DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi...

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1 DAFTAR PUSTAKA 1. Indonesia Society of Intensive Care Unit. [cited 2012 Sept 23]. Available from http://www.perdici.org/ 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen Farmakologi dan Terapeutik FKUI, 2009: 804-810 3. Adi Satrio. Pengaruh pemberian heparin subkutan dan heparin intravena sebagai profilaksis thrombosis vena dalam (TVD) terhadap PTT/K dan jumlah trombosit pada pasien di ICU RSUP DR. Kariadi Semarang. 2013. [cited 2013 February 28]. Available from eprints.undip.ac.id/ 4. Sam Schulman. Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment American College of Chest Physicians Evidence Based Clinical Practice Guidelines (8th Edition). (CHEST 2008; 133:257S298S). [cited 2012 Sept 29]. Available from http://publications.chestnet.org 5. Maureen A Smythe. Use of the Activated Partial Thromboplastin Time for Heparin Monitoring. (Am J Clin Pathol 2001;115:148-155). [cited 2013 February 28]. Available from http://ajcp.ascpjournals.org 6. Syed Reza. Assessment of Bleeding Risk in Patients on Antiplatelet and Anticoagulant Therapy. 2012. [cited 2013 February 28]. Available from http://www.priory.com/medicine/bleeding_risk.htm 7. Ridzky Djanuar. Perbandingan pemberian heparin intravena dan subkutan terhadap kadar PPT dan PTTK pada pencegahan Deep Vein Thrombosis. . 2012. [cited 2013 Jun 28]. Available from eprints.undip.ac.id/ brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by Diponegoro University Institutional Repository

Transcript of DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi...

Page 1: DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

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DAFTAR PUSTAKA

1. Indonesia Society of Intensive Care Unit. [cited 2012 Sept 23]. Available

from http://www.perdici.org/

2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan,

Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

Farmakologi dan Terapeutik FKUI, 2009: 804-810

3. Adi Satrio. Pengaruh pemberian heparin subkutan dan heparin intravena

sebagai profilaksis thrombosis vena dalam (TVD) terhadap PTT/K dan

jumlah trombosit pada pasien di ICU RSUP DR. Kariadi Semarang. 2013.

[cited 2013 February 28]. Available from eprints.undip.ac.id/

4. Sam Schulman. Hemorrhagic Complications of Anticoagulant and

Thrombolytic Treatment American College of Chest Physicians Evidence

Based Clinical Practice Guidelines (8th Edition). (CHEST 2008;

133:257S–298S). [cited 2012 Sept 29]. Available from

http://publications.chestnet.org

5. Maureen A Smythe. Use of the Activated Partial Thromboplastin Time for

Heparin Monitoring. (Am J Clin Pathol 2001;115:148-155). [cited 2013

February 28]. Available from http://ajcp.ascpjournals.org

6. Syed Reza. Assessment of Bleeding Risk in Patients on Antiplatelet and

Anticoagulant Therapy. 2012. [cited 2013 February 28]. Available from

http://www.priory.com/medicine/bleeding_risk.htm

7. Ridzky Djanuar. Perbandingan pemberian heparin intravena dan subkutan

terhadap kadar PPT dan PTTK pada pencegahan Deep Vein Thrombosis. .

2012. [cited 2013 Jun 28]. Available from eprints.undip.ac.id/

brought to you by COREView metadata, citation and similar papers at core.ac.uk

provided by Diponegoro University Institutional Repository

Page 2: DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

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8. Riskiawan Angga. Pengaruh pemberian heparin intravena sebagai

profilaksis Deep Vein Thrombosis terhadap nilai PPT dan PTTK. 2012.

[cited 2013 Jun 28]. Available from eprints.undip.ac.id/

9. Jack Hirsh, Theodore E. Warkentin, et al. Heparin and Low-Molecular-

Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing,

Monitoring, Efficacy, and Safety (CHEST 2004; 126:188S–20). [cited

2012 Sept 28]. Available from http://publications.chestnet.org

10. Jack Hirsh, Kenneth A. Bauer, et al. Parenteral Anticoagulants. American

College of Chest Physicians Evidence-Based Clinical Practice Guidelines

(8th Edition) (CHEST 2008; 133:141S–159S). [cited 2012 Sept 28].

