an Dan Nilai Ic50
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ANTIOKSIDAN DAN NILAI IC 50 DARI BERBAGAI TURUNAN HIDROKSIKALKON Struktur Senyawa IC 50 (1x10 -5 M) Metode No Mr = 224 g/mol 9% (5x10 -3 M) (2) 100,08 ppm DPPH 1 a Mr = 224 g/mol 500 (1) 1120 ppm DPPH 2 a Mr = 224 g/mol 1% (5x10 -3 M) (2) 11,2 ppm DPPH 3 a Mr = 240 g/mol 7% (5x10 -3 M) (2) 84 ppm DPPH 4 a Mr = 256 g/mol 5.0 (1) 12,8 ppm DPPH 5 a Mr = 256 g/mol 11% (5x10 -3 M) (2) 28,16 ppm DPPH 6 a Mr = 272 g/mol 2.7 (1) 7,34 ppm DPPH 7 a Mr = 272 g/mol 100.0 (1) 272 ppm DPPH 8 a
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Transcript of an Dan Nilai Ic50
ANTIOKSIDAN DAN NILAI IC50
DARI BERBAGAI TURUNAN HIDROKSIKALKONStruktur Senyawa IC50 (1x10-5 M) Metode No
Mr = 224 g/mol
9% (5x10-3 M) (2)
100,08 ppmDPPH 1a
Mr = 224 g/mol
500 (1)
1120 ppmDPPH 2a
Mr = 224 g/mol
1% (5x10-3 M) (2)
11,2 ppmDPPH 3a
Mr = 240 g/mol
7% (5x10-3 M) (2)
84 ppmDPPH 4a
Mr = 256 g/mol
5.0 (1)
12,8 ppm DPPH 5a
Mr = 256 g/mol
11% (5x10-3 M) (2)
28,16 ppm DPPH 6a
Mr = 272 g/mol
2.7 (1)
7,34 ppmDPPH 7a
Mr = 272 g/mol
100.0 (1)
272 ppm DPPH 8a
Mr = 288 g/mol
3.1 (1)
8,93 ppm DPPH 9a
Mr = 286 g/mol
13.0 (1)
37,18 ppm DPPH 10a
a) David Kozlowski, Patrick Trouillas, Claude Calliste, Philippe Marsal, Roberto Lazzaroni, and Jean-Luc Duroux, Density Functional Theory Study of the Conformational, Electronic, and Antioxidant Properties of Natural Chalcones J. Phys. Chem. A 2007, 111, 1138-1145
1. IC50 represents the chalcone concentration required to reduce the DPPH electron spin resonance (ESR) signal by 50%. Standard deviations are <10%.
2. Values given in brackets represent the inhibition percentage at 5x10 -3 M for compounds with IC50
>500.0 x 10-5
96.38(µg/mL) DPPH 11b
107(µg/mL) DPPH 12b
88.41(µg/mL) DPPH 13b
86.70(µg/mL) DPPH 14b
96.24(µg/mL) DPPH 15b
a) Belsare D .P., Pal S.C.,Kazi A .A., Kankate R.S.,Vanjari S.S, Evaluation of Antioxidant Activity of Chalcones and Flavonoids, International Journal of ChemTech Research, 2010, Vol.2, No.2, pp 1080-1089
