Lampiran 1. Ethical clearance - core.ac.uk · kalsifikasi intrakranial, ventrikulomegali, atrofi...

69

LAMPIRAN

Lampiran 1. Ethical clearance

70

Lampiran 2. Ijin penelitian

71

Lampiran 3. Informed consent

JUDUL PENELITIAN : HUBUNGAN ABNORMALITAS HASIL CT-SCAN

DENGAN DEVELOPMENTAL DELAYED PADA

PASIEN SUSPEK INFEKSI CYTOMEGALOVIRUS

KONGENITAL

INSTANSI PELAKSANA : FAKULTAS KEDOKTERAN UNIVERSITAS

DIPONEGORO

Persetujuan Setelah Penjelasan

(INFORMED CONSENT)

Bapak/Ibu Yth :

Saya Wilujeng Puja Sari, mahasiswa Fakultas Kedokteran Universitas Diponegoro Semarang,

Program Studi Kedokteran Umum. Saya bermaksud melakukan penelitian mengenai “Hubungan

Abnormalitas Hasil CT-Scan terhadap Developmental Delayed pada Pasien Suspek Infeksi

Cytomegalovirus Kongenital”. Penelitian ini dilakukan sebagai tahap akhir dalam penyelesaian

studi di Fakultas Kedokteran Universitas Diponogoro, Program Studi Kedokteran Umum. Pada

penelitian ini akan dilakukan pengumpulan data pada catatan medis untuk mengetahui apakah

kalsifikasi intrakranial, ventrikulomegali, atrofi cerebri, serta kelianan minor lainnya secara

sendiri-sendiri atau bersama-sama merupakan faktor resiko terjadinya developmental delayed pada

pasien suspek infeksi CMV kongenital. Peneliti akan menjaga kerahasiaan identitas dan informasi

yang diberikan dan hanya digunakan untuk kepentingan penelitian.

Terima kasih atas kerjasama Bapak/Ibu/Sdr.

Setelah mendengar dan memahami penjelasan Penelitian, dengan ini saya menyatakan

SETUJU / TIDAK SETUJU

Untuk ikut sebagai responden / sampel penelitian.

Semarang,

Saksi : Nama Terang :

Nama Terang : Alamat :

Alamat :

72

Lampiran 4. Hasil Analisis

Frequencies

Jenis Kelamin

Frequency Percent Valid Percent

Cumulative

Percent

Valid Laki-laki 20 71.4 71.4 71.4

Perempuan 8 28.6 28.6 100.0

Total 28 100.0 100.0

Descriptives

Descriptive Statistics

N Minimum Maximum Mean Std. Deviation

Usia (bulan) 28 1 59 15.36 15.404

Valid N (listwise) 28

FREQUENCIES VARIABLES=AbnormalitasCTScan

/PIECHART FREQ

/ORDER=ANALYSIS.

N Valid 28

Missing 0

73

Frequencies

Statistics

Abnormalitas CT Scan

N Valid 28

Missing 0

Abnormalitas CT Scan


Cumulative

Percent

Valid Ya 22 78.6 78.6 78.6

Tidak 6 21.4 21.4 100.0

Total 28 100.0 100.0

FREQUENCIES VARIABLES=Kalsifikasi Ventrikulomegali AtrofiCerebri KelMinorLain

/PIECHART FREQ

/ORDER=ANALYSIS.

Frequencies

Statistics

Kalsifikasi

Intracranial Ventrikulomegali Atrofi Cerebri

Kelainan Minor

Lainnya

N Valid 28 28 28 28

Missing 0 0 0 0

74

Frequency Table

Kalsifikasi Intracranial


Cumulative

Percent

Valid Ya 7 25.0 25.0 25.0

Tidak 21 75.0 75.0 100.0

Total 28 100.0 100.0

Ventrikulomegali


Cumulative

Percent

Valid Ya 5 17.9 17.9 17.9

Tidak 23 82.1 82.1 100.0

Total 28 100.0 100.0

Atrofi Cerebri


Cumulative

Percent

Valid Ya 10 35.7 35.7 35.7

Tidak 18 64.3 64.3 100.0

Total 28 100.0 100.0

Kelainan Minor Lainnya


Cumulative

Percent

Valid Ya 16 57.1 57.1 57.1

Tidak 12 42.9 42.9 100.0

Total 28 100.0 100.0

75

Pie Chart

FREQUENCIES VARIABLES=Developmentaldelayed

/PIECHART FREQ

/ORDER=ANALYSIS.