Available from http://publications.chestnet.org

11. Levitan N, Dowlati A, et al. Rates of initial and recurrent thromboembolic

disease among patients with malignancy versus those without malignancy.

Risk analysis using Medicare claims data. 1999 (Sep);78(5):285–91. [cited

2013 May 28]. Available from www.ncbi.nlm.nih.gov/pubmed/10499070

12. Goitom Hagos, M.D. Lower Extremity Deep Vein Thrombosis among

Intensive Care Patients in Orotta, National Referral Hospital, Asmara,

Eritrea, JEMA; 2008. ) [cited 2013 May 28]. Available from

www.ajol.info/index.php/jema/.../40736

13. Michael K Gould. LMWH compare with UHF for treatment of Deep

Acute Vein Thrombosis – A cost effectiveness analysis. (Ann Intern

Med.2001;130:789-799). [cited 2012 Sept 26]. Available from

http://publications.chestnet.org

14. Theodore E. Warkentin. Prevalence and Risk of Preexisting Heparin-

Induced Thrombocytopenia Antibodies in Patients With Acute VTE.

(CHEST 2011; 140(2):366–373). [cited 2012 Sept 30]. Available from

http://publications.chestnet.org

15. Gennari C, Martini G. Secondary osteoporosis. 10(3):214-24 1998 Jun.

Institut of Medical Pathology, University of Siena, Italy. [cited 2012 oct

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1]. [cited 2012 Sept 28]. Available from

http://www.ncbi.nlm.nih.gov/pubmed

16. M.R. Caballeroand M. Allergy to heparin: A new vitrodiagnostic

technique. Allergy and Immunopathology 2003;31(6):324-8. Departament

Allergy and Immunology, Faculty of Medicine, University de Navarra,

Pamplona. Spain. [cited 2012 Oct 1]. [cited 2012 Sept 28]. Available from

http://www.ncbi.nlm.nih.gov/pubmed

17. Ronald, Reagan. Anticoagulant Management Program and Guidelines.

UCLA Medical Center. 2008. [cited 2012 Sept 28]. Available from

http://medres.med.ucla.edu/guidelines

18. Peterson D, Harward S, Lawson J.H. Anticoagulation strategies for

venous thromboembolism. Perspect Vasc Surg Endovasc Ther 2009;

21;125. ) [cited 2012 Sept 28]. Available from

http://www.ncbi.nlm.nih.gov/pubmed

19. Suharti C. Dasar-DasarHemostasis.Dalam :Aru W Sundarudkk. (editor)

Buku Ajar Ilmu Penyakit Dalam.Edisi keempat.Jakarta. Pusat Penerbitan

Departemen Ilmu Penyakit Dalam. Edisi keempat. Jakarta. Pusat

Penerbitan Departemen Ilmu Penyakit Dalam FKUI.2006

20. Wijanda Hidajati S. Stabilitas sampel plasma sitrat selama penyimpanan

untuk pemeriksaan APTT dan PT. (Dept Patologi Klinik 2012).[cited 2013

February 28]. Available from http://penelitian.unair.ac.id/artikel_dosen

21. Kitchen S. Prothrombine time and INR. 2010. [cited 2013 Jun 28].

Available from http://pathology.vcu.edu/clinical/coag/PT%20INR.Pdf

22. Roger S. Riley. Activated Partial Thromboplastin Time (APTT). April

2005. [cited 2013 February 28]. Available from http://pathology.vcu.edu

23. Agnelli G, Caprini JA. The Prophylaxis of Venous Thrombosis in Patients

with Cancer Undergoing Major Abdominal Surgery: emerging options. J

Surg Oncol 2007;96:265-272. [cited 2013 February 28]. Available from

http://ncbi.nlm.nih.gov/pubmed/17474075

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24. Gottfried EL and Adachi MM, "Prothrombin Time and Activated Partial

