LAMPIRAN A DATA SKRINING FARMAKOLOGI Data Skrining ...
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LAMPIRAN A DATA SKRINING FARMAKOLOGI Data Skrining Farmakologi Kelompok Kontrol Mencit Betina No Uji Skrining Hewan 1 Hewan 2 Hewan 3 0 30 60 120 240 0 30 60 120 240 0 30 60 120 240 1 Platform 48 36 19 12 48 15 5 7 7 7 11 5 18 2 7 2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18 Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19 Urinasi 0 0 0 1 0 0 0 0 1 0 0 0 1 0 1 20 Defekasi 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 58
Transcript of LAMPIRAN A DATA SKRINING FARMAKOLOGI Data Skrining ...
LAMPIRAN A
DATA SKRINING FARMAKOLOGI
Data Skrining Farmakologi Kelompok Kontrol Mencit Betina
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 48 36 19 12 48 15 5 7 7 7 11 5 18 2 7
2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
19 Urinasi 0 0 0 1 0 0 0 0 1 0 0 0 1 0 1
20 Defekasi 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0
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Data Skrining Farmakologi Kelompok Kontrol Mencit Jantan
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 7 18 19 13 20 0 6 14 28 16 1 6 0 4 6
2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 0 0 0 0 0 1 0 0 0 0 1 0 1 1 1
19 Urinasi 0 0 0 1 1 1 0 0 1 0 0 1 0 0 0
20 Defekasi 0 2 1 1 0 1 0 0 0 1 1 1 0 1 0
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Data Skrining Farmakologi Kelompok Asam-(3-klorometil)benzoil salisilat Mencit Betina
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 11 1 18 7 3 8 1 9 32 19 28 2 0 0 0
2 Akt. Motorik 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 1 1 0 0 0 1 1 1 0 0 0 0 0 0 1
19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
20 Defekasi 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1
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Data Skrining Farmakologi Kelompok Asam-(3-klorometil)benzoilsalisilat Mencit Jantan
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 7 12 3 0 0 8 2 4 0 8 1 1 3 2 0
2 Akt. Motorik 1 1 1 1 0 1 1 1 1 0 1 1 1 1 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 0 1 1 0 0 0 0 1 0 0 1 1 0 1 1
19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
20 Defekasi 0 0 1 0 0 0 0 0 0 0 1 0 2 0 3
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Data Skrining Farmakologi Kelompok Asam-(4-klorometil)benzoil salisilat Mencit Betina
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 36 5 3 1 0 28 1 2 0 0 19 6 3 2 0
2 Akt. Motorik 1 1 1 1 1 1 0 0 0 0 1 0 0 0 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 0 0 0 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0
19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
20 Defekasi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2
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Data Skrining Farmakologi Kelompok Asam-(4-klorometil)benzoil salisilat Mencit Jantan
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 23 4 0 0 4 2 2 1 0 2 6 7 0 2 2
2 Akt. Motorik 1 1 0 0 0 1 0 1 0 0 1 1 0 0 0
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 0 0 0 0 1 1 1 1 1
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0
13 Sikap Tubuh 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
14 Menggelantung 1 1 1 1 1 1 0 0 0 0 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0
19 Urinasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
20 Defekasi 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
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Data Skrining Farmakologi Kelompok Asetosal Mencit Betina
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 12 9 0 3 0 5 0 2 1 0 25 4 7 16 4
2 Akt. Motorik 1 1 0 0 0 1 1 1 1 1 1 1 1 1 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 1 1 0 0 0 0 1 0 0 1 0 0 0 0 0
19 Urinasi 0 0 0 0 0 1 0 0 1 1 1 2 0 0 1
20 Defekasi 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
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Data Skrining Farmakologi Kelompok Asetosal Mencit Jantan
No Uji Skrining Hewan 1 Hewan 2 Hewan 3
0 30 60 120 240 0 30 60 120 240 0 30 60 120 240
1 Platform 13 1 3 0 0 9 20 9 0 0 9 9 11 9 6
2 Akt. Motorik 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1
3 Straub 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
4 Piloereksi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
5 Ptosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6 R. Pineal 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
7 R. Kornea 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
8 R. Fleksi 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
9 Haffner 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
10 Lakrimasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
11 Salivasi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12 Katalepsi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
13 Sikap Tubuh 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
14 Menggelantung 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
15 Retablisemen 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
16 Kolik Ach 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
17 Mortalitas 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
18 Grooming 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
19 Urinasi 0 1 0 0 1 1 0 0 0 0 2 0 0 1 1
20 Defekasi 1 2 0 0 0 1 0 0 0 0 0 0 0 1 0
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LAMPIRAN B
