Apoptosis AAM

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Cell Death

description

APOPTOSIS

Transcript of Apoptosis AAM

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Cell Death

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Definisi Cell Death

• Kegagalan sel untuk memelihara fungsi utamanya.

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Cell death

• Apoptosis• Autofagi• Necrosis

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Definisi Apoptosis• Apoptosis atau kematian cell terprogram,

adalah suatu komponen normal

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1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239–257

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744427/)2. jkh

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Apoptosis

• Apoptosis is accompanied by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes (in vivo). 1

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• manifesting several among these morphological features.

• It is worth noting that it is not correct to assume that ‘programmed cell death’ (PCD)

• It occurs during physiological development,

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http://www.ncbi.nlm.nih.gov/books/NBK26873/

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• The cell shrinks and condenses. The cytoskeleton collapses, the nuclear envelopedisassembles, and the nuclear DNA breaks up into fragments.

• Most importantly, the cell surface is altered, displaying properties that cause the dying cell to be rapidly phagocytosed, either by a neighboring cell or by amacrophage (a specialized phagocytic cell, discussed in Chapter 24), before any leakage of its contents occurs (Figure 17-37).