Thromboplastin Time Can Be Performed on the First Tube,"Am J Clin

Pathol, 1997, 107(6):681-3. [cited 2013 Jun 28]. Available from

http://ncbi.nlm.nih.gov/pubmed/9169665

25. Sukrisman L. Trombosis Vena Dalam dan Emboli Paru dalam Ilmu

Penyakit Dalam. Penerbit FKUI. Jakarta, 2006; 802-03

26. William H. Geerts. Prevention of Venous Thromboembolism. (CHEST

2008; 133:381S–453S). [cited 2013 July 2]. Available from

http://publications.chestnet.org

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Page 6: DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

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No Register Diagnosis JK Usia L.R BB Rute Jenis

1 C264762 Post CABG Wanita 59 6 49 IV UHF

2 C272181 Post OP DVR Laki-laki 24 7 65 IV UHF

3 C285953 Post Laparatomi Laki-laki 52 7 75 IV UHF

4 C276475 Post Histerektomi Wanita 46 5 53 IV UHF

5 C283471 Post Laparatomi Laki-laki 71 4 50 IV UHF

6 C283444 Post Laparatomi Wanita 28 7 70 IV UHF

7 C277275 Post OP DVR Wanita 17 4 37 IV UHF

8 C072726 Post Craniotomi Wanita 52 4 50 IV UHF

9 C284326 Post Laparatomi Wanita 23 7 50 IV UHF

10 C263161 Post OP URS Laki-laki 61 6 80 IV UHF

11 C273627 Post TPM Laki-laki 70 4 60 IV UHF

12 C284590

Post Fiksasi

Interna Laki-laki 50 5 45 IV UHF

13 C287341 Post Thoracotomi Laki-laki 29 6 70 IV UHF

14 C274874 Post Laparatomi Wanita 46 4 50 IV UHF

15 C285394 Post Craniotomi Wanita 31 5 45 IV UHF

16 C279894 Post Laparatomi Wanita 47 6 50 IV UHF

17 C282255 Post Thoracotomi Laki-laki 63 4 50 IV UHF

18 C278454 Post CABG Laki-laki 53 4 65 IV UHF

19 C222772

Post OP Kista

Ovarii Wanita 43 4 50 IV UHF

20 C264314

Post OP Tumor

Ovarii Wanita 41 7 40 IV UHF

21 C279975 Post Thoracotomi Laki-laki 44 4 65 IV UHF

22 C295047 Post Sectio Wanita 18 4 45 IV UHF

23 C285953 Post Laparatomi Laki-laki 52 7 50 IV UHF

24 C273019

Post

Oovaringektomi Wanita 50 7 65 IV UHF

25 C288064 Post Sectio Wanita 35 7 45 IV UHF

26 C293794 Post Histerektomi Wanita 15 5 50 IV UHF

27 C292436 Post Laparatomi Wanita 70 5 65 IV UHF

28 C291327 Post Laparatomi Wanita 48 6 50 IV UHF

29 C257977 Post CABG Wanita 44 7 70 IV UHF

30 B003309 Post EGD Biopsi Laki-laki 68 7 50 IV UHF

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L.H Dosis skor sebelum skor sesudah