Frequencies

Statistics

Developmental Delayed

N Valid 28

Missing 0

76



Cumulative

Percent

Valid Ya 21 75.0 75.0 75.0

Tidak 7 25.0 25.0 100.0

Total 28 100.0 100.0

CROSSTABS

/TABLES=AbnormalitasCTScan BY Developmentaldelayed

/FORMAT=AVALUE TABLES

/STATISTICS=CHISQ RISK

/CELLS=COUNT ROW

/COUNT ROUND CELL.

Crosstabs

Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent

Abnormalitas CT Scan *


28 100.0% 0 .0% 28 100.0%

77

Abnormalitas CT Scan * Developmental Delayed Crosstabulation


Total Ya Tidak

Abnormalitas CT Scan Ya Count 20 2 22

% within Abnormalitas CT

Scan

90.9% 9.1% 100.0%

Tidak Count 1 5 6


Scan

16.7% 83.3% 100.0%

Total Count 21 7 28


Scan

75.0% 25.0% 100.0%

Chi-Square Tests

Value df

Asymp. Sig. (2-

sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)

Pearson Chi-Square 13.859a 1 .000

Continuity Correctionb 10.182 1 .001

Likelihood Ratio 12.680 1 .000

Fisher's Exact Test .001 .001

Linear-by-Linear

Association

13.364 1 .000

N of Valid Cases 28

a. 2 cells (50,0%) have expected count less than 5. The minimum expected count is 1,50.

b. Computed only for a 2x2 table

Risk Estimate

Value

95% Confidence Interval

Lower Upper

Odds Ratio for Abnormalitas CT

Scan (Ya / Tidak)

50.000 3.741 668.350

For cohort Developmental

Delayed = Ya

5.455 .907 32.803


Delayed = Tidak

.109 .028 .429

N of Valid Cases 28

78

CROSSTABS

/TABLES=Kalsifikasi BY Developmentaldelayed



/CELLS=COUNT ROW

/COUNT ROUND CELL.

Crosstabs


Cases

Valid Missing Total


Kalsifikasi Intracranial *


28 100.0% 0 .0% 28 100.0%

Kalsifikasi Intracranial * Developmental Delayed Crosstabulation


Total Ya Tidak

Kalsifikasi Intracranial Ya Count 7 0 7

% within Kalsifikasi

Intracranial

100.0% .0% 100.0%

Tidak Count 14 7 21


Intracranial

66.7% 33.3% 100.0%

Total Count 21 7 28


Intracranial

75.0% 25.0% 100.0%

Chi-Square Tests

Value df

Asymp. Sig. (2-

sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)





Linear-by-Linear

Association

3.000 1 .083

N of Valid Cases 28

79



CROSSTABS

/TABLES=Ventrikulomegali BY Developmentaldelayed



/CELLS=COUNT ROW

/COUNT ROUND CELL

Crosstabs


Cases

Valid Missing Total


Ventrikulomegali *


28 100.0% 0 .0% 28 100.0%

Ventrikulomegali * Developmental Delayed Crosstabulation


Total Ya Tidak

Ventrikulomegali Ya Count 5 0 5

% within Ventrikulomegali 100.0% .0% 100.0%

Tidak Count 16 7 23

% within Ventrikulomegali 69.6% 30.4% 100.0%

Total Count 21 7 28

% within Ventrikulomegali 75.0% 25.0% 100.0%

Risk Estimate

Value


Lower Upper


Delayed = Ya

1.500 1.109 2.030

N of Valid Cases 28

80

Chi-Square Tests

Value df

Asymp. Sig. (2-

sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)


Continuity Correctionb .730 1 .393



Linear-by-Linear

Association

1.957 1 .162

N of Valid Cases 28



Risk Estimate

Value


Lower Upper


Delayed = Ya

1.438 1.097 1.884

N of Valid Cases 28

CROSSTABS

/TABLES=AtrofiCerebri BY Developmentaldelayed



/CELLS=COUNT ROW

/COUNT ROUND CELL.