DATA PENIMBANGAN BOBOT HEWAN COBA PASCA PERLAKUAN
1. Kontrol
a. Mencit Betina
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 18 20 20 21 22 21 22 22 22 21 21 22 22 24 23
2 20 20 21 23 23 22 24 23 23 23 24 25 25 25 24
3 19 20 21 22 23 23 24 22 22 22 24 25 25 24 25
Ʃ 57 60 62 66 68 66 70 67 67 66 69 72 72 73 72
Rata2 19,0 20,0 20,7 22,0 22,7 22,0 23,3 22,3 22,3 22,0 23,0 24,0 24,0 24,3 24,0
SD 1,00 0,00 0,58 1,00 0,58 1,00 1,15 0,58 0,58 1,00 1,73 1,73 1,73 0,58 1,00
b. Mencit Jantan
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 18 22 19 21 22 22 22 19 20 23 22 24 24 24 21
2 19 20 23 24 24 25 24 24 24 26 25 25 26 25 24
3 21 22 22 22 23 24 24 23 24 25 26 26 27 25 25
Ʃ 58 64 64 67 69 71 70 66 68 74 73 75 77 74 70
Rata2 19,3 21,3 21,3 22,3 23,0 23,7 23,3 22,0 22,7 24,7 24,3 25,0 25,7 24,7 23,3
SD 1,53 1,15 2,08 1,53 1,00 1,53 1,15 2,65 2,31 1,53 2,08 1,00 1,53 0,58 2,08
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2. Asam-(3-klorometil)benzoilsalisilat
a. Mencit Betina
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 17 18 18 19 21 21 22 22 23 21 21 22 24 24 23
2 17 18 18 19 19 20 22 20 18 17 19 19 19 20 20
3 17 17 17 17 17 17 19 17 16 15 16 16 18 18 17
Ʃ 51 53 53 55 57 58 63 59 57 53 56 57 61 62 60
Rata2 17,0 17,7 17,7 18,3 19,0 19,3 21,0 19,7 19,0 17,7 18,7 19,0 20,3 20,7 20,0
SD 0,00 0,58 0,58 1,15 2,00 2,08 1,73 2,52 3,61 3,06 2,52 3,00 3,21 3,06 3,00
b. Mencit Jantan
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 22 24 25 25 27 28 31 31 32 31 32 32 32 32 33
2 21 20 21 22 22 25 23 25 25 27 27 26 27 27 28
3 24 24 24 25 25 24 26 26 27 26 27 27 25 27 27
Ʃ 67 68 70 72 74 77 80 82 84 84 86 85 84 86 88
Rata2 22,3 22,7 23,3 24,0 24,7 25,7 26,7 27,3 28,0 28,0 28,7 28,3 28,0 28,7 29,3
SD 1,53 2,31 2,08 1,73 2,52 2,08 4,04 3,21 3,61 2,65 2,89 3,21 3,61 2,89 3,21
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3. Asam-(4-klorometil)benzoilsalisilat
a. Mencit Betina
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 16 14 13 13 16 16 15 16 17 16 16 19 20 21 21
2 19 18 18 19 20 21 20 19 19 19 22 22 21 22 21
3 20 20 21 22 22 23 23 22 22 23 24 24 25 25 26
Ʃ 55 52 52 54 58 60 58 57 58 58 62 65 66 68 68
Rata2 18,3 17,3 17,3 18,0 19,3 20,0 19,3 19,0 19,3 19,3 20,7 21,7 22,0 22,7 22,7
SD 2,08 3,06 4,04 4,58 3,06 3,61 4,04 3,00 2,52 3,51 4,16 2,52 2,65 2,08 2,89
b. Mencit Jantan
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 27 29 29 29 32 32 34 34 36 34 34 34 34 34 34
2 24 24 23 23 25 26 28 29 32 31 29 30 29 29 28
3 26 24 24 28 29 29 29 29 28 27 28 26 25 26 28
Ʃ 77 77 76 80 86 87 91 92 96 92 91 90 88 89 90
Rata2 25,7 25,7 25,3 26,7 28,7 29,0 30,3 30,7 32,0 30,7 30,3 30,0 29,3 29,7 30,0
SD 1,53 2,89 3,21 3,21 3,51 3,00 3,21 2,89 4,00 3,51 3,21 4,00 4,51 4,04 3,46
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4. Asetosal
a. Mencit Betina
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 26 26 25 25 26 27 30 30 29 29 29 30 30 29 32
2 24 24 24 25 25 24 24 24 24 24 25 25 26 26 27
3 18 21 18 18 28 29 20 21 21 21 23 22 23 25 26
Ʃ 68 71 67 68 79 80 74 75 74 74 77 77 79 80 85
Rata2 22,7 23,7 22,3 22,7 26,3 26,7 24,7 25,0 24,7 24,7 25,7 25,7 26,3 26,7 28,3
SD 4,16 2,52 3,79 4,04 1,53 2,52 5,03 4,58 4,04 4,04 3,06 4,04 3,51 2,08 3,21
b. Mencit Jantan
Hewan
Coba
Hari ke-
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
1 22 23 25 24 24 22 22 22 23 23 23 25 24 24 25
2 22 23 25 24 24 23 23 23 22 22 23 25 26 26 28
3 22 22 23 23 23 21 19 19 20 21 21 22 23 23 23
Ʃ 66 68 73 71 71 66 64 64 65 66 67 72 73 73 76
Rata2 22,0 22,7 24,3 23,7 23,7 22,0 21,3 21,3 21,7 22,0 22,3 24,0 24,3 24,3 25,3
SD 0,00 0,58 1,15 0,58 0,58 1,00 2,08 2,08 1,53 1,00 1,15 1,73 1,53 1,53 2,52
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LAMPIRAN C
PENGAMATAN MAKROSKOPIS DAN PENIMBANGAN BOBOT
ORGAN HEWAN COBA
Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok
kontrol : (1) jantung (2) paru-paru (3) hati (4) lambung (5)
pankreas (6) ginjal (7) anak ginjal (8) ovarium
Keterangan : Hasil pengamatan makroskopis lambung mencit betina
kelompok kontrol
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Ovarium
1 120,4 220,2 1423,6 249,9 336,1 7,3 151,0 184,8
2 117,4 176,4 1231,5 406,6 287,2 5,5 104,5 150,1
3 124,0 155,9 1335,9 406,6 287,2 6,5 104,5 150,1
Rata2 120,6 184,2 1330,3 354,4 303,5 6,4 120,0 161,7
SD 3,30 32,85 96,17 90,47 28,23 0,90 26,85 20,03
Keterangan : Hasil penimbangan bobot organ mencit betina kelompok
kontrol
1 1 1
2
2
2 3
3
3
4
4
4
5
5
5
8
8
8
6
6 6
7
7
7
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Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok
kontrol : (1) jantung (2) paru-paru (3) hati (4) lambung (5)
pankreas (6) ginjal (7) anak ginjal (8) testis (9) vas deferens
Keterangan : Hasil pengamatan makroskopis lambung mencit jantan
kelompok kontrol
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Testis
Vas
Deferens
1 90,1 169,9 1185,8 327,6 310,5 0,8 36,2 126,5 22,6
2 101,0 185,8 1462,0 239,8 398,0 1,7 90,2 163,7 70,3
3 113,8 177,7 1145,5 395,3 337,3 1,6 46,8 170,4 39,5
Rata2 101,6 177,8 1264,4 320,9 348,6 1,4 57,7 153,5 44,1
SD 11,86 7,95 172,28 77,97 44,83 0,49 28,61 23,65 24,19
Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok
kontrol
1
1
1
2
2 2 3
3 3 4
4
4 5
5 5 6
6
6
7 7 7
8 8 8 9 9
9
72
Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok
Asam-(3-klorometil)benzoil salisilat : (1) jantung (2) paru-
paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak
ginjal (8) ovarium
Keterangan : Hasil pengamatan makroskopis lambung mencit kelompok
Asam-(3-klorometil)benzoil salisilat
Hewan
Coba
Berat Organ (g/10g BB)
Jantung Paru2 Hati Lambung Ginjal Anak Ginjal Pankreas Ovarium
1 108,4 177,9 1273,8 282,3 323,5 9,3 119,6 54,9
2 75,5 192,9 1198,3 381,0 364,8 6,5 106,5 306,2
3 76,2 144,2 1054,8 516,7 226,5 3,0 146,1 77,0
Rata2 86,7 171,7 1175,6 393,3 304,9 6,3 124,1 146,0
SD 18,80 24,94 111,25 117,69 70,99 3,16 20,17 139,15
Keterangan : Hasil penimbangan bobot organ mencit betina kelompok
Asam-(3-klorometil)benzoil salisilat
1
1
1
2
2 2
3
3 3
4
4
4
5 5 5
6 6
6
7
7 7
8
8 8
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Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok
Asam-(3-klorometil)benzoil salisilat : (1) jantung (2) paru-
paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak
ginjal (8) testis (9) vas deferens
Keterangan : Hasil pengamatan makroskopis lambung mencit jantan
kelompok Asam-(3-klorometil)benzoil salisilat
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Testis
Vas
Deferens
1 121,2 174,2 1530,0 321,3 436,1 5,0 137,0 172,9 84,3
2 128,9 198,4 1982,5 389,1 419,7 5,0 147,7 172,8 104,4
3 135,6 224,3 2256,7 541,1 473,8 4,9 317,8 167,5 108,6
Rata2 128,6 199,0 1923,1 417,2 443,2 5,0 200,8 171,1 99,1
SD 7.21 25.05 366.98 112.56 27.74 0.06 101.44 3.09 12.99
Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok
Asam-(3-klorometil)benzoil salisilat
1 1
1 2 2
2
3
3 3
4
4
4
5
5
5
6
6
6
7
7
7
8
8
8 9
9
9
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Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok
Asam-(4-klorometil)benzoil salisilat : (1) jantung (2) paru-
paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak
ginjal (8) ovarium
Keterangan : Hasil pengamatan makroskopis lambung mencit betina
kelompok Asam-(4-klorometil)benzoil salisilat
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Ovarium
1 95,7 183,9 1448,4 246,2 278,6 12,4 148,3 37,7
2 122,9 158,0 1179,9 461,6 302,6 8,4 109,4 166,7
3 127,3 185,9 1323,4 303,8 307,8 9,8 129,9 163,5
Rata2 115,3 175,9 1317,2 337,2 296,3 10,2 129,2 122,6
SD 17.,12 15,56 134,36 111,52 15,58 2,03 19,46 73,57
Keterangan : Hasil penimbangan bobot organ mencit betina kelompok
Asam-(4-klorometil)benzoil salisilat
1
1 1
2 2
2
3
3
3
4 4 4
5
5
5
6
6
6
7 7
7
8
8
8
75
Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok
Asam-(4-klorometil)benzoil salisilat : (1) jantung (2) paru-
paru (3) hati (4) lambung (5) pankreas (6) ginjal (7) anak
ginjal (8) testis (9) vas deferens
Keterangan : Hasil pengamatan makroskopis lambung mencit jantan
kelompok Asam-(4-klorometil)benzoil salisilat
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Testis
Vas
Deferens
1 155,5 253,9 1855,2 333,6 593,8 7,1 94,7 321,2 116,5
2 110,2 187,1 1567,5 600,0 520,0 5,5 143,9 259,2 142,8
3 134,7 215,6 1478,6 379,8 428,9 5,7 71,3 168,7 125,7
Rata2 133,5 218,9 1633,8 437,8 514,2 6,1 103,3 249,7 128,3
SD 22,68 33,52 196,85 142,36 82,60 0,87 37,06 76,69 13,35
Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok
Asam-(4-klorometil)benzoil salisilat
1
1
2
2 3
3
4 4
5 5
6
6 7
7
8 8
9 9
76
Keterangan : Hasil pengamatan makroskopis organ mencit betina kelompok
Asetosal : (1) jantung (2) paru-paru (3) hati (4) lambung (5)
pankreas (6) ginjal (7) anak ginjal (8) ovarium
Keterangan : Hasil pengamatan makroskopis lambung mencit betina
kelompok Asetosal
Keterangan : Hasil penimbangan bobot organ mencit betina kelompok
Asetosal
Hewan
Coba
Berat Organ (g/10g BB)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Ovarium
1 128,6 296,4 1190,8 298,6 315,7 4,7 126,0 97,6
2 135,7 195,4 1138,7 239,8 268,7 5,3 117,8 108,8
3 139,8 218,7 1209,6 196,7 297,7 6,5 106,7 87,5
Rata2 134,7 236,8 1179,7 245,0 294,0 5,5 116,8 98,0
SD 5,67 52,89 36,73 51,15 23,71 0,92 9,69 10,65
1
1
1
2 2
2 3 3 3
4
4
4 5
5 5
6 6
6
7
7
7
8
8
8
77
Keterangan : Hasil pengamatan makroskopis organ mencit jantan kelompok
Asetosal : (1) jantung (2) paru-paru (3) hati (4) lambung (5)
pankreas (6) ginjal (7) anak ginjal (8) testis (9) vas deferens
Keterangan : Hasil pengamatan makroskopis lambung mencit jantan
kelompok Asetosal
Hewan
Coba
Berat Organ (mg)
Jantung Paru2 Hati Lambung Ginjal Anak
Ginjal Pankreas Testis
Vas
Deferens
1 97,5 156,2 1434,3 408,5 345,4 2,5 60,9 219,0 47,8
2 121,6 194,6 1440,3 383,1 370,8 1,6 50,8 165,1 94,1
3 113,3 174,7 1388,9 557,0 347,6 5,5 54,9 164,5 53,6
Rata2 110,8 175,2 1421,2 449,5 354,6 3,2 55,5 182,9 65,2
SD 12,24 19,20 28,10 93,93 14,07 2,04 5,08 31,29 25,22
Keterangan : Hasil penimbangan bobot organ mencit jantan kelompok
Asetosal
1 1 1 2
2
2 3 3
3
4
4
4 5
5
5
6
6 6 7
7
7 8 8
8 9 9
9
78
LAMPIRAN D
HASIL STATISTIK PENINGKATAN BERAT BADAN HEWAN COBA
Mencit Betina Descriptives
Peningkatan_Berat_Badan
N Mean Std.
Deviation Std. Error
95% Confidence Interval for Mean
Minimum Maximum Lower Bound Upper Bound
Kontrol 3 24.0000 1.00000 .57735 21.5159 26.4841 23.00 25.00
3-klorometil 3 20.0000 3.00000 1.73205 12.5476 27.4524 17.00 23.00
4-klorometil 3 22.6667 2.88675 1.66667 15.4956 29.8378 21.00 26.00
Asetosal 3 28.3333 3.21455 1.85592 20.3479 36.3187 26.00 32.00
Total 12 23.7500 3.88763 1.12226 21.2799 26.2201 17.00 32.00
Test of Homogeneity of Variances
Peningkatan_Berat_Badan
Levene Statistic df1 df2 Sig.