PTo PTc APTTo APTTc PT1 PTc APTT1 APTTc

6 500 13.7 13.7 38.9 31.9 13.9 13.3 44.6 31.9

7 500 18.1 13.7 42 32.3 19 14.4 45.4 31.9

4 500 14.8 13.6 39.5 31.5 13.3 13.4 37.1 31.5

5 500 15.2 14.1 41.2 31.8 16.3 14 40.1 31.9

4 500 15.6 14.5 35.1 32.5 14.9 14.5 41.5 32.5

7 500 16.7 10.6 40.5 34.9 18.3 10.6 39 35

4 500 17.8 13.8 45.2 32.6 17.3 13.8 43.5 32.6

4 500 10.6 10.9 43.2 33.3 10.8 10.6 45.6 34.1

7 500 13.9 14.5 40.7 32.5 15.7 10.2 43.1 33.5

6 500 15.9 14.5 42.3 31.8 17 14.4 47.1 32

4 500 15.4 13.1 41.8 31.7 18.3 13.4 43.8 32.1

5 500 18.1 14.5 39.5 32.5 21.2 14.5 41.3 32.5

6 500 11.7 11.2 37.6 33.2 15 12.5 40.4 33.2

4 500 15.2 13.7 40.3 29 15 13.7 38.6 29

5 500 10.7 10.5 37.6 30.5 13.8 14.1 36.8 29.3

4 500 15.3 14.1 40.7 31.4 14.2 14.1 41.5 29.8

4 500 14.5 13.8 38.6 29.5 14.1 14.3 39.6 29.3

5 500 16.5 13.7 38.1 29 15.8 10.9 40.3 34.1

4 500 13 11.3 35.1 31.4 12 14 34.4 33.8

5 500 15.5 13.7 32.7 29 14.2 10.8 37.4 31.6

4 500 14.2 13.7 40.1 29 14 13.7 37.1 29

4 500 10 11.6 40.9 34.6 13 11.6 39.1 34.5

5 500 14.3 14.4 41.7 30.3 16.5 14.4 45.1 30.3

7 500 13.2 12.6 37.4 34 14 12.5 41.9 33.8

7 500 11.9 11 39.2 32 13.5 10.9 38.9 31.5

5 500 13.4 14.4 36 30.3 13.8 10.1 38.3 32

5 500 14.2 12.9 37.5 34 14 13 41 33.5

6 500 14.4 13.9 33.1 29.3 14.2 11.6 36.2 35

7 500 15.4 14 38.2 29.4 17 14.3 38.4 29.4

10 500 14.2 13.9 39.9 32.5 14.1 13.9 41.4 32.5

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skor sebelum keluar ICU

PTx PTc APTTx APTTc

17.9 14.1 47.4 31.7

21.1 12.1 53 31.7

16.1 13.7 39.7 32.3

18.5 13.8 43.8 31.6

16.9 14.3 45.8 32.5

20.4 10.7 44.4 37.2

18 10.9 46.3 33.9

10.5 10.7 43.1 33.9

18 10.1 46.4 34.2

19.2 14.5 51 31.9

17.9 13.2 51.6 31.9

24.6 10.1 43 32.2

15.1 12.1 42 33.2

15.1 13.8 44 29.3

20.3 14.2 38.7 29.3

19 13.8 40.7 29.5

13.1 19.4 42 34.4

15.2 11 44.4 34

11.9 11 39.5 33.4

18.9 11.2 46.3 33.8

13.5 13.8 40.2 29

17.1 11.5 39 34.5

19 13.7 49.5 29.8

18.4 12.5 44 33.4

18 11.2 46 31.3

19.7 13.7 48.2 29.8

18.5 13.5 43.9 32.7

19.2 10.5 42.6 34.5

19.2 14 40.8 29.6

21.5 10.4 47.6 35.1

PTo

PT sebelum mendapat heparin

APTTo APPT sebelum mendapat heparin

PT1 PT sesudah mendapat heparin

APTT1 APTT sesudah mendapat heparin

PTx PT sebelum keluar ICU

APTTx APTT sebelum keluar ICU

PTc PT kontrol

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Output SPSS

Descriptives

14.4467 .37758

13.6744

15.2189

14.4796

14.4500

4.277

2.06810

10.00

18.10

8.10

2.18

-.322 .427

.027 .833

39.1533 .52016

38.0895

40.2172

39.2056

39.5000

8.117

2.84905

32.70

45.20

12.50

3.40

-.434 .427

.301 .833

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquartile Range

Skewness

Kurtosis

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquartile Range

Skewness

Kurtosis

PT sebelum

menerima Heparin

APTT sebelum

menerima Heparin

Stat istic Std. Error

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Descriptives

15.1400 .40174

14.3184

15.9616

15.0630

14.2000

4.842

2.20041

10.80

21.20

10.40

2.75

.768 .427

.881 .833

40.6167 .57358

39.4436

41.7898

40.5963

40.3500

9.870

3.14161

34.40

47.10

12.70

4.83

.223 .427

-.564 .833

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquartile Range

Skewness

Kurtosis

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquartile Range

Skewness

Kurtosis

PT setelah

menerima Heparin

APTT setelah

menerima Heparin

Stat istic Std. Error

Page 12: DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

