Daya Sebar
Daya Lekat (cm2)
Warna Bentuk Bau
0 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,46 130 9,63 4,83
1 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,53 157 8,86 4,80
2 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,45 130 9,03 4,90
3 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,47 120 8,78 4,73
4 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,46 140 9,11 4,90
5 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,55 137 9,41 4,73
6 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,49 157 9,36 4,80
Lampiran 4. Lanjutan…
FII Vaselin album-cera alba 90%:10%
Siklus
Pengujian
Organoleptik
Homogenitas
pH
Viskositas
(dPa-s)
Daya Seba
r
Daya Lekat (cm2)
Warna
Bentuk
Bau
0 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,49 103 13,17 4,30
1 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,46 120 11,33 4,30
2 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,54 110 11,80 4,40
3 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,56 110 10,36 4,36
4 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,55 110 10,27 4,30
5 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,54 113 12,14 4,30
6 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,52 93 10,51 4,30
Lampiran 4. Lanjutan…
F3. Vaselin album -cera alba 100%:0%
Siklus
Pengujian
Organoleptik Homogenitas
pH
Viskositas (dPa-s)
Daya Sebar
Daya Lekat (cm2)
Warna
Bentuk
Bau
0 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,49 70 14,93 4,00
1 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,47 83 15,09 3,90
2 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,45 83 14,99 3,96
3 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,52 80 15,76 3,90
4 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,57 83 15,59 3,96
5 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,52 70 14,86 3,80
6 Hijau Kecoklatan
Semi Padat
Khas Daun
Homogen 5,52 83 15,55 3,83
Lampiran 5. Gambar Uji Sifat Fisik Salep
Lampiran 6. Gambar Hasil Uji Stabilitas Fisik Salep
Lampiran 7. Surat Keterangan Laboratorium Bagian Farmasetika
Lampiran 8. Surat Keterangan Laboratorium Bagian Farmasetika