Crosstabs


Cases

Valid Missing Total


Atrofi Cerebri *


28 100.0% 0 .0% 28 100.0%

81

Atrofi Cerebri * Developmental Delayed Crosstabulation


Total Ya Tidak

Atrofi Cerebri Ya Count 10 0 10

% within Atrofi Cerebri 100.0% .0% 100.0%

Tidak Count 11 7 18

% within Atrofi Cerebri 61.1% 38.9% 100.0%

Total Count 21 7 28

% within Atrofi Cerebri 75.0% 25.0% 100.0%

Chi-Square Tests

Value df

Asymp. Sig. (2-

sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)





Linear-by-Linear

Association

5.000 1 .025

N of Valid Cases 28



Risk Estimate

Value


Lower Upper


Delayed = Ya

1.636 1.132 2.366

N of Valid Cases 28

CROSSTABS

/TABLES=KelMinorLain BY Developmentaldelayed



/CELLS=COUNT ROW

/COUNT ROUND CELL.

82

Crosstabs


Cases

Valid Missing Total


Kelainan Minor Lainnya *


28 100.0% 0 .0% 28 100.0%

Kelainan Minor Lainnya * Developmental Delayed Crosstabulation


Total Ya Tidak

Kelainan Minor Lainnya Ya Count 14 2 16

% within Kelainan Minor

Lainnya

87.5% 12.5% 100.0%

Tidak Count 7 5 12


Lainnya

58.3% 41.7% 100.0%

Total Count 21 7 28


Lainnya

75.0% 25.0% 100.0%

Chi-Square Tests

Value df

Asymp. Sig. (2-

sided)

Exact Sig. (2-

sided)

Exact Sig. (1-

sided)





Linear-by-Linear Association 3.000 1 .083

N of Valid Cases 28



83

Risk Estimate

Value


Lower Upper

Odds Ratio for Kelainan Minor

Lainnya (Ya / Tidak)

5.000 .767 32.574


Delayed = Ya

1.500 .898 2.505


Delayed = Tidak

.300 .070 1.291

N of Valid Cases 28

Logistic Regression

LOGISTIC REGRESSION VARIABLES Developmentaldelayed

/METHOD=ENTER Kalsifikasi AtrofiCerebri KelMinorLain

/PRINT=CI(95)

/CRITERIA=PIN(0.05) POUT(0.10) ITERATE(20) CUT(0.5).

Block 1: Method = Backward Stepwise (Wald)

Omnibus Tests of Model Coefficients

Chi-square df Sig.

Step 1 Step 11.898 3 .008

Block 11.898 3 .008

Model 11.898 3 .008

Step 2a Step -5.259 1 .022

Block 6.639 2 .036

Model 6.639 2 .036

Step 3a Step -4.875 1 .027

Block 1.763 1 .184

Model 1.763 1 .184

Step 4a Step -1.763 1 .184

Step 5 Step 6.182 1 .013

Block 6.182 1 .013

Model 6.182 1 .013

a. A negative Chi-squares value indicates that the Chi-squares value

has decreased from the previous step.

84

Model Summary

Step -2 Log likelihood

Cox & Snell R

Square

Nagelkerke R

Square

1 17.199a .346 .536

2 22.458a .211 .327

3 27.333b .061 .094

4 29.096c .000 .000

5 22.915a .198 .307

a. Estimation terminated at iteration number 20 because maximum

iterations has been reached. Final solution cannot be found.

b. Estimation terminated at iteration number 5 because parameter

estimates changed by less than .001.

c. Estimation terminated at iteration number 4 because parameter

estimates changed by less than .001.

