Jurnal Radiologi IndonesiaINDONESIAN JOURNAL OF RADIOLOGY

Oiterbitkan oleh:

PERHIMPUNAN DOKTER SPESIALIS RAOIOLOGI INDONESIA(POSRI)

SUSUNAN REDAKSI

Penasehat (Advisor) :Ketua Perhimpunan Dokter Speslalis Radlologi Indonesia

Kewa Koleglum Radiologl Indonesia

Ketua Penyunting (Chief Editor) :Prof. dr, Arif Faisal, Sp.Rad(K) DHSM

Dewan Penyunting (Associate Editors) :Dr. dr, Una Choridah, Sp.Rad(K)

Dr. dr. Anggraini Owi S, 5p.Rad(K)Dr. dr. Yuyun Yueniwati, Sp.Rad(K)

Dr. dr, Elysanti Dwi Martadiani, Sp.RadDr. dr, Hermina Sukmaningtyas, M.Kes, Sp.Rad

dr, Yana Supnatna, Ph.D, Sp.Rad

Mitra Bebestari (Peer Review) :Prof. Dr. dr, Rista D. Soellkno, Sp.Rad(K), M.Kes

Prof. Or. dr. Bachtiar Murtala, Sp.Rad(K)Prof. Dr. dr. Muhammad lIyas, Sp.Rad(K)Prof. Shoichi 0 Takekawa - Fukushima

Dr. dr. Prijo Sidipratomo, Sp.Rad(K)Dr. dr. Aliza G. Icksan, Sp.Rad(K)

Brigjen TNI dr. Terawan Agus Putranto, Sp.Rad(K)dr. Bambang Budyatmoko, Sp.Rad(K)

dr. Sri Andreani Utomo, Sp.Rad(K)dr.Kardinah, Sp.Rad(K)

Bendahara (Finance) :dr. Vonny N Tubagus, Sp.Rad(K)

Sirkulasi dan Distribusi (Circulation and Distribution) :dr. Amri Wicaksono Pribadi

dr, Nurhuda Hendra Setyawandr. Noor Hadi

Satria Destyawan, STAziz Ardi Nugraha, 5T

Rekening Jurnal Radlologi IndonesiaBank Mandlri Cab. RSCM

a.n. Perhimpunan Dokter 5pesialis Radiologi Indonesia No. 1220005641173

Alamat RedaksiPerhimpunan Dokter 5pesialls Radiologi Indonesiad/a Bagian Radiologi FK UGM / RSUP Dr. Sardjito

JI. Kesehatan No.1., Sekip, Yogyakarta 55281.Telp/Fax: 0274·631037

email: jurnalradiologiindonesia@gmail.com

Jumal Radiologi lndonesla diterbitkan 3 kai dalam setat-un (Mei, Se,xerroer, Januari) oleh Perhirrpunan Dokter SpesiaisRaddogi Indoresia (PDSRI).JumaJ Radologi Inoonesia memuat karangan asfi yarg berhwun~n dergan Radologi dan lmejirg, dalam bentvk hasil

perelitian tinjauan pustaka, gagasan, opini, resensi seta bentuk bentuk karargan dalam aspek keilmuan dan penelitian.Karargan yarg dimuat merjadi targgung jiM'Clb pergarang dan tidak pertu rrencerminkan pendapat Penasehat, Penyuntirg,maupun Mitra Sebestari.

PERBANDINGAN PENYANGATAN SENYAWA PENGONTRASNANO PARTIKEL EMAS DENDRIMER POLY(AMIDOAMINE)KONSENTRASI DAN DELAY TIME BERBEDA PADA HEPAR

TIKUS DENGAN PEMERIKSAAN COMPUTED TOMOGRAPHY

Indrarini t.lstyowat!', Rista D. Soetiknc-, Leni Santiana!

'Peserta Program Pendidikan Spesialis I (PPDS)Program Studi Radiologi, FK UnpadlRSUP dr. Hasan Sadikin BandunglGuru Besar DepartemenlSMF Radiologi FK UnpadlRSUP dr.Hasan Sadikin Bandung

'Star Pengajar DepartemenlSMF Radiologi FK UnpadlRSUP dr.Hasan Sadikin Bandung

Enhancement Comparison of Dendrimer Poly (Amidoamin) Nano-ParticleContrast Agent with Different Concentration and Delay Time in the Rat Liver

using Computed Tomography

ABSTRACT

Background: Computed tomography (CT) is one of the diagnostic imaging tool that Is most commonly available In hospitalstoday. But unlike Magnetic Resonance Imaging (MRI) and nuclear medicine Imaging modalities, CT has not been considered as amolecular imaging modality because It does not have a specific-targeted contrast agents. Diagnostic quality of CT scans can beimproved by using specific-targeted contrast agents. Gold nanoparticles (AuNPs) can be used as X-ray contrast agents that canovercome some of the limitations of the iodine-based contrast agents. Higher atomic numbers than iodine and its ability to be ableto bind to the dendrimer support that AuNPScould be developed asa specific-targeted contrast agents.

Objective.s: The purpose of this study was to determine the enhancement relationship of AuNPs-Poly(amido)amine in the rat liverwith different concentration and delay time on CT scans.

Materials and Methods: This research is an experimental study with a statistical analysis to determine enhancement differenceson rat liver given AuNPs-PAMAM with different concentration and delay time. The samples were divided into 4 groups, eachconsisting of 6 rats, The independent variables in this study were the delay time and the concentration of AuNPs-PAMAM, thedependent variables was the enhancement on rat liver.

Results: The results obtained showed that the average value enhancement of AuNPs-PAMAM is highest in 10 minutes delay timeat a concentration of 1 mg/dL Statistical analysis showed that there were significant differences between AuNPs·PAMAMcontrastenhancement in the rat liver with different concentration and delay time on CT scan with p-value lessthan alpha (0.000 <0.05).

Conclusions: Concentration and delay time contribute to the average value enhancement of AuNPs-PAMAM contrast agent on CTscan. This new type of contrast agent can be further developed asa more specific-targeted contrast agent for CTscan examination.

Keywords: Gold Nano Particles, Pattern of Enhancement, CT scan

JURNAL RADIOLOGIINDONESIA IVolume 1 Nomor 3, Jenueri 2016 131