1.360 3 8 .323
ANOVA
Peningkatan_Berat_Badan
Sum of Squares df Mean Square F Sig.
Between Groups 108.917 3 36.306 5.066 .030
Within Groups 57.333 8 7.167
Total 166.250 11
79
Multiple Comparisons
Peningkatan_Berat_Badan LSD
(I) Kelompok (J) Kelompok Mean
Difference (I-J) Std. Error Sig.
95% Confidence Interval
Lower Bound Upper Bound
kontrol 3-klorometil 4.00000 2.18581 .105 -1.0405 9.0405
4-klorometil 1.33333 2.18581 .559 -3.7072 6.3738
Asetosal -4.33333 2.18581 .083 -9.3738 .7072
3-klorometil Kontrol -4.00000 2.18581 .105 -9.0405 1.0405
4-klorometil -2.66667 2.18581 .257 -7.7072 2.3738
Asetosal -8.33333* 2.18581 .005 -13.3738 -3.2928
4-klorometil Kontrol -1.33333 2.18581 .559 -6.3738 3.7072
3-klorometil 2.66667 2.18581 .257 -2.3738 7.7072
Asetosal -5.66667* 2.18581 .032 -10.7072 -.6262
asetosal Kontrol 4.33333 2.18581 .083 -.7072 9.3738
3-klorometil 8.33333* 2.18581 .005 3.2928 13.3738
4-klorometil 5.66667* 2.18581 .032 .6262 10.7072
*. The mean difference is significant at the 0.05 level.
Mencit Jantan
Descriptives
Peningkatan_Berat_Badan
N Mean Std.
Deviation Std. Error
95% Confidence Interval for Mean
Minimum Maximum Lower Bound Upper Bound
kontrol 3 23.3333 2.08167 1.20185 18.1622 28.5045 21.00 25.00
3-klorometil 3 29.3333 3.21455 1.85592 21.3479 37.3187 27.00 33.00
4-klorometil 3 30.0000 3.46410 2.00000 21.3947 38.6053 28.00 34.00
asetosal 3 25.3333 2.51661 1.45297 19.0817 31.5849 23.00 28.00
Total 12 27.0000 3.78994 1.09406 24.5920 29.4080 21.00 34.00
Test of Homogeneity of Variances
Peningkatan_Berat_Badan
Levene Statistic df1 df2 Sig.
.672 3 8 .593
80
ANOVA
Peningkatan_Berat_Badan
Sum of Squares df Mean Square F Sig.
Between Groups 92.000 3 30.667 3.717 .061
Within Groups 66.000 8 8.250
Total 158.000 11
Multiple Comparisons
Peningkatan_Berat_Badan LSD
(I) Kelompok (J) Kelompok Mean
Difference (I-J) Std. Error Sig.
95% Confidence Interval
Lower Bound Upper Bound
Kontrol 3-klorometil -6.00000* 2.34521 .034 -11.4081 -.5919
4-klorometil -6.66667* 2.34521 .022 -12.0747 -1.2586
Asetosal -2.00000 2.34521 .419 -7.4081 3.4081
3-klorometil Kontrol 6.00000* 2.34521 .034 .5919 11.4081
4-klorometil -.66667 2.34521 .783 -6.0747 4.7414
Asetosal 4.00000 2.34521 .126 -1.4081 9.4081
4-klorometil Kontrol 6.66667* 2.34521 .022 1.2586 12.0747
3-klorometil .66667 2.34521 .783 -4.7414 6.0747
Asetosal 4.66667 2.34521 .082 -.7414 10.0747
Asetosal Kontrol 2.00000 2.34521 .419 -3.4081 7.4081
3-klorometil -4.00000 2.34521 .126 -9.4081 1.4081
4-klorometil -4.66667 2.34521 .082 -10.0747 .7414
*. The mean difference is significant at the 0.05 level.
81
LAMPIRAN E
HASIL STATISTIK PENIMBANGAN BOBOT ORGAN HEWAN COBA
Mencit Betina
Descriptives
N Mean Std.
Deviation Std. Error
95% Confidence Interval for Mean
Minimum Maximum Lower
Bound Upper Bound
Jantung Kontrol 3 12.0600 .33045 .19079 11.2391 12.8809 11.74 12.40
3-klorometil 3 8.6700 1.87960 1.08519 4.0008 13.3392 7.55 10.84
4-klorometil 3 11.5300 1.71161 .98820 7.2781 15.7819 9.57 12.73
Asetosal 3 13.4700 .56666 .32716 12.0623 14.8777 12.86 13.98
Total 12 11.4325 2.13932 .61757 10.0732 12.7918 7.55 13.98
Paru Kontrol 3 18.4167 3.28461 1.89637 10.2573 26.5761 15.59 22.02
3-klorometil 3 17.1667 2.49412 1.43998 10.9709 23.3624 14.42 19.29
4-klorometil 3 17.5933 1.55629 .89852 13.7273 21.4594 15.80 18.59
Asetosal 3 23.6833 5.28854 3.05334 10.5459 36.8208 19.54 29.64
Total 12 19.2150 4.01233 1.15826 16.6657 21.7643 14.42 29.64
Hati Kontrol 3 1.3303E2 9.61709 5.55243 109.1432 156.9235 123.15 142.36
3-klorometil 3 1.1756E2 11.12456 6.42277 89.9284 145.1983 105.48 127.38
4-klorometil 3 1.3172E2 13.43562 7.75706 98.3474 165.0993 117.99 144.84
asetosal 3 1.1797E2 3.67302 2.12062 108.8457 127.0943 113.87 120.96
Total 12 1.2507E2 11.53582 3.33010 117.7430 132.4020 105.48 144.84
Lambung Kontrol 3 35.4367 9.04708 5.22333 12.9625 57.9109 24.99 40.66
3-klorometil 3 39.3633 11.72615 6.77010 10.2340 68.4927 28.32 51.67
4-klorometil 3 33.7200 11.15166 6.43842 6.0177 61.4223 24.62 46.16
asetosal 3 24.5033 5.11512 2.95321 11.7967 37.2100 19.67 29.86
Total 12 33.2558 9.98358 2.88201 26.9126 39.5991 19.67 51.67
Ginjal Kontrol 3 30.3500 2.82324 1.63000 23.3367 37.3633 28.72 33.61
3-klorometil 3 30.4933 7.09948 4.09889 12.8572 48.1294 22.65 36.48
4-klorometil 3 29.6333 1.55760 .89928 25.7640 33.5026 27.86 30.78
asetosal 3 29.4033 2.37136 1.36910 23.5126 35.2941 26.87 31.57
Total 12 29.9700 3.50848 1.01281 27.7408 32.1992 22.65 36.48
Anak_Ginjal Kontrol 3 .6433 .09018 .05207 .4193 .8674 .55 .73
3-klorometil 3 .6267 .31565 .18224 -.1574 1.4108 .30 .93
4-klorometil 3 1.0200 .20298 .11719 .5158 1.5242 .84 1.24
asetosal 3 .5500 .09165 .05292 .3223 .7777 .47 .65
82
Total 12 .7100 .25477 .07355 .5481 .8719 .30 1.24
Pankreas Kontrol 3 12.0000 2.68468 1.55000 5.3309 18.6691 10.45 15.10
3-klorometil 3 12.4067 2.01743 1.16477 7.3951 17.4182 10.65 14.61
4-klorometil 3 12.9200 1.94594 1.12349 8.0860 17.7540 10.94 14.83
asetosal 3 11.6833 .96862 .55924 9.2771 14.0895 10.67 12.60
Total 12 12.2525 1.77293 .51180 11.1260 13.3790 10.45 15.10
Ovarium Kontrol 3 16.1667 2.00341 1.15667 11.1899 21.1434 15.01 18.48
3-klorometil 3 14.6033 13.91478 8.03370 -19.9629 49.1696 5.49 30.62
4-klorometil 3 12.2633 7.35718 4.24767 -6.0129 30.5396 3.77 16.67
asetosal 3 9.7967 1.06547 .61515 7.1499 12.4434 8.75 10.88
Total 12 13.2075 7.23305 2.08800 8.6118 17.8032 3.77 30.62
Test of Homogeneity of Variances
Levene Statistic df1 df2 Sig.