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Descriptives

17.7267 .53920

16.6239

18.8294

17.7778

18.2000

8.722

2.95331

10.50

24.60

14.10

3.33

-.473 .427

.843 .833

44.4967 .69140

43.0826

45.9107

44.3667

44.0000

14.341

3.78695

38.70

53.00

14.30

4.95

.461 .427

-.323 .833

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquart ile Range

Skewness

Kurtosis

Mean

Lower Bound

Upper Bound

95% Conf idence

Interv al for Mean

5% Trimmed Mean

Median

Variance

Std. Dev iat ion

Minimum

Maximum

Range

Interquart ile Range

Skewness

Kurtosis

PT sebelum

pasien keluar ICU

APTT sebelum

pasien keluar ICU

Stat istic Std. Error

Page 13: DAFTAR PUSTAKA - CORE · 2019. 2. 14. · 2. Dewoto, H.R, et al. Buku Farmakologi dan Terapi edisi 5 : Antikoagulan, Antitrombotik, Trombolitik dan Hemostatik. Jakarta: Departemen

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Tests of Normality

.119 30 .200* .962 30 .352

.102 30 .200* .974 30 .648

.199 30 .004 .939 30 .085

.089 30 .200* .980 30 .822

.190 30 .007 .952 30 .190

.110 30 .200* .965 30 .417

PT sebelum

menerima Heparin

APTT sebelum

menerima Heparin

PT setelah

menerima Heparin

APTT setelah

menerima Heparin

PT sebelum

pasien keluar ICU

APTT sebelum

pasien keluar ICU

Stat ist ic df Sig. Stat ist ic df Sig.

Kolmogorov-Smirnova

Shapiro-Wilk

This is a lower bound of the true signif icance.*.

Lillief ors Signif icance Correctiona.

Paired Samples Statistics

14.4467 30 2.06810 .37758

15.1400 30 2.20041 .40174

PT sebelum

menerima Heparin

PT setelah

menerima Heparin

Pair

1

Mean N Std. Dev iat ion

Std. Error

Mean

Paired Samples Test

-.69333 1.44650 .26409 -1.23347 -.15320 -2.625 29 .014

PT sebelum menerima

Heparin - PT setelah

menerima Heparin

Pair

1

Mean Std. Dev iation

Std. Error

Mean Lower Upper

95% Conf idence

Interv al of the

Dif f erence

Paired Dif f erences

t df Sig. (2-tailed)

Paired Samples Statistics

15.1400 30 2.20041 .40174

17.7267 30 2.95331 .53920

PT setelah

menerima Heparin

PT sebelum

pasien keluar ICU

Pair

1

Mean N Std. Dev iat ion

Std. Error

Mean

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Paired Samples Test

-2.58667 2.30856 .42148 -3.44870 -1.72463 -6.137 29 .000

PT setelah menerima

Heparin - PT sebelum

pasien keluar ICU

Pair

1

Mean Std. Dev iat ion

Std. Error

Mean Lower Upper

95% Conf idence

Interv al of the

Dif f erence

Paired Dif f erences

t df Sig. (2-tailed)

Paired Samples Statistics

39.1533 30 2.84905 .52016

40.6167 30 3.14161 .57358

APTT sebelum

menerima Heparin

APTT setelah

menerima Heparin

Pair

1

Mean N Std. Dev iat ion

Std. Error

Mean

Paired Samples Test

-1.46333 2.55079 .46571 -2.41581 -.51085 -3.142 29 .004

APTT sebelum menerima

Heparin - APTT setelah

menerima Heparin

Pair

1

Mean Std. Dev iat ion

Std. Error

Mean Lower Upper

95% Conf idence

Interv al of the

Dif f erence

Paired Dif f erences

t df Sig. (2-tailed)

Paired Samples Statistics

40.6167 30 3.14161 .57358

44.4967 30 3.78695 .69140

APTT setelah

menerima Heparin

APTT sebelum

pasien keluar ICU

Pair

1

Mean N Std. Dev iat ion

Std. Error

Mean

Paired Samples Test

-3.88000 2.78622 .50869 -4.92039 -2.83961 -7.627 29 .000

APTT setelah menerima

Heparin - APTT sebelum

pasien keluar ICU

Pair

1

Mean Std. Dev iat ion

Std. Error

Mean Lower Upper

95% Conf idence

Interv al of the

Dif f erence

Paired Dif f erences

t df Sig. (2-tailed)

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