Classification Tablea

Observed

Predicted


Percentage Correct

Ya Tidak

Step 1 Developmental Delayed Ya 19 3 86.4

Tidak 2 4 66.7

Overall Percentage 82.1


Tidak 6 0 .0



Tidak 6 0 .0



Tidak 6 0 .0



Tidak 6 0 .0


a. The cut value is .500

85

Variables in the Equationc

B S.E. Wald df Sig. Exp(B)

95% C.I.for

EXP(B)

Lower Upper

Step

1a

Kalsifikasi 20.666 13741.842 .000 1 .999 944191775.979 .000 .

AtrofiCerebri 20.492 11832.343 .000 1 .999 793357780.263 .000 .

KelMinorLain .981 1.155 .722 1 .396 2.667 .277 25.636

Constant -

83.989 36268.028 .000 1 .998 .000

Step

2a

AtrofiCerebri 20.274 12629.568 .000 1 .999 638024225.546 .000 .

KelMinorLain .693 1.041 .443 1 .505 2.000 .260 15.381

Constant -

42.340 25259.137 .000 1 .999 .000

Step

3a

KelMinorLain 1.253 .973 1.658 1 .198 3.500 .520 23.559

Constant -3.199 1.631 3.845 1 .050 .041

Step

4a

Constant -1.299 .461 7.958 1 .005 .273

Step

5b

AtrofiCerebri 20.510 12710.151 .000 1 .999 807737459.492 .000 .

Constant -

41.713 25420.301 .000 1 .999 .000

a. Variable(s) entered on step 1: Kalsifikasi, AtrofiCerebri, KelMinorLain.

b. Variable(s) entered on step 5: AtrofiCerebri.

c. Stepwise procedure stopped because removing the least significant variable results in a previously fitted

model.

86

Variables not in the Equation

Score df Sig.

Step 2a Variables Kalsifikasi 3.680 1 .055

Overall Statistics 3.680 1 .055

Step 3b Variables Kalsifikasi 2.717 1 .099

AtrofiCerebri 3.438 1 .064


Step 4c Variables Kalsifikasi 2.545 1 .111


KelMinorLain 1.768 1 .184


Step 5c Variables Kalsifikasi 3.462 1 .063

KelMinorLain .450 1 .502


a. Variable(s) removed on step 2: Kalsifikasi.

b. Variable(s) removed on step 3: AtrofiCerebri.

c. Variable(s) removed on step 4: KelMinorLain.

Score df Sig.

Step 0 Variables Kalsifikasi 3.111 1 .078

KelMinorLain .778 1 .378



87

Lampiran 5. Biodata

Identitas

Nama : Wilujeng Puja Sari

NIM : 22010110110042

Tempat / tanggal lahir : Samarinda / 30 Agustus 1992

Jenis Kelamin : Perempuan

Alamat : Jalan Panglima Batur Gg. 2 No. 31 Samarinda

Nomor HP : 085742470742

e-mail : [email protected]

Riwayat Pendidikan Formal

1. SD : SD Negeri 004 Samarinda Lulus tahun : 2004

2. SMP : SMP Negeri 1 Samarinda Lulus tahun : 2007

3. SMA : SMA Negeri 1 Samarinda Lulus tahun : 2010

4. Pendidikan Dokter – Fak. Kedokteran UNDIP Masuk tahun : 2010

mailto:[email protected]

88

Keanggotaan Organisasi

1. RISET - BEM KU FK UNDIP Tahun 2010 s/d 2011

2. RISET - HIMA KU UNDIP Tahun 2011 s/d 2012

3. PROJECT AFFAIR - HIMA KU UNDIP Tahun 2012 s/d 2013

4. MER-C SEMARANG Tahun 2013 s/d sekarang

Lampiran 1. Ethical clearance - core.ac.uk · kalsifikasi intrakranial, ventrikulomegali, atrofi...

Documents

Transcript of Lampiran 1. Ethical clearance - core.ac.uk · kalsifikasi intrakranial, ventrikulomegali, atrofi...