Jantung 5.302 3 8 .026
Paru 2.139 3 8 .173
Hati .851 3 8 .504
Lambung .793 3 8 .531
Ginjal 3.323 3 8 .077
Anak_Ginjal 1.582 3 8 .268
Pankreas 1.280 3 8 .346
Ovarium 8.486 3 8 .007
83
ANOVA
Sum of Squares Df
Mean Square F Sig.
Jantung Between Groups 36.558 3 12.186 7.072 .012
Within Groups 13.786 8 1.723
Total 50.344 11
Paru Between Groups 82.286 3 27.429 2.315 .152
Within Groups 94.800 8 11.850
Total 177.086 11
Hati Between Groups 643.325 3 214.442 2.091 .180
Within Groups 820.502 8 102.563
Total 1463.827 11
Lambung Between Groups 356.638 3 118.879 1.286 .344
Within Groups 739.753 8 92.469
Total 1096.390 11
Ginjal Between Groups 2.558 3 .853 .051 .984
Within Groups 132.846 8 16.606
Total 135.404 11
Anak_Ginjal Between Groups .399 3 .133 3.383 .075
Within Groups .315 8 .039
Total .714 11
Pankreas Between Groups 2.571 3 .857 .214 .884
Within Groups 32.005 8 4.001
Total 34.576 11
Ovarium Between Groups 69.691 3 23.230 .367 .779
Within Groups 505.796 8 63.225
Total 575.487 11
84
Multiple Comparisons
LSD
Dependent Variable (I) Kelompok (J) Kelompok
Mean Difference (I-J) Std. Error Sig.
95% Confidence Interval
Lower Bound
Upper Bound
Jantung Kontrol 3-klorometil 3.39000* 1.07182 .013 .9184 5.8616
4-klorometil .53000 1.07182 .634 -1.9416 3.0016
asetosal -1.41000 1.07182 .225 -3.8816 1.0616
3-klorometil Kontrol -3.39000* 1.07182 .013 -5.8616 -.9184
4-klorometil -2.86000* 1.07182 .028 -5.3316 -.3884
asetosal -4.80000* 1.07182 .002 -7.2716 -2.3284
4-klorometil Kontrol -.53000 1.07182 .634 -3.0016 1.9416
3-klorometil 2.86000* 1.07182 .028 .3884 5.3316
asetosal -1.94000 1.07182 .108 -4.4116 .5316
asetosal Kontrol 1.41000 1.07182 .225 -1.0616 3.8816
3-klorometil 4.80000* 1.07182 .002 2.3284 7.2716
4-klorometil 1.94000 1.07182 .108 -.5316 4.4116
Paru Kontrol 3-klorometil 1.25000 2.81069 .668 -5.2315 7.7315
4-klorometil .82333 2.81069 .777 -5.6581 7.3048
asetosal -5.26667 2.81069 .098 -11.7481 1.2148
3-klorometil Kontrol -1.25000 2.81069 .668 -7.7315 5.2315
4-klorometil -.42667 2.81069 .883 -6.9081 6.0548
asetosal -6.51667* 2.81069 .049 -12.9981 -.0352
4-klorometil Kontrol -.82333 2.81069 .777 -7.3048 5.6581
3-klorometil .42667 2.81069 .883 -6.0548 6.9081
asetosal -6.09000 2.81069 .062 -12.5715 .3915
asetosal Kontrol 5.26667 2.81069 .098 -1.2148 11.7481
3-klorometil 6.51667* 2.81069 .049 .0352 12.9981
4-klorometil 6.09000 2.81069 .062 -.3915 12.5715
Hati Kontrol 3-klorometil 15.47000 8.26893 .098 -3.5982 34.5382
4-klorometil 1.31000 8.26893 .878 -17.7582 20.3782
asetosal 15.06333 8.26893 .106 -4.0049 34.1315
3-klorometil Kontrol -15.47000 8.26893 .098 -34.5382 3.5982
4-klorometil -14.16000 8.26893 .125 -33.2282 4.9082
asetosal -.40667 8.26893 .962 -19.4749 18.6615
4-klorometil Kontrol -1.31000 8.26893 .878 -20.3782 17.7582
3-klorometil 14.16000 8.26893 .125 -4.9082 33.2282
asetosal 13.75333 8.26893 .135 -5.3149 32.8215
85
asetosal Kontrol -15.06333 8.26893 .106 -34.1315 4.0049
3-klorometil .40667 8.26893 .962 -18.6615 19.4749
4-klorometil -13.75333 8.26893 .135 -32.8215 5.3149
Lambung Kontrol 3-klorometil -3.92667 7.85150 .630 -22.0323 14.1789
4-klorometil 1.71667 7.85150 .832 -16.3889 19.8223
asetosal 10.93333 7.85150 .201 -7.1723 29.0389
3-klorometil Kontrol 3.92667 7.85150 .630 -14.1789 22.0323
4-klorometil 5.64333 7.85150 .493 -12.4623 23.7489
asetosal 14.86000 7.85150 .095 -3.2456 32.9656
4-klorometil Kontrol -1.71667 7.85150 .832 -19.8223 16.3889
3-klorometil -5.64333 7.85150 .493 -23.7489 12.4623
asetosal 9.21667 7.85150 .274 -8.8889 27.3223
asetosal Kontrol -10.93333 7.85150 .201 -29.0389 7.1723
3-klorometil -14.86000 7.85150 .095 -32.9656 3.2456
4-klorometil -9.21667 7.85150 .274 -27.3223 8.8889
Ginjal Kontrol 3-klorometil -.14333 3.32723 .967 -7.8159 7.5293
4-klorometil .71667 3.32723 .835 -6.9559 8.3893
asetosal .94667 3.32723 .783 -6.7259 8.6193
3-klorometil Kontrol .14333 3.32723 .967 -7.5293 7.8159
4-klorometil .86000 3.32723 .803 -6.8126 8.5326
asetosal 1.09000 3.32723 .752 -6.5826 8.7626
4-klorometil Kontrol -.71667 3.32723 .835 -8.3893 6.9559
3-klorometil -.86000 3.32723 .803 -8.5326 6.8126
asetosal .23000 3.32723 .947 -7.4426 7.9026
asetosal Kontrol -.94667 3.32723 .783 -8.6193 6.7259
3-klorometil -1.09000 3.32723 .752 -8.7626 6.5826
4-klorometil -.23000 3.32723 .947 -7.9026 7.4426
Anak_Ginjal Kontrol 3-klorometil .01667 .16195 .921 -.3568 .3901
4-klorometil -.37667* .16195 .048 -.7501 -.0032
asetosal .09333 .16195 .580 -.2801 .4668
3-klorometil Kontrol -.01667 .16195 .921 -.3901 .3568
4-klorometil -.39333* .16195 .041 -.7668 -.0199
asetosal .07667 .16195 .649 -.2968 .4501
4-klorometil Kontrol .37667* .16195 .048 .0032 .7501
3-klorometil .39333* .16195 .041 .0199 .7668
asetosal .47000* .16195 .020 .0965 .8435
asetosal Kontrol -.09333 .16195 .580 -.4668 .2801
3-klorometil -.07667 .16195 .649 -.4501 .2968
4-klorometil -.47000* .16195 .020 -.8435 -.0965
86
Pankreas Kontrol 3-klorometil -.40667 1.63312 .810 -4.1726 3.3593
4-klorometil -.92000 1.63312 .589 -4.6860 2.8460
asetosal .31667 1.63312 .851 -3.4493 4.0826
3-klorometil Kontrol .40667 1.63312 .810 -3.3593 4.1726
4-klorometil -.51333 1.63312 .761 -4.2793 3.2526
asetosal .72333 1.63312 .670 -3.0426 4.4893
4-klorometil Kontrol .92000 1.63312 .589 -2.8460 4.6860
3-klorometil .51333 1.63312 .761 -3.2526 4.2793
asetosal 1.23667 1.63312 .471 -2.5293 5.0026
asetosal Kontrol -.31667 1.63312 .851 -4.0826 3.4493
3-klorometil -.72333 1.63312 .670 -4.4893 3.0426
4-klorometil -1.23667 1.63312 .471 -5.0026 2.5293
Ovarium Kontrol 3-klorometil 1.56333 6.49228 .816 -13.4079 16.5346
4-klorometil 3.90333 6.49228 .564 -11.0679 18.8746
asetosal 6.37000 6.49228 .355 -8.6012 21.3412
3-klorometil Kontrol -1.56333 6.49228 .816 -16.5346 13.4079
4-klorometil 2.34000 6.49228 .728 -12.6312 17.3112
asetosal 4.80667 6.49228 .480 -10.1646 19.7779
4-klorometil Kontrol -3.90333 6.49228 .564 -18.8746 11.0679
3-klorometil -2.34000 6.49228 .728 -17.3112 12.6312
asetosal 2.46667 6.49228 .714 -12.5046 17.4379
asetosal Kontrol -6.37000 6.49228 .355 -21.3412 8.6012
3-klorometil -4.80667 6.49228 .480 -19.7779 10.1646
4-klorometil -2.46667 6.49228 .714 -17.4379 12.5046
*. The mean difference is significant at the 0.05 level.
87
Mencit Jantan Descriptives
N Mean Std.
Deviation Std. Error
95% Confidence Interval for Mean
Minimum Maximum Lower
Bound Upper Bound
Jantung kontrol 3 10.1633 1.18627 .68489 7.2165 13.1102 9.01 11.38
3-klorometil 3 12.8567 .72058 .41603 11.0667 14.6467 12.12 13.56
4-klorometil 3 13.3467 2.26752 1.30915 7.7138 18.9795 11.02 15.55
asetosal 3 11.0800 1.22430 .70685 8.0387 14.1213 9.75 12.16
Total 12 11.8617 1.83911 .53091 10.6931 13.0302 9.01 15.55
Paru kontrol 3 17.7800 .79505 .45902 15.8050 19.7550 16.99 18.58
3-klorometil 3 19.8967 2.50548 1.44654 13.6727 26.1206 17.42 22.43
4-klorometil 3 21.8867 3.35196 1.93525 13.5599 30.2134 18.71 25.39
asetosal 3 17.5167 1.92043 1.10876 12.7461 22.2873 15.62 19.46
Total 12 19.2700 2.71809 .78465 17.5430 20.9970 15.62 25.39
Hati kontrol 3 1.2678E2 16.88919 9.75098 84.8216 168.7317 115.55 146.20
3-klorometil 3 1.9231E2 36.69775 21.18745 101.1444 283.4689 153.00 225.67
4-klorometil 3 1.6338E2 19.68511 11.36520 114.4762 212.2772 147.86 185.52
asetosal 3 1.4212E2 2.81043 1.62260 135.1352 149.0982 138.89 144.03
Total 12 1.5614E2 32.06883 9.25747 135.7686 176.5197 115.55 225.67
Lambung kontrol 3 32.0900 7.79662 4.50138 12.7221 51.4579 23.98 39.53
3-klorometil 3 41.7167 11.25558 6.49841 13.7563 69.6771 32.13 54.11
4-klorometil 3 43.7800 14.23560 8.21893 8.4168 79.1432 33.36 60.00
asetosal 3 44.9533 9.39314 5.42313 21.6195 68.2872 38.31 55.70
Total 12 40.6350 10.72336 3.09557 33.8217 47.4483 23.98 60.00
Ginjal kontrol 3 34.8600 4.48311 2.58833 23.7233 45.9967 31.05 39.80
3-klorometil 3 44.3200 2.77400 1.60157 37.4290 51.2110 41.97 47.38
4-klorometil 3 51.4233 8.26011 4.76898 30.9041 71.9426 42.89 59.38
asetosal 3 35.4600 1.40727 .81249 31.9642 38.9558 34.54 37.08
Total 12 41.5158 8.29563 2.39474 36.2450 46.7866 31.05 59.38
Anak_Ginjal kontrol 3 .1367 .04933 .02848 .0141 .2592 .08 .17
3-klorometil 3 .4967 .00577 .00333 .4823 .5110 .49 .50
4-klorometil 3 .6100 .08718 .05033 .3934 .8266 .55 .71
asetosal 3 .3200 .20421 .11790 -.1873 .8273 .16 .55
Total 12 .3908 .21108 .06093 .2567 .5249 .08 .71
Pankreas kontrol 3 5.7733 2.86121 1.65192 -1.3343 12.8810 3.62 9.02
3-klorometil 3 20.0867 10.14949 5.85981 -5.1261 45.2994 13.70 31.79
88
4-klorometil 3 10.2967 3.65088 2.10784 1.2274 19.3660 7.13 14.29
asetosal 3 5.5533 .50797 .29328 4.2915 6.8152 5.08 6.09
Total 12 10.4275 7.77980 2.24583 5.4845 15.3705 3.62 31.79
Testis kontrol 3 15.3533 2.36500 1.36543 9.4783 21.2283 12.65 17.04
3-klorometil 3 17.1067 .30892 .17836 16.3393 17.8741 16.75 17.29
4-klorometil 3 24.9700 7.66926 4.42785 5.9185 44.0215 16.87 32.12
asetosal 3 18.2867 3.12938 1.80675 10.5129 26.0605 16.45 21.90
Total 12 18.9292 5.28838 1.52662 15.5691 22.2892 12.65 32.12
Vas_Deferens
kontrol 3 4.4133 2.41852 1.39633 -1.5946 10.4213 2.26 7.03
3-klorometil 3 9.9100 1.29881 .74987 6.6836 13.1364 8.43 10.86
4-klorometil 3 12.8333 1.33463 .77055 9.5179 16.1487 11.65 14.28
asetosal 3 6.5167 2.52243 1.45632 .2506 12.7827 4.78 9.41
Total 12 8.4183 3.75961 1.08530 6.0296 10.8071 2.26 14.28
Test of Homogeneity of Variances
Levene Statistic df1 df2 Sig.
Jantung .978 3 8 .450
Paru 1.061 3 8 .418
Hati 2.825 3 8 .107
Lambung .771 3 8 .542
Ginjal 1.893 3 8 .209
Anak_Ginjal 6.375 3 8 .016
Pankreas 7.837 3 8 .009
Testis 3.318 3 8 .078
Vas_Deferens 1.133 3 8 .392
89
ANOVA
Sum of Squares df
Mean Square F Sig.
Jantung Between Groups 20.072 3 6.691 3.124 .088
Within Groups 17.134 8 2.142
Total 37.206 11
Paru Between Groups 37.602 3 12.534 2.296 .154
Within Groups 43.666 8 5.458
Total 81.268 11
Hati Between Groups 7257.769 3 2419.256 4.773 .034
Within Groups 4054.742 8 506.843
Total 11312.511
11
Lambung Between Groups 308.178 3 102.726 .859 .500
Within Groups 956.718 8 119.590
Total 1264.896 11
Ginjal Between Groups 560.985 3 186.995 7.632 .010
Within Groups 196.006 8 24.501
Total 756.992 11
Anak_Ginjal Between Groups .387 3 .129 9.956 .004
Within Groups .104 8 .013
Total .490 11
Pankreas Between Groups 416.206 3 138.735 4.447 .041
Within Groups 249.571 8 31.196
Total 665.778 11
Testis Between Groups 159.038 3 53.013 2.854 .105
Within Groups 148.598 8 18.575
Total 307.636 11
Vas_Deferens Between Groups 124.121 3 41.374 10.555 .004
Within Groups 31.360 8 3.920
Total 155.481 11
90
Multiple Comparisons
LSD
Dependent Variable (I) Kelompok (J) Kelompok
Mean Difference (I-J) Std. Error Sig.
95% Confidence Interval
Lower Bound
Upper Bound
Jantung kontrol 3-klorometil -2.69333 1.19492 .054 -5.4488 .0622
4-klorometil -3.18333* 1.19492 .029 -5.9388 -.4278
asetosal -.91667 1.19492 .465 -3.6722 1.8388
3-klorometil kontrol 2.69333 1.19492 .054 -.0622 5.4488
4-klorometil -.49000 1.19492 .693 -3.2455 2.2655
asetosal 1.77667 1.19492 .175 -.9788 4.5322
4-klorometil kontrol 3.18333* 1.19492 .029 .4278 5.9388
3-klorometil .49000 1.19492 .693 -2.2655 3.2455
asetosal 2.26667 1.19492 .094 -.4888 5.0222
asetosal kontrol .91667 1.19492 .465 -1.8388 3.6722
3-klorometil -1.77667 1.19492 .175 -4.5322 .9788
4-klorometil -2.26667 1.19492 .094 -5.0222 .4888
Paru kontrol 3-klorometil -2.11667 1.90758 .299 -6.5156 2.2822
4-klorometil -4.10667 1.90758 .063 -8.5056 .2922
asetosal .26333 1.90758 .894 -4.1356 4.6622
3-klorometil kontrol 2.11667 1.90758 .299 -2.2822 6.5156
4-klorometil -1.99000 1.90758 .327 -6.3889 2.4089
asetosal 2.38000 1.90758 .247 -2.0189 6.7789
4-klorometil kontrol 4.10667 1.90758 .063 -.2922 8.5056
3-klorometil 1.99000 1.90758 .327 -2.4089 6.3889
asetosal 4.37000 1.90758 .051 -.0289 8.7689
asetosal kontrol -.26333 1.90758 .894 -4.6622 4.1356
3-klorometil -2.38000 1.90758 .247 -6.7789 2.0189
4-klorometil -4.37000 1.90758 .051 -8.7689 .0289
Hati kontrol 3-klorometil -65.53000* 18.38193 .007 -107.9188 -23.1412
4-klorometil -36.60000 18.38193 .082 -78.9888 5.7888
asetosal -15.34000 18.38193 .428 -57.7288 27.0488
3-klorometil kontrol 65.53000* 18.38193 .007 23.1412 107.9188
4-klorometil 28.93000 18.38193 .154 -13.4588 71.3188
asetosal 50.19000* 18.38193 .026 7.8012 92.5788
4-klorometil kontrol 36.60000 18.38193 .082 -5.7888 78.9888
3-klorometil -28.93000 18.38193 .154 -71.3188 13.4588
asetosal 21.26000 18.38193 .281 -21.1288 63.6488
91
asetosal kontrol 15.34000 18.38193 .428 -27.0488 57.7288
3-klorometil -50.19000* 18.38193 .026 -92.5788 -7.8012
4-klorometil -21.26000 18.38193 .281 -63.6488 21.1288
Lambung kontrol 3-klorometil -9.62667 8.92897 .312 -30.2169 10.9636
4-klorometil -11.69000 8.92897 .227 -32.2802 8.9002
asetosal -12.86333 8.92897 .188 -33.4536 7.7269
3-klorometil kontrol 9.62667 8.92897 .312 -10.9636 30.2169
4-klorometil -2.06333 8.92897 .823 -22.6536 18.5269
asetosal -3.23667 8.92897 .726 -23.8269 17.3536
4-klorometil kontrol 11.69000 8.92897 .227 -8.9002 32.2802
3-klorometil 2.06333 8.92897 .823 -18.5269 22.6536
asetosal -1.17333 8.92897 .899 -21.7636 19.4169
asetosal kontrol 12.86333 8.92897 .188 -7.7269 33.4536
3-klorometil 3.23667 8.92897 .726 -17.3536 23.8269
4-klorometil 1.17333 8.92897 .899 -19.4169 21.7636
Ginjal kontrol 3-klorometil -9.46000* 4.04152 .047 -18.7798 -.1402
4-klorometil -16.56333* 4.04152 .003 -25.8831 -7.2436
asetosal -.60000 4.04152 .886 -9.9198 8.7198
3-klorometil kontrol 9.46000* 4.04152 .047 .1402 18.7798
4-klorometil -7.10333 4.04152 .117 -16.4231 2.2164
asetosal 8.86000 4.04152 .060 -.4598 18.1798
4-klorometil kontrol 16.56333* 4.04152 .003 7.2436 25.8831
3-klorometil 7.10333 4.04152 .117 -2.2164 16.4231
asetosal 15.96333* 4.04152 .004 6.6436 25.2831
asetosal kontrol .60000 4.04152 .886 -8.7198 9.9198
3-klorometil -8.86000 4.04152 .060 -18.1798 .4598
4-klorometil -15.96333* 4.04152 .004 -25.2831 -6.6436
Anak_Ginjal kontrol 3-klorometil -.36000* .09289 .005 -.5742 -.1458
4-klorometil -.47333* .09289 .001 -.6875 -.2591
asetosal -.18333 .09289 .084 -.3975 .0309
3-klorometil kontrol .36000* .09289 .005 .1458 .5742
4-klorometil -.11333 .09289 .257 -.3275 .1009
asetosal .17667 .09289 .094 -.0375 .3909
4-klorometil kontrol .47333* .09289 .001 .2591 .6875
3-klorometil .11333 .09289 .257 -.1009 .3275
asetosal .29000* .09289 .014 .0758 .5042
asetosal kontrol .18333 .09289 .084 -.0309 .3975
3-klorometil -.17667 .09289 .094 -.3909 .0375
4-klorometil -.29000* .09289 .014 -.5042 -.0758
92
Pankreas kontrol 3-klorometil -14.31333* 4.56044 .014 -24.8297 -3.7969
4-klorometil -4.52333 4.56044 .350 -15.0397 5.9931
asetosal .22000 4.56044 .963 -10.2964 10.7364
3-klorometil kontrol 14.31333* 4.56044 .014 3.7969 24.8297
4-klorometil 9.79000 4.56044 .064 -.7264 20.3064
asetosal 14.53333* 4.56044 .013 4.0169 25.0497
4-klorometil kontrol 4.52333 4.56044 .350 -5.9931 15.0397
3-klorometil -9.79000 4.56044 .064 -20.3064 .7264
asetosal 4.74333 4.56044 .329 -5.7731 15.2597
asetosal kontrol -.22000 4.56044 .963 -10.7364 10.2964
3-klorometil -14.53333* 4.56044 .013 -25.0497 -4.0169
4-klorometil -4.74333 4.56044 .329 -15.2597 5.7731
Testis kontrol 3-klorometil -1.75333 3.51898 .632 -9.8681 6.3614
4-klorometil -9.61667* 3.51898 .026 -17.7314 -1.5019
asetosal -2.93333 3.51898 .429 -11.0481 5.1814
3-klorometil kontrol 1.75333 3.51898 .632 -6.3614 9.8681
4-klorometil -7.86333 3.51898 .056 -15.9781 .2514
asetosal -1.18000 3.51898 .746 -9.2948 6.9348
4-klorometil kontrol 9.61667* 3.51898 .026 1.5019 17.7314
3-klorometil 7.86333 3.51898 .056 -.2514 15.9781
asetosal 6.68333 3.51898 .094 -1.4314 14.7981
asetosal kontrol 2.93333 3.51898 .429 -5.1814 11.0481
3-klorometil 1.18000 3.51898 .746 -6.9348 9.2948
4-klorometil -6.68333 3.51898 .094 -14.7981 1.4314
Vas_Deferens
kontrol 3-klorometil -5.49667* 1.61658 .009 -9.2245 -1.7688
4-klorometil -8.42000* 1.61658 .001 -12.1478 -4.6922
asetosal -2.10333 1.61658 .229 -5.8312 1.6245
3-klorometil kontrol 5.49667* 1.61658 .009 1.7688 9.2245
4-klorometil -2.92333 1.61658 .108 -6.6512 .8045
asetosal 3.39333 1.61658 .069 -.3345 7.1212
4-klorometil kontrol 8.42000* 1.61658 .001 4.6922 12.1478
3-klorometil 2.92333 1.61658 .108 -.8045 6.6512
asetosal 6.31667* 1.61658 .004 2.5888 10.0445
asetosal kontrol 2.10333 1.61658 .229 -1.6245 5.8312
3-klorometil -3.39333 1.61658 .069 -7.1212 .3345
4-klorometil -6.31667* 1.61658 .004 -10.0445 -2.5888
*. The mean difference is significant at the 0.05 level.
93
LAMPIRAN F
TABEL